162 research outputs found
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
- Author
- A Eslamboli
- A Reich
- A Sandebring
- A Sandebring
- A Voigt
- A Wood-Kaczmar
- A. Kathrin Lutz
- Aaron Voigt
- AB Singleton
- AH Schapira
- AHV Schapira
- AK Lutz
- AM Cuervo
- Andrea Reinartz
- B Panaretou
- Björn Falkenburger
- C Lo Bianco
- CD Marsden
- CN Im
- DD Song
- DP Karpinar
- E Costantino
- EH Norris
- Ellen Gerhardt
- EM Valente
- Erin K. Butler
- F Bayersdorfer
- F Kamp
- F Xiang
- FJ Lee
- G Du
- G Hua
- G Liu
- G Patki
- H BĂŒeler
- H Snyder
- Harry T. Orr
- HH Liou
- I Leav
- J Bilen
- J Chen
- J Fuchs
- JA Botella
- Jane P. Toegel
- JM Shulman
- JW Pridgeon
- Jörg B. Schulz
- KA Conway
- KF Winklhofer
- KJ Livak
- KM Semchuk
- KM Strauss
- Konstanze F. Winklhofer
- L Devi
- L Novikova
- L Petrucelli
- L Stefanis
- LJ Hsu
- LJ Martin
- M Farrer
- M Lakso
- M Martinez-Vicente
- M Takahashi
- M Vila
- MB Feany
- MC Chartier-Harlin
- ME Gegg
- MG Spillantini
- MJ Volles
- MM Muqit
- MS Parihar
- MS Parihar
- N Exner
- N Montesano Gesualdi
- NM Gesualdi
- Peter Karsten
- PK Auluck
- PM Abou-Sleiman
- PM Keeney
- R Mayeux
- R Shaltiel-Karyo
- RK Dagda
- S Costello
- S Hwang
- S Shavali
- S Singh
- T Kitada
- TJ van Ham
- V Loeb
- VA Morais
- WD Parker Jr
- WS Choi
- WW Li
- WW Smith
- Y Masuda
- Y Mizuno
- Y Tanaka
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2012
- Field of study
Overexpression or mutation of α-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function. We used a whole-genome screen in the fruit fly Drosophila melanogaster to search for novel genetic modifiers of human [A53T]α-Synucleinâinduced neurotoxicity. Decreased expression of the mitochondrial chaperone protein tumor necrosis factor receptor associated protein-1 (TRAP1) was found to enhance age-dependent loss of fly head dopamine (DA) and DA neuron number resulting from [A53T]α-Synuclein expression. In addition, decreased TRAP1 expression in [A53T]α-Synucleinâexpressing flies resulted in enhanced loss of climbing ability and sensitivity to oxidative stress. Overexpression of human TRAP1 was able to rescue these phenotypes. Similarly, human TRAP1 overexpression in rat primary cortical neurons rescued [A53T]α-Synucleinâinduced sensitivity to rotenone treatment. In human (non)neuronal cell lines, small interfering RNA directed against TRAP1 enhanced [A53T]α-Synucleinâinduced sensitivity to oxidative stress treatment. [A53T]α-Synuclein directly interfered with mitochondrial function, as its expression reduced Complex I activity in HEK293 cells. These effects were blocked by TRAP1 overexpression. Moreover, TRAP1 was able to prevent alteration in mitochondrial morphology caused by [A53T]α-Synuclein overexpression in human SH-SY5Y cells. These results indicate that [A53T]α-Synuclein toxicity is intimately connected to mitochondrial dysfunction and that toxicity reduction in fly and rat primary neurons and human cell lines can be achieved using overexpression of the mitochondrial chaperone TRAP1. Interestingly, TRAP1 has previously been shown to be phosphorylated by the serine/threonine kinase PINK1, thus providing a potential link of PINK1 via TRAP1 to α-Synuclein
Supplementary material from "The biogeography of community assembly: latitude and predation drive variation in community trait distribution in a guild of epifaunal crustaceans"
- Author
- Boström Christoffer
- Boyer Katharyn
- Cusson Mathieu
- Duffy Emmett
- Eklöf Johan
- Engelen Aschwin H.
- Eriksson Britas Klemens
- Fodrie Fredrick Joel
- Griffin John N.
- Gross Collin P.
- Hereu Clara M.
- Hori Masakazu
- Hovel Kevin
- Hughes A. Randall
- Ivanov Mikhail V.
- Jorgensen Pablo
- Kardish Melissa R.
- Kruschel Claudia
- Lee Kun-Seop
- Lefcheck Jonathan
- McGlathery Karen J.
- Moksnes Per-Olav
- Nakaoka Masahiro
- O'Connor Mary
- O'Connor Nessa E.
- Olsen Jeanine
- Orth Robert J.
- Peterson Bradley J.
- Reiss Henning
- Reynolds Pamela L.
- Rossi Francesca
- Ruesink Jennifer
- Sotka Erik E.
- Stachowicz J. J.
- Thormar Jonas
- TomĂ s Fiona
- Unsworth Richard
- Voigt Erin
- Whalen Matthew A.
- Ziegler Shelby
- Publication venue
- Figshare
- Publication date
- 09/02/2022
- Field of study
While considerable evidence exists of biogeographic patterns in the intensity of species interactions, the influence of these patterns on variation in community structure is less clear. Studying how the distributions of traits in communities vary along global gradients can inform how variation in interactions and other factors contribute to the process of community assembly. Using a model selection approach on measures of trait dispersion in crustaceans associated with eelgrass (Zostera marina) spanning 30° of latitude in two oceans, we found that dispersion strongly increased with increasing predation and decreasing latitude. Ocean and epiphyte load appeared as secondary predictors; Pacific communities were more overdispersed while Atlantic communities were more clustered, and increasing epiphytes were associated with increased clustering. By examining how species interactions and environmental filters influence community structure across biogeographic regions, we demonstrate how both latitudinal variation in species interactions and historical contingency shape these responses. Community trait distributions have implications for ecosystem stability and functioning, and integrating large-scale observations of environmental filters, species interactions and traits can help us predict how communities may respond to environmental change.This research was funded by National Science Foundation grants to J.E.D., J.J.S. and K.A.H. (NSF-OCE 1336206, OCE 1336905, and OCE 1336741). C.B. was funded by the Ă
bo Akademi University Foundation.Peer reviewe
QF2011: a protocol to study the effects of the Queensland flood on pregnant women, their pregnancies, and their children's early development
- Author
- A Brunet
- A Catalani
- A Charil
- A Charil
- A Forti
- A Hayashi
- A Kapoor
- A Morawska
- A Rodriguez
- A Rodriguez
- AC Huizink
- AC McFarlane
- AD Anastopolous
- AH Barton
- AL Fowden
- Alain Brunet
- Anne-Marie Turcotte-Tremblay
- BL Green
- BL Green
- BR Bergh Van den
- BR Sarason
- Brett M McDermott
- C Braehler
- C Kirschbaum
- C Obel
- CA Smith
- Cathy Vaillancourt
- CD Spielberger
- CJ Rash
- CLM Keyes
- CR Marmar
- CS Carver
- D Bricker
- D Couret
- D Couret
- D Wechsler
- David P Laplante
- DJ Barker
- DJ Barker
- DJ Walder
- DJ Walder
- DK Kinney
- DK Kinney
- DP Bernstein
- DP Bernstein
- DP Laplante
- DP Laplante
- DP Laplante
- DS Weiss
- E Bromet
- E Oken
- EA Shirtcliff
- EB Schwartz
- EL Quarantelli
- Elizabeth M Hurrion
- Erin Yong Ping
- F Oberklaid
- F Veru
- Gabrielle Simcock
- GC Gleser
- GE Lash
- GP Chrousos
- GW Brown
- H David McIntyre
- HE Nelson
- Helen Stapleton
- HM Wellman
- IG Sarason
- IG Sarason
- J Os van
- J Perner
- J Wacker
- JL Cox
- JL Cox
- JL Hudson
- JR Crawford
- JR Crawford
- JR Crawford
- K Alderman
- K Bergman
- K-A Grant
- K-A Grant
- KA Egliston
- KE Beery
- Kelsey N Dancause
- KI Pargament
- KN Dancause
- KN Dancause
- KN Dancause
- L Cao-Lei
- L Cao-Lei
- L Fenson
- L Fenson
- L Katz
- LAM Welberg
- Laura Shoo
- LM Dunn
- LR Turner
- LS Radloff
- M Asher
- M Boudou
- M Campbell
- M Creamer
- M Fukuda
- M Korkman
- M Peterka
- M Prior
- M Voigt
- M Weinstock
- M Weinstock
- M Weinstock
- M-E Mathieu
- MA Easterbrooks
- Marie-Paule Austin
- Mark Harris
- MF Lechat
- Michael W OâHara
- MJ Briggs-Gowan
- MM Antony
- MO Huttenen
- MR Gunnar
- MR Sanders
- MT Tu
- N Asukai
- N Bayley
- Nicole Reilly
- NM Talge
- Norbert Schmitz
- P Craig
- P Ellwood
- P Pall
- Paul A Dawson
- PF Lovibond
- Q Schiermeier
- R Bolin
- R Gitau
- R Norton
- RE O'Carroll
- RL Brock
- RR Abidin
- RS Lazarus
- RS Lazarus
- RS Lazarus
- S Avishai-Eliner
- S Baron-Cohen
- S Cohen
- S Entringer
- S Folkman
- S Goldstein
- S King
- S King
- S King
- S Tracy
- SA Mednick
- Sally K Tracy
- SH Spence
- SK Tracy
- SL Clemens
- SM Wyatt
- Sue Kildea
- Sue Kruske
- Suzanne King
- T Achenbach
- T Field
- T Kawamura
- T Paus
- T Ventura
- TG O'Connor
- TG O'Connor
- TJ D'Zurilla
- TM Mayhew
- V Glover
- V Glover
- Vanessa E Cobham
- W Mischel
- X Cao
- Z Biringen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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Precise interpolar phasing of abrupt climate change during the last ice age
- Author
- Adrian Betty
- Ahn Jinho
- Albert Mary
- Alley Richard B.
- Baggenstos Daniel
- Bauska Thomas K.
- Bay Ryan C.
- Bencivengo Brian B.
- Bentley Charles R.
- Brook Edward J.
- Buizert Christo
- Chellman Nathan J.
- Clow Gary D.
- Cole-Dai Jihong
- Conway Howard
- Cravens Eric
- Cuffey Kurt M.
- Dunbar Nelia W.
- Edwards Jon S.
- Fegyveresi John M.
- Ferris Dave G.
- Fitzpatrick Joan J.
- Fudge T. J.
- Gibson Chris J.
- Gkinis Vasileios
- Goetz Joshua J.
- Gregory Stephanie
- Hargreaves Geoffrey M.
- Iverson Nels
- Johnson Jay A.
- Jones Tyler R.
- Kalk Michael L.
- Kippenhan Matthew J.
- Koffman Bess G.
- Kreutz Karl
- Kuhl Tanner W.
- Lebar Donald A.
- Lee James E.
- Marcott Shaun A.
- Markle Bradley R.
- Maselli Olivia J.
- McConnell Joseph R.
- McGwire Kenneth C.
- Mitchell Logan E.
- Mortensen Nicolai B.
- Neff Peter D.
- Nishiizumi Kunihiko
- Nunn Richard M.
- Orsi Anais J.
- Pasteris Daniel R.
- Pedro Joel B.
- Pettit Erin C.
- Price P. Buford
- Priscu John C.
- Rhodes Rachael H.
- Rosen Julia L.
- Schauer Andrew J.
- Schoenemann Spruce W.
- Sendelbach Paul J.
- Severinghaus Jeffrey P.
- Shturmakov Alexander J.
- Sigl Michael
- Slawny Kristina R.
- Souney Joseph M.
- Sowers Todd A.
- Spencer Matthew K.
- Steig Eric J.
- Taylor Kendrick C.
- Twickler Mark S.
- Vaughn Bruce H.
- Voigt Donald E.
- Waddington Edwin D.
- Welten Kees C.
- Wendricks Anthony W.
- White James W. C.
- Winstrup Mai
- Wong Gifford J.
- Woodruff Thomas E.
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
The last glacial period exhibited abrupt DansgaardâOeschger climatic oscillations, evidence of which is preserved in a variety of Northern Hemisphere palaeoclimate archivesÂč. Ice cores show that Antarctica cooled during the warm phases of the Greenland DansgaardâOeschger cycle and vice versa[superscript 2,3], suggesting an interhemispheric redistribution of heat through a mechanism called the bipolar seesaw[superscript 4â6]. Variations in the Atlantic meridional overturning circulation (AMOC) strength are thought to have been important, but much uncertainty remains regarding the dynamics and trigger of these abrupt events[superscript 7â9]. Key information is contained in the relative phasing of hemispheric climate variations, yet the large, poorly constrained difference between gas age and ice age and the relatively low resolution of methane records from Antarctic ice cores have so far precluded methane-based synchronization at the required sub-centennial precision[superscript 2,3,10]. Here we use a recently drilled high-accumulation Antarctic ice core to show that, on average, abrupt Greenland warming leads the corresponding Antarctic cooling onset by 218 ± 92 years (2Ï) for DansgaardâOeschger events, including the BĂžlling event; Greenland cooling leads the corresponding onset of Antarctic warming by 208 ± 96 years. Our results demonstrate a north-to-south directionality of the abrupt climatic signal, which is propagated to the Southern Hemisphere high latitudes by oceanic rather than atmospheric processes. The similar interpolar phasing of warming and cooling transitions suggests that the transfer time of the climatic signal is independent of the AMOC background state. Our findings confirm a central role for ocean circulation in the bipolar seesaw and provide clear criteria for assessing hypotheses and model simulations of DansgaardâOeschger dynamics
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belardinelli Daniele
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- Benedetto V.
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- Bera Sayantani
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- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
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- enea romano antonio
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- Erasmo Peña Arellano Fabiån
- Errico Luciano
- error error
- error error
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- Estevez Dimitri
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- felicetti riccardo
- Fenyvesi Edit
- Ferguson Deborah
- ferraiuolo sarah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Figura PrzemysĆaw
- Fiori Alessio
- Fiori Irene
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- FIUMARA VINCENZO.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Foley E. M.
- Fong H.
- Fornal Bartosz
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- Virtuoso Andrea
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
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- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
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- Barton Mark Andrew
- Bartos I.
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- De Laurentis Martina
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- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
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- Depasse Antoine
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- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
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- Dietrich Tim
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- Duval Hannah
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- Eddolls Graeme
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- Effler Anamaria
- Eichholz Johannes
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- Eisenmann M.
- Eisenstein R. A.
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- Eka Setyawati Yoshinta
- Elizabeth Ramirez Guevara Karla
- Engelby E.
- Engl A. J.
- Erasmo Peña Arellano Fabiån
- Errico L.
- error error
- error error
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- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans C. R.
- Evans Matthew J.
- Evans T. M.
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- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fair H.
- Fairhurst Stephen
- Fan Pinchen
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- Fauchon-Jones E. J.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Feicht J.
- Fejer M. M.
- Fenyvesi Edit
- Ferguson Deborah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Fritschel P.
- Frolov V. V.
- Fujii S.
- Fukunaga I.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Gais J.
- Galaudage S.
- Gallardo S.
- Gamba Rossella
- Ganapathy Dhruva
- Ganguly Apratim
- Gaonkar S. G.
- Garaventa Barbara
- Garcia-Bellido Juan
- GarcĂa QuirĂłs Cecilio
- GarcĂa-NĂșñez C.
- Gardner James W.
- Gardner K. A.
- Gargiulo J.
- Garufi Fabio
- Gasbarra Claudio
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- Gayathri V.
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- Grado Aniello
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- GRANATA VERONICA.
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- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
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- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Armato F.
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- Aronson Scott
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- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
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- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
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- Baillie Kenneth
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- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
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- Bamford Amy
- Bamford Peter
- Banach Dorota
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- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
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- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
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- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
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- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
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- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
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- Bergin Colin
- Berry Lindsay R.
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- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
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- Bradley Paul
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- Cherian Shiney
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- Couillard-ChĂ©nard Ămilie
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- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
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- Dawson Laura Ann
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- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
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- De Neef Mark
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- Degracia Anna
- del Sorbo Lorenzo
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- del Prado Michael
- Demetriou Carrie
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- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
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- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
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- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
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- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
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- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
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- Faulkner Beverley
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- Felton Tim
- Fennessy Gerard
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- Ferguson Susan
- Fergusson Dean
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- Fernando Gloria
- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
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- Fierens Jan
- Finch Cheryl
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- Foulds Angela
- Fowler Rob
- Fowler Robert
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- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
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- Frise Matthew
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- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
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- Garcia Sara
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- Garot Denis
- Garrard Hywel
- Garrard William
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- Ghaffari Mehrdad
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- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
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- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
- Glister Georgina
- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
- GrauNovellas Neus
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- Gresham Rebecca
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- Grieve Richard
- Grimm Patrick
- Grimmer Lisa
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- Gross Jamie
- GrĂŒnewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
- Gupta Abhinav
- Gurung Anita
- Guérin Emmanuelle
- GĂłmez Francisco
- Göpel Siri
- Habeichi Wadih
- Habraken Hannah
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- Haiba Khalid
- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
- Hanisch Alexis
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- Hansen Dan
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- Harden Lesley
- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
- Hassan Noor
- Hausermann Marie-Helene
- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
- Hayes Leanne
- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
- Henning Jeremy
- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
- Holbrook Catherine
- Holland Andrew
- Holland Nicky
- Holland Susan
- Hollos Laszlo
- Homes Jennifer
- Honda Hitoshi
- Hope David
- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
- Hussain Sajid
- Hutchinson Christina
- Hutton Paula
- HĂŒning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
- Isgro Graziella
- Isguzar Agah
- Ishani Pramodya
- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
- Jackson Susan
- Jacob Reni
- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
- Jennings Stacey
- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
- Jindai Kazuaki
- John Maya
- Johns Magaret
- Johnson David
- Johnson Paul
- Johnson Rebekah
- Johnson Toby
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- Jones Andrea
- Jones Cathy
- Jones Dawn
- Jones Emily
- Jones Jessica
- Jones Samantha
- Jongebloed Katherine
- Joseph Sibet
- Joseph Treesa
- Joyce Kirsten
- Juffermans Nicole
- Juhaz Vera
- Kadam Umesh
- Kalamar ?iga
- Kalchko-Veyssal Selver
- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
- Kamel Toufik
- Kampschreur Linda
- Kamra Maneesha
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- Kannan Santhana
- Kannan Thogulava
- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kassir Sandy
- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
- Kaye Callum
- Kazi Aayesha
- KC Shirish
- KC Shirsh
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- Keatley Claire
- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
- Keijzer-Timmers Nicole
- Kell Kay
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- Kelly Niamh
- Kelsall Olivia
- Kendrick Sara
- Kernan Maeve
- Kerslake Ian
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- Khan Meherunnisa
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- Khare Divya
- Khoso Nasir
- Khoud Ahmed
- Khwaja Kosar
- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirk Jill
- Kirk Rosemary
- Kirkby Amy
- Kirkham Simon
- Kit Barbara
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- Kittridge Lauren
- Klein Daniela
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- Kluge Stefan
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
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- Kolanos Steffi
- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
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- Kunz Kevin
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- Kutsogiannis Demetrios
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- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lambert Bridget
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- Lampro Lamprini
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- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
- Limb James
- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
- Lockett Teresa
- Logan Meg
- Lomme Kaatje
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- Luitel Subekshya
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- LĂłpez Rafael
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- MacKay Lynn
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- Maharjan Mili
- Maharjan Radhika
- Maharjan Sabi
- Maiden Matthew
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- Malakouti Salim
- Male Michelle
- Malfroy Sylvain
- Mali Sharmila
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- Marin-Corral Judith
- Marin?ek Martin
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- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
- Martin Jane
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- Martin Timothy
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- Masse Marie-Helene
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- Mathew Meghena
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- Matthews Julie
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- Mayangao Irving
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- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
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- McCracken Phoebe
- McCreary Erin
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- McCullagh Iain
- McCullagh Liz
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- McCullough James
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- McEldrew Ben
- McEldrew Rebecca
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- McGloughlin Steve
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
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- Mckeon Laurie
- Mclaughlan Danielle
- McMaster Moyra
- McMillan Alexandra
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- McMillan Helen
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- McNamara Amanda
- McNamara Robert
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- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Meziani Ferhat
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- Vaara Suvi
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- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
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- van der Eng Hetty
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- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
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- Vignesh C
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- Watpool Irene
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- Webb Steve A.
- Weber Lisa
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- Wetzold Richard
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- Wilby Elizabeth
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- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
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- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
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- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Seawater carbonate chemistry and calcification rate of eastern oyster Crassostrea virginica, 2011
- Publication venue
- PANGAEA
- Publication date
- 10/03/2011
- Field of study
Anthropogenic carbon dioxide (CO2) emissions reduce pH of marine waters due to the absorption of atmospheric CO2 and formation of carbonic acid. Estuarine waters are more susceptible to acidification because they are subject to multiple acid sources and are less buffered than marine waters. Consequently, estuarine shell forming species may experience acidification sooner than marine species although the tolerance of estuarine calcifiers to pH changes is poorly understood. We analyzed 23 years of Chesapeake Bay water quality monitoring data and found that daytime average pH significantly decreased across polyhaline waters although pH has not significantly changed across mesohaline waters. In some tributaries that once supported large oyster populations, pH is increasing. Current average conditions within some tributaries however correspond to values that we found in laboratory studies to reduce oyster biocalcification rates or resulted in net shell dissolution. Calcification rates of juvenile eastern oysters, Crassostrea virginica, were measured in laboratory studies in a three-way factorial design with 3 pH levels, two salinities, and two temperatures. Biocalcification declined significantly with a reduction of ~0.5 pH units and higher temperature and salinity mitigated the decrease in biocalcification
The Mitochondrial Chaperone Protein TRAP1 Mitigates alpha-Synuclein Toxicity
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
- âŠ