Exploring Fatigue in Inflammatory Bowel Disease Patients

Abstract Fatigue is a common phenomenon in IBD patients, which contributes significantly to the burden of the disease. The pathophysiology of IBD-related fatigue is considered multifactorial, but at present the underlying mechanisms are largely unknown. Based on the literature and the data presented in this thesis, we propose a multifactorial conceptual model in which both somatic and psychological factors are accounted for fatigue

Dynamic testing of gifted and average-ability children's analogy problem solving: Does executive functioning play a role?

Article / Letter to editorInstituut Psychologie;Instituut Psychologie;Instituut Psychologie;Instituut Psychologi

Dynamic testing of gifted and average-ability children's analogy problem solving: Does executive functioning play a role?

Article / Letter to editorInstituut Psychologie;Instituut Psychologie;Instituut Psychologie;Instituut Psychologi

Dynamic testing of gifted and average-ability children's analogy problem solving: Does executive functioning play a role?

status: publishe

Dynamic testing of gifted and average-ability children's analogy problem solving: Does executive functioning play a role?

Article / Letter to editorInstituut Psychologie;Instituut Psychologie;Instituut Psychologie;Instituut Psychologi

Constraining ^(26)Al+p resonances using ^(26)Al(^3He,d)^(27)Si

The ^(26)Al(^3He,d)^(27)Si reaction was measured from 0°≤θ_(c.m.)≤35° at E(^3He)=20 MeV using a quadrupole-dipole-dipole-dipole magnetic spectrometer. States in ^(27)Si were observed above the background at 7652 and 7741 keV and upper limits were set for the state at 7592 keV. Implications for the ^(26)Al(p,γ)^(27)Si stellar reaction rate are discussed

Drop impact upon micro- and nanostructured superhydrophobic surfaces

We experimentally investigate drop impact dynamics onto different superhydrophobic surfaces, consisting of regular polymeric micropatterns and rough carbon nanofibers, with similar static contact angles. The main control parameters are the Weber number \We and the roughness of the surface. At small \We, i.e. small impact velocity, the impact evolutions are similar for both types of substrates, exhibiting Fakir state, complete bouncing, partial rebouncing, trapping of an air bubble, jetting, and sticky vibrating water balls. At large \We, splashing impacts emerge forming several satellite droplets, which are more pronounced for the multiscale rough carbon nanofiber jungles. The results imply that the multiscale surface roughness at nanoscale plays a minor role in the impact events for small \We \apprle 120 but an important one for large \We \apprge 120. Finally, we find the effect of ambient air pressure to be negligible in the explored parameter regime \We \apprle 150Comment: 8 pages, 7 figure

Guideline versus non-guideline based management of rectal cancer in octogenarians

The number of octogenarians with rectal adenocarcinoma is growing. Current guidelines seem difficult to apply on octogenarians which may result in non-adherence. The aim of this retrospective cohort study is to give insight in occurrence of treatment-related complications, hospitalisations and survival among octogenarians treated according to guidelines versus octogenarians treated otherwise. 108 octogenarians with rectal adenocarcinoma were identified by screening of medical records. 22 patients were excluded for treatment process analysis because of stage IV disease or unknown stage. Baseline characteristics, diagnostic process, received treatment, motivation for deviation from guidelines, complications, hospitalisations and date of death were documented. Patients were divided in two groups depending on adherence to treatment guidelines. Differences in baseline characteristics, treatment-related complications and survival between both groups were evaluated. Diagnosis and treatment according to guidelines occurred in 95 and 54% of the patients, respectively. When documented, patient's preference and comorbidities were major reasons to deviate from guidelines. 66% of patients who were treated according to guidelines experienced complications versus 34% of those treated otherwise (p = 0.02). After adjustment for differences in age and polypharmacy, this association was not significant. Patients treated according to the guideline had better survival 18 months after diagnosis (80 versus 56%, p = 0.02). Treating octogenarians with rectal cancer according to guidelines seem to lead to better overall survival, but may lead to a high risk of complications. This may jeopardise quality of life. More and prospective studies in octogenarians with rectal cancer are needed to customize guidelines for these patients

A Fractal Analysis of the HI Emission from the Large Magellanic Cloud

A composite map of HI in the LMC using the ATCA interferometer and the Parkes multibeam telescope was analyzed in several ways in an attempt to characterize the structure of the neutral gas and to find an origin for it. Fourier transform power spectra in 1D, 2D, and in the azimuthal direction were found to be approximate power laws over 2 decades in length. Delta-variance methods also showed the same power-law structure. Detailed models of these data were made using line-of-sight integrals over fractals that are analogous to those generated by simulations of turbulence with and without phase transitions. The results suggested a way to measure directly for the first time the line-of-sight thickness of the cool component of the HI disk of a nearly face-on galaxy. The signature of this thickness was found to be present in all of the measured power spectra. The character of the HI structure in the LMC was also viewed by comparing positive and negative images of the integrated emission. The geometric structure of the high-emission regions was found to be filamentary, whereas the geometric structure of the low-emission (intercloud) regions was found to be patchy and round. This result suggests that compressive events formed the high-emission regions, and expansion events, whether from explosions or turbulence, formed the low-emission regions. The character of the structure was also investigated as a function of scale using unsharp masks. All of these results suggest that most of the ISM in the LMC is fractal, presumably the result of pervasive turbulence, self-gravity, and self-similar stirring.Comment: 30 pages, 21 figures, scheduled for ApJ Vol 548n1, Feb 10, 200

A Test of the Standard Hypothesis for the Origin of the HI Holes in Holmberg II

The nearby irregular galaxy Holmberg II has been extensively mapped in HI using the Very Large Array (VLA), revealing intricate structure in its interstellar gas component (Puche et al. 1992). An analysis of these structures shows the neutral gas to contain a number of expanding HI holes. The formation of the HI holes has been attributed to multiple supernova events occurring within wind-blown shells around young, massive star clusters, with as many as 10-200 supernovae required to produce many of the holes. From the sizes and expansion velocities of the holes, Puche et al. assigned ages of ~10^7 to 10^8 years. If the supernova scenario for the formation of the HI holes is correct, it implies the existence of star clusters with a substantial population of late-B, A and F main sequence stars at the centers of the holes. Many of these clusters should be detectable in deep ground-based CCD images of the galaxy. In order to test the supernova hypothesis for the formation of the HI holes, we have obtained and analyzed deep broad-band BVR and narrow-band H-alpha images of Ho II. We compare the optical and HI data and search for evidence of the expected star clusters in and around the HI holes. We also use the HI data to constrain models of the expected remnant stellar population. We show that in several of the holes the observed upper limits for the remnant cluster brightness are strongly inconsistent with the SNe hypothesis described in Puche et al. Moreover, many of the HI holes are located in regions of very low optical surface brightness which show no indication of recent star formation. Here we present our findings and explore possible alternative explanations for the existence of the HI holes in Ho II, including the suggestion that some of the holes were produced by Gamma-ray burst events.Comment: 30 pages, including 6 tables and 3 images. To appear in Astron. Journal (June 1999