15 research outputs found
Canoodling with careers: cross-team working in information literacy
- Publication venue
- Publication date
- 01/01/2014
- Field of study
This workshop will explore how support services can work together to deliver information literacy across an institution. Traditionally Librarians have collaborated solely with Academics to develop and deliver information literacy interventions and support for students, but Librarian teams are very often co-located in teams providing wider services. This can include working in professional teams encompassing careers and employability professionals, learning technologists, study skills/academic skills teachers and IT skills trainers. At University of Derby the Library service is part of the Institute for Learning Enhancement and Innovation, which encompasses all of these services. This workshop will build upon work done by the three presenters, who are based at the Buxton campus, to find linkages between the work of Library Academic Services team of Subject Librarians and the work done by the Careers Consultants. Working together, the presenters found that both teams were developing and delivering sessions around the same core set of digital and information literacy skills, but from different perspectives. This has led to the development and delivery of joint compulsory lectures and workshops, voluntary workshops, and a joint ‘roaming’ service to students based at the multiple sites around the town. Delivered as a workshop, this session will engage participants in a range of group work activities, including: ‘Identifying overlapping skills teaching within support teams’, ‘What makes teams work? How can diverse teams work together on IL?’ and ‘Discussion on issues and good practice sharing’. The first two of these activities will involve a group discussion and a mind mapping activity on the personality and cultural dimensions of working with members of others teams. The good practice sharing will take the form of a ‘speed dating’ style activity where participants move around the room gaining new ideas and passing on experiences. Attending this workshop will allow participants to share good practice and will benefit from identifying opportunities for cross-team working within their own institution. In addition they will gain ideas on how to approach members of other teams to facilitate information literacy projects
Rheumatoid arthritis - treatment: 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis
- Author
- Ahmad Yasmeen
- Al-Kashi Adam
- Alten Rieke
- Andres Roman Ivorra Jose
- Aranda Richard
- Aranda Richard
- Ashcroft Darren M.
- Atkinson Francesca
- Atzeni Fabiola
- Baker D.
- Baraf Herbert
- Baratelle A.
- Bathon J.
- Bathon Joan
- Becker Jean-Claude
- Becker Jean-Claude
- Behrens Frank
- Beirne Paul
- Bernasconi Corrado
- Beutler A.
- Bingham Clifton
- Bingham Sarah J.
- Blackler Laura
- Blunn Karina J.
- Bolce R.
- Breedveld Ferdinand C.
- Breslin Anne
- Buch Maya
- Burgos-Vargas Ruben
- Burke Laura
- Burkhardt Harald
- Burmester Gerd
- Bykerk Vivian P.
- Chai Akiko
- Chernajovsky Yuti
- Chung Carol Y.
- Cifaldi Mary
- Cohen Roger
- Cohen Stanley B.
- Conaghan P. G.
- Covucci Allison
- Curtis Jeffrey
- Curtis Jeffrey
- Curtis Jeffrey
- Dass Shouvik
- Davies Rebecca
- De Bari Cosimo
- De Silva Chulanie
- Decktor D.
- Dehoratius R.
- Delaet Ingrid
- Dell'Accio Francesco
- Dennison Elaine
- Dougados Maxime
- Dougados Maxime
- Doyle M. K.
- Dudler Jean
- Durez Patrick
- Ehrenstein Michael R.
- El-Kadi H.
- Elashoff M.
- Elegbe Ayanbola
- Ellis Shawn D.
- Eltawil Noha
- Emery P.
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Eveslage Maria
- Fan H.
- Farmer Pamela
- Faurholm Bjarne
- Fichtner Andreas
- Fleischmann R.
- Fleischmann R.
- Fleischmann R.
- Fleischmann Roy
- Fleischmann Roy M.
- Fleischmann Roy M.
- Fuji Takeshi
- Furst Dan
- Furst Daniel E.
- Furst Daniel E.
- Galloway James
- Genant Harry
- Genovese M.
- Genovese M. C.
- Genovese M. C.
- Genovese Mark C.
- Genovese Mark C.
- Goldman J.
- Goldring Mary
- Gomez-Reino Juan
- Gould David
- Gujrathi Sheila
- Gullick Nicola J.
- Gullick Nicola J.
- Guo Yonghua
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Hamilton Jennifer
- Haraoui Boulos
- Haraoui Boulos
- Heatley Rebecca
- Herzer Peter
- Heycock Carol
- Hochberg Marc
- Hogan Vanessa
- Holweg Cecile
- Hsia E. C.
- Hsia E. C.
- Hsia E. C.
- Hughes Chris
- Hutchinson David G.
- Hyrich Kimme
- Hyrich Kimme L.
- Iaremenko Oleg
- Ince Akgun
- Jameson Karen
- Jones Tim
- Kahan Andre
- Kary Sonja
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kellner H.
- Kelly Clive
- Kelly Sheila
- Keystone E.
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Khan Nadar
- Khanna Dinesh
- Khraishi Majed
- Kiely Patrick
- Kim L.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirkham Bruce W.
- Kleinert Stefan
- Knight Gregory D.
- Koehm Michaela
- Kremer J.
- Kremer Joel M.
- Krummel-Lorenz Brigitte
- Kummerfeld Sarah
- Kupper Hartmut
- Kupper Hartmut
- Kvien Tore
- Landewe Robert
- Landewe Robert
- Landewe Robert
- Lawson Richard
- Le Bars Manuela
- Lehane Patricia
- Leirisalo-Repo M.
- Li Tracy
- Liebhaber Anke
- Listing Joachim
- Liu H.
- Lloyd Lois A.
- Long Simon G.
- Luggen Michael
- Lugli Helena
- Luijtens Kristel
- Luijtens Kristel
- Lunt Mark
- Lunt Mark
- Luo Allison
- Macey Katherine M.
- Malamet Raymond
- Malik Saadia
- Manzo Antonio
- Mariette Xavier
- Marrelli Alessandra
- Matteson E. L.
- Matteson E. L.
- Matteson Eric L.
- Matucci Cerenic Marco
- McDowell Jackie
- Mela Christopher M.
- Mendelsohn A.
- Mikitenko Ganna
- Mistlin Alan
- Moreland Larry
- Mozaffarian Neelufar
- Mozaffarian Neelufar
- Nikiphorou Elena
- Nishikawa Masataka
- Nissim Ahuva
- Notley Clare A.
- Nurmohamed Michael T.
- Oakley Stephen
- Oezer Uemit
- Owaki Hajime
- Owen Catherine
- Panayi Gabriel
- Pappu Ramesh
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Pavelka Karel
- Pavelka Karel
- Potempa Jan
- Qi Keqin
- Quirke Anne-Marie
- Rahman M. U.
- Rees Jonathon
- Reiss William
- Reynard Mark
- Reynolds Alan
- Ritchlin C.
- Rizzo Warren
- Robles Manuel
- Roy Sanjoy
- Rynne Martin
- Sague S.
- Saravanan Vadivelu
- Scharbatke Eva C.
- Schechtman Joy
- Schiff Michael
- Schiff Michael
- Seed Michael
- Shah Devron
- Shaw Tim
- Sibilia Jean
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Soliman Moetaza M.
- Stancati Andrea
- Strand Vibeke
- Strangfeld Anja
- Subang Christina
- Sweetser Marianne
- Sweetser Marianne T.
- Symmons Deborah
- Taylor Monet
- Taylor Peter
- Taylor Peter
- Teng Onno
- Tony Hans-Peter
- Torbeyns Anne
- Townsend Michael
- Unnebrink Kristina
- van der Heijde D.
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van Laar Jacob M.
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- Venables Patrick
- Vencovsky Jiri
- Vernon Emma
- Vernon Emma
- Vital Edward M.
- Walsh Claire
- Walsh David A.
- Wang J.
- Wasco M. C.
- Watson Kath
- Watson Kath D.
- Watson Kath D.
- Wegner Natalia
- Weinblatt Michael
- Weinblatt Michael
- Westhovens Rene
- Westhovens Rene
- Weyer Gerd
- Williams Richard
- Williams Richard B.
- Williams Sarah
- Winyard Paul
- Xu W.
- Yazici Yusuf
- Young Adam
- Young Adam
- Zain Amir
- Zanetakis E.
- Zink Angela
- Álvaro-Gracia Jose
- Östör Andrew
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50 mg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50 mg/week for over 50 kg, 40 mg/week for 40 to 50 kg and 20 to 30 mg/week for under 40 kg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient died of sepsis caused by decubitus ulcer infection. DAS28-CRP score was decreased from 3.9 to 2.7 significantly. Although CRP was decreased from 1.50 to 0.93 mg/dl, it wasn't significant. Matrix metalloproteinase (MMP)-3 was decreased from 220.0 to 174.2 ng/ml significantly. Glutamate pyruvate transaminase (GPT) was increased from 19 to 35 U/l and number of leukocyte was decreased from 7832 to 6271 significantly. DAS28-CRP, CRP, and MMP-3 were improved significantly with MTX, although they weren't without MTX. Increase of GPT and leukopenia were seen significantly with MTX, although they weren't without MTX. Conclusions: It was reported that the risks of IP caused by LEF in Japanese RA patients were past IP history, loading dose administration and low BW. Addition of low-dose LEF is a potent safe alternative for the patients showing unsatisfactory response to current medicines, but need to pay attention for liver function and infection caused by leukopenia, especially with MTX. Disclosure statement: The authors have declared no conflicts of interes
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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- Cárcel Fernández Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
- Forbes Andrew
- Forbes Loretta
- Forton Daniel
- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
- Hall Andrew
- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Haniffa Rashan
- Haniffa Rashan
- Hanson Jane
- Harford Rachel
- Harland Cain
- Harrington Kate
- Harris Nichola
- Harrison Susie
- Hart Ciaran
- Harvala-Simmonds Heli
- Harvey Daniel
- Harward Meg
- Hawcutt Daniel
- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
- Johns Maggie
- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
- Kalchthaler Kyle
- Kalogirou Michael
- Kamel Toufik
- Karachi Tim
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kayani Abdul
- Kazemi Alex
- Keen Alexandra
- Keenan Samantha
- Keet Owen
- Kell Kay
- Kelly Martin
- Kelsall Olivia
- Kernan Maeve
- Kersiake Ian
- Khalid Imrana
- Khare Divya
- Kiiski Heikki
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirkby Amy
- Klinikum Neukölln Vivantes
- Kluge Stefan
- Knott Cameron
- Kol Mark
- Kolanos Steffi
- Koppen Cassandra
- Kosa Alma Gabriela
- Kotarski Viktor
- Kovács Sándor
- Kreß Gabriele
- Krishnamurthy Vinodh
- Kruger Peter
- Kruger Peter
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kunz Kevin
- Kurenda Catherine
- Kutleša Marko
- Kušan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lamb Thomas
- Lamonagne Francois
- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco Cécile
- Lesona Eden
- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- León López Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
- L’Hotellier Sylvie
- Mackay Callum
- Mackay Euan
- MacLennan Sheila
- Maguire Teena
- Magyar István
- Maiden Matthew
- Makowski Arystarch
- Malakoutis Salim
- Malfroy Sylvain
- Malissin Isabelle
- Maloney Carolyn
- Manax Victoria
- Mandadapu Vineela
- Mangindaan Yara
- Maquigneau Natacham
- Marabi Yaseen
- Mariappa Vasanth
- Marin-Corral Judith
- Markgraf Rene
- Marroquin Oscar
- Marshall John
- Marshall John
- Marshall Nicola
- Mart Emma
- Marten Nicole
- Martin Jane
- Martin Timothy
- Martynoga Robert
- Maselli Astrid
- Masse Marie-Helene
- Mateo López Maria Isabel
- Matsa Ramprasad
- Mattocks Lehentha
- Maxime Virginie
- Mc Goldrick Clare
- Mc Master Moyra
- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
- McCallum Peter
- McClintock Declan
- McConnochie Rachael
- McCracken Phobe
- McCue Claire
- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
- McGlothin Anna
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGuigan Peter
- McGuinness Shay
- McGuinness Shay
- McIntyre Lauralyn
- McLachlan Danielle
- McMillan Alexandra
- McNamara Robert
- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan
- McVerry Bryan
- McWilliam Stephen
- Megarbane Bruno
- Mehrtens Jan
- Menon David
- Menzies Daniel
- Mercier Emmanuelle
- Mercier Romain
- Meredith Megan
- Metherell Stella
- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Mfuko Celina
- Mguni Nhlanhla
- Middeldopr Saskia
- Miezitis Sydney
- Millen Tina
- Miller Eliza
- Mills Gary
- Miln Rebecca
- Mineall Sarah
- Mirković Gordan
- Misak Cheryl
- Misztal Beata
- Mitchard Sarah
- Moine Pierre
- Monchi Mehran
- Moneer Hagazy Mohamned
- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
- Moore Lorraine
- Morel Guillaume
- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
- Morris Sheila
- Morrison Lynette
- Mouncey Paul
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- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
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- Zarychanski Ryan
- Zhao Xiao Bei
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- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
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- Cao Qinhao
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- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
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- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
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- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
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- Crone Michael Andrew
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- Cruz Frida
- Cubukcu Hande
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- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
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- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
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- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
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- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
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- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
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- El Moubayed Yorgo
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- Farrell Jennifer
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- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
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- Fulton Leah
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- Gahagan Maddison
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- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
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- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
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- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
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- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
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- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
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- Alshawadfy Abdelrhman
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- Oncel Muhammed Miran
- Oncel Mustafa
- Ong Chui Foong
- Ong Elynn
- Onimisi-Yusuf Farida
- Onwuhafua Polite Iwedike
- Orchard-Hall Francesca
- Orewole Tesleem
- Oruade Justina
- Osama Manar
- Osher Lana
- Osher Lana
- Osman Fatima
- Osman Omer
- Osman Walaa
- Othman Dina
- Othman Safaa
- Outhred Tim
- Ouyahia Amel
- Ouzounidis Nikolaos
- Ozbilen Melis
- Ozcelik Mehmet Faik
- Ozdemir Zeynep
- Ozer Yıldırım
- Ozkan Esin
- Ozkan Esin
- Pai Vivian
- Painter Matthew
- Palacios Diana Sofia Garces
- Palacios Diana Sofia Garces
- Palaniappan Ramanathan Rm
- Pang Siyuan
- Pantoja Maria Alejandra Nanez
- Papanikolaou Evangelos
- Parajuli Dikshya
- Parange Anupam
- Park Heejun
- Park Jin Hyuk (David)
- Park Melissa
- Park Melissa
- Patel Diya
- Patel Rohan
- Pathak Upasana
- Pathak Upasana
- Patil Aditya
- Patil Chinmai
- Paul Rohit
- Pearce Liam
- Pegorer Amanda Gonzalez
- Pehlivan Dilan
- Peker Joshua
- Penneru Sai Harshitha
- Pereira Ashley
- Pesce Antonio
- Peters Luke
- Petrarulo Francesca
- Pham Andrew
- Phan Victoria
- Phu Rachel
- Pilgrim Charles
- Pillai Anil Kumar Sree Kumar
- Pockney Peter
- Pockney Peter
- Podder Nayanika
- Polat Süleyman
- Polo Samantha
- Pothukuchi Prasanna
- Pottier Mark
- Pozzi Isabella
- Prasad Shaamnil
- Prasad Shalvin
- Prinsloo Duron
- Proud David
- Qattawi Taima’
- Qazi Arisha
- Qian Gemma
- Qian Helena
- Quadros Dwain
- Quek Nicholas
- Quinlan Liam
- Qureshi Faiza
- Radovanovich Jess
- Rae Hamish
- Rafaei Rawan
- Rafea Reem
- Ragab Ahmed
- Ragab Mohammed
- Rais Mounira
- Raj Mariolyn
- Raja Sajjan
- Rajabi Munia
- Rajesh Krishnankutty
- Raji Hadijat Olaide
- Ramadan Mohamed
- Ramadan Mohamed F
- Ramlee Afiq Aizat
- Ramphal Shanay
- Rashed Osama Fathy Ali Ali
- Rasheed Ayat
- Raslan Bassma
- Rasslan Esraa
- Rathnayake Athulya
- Ratnayake Milidu
- Ratnayake Milidu
- Raubenheimer Kyle
- Raubenheimer Kyle
- Raubenheimer Kyle
- Rauf Abdul
- Ravi Anjana
- Rawal Alisha
- Raza Muhammad
- Razmi Akeedh
- Reed Catherine
- Rehfisch Peter
- Rehman Saif Ur
- Reinke Caroline
- Reis Murat Emre
- Ren Seifei
- Restini Enrico
- Reyes Bernardo Alfonso Fernández
- Rhuma Heba
- Richter Konrad
- Rifaioglu Kerem
- Roata Cristian Ene
- Robinson Samuel
- Romano Angela
- Rosello-Añon Alejandro
- Roshdy Mo'men
- Ross Jessica Stott
- Ross Poppy
- Rossaak Jeremy
- Roth Charles
- Rottoli Matteo
- Ruiz Enrique
- Rumble William
- Rusli Siti Mayuha
- Russo Iris Shari
- Saad Mahmoud M
- Saada Hind
- Saber Mona
- Sabry Ahmed Abdelfatah
- Sabuncu Kubilay
- Sadauskas Tomas
- Sadek Mirna
- Saeed Abdallah
- Saeed Umar
- Safar Amna
- Saha Sushanth
- Sahin Berfin İlgaz
- Sahin Melek
- Sajo Isa Mienda
- Sakr Ahmed
- Sakthivel Mahesh
- Salah Asmaa
- Salah Doaa
- Salah Mohamed
- Salah Salem
- Salaheldein Mohamed
- Salameh Alaa Eddin
- Salawu Adedayo
- Salawu Hafeez
- Saleh Ahmad
- Saleh Sara Ahmed
- Salem Ebrahim
- Salem Mohammed
- Saliaris Konstantinos
- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
- Samalavicius Narimantas
- Sami Wesam
- Sammour Tarik
- Sampatha-Waduge Tharushi
- Sanad Aly
- Sandhu Jaspreet Kaur
- Sanguesa Maria Jose
- Sani Samuel Ali
- Sanli Ahmet Necati
- Sanz-Romera Jorge
- Sara Rachel
- Saraçoğlu Ayten
- Sarafi Aikaterini
- Sarangadasa Pavatharane
- Sarhan Osama
- Sarı Ahmet Can
- Sarih Monira
- Sarwar Albash
- Sathasivam Vinogi
- Sathiyaseelan Avinash
- Sawaftah Khaled
- Sayed Ahmed M
- Sayed Mohamed Al
- Sayed Yasmeen
- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
- Schizas Dimitrios
- Segaran Sharrada
- Seldon Alexandra
- Selim Kamar
- Selim Osama
- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
- Shaaban Abdelrahman
- Shaban Aya
- Shaban Walid
- Shabaneh Amin
- Shafaat Amna
- Shagroun Esra
- Shah Jainil
- Shah Jainil
- Shahat Mohammed A
- Shaheen Nourhan
- Shahin Mahmoud
- Shalaby Mostafa
- Shalalfeh Sa'ed
- Shaltout Asmaa S
- Shamshoon Kerollos
- Shanag Hadeel
- Shanahan James
- Shang Mengge
- Shannaq Rabab
- Shaqran Osama Al
- Sharma Sonakshi
- Sharp James
- Shaw Haylee
- Shaw Henry
- Shehab Ali Fahmy
- Shehahda Sireen
- Shehata Mena
- Shen Yijia
- Sherif Yara
- Sheriff Arfaan
- Shetwan Sundes
- Shipa Ahmed
- Shiru Mariam Motunrayo
- Shrestha Pallavi
- Shuaibu Ibrahim Shaphat
- Shui Amanda
- Sibic Osman
- Sierra Oscar Alonso Verduzco
- Silem Yousra Othman Reham
- Silva Yannick De
- Silverii Julia
- Simiona Levi
- Simonetti Marta
- Singer David
- Singh Abhinav
- Singh Gopal
- Singh Jasraaj
- Singh Madhavi
- Singh Ramnik
- Singh Surya
- Singh Surya
- Singhal Megan
- Sinha Akansha
- Siribaddana Venesa
- Sivakumar Gananadha
- Sivakumar Seiyon
- Sivasuthan Goutham
- Sivrikaya Ramazan Kemal
- Skalidou Smaragda
- Skoufias Spyridon
- Slavec Mark
- Smadi Rayyan
- Smith Corinne
- Smith Nicolas
- Smith Quintin
- Smitham Peter
- Snider Ruth
- Sobhy George
- Soek Jenny
- Sofian Ahmad Anuar
- Soh Isabel
- Soh Jien Yen
- Soh Qi Rui
- Soh Rachel TingQian
- Sok Rumnea
- Sokmen Selman
- Solagbade Remi Sanyaolu
- Solanki Krisha
- Solar Caitlin Del
- Soliman Keroles
- Soliman Mahmoud Ayman
- Soliman Nisha Bianca
- Soliman Randa
- Soltan Hatem
- Songden Zumnan
- Soni Akshay
- Soula Enas
- Soytas Mustafa
- Sriranjan Roshni
- Sritharan Mithra
- Srivastava Shambhavi
- Standish Lucy
- Stavratis Fotios
- Stevens Sean
- Stewart Peter
- Stokes Andrew
- Struthers Jamie
- Studd Rod
- Sulaiman Bilal
- Suleiman Khadijah Richifa
- Suliman Hozifa Mohamed Abdalla
- Suliman Merna Ezz
- Sun Kexin
- Sun Phoebe
- Sun Selena
- Sung Nakjun
- Surkitt Amy
- Suttor Sean
- Swalem Aisha
- Swan Daniel
- Swansson Will
- Sweetapple Amie
- Syed Saifulla
- Syllaios Athanasios
- Symeonidis Savvas
- Şen Eminenur
- Şenödeyici Eylül
- Tabak Elif Zeynep
- Taha Hala Abdelhalim Mohamed
- Taha Ibrahim
- Taha Omima
- Tahir Farah
- Tahir Izza
- Taingson Mathew Chum
- Talaat Omnia
- Talavera Elena
- Taman Mohamed
- Tan Kevin
- Tan Sarah
- Tan Sarah
- Tan Suqi
- Tan Wen Po Jonathan
- Tandogan Yusuf Iskender
- Tang Howard
- Tang Patrick
- Tang-Ieam Pattarapan
- Tao Steve
- Tarek Yousef
- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
- Tay Kai Yun Jodene
- Taylor Emily
- Taylor Isobel
- Teema Eman
- Telci Hatice
- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
- Tran Will
- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Effects of eight neuropsychiatric copy number variants on human brain structure
- Author
- Aaronson Benjamin
- Ackerman Sean
- Addor Marie-Claude
- Alupay Hanalore
- Andrieux Joris
- Ankenman Katy
- Anwar Ayesha
- Arveiler Benoît
- Atwell Constance
- Baujat Geneviève
- Bearden Carrie E.
- Beaudet Arthur L.
- Belfiore Marco
- Benedetti Marta
- Berg Jessica
- Berman Jeffrey
- Berry Leandra N.
- Bibb Audrey L.
- Blaskey Lisa
- Bonneau Dominique
- Bouquillon Sonia
- Boute Odile
- Bowe Alexandra
- Brennan Jonathan
- Brewton Christie M.
- Brusco Alfredo
- Buckner Randy
- Bukshpun Polina
- Burko Jordan
- Busa Tiffany
- Bzdok Danilo
- Caberg Jean- Hubert
- Cali Phil
- Campe Katherine Loftus
- Campion Dominique
- Cavanagh Alyss Lian
- Cerban Bettina
- Chakravarty Mallar
- Chang Yishin
- Charlebois Audrey-Rose
- Cheong Maxwell
- Chow Vivian
- Chu Zili
- Chudnovskaya Darina
- Colombert Vanessa
- Cordier Marie-Pierre
- Cornew Lauren
- Côté Valérie
- Dale Corby
- David Albert
- Debray François-Guillaume
- Deguire Florence
- Dell John
- Delrue Marie-Ange
- Dempsey Allison G.
- Deschamps Trent
- Doco-Fenzy Martine
- Douard Elise
- Draganski Bogdan
- Dunkhase-Heinl Ulrike
- Earl Rachel
- Edery Patrick
- Edgar James
- Elgin Jenna
- Evans Yolanda L.
- Fagerberg Christina
- Faivre Laurence
- Findlay Anne
- Fischbach Gerald D.
- Fisk Charlie
- Forzano Francesca
- Fregeau Brieana
- Gaetz Bill
- Gaetz Leah
- Gallagher Anne Snow
- Garza Silvia
- Genevieve David
- Gerdts Jennifer
- Giachino Daniela
- Glenn Orit
- Gobuty Sarah E.
- Golembski Rachel
- Greenup Marion
- Guichet Agnès
- Guillin Olivier
- Gérard Marion
- Hall Jeremy
- Heiken Kory
- Hines Katherine
- Hinkley Leighton
- Huguet Guillaume
- Héron Delphine
- Isidor Bertrand
- Jackson Frank I.
- Jacquemont Sébastien
- Jacquette Aurélia
- Jaillard Sylvie
- Jean-Louis Martineau
- Jenkins Julian
- Jeremy Rita J.
- Johnson Kelly
- Journel Hubert
- Kanne Stephen M.
- Keehn Rebecca McNally
- Keren Boris
- Kessler Sudha
- Khan Sarah Y.
- Ku Matthew
- Kumar Kuldeep
- Kuschner Emily
- Kushan Leila
- Laakman Anna L.
- Lacombe Didier
- LaGuerre Kevin
- Lam Peter
- Lasala Morgan W.
- Le Caignec Cédric
- Lebon Sébastien
- Lee Hana
- Lemaître Marie-Pierre
- Lespinasse James
- Levy Susan
- Linden David E. J.
- Lippé Sarah
- Llorens Ashlie V.
- Luks Tracy L.
- Maillard Anne M.
- Marco Elysa J.
- Martin Alastair J.
- Martin Charles-Olivier
- Martin Stephen
- Martin-Brevet Sandra
- Marzano Gabriela
- Masson Christina
- Mathieu-Dramart Michèle
- McGovern Kathleen E.
- Melie-Garcia Lester
- Mercier Sandra
- Mignot Cyril
- Miller David T.
- Miller Fiona K.
- Missirian Chantal
- Modenato Claudia
- Moreau Clara
- Moss Timothy J.
- Murray Rebecca
- Nagarajan Srikantan S.
- Nowell Kerri P.
- Olson Jennifer Endre
- Owen Julia
- Owen Michael J.
- Paal Andrea M.
- Packer Alan
- Page Patricia Z.
- Pain Aurèlie
- Paul Brianna M.
- Peters Alana
- Peterson Danica
- Petit Florence
- Pilekær Sørensen Kristina
- Pinson Lucile
- Plessis Ghislaine
- Poduri Annapurna
- Pojman Nicholas J.
- Porche Ken
- Prieur Fabienne
- Proud Monica B.
- Qasmieh Saba
- Ramocki Melissa B.
- Raymond Alexandre
- Reilly Beau
- Richetin Sonia
- Roberts Timothy P. L.
- Rodriguez-Herreros Borja
- Rooryck-Thambo Caroline
- Rossi Massimiliano
- Sanlaville Damien
- Schlott Kristiansen Britta
- Schluth-Bolard Caroline
- Schramm Catherine
- Shaw Dennis
- Silva Ana I.
- Sinha Tuhin
- Sloan-Béna Frédérique
- Smith-Packard Bethanny
- Swarnakar Vivek
- Tamer Petra
- Thieu Tony
- Thébault-Dagher Fanny
- Till Marianne
- Triantafallou Christina
- Van Den Bree Marianne B. M.
- Van Haelst Mieke
- Van Maldergem Lionel
- Vaughan Roger
- Wakahiro Mari
- Wallace Arianne
- Ward Tracey
- Wenegrat Julia
- Wolken Anne
- Younis Nadine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/07/2021
- Field of study
Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date neuroimaging studies have typically been carried out one mutation at a time, showing that CNVs have large effects on brain anatomy. Here, we aimed to characterize and quantify the distinct brain morphometry effects and latent dimensions across 8 neuropsychiatric CNVs. We analyzed T1-weighted MRI data from clinically and non-clinically ascertained CNV carriers (deletion/duplication) at the 1q21.1 (n = 39/28), 16p11.2 (n = 87/78), 22q11.2 (n = 75/30), and 15q11.2 (n = 72/76) loci as well as 1296 non-carriers (controls). Case-control contrasts of all examined genomic loci demonstrated effects on brain anatomy, with deletions and duplications showing mirror effects at the global and regional levels. Although CNVs mainly showed distinct brain patterns, principal component analysis (PCA) loaded subsets of CNVs on two latent brain dimensions, which explained 32 and 29% of the variance of the 8 Cohen’s d maps. The cingulate gyrus, insula, supplementary motor cortex, and cerebellum were identified by PCA and multi-view pattern learning as top regions contributing to latent dimension shared across subsets of CNVs. The large proportion of distinct CNV effects on brain morphology may explain the small neuroimaging effect sizes reported in polygenic psychiatric conditions. Nevertheless, latent gene brain morphology dimensions will help subgroup the rapidly expanding landscape of neuropsychiatric variants and dissect the heterogeneity of idiopathic conditions
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
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- Bonten Marc J. M.
- Borgatta Barbara
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- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
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- Depuydt Pieter
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- Derde Lennie P. G.
- Deshpande Kush
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- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
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- Estcourt Lise J.
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- Goebeler M.E.
- Golden David
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- Gordon Anthony C.
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- Haldeos Anne
- Hall Alistair S
- Hall Amelia
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- Higgins Alisa M.
- Hill Claire
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- Hornsby James
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- Horvat Christopher M.
- Howcroft Clare
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- Huang David T.
- Hughes Debbie
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- Kim Edy Y.
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- Kremling Julius
- Kreß Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
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- Lawler Patrick R.
- Le Basnier Elliot
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- Liu Theresa
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- Marshall Lucy
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- McAdams David
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- McCarthy Aine
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- McKee Madeleine
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- McVerry Bryan J.
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- Yamashita Chizuru
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- Yarad Elizabeth
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- Yates David
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- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
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- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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- Zho Hui
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2017
- Field of study