Conflict of Laws - Jurisdiction - Minimum Contacts

The outer limits of constitutionally valid jurisdiction are not exceeded by asserting jurisdiction over a service corporation doing business solely in a foreign state, if such corporation does a negligent act in the foreign state which causes injury in the state of the forum. Roche v. Floral Rental Corporation, 95 N.J. Super. 555, 232 A.2d 162 (1967), appeal docketed, No.___, N.J. Sup. Ct. (1967)

Tako-tsubo Syndrome as First Manifestation in a Case of Pheochromocytoma Developed From a Non-functional Adrenal Incidentaloma

Abstract Background: Pheochromocytoma is a catecholamine secreting tumor that, in extremely rare cases, may develop over time from a non-functional adrenal adenoma. Catecholamine excess can lead to a kind of cardiomyopathy similar to that seen in tako-tsubo syndrome (TTS). Case report: A 69 years old female with a history of type 2 diabetes, hypertension, and a non-functional right adrenal adenoma diagnosed 3 years earlier was referred to our center for further investigations. During the evaluation, she had a hypertensive crisis with chest pain, tachycardia, and diaphoresis. Suspecting an acute coronary syndrome, she underwent coronary angiography, which showed the typical features of TTS. The high 24 h-urinary metanephrines excretion and abdominal MRI findings were suggestive of pheochromocytoma. Right laparoscopic adrenalectomy was performed, with the resolution of all symptoms. Pathology findings confirmed the diagnosis of pheochromocytoma. After 12 months, the patient was still asymptomatic, with the echocardiography displaying a complete recovery of the left-ventricular function. Conclusions: The development of a pheochromocytoma from an adrenal non functional adenoma is an extremely rare event, but potentially life-threating because of the catecholamine-associated cardiovascular toxicity. In particular, TTS is a form of cardiomyopathy that has been increasingly described as associated with catecholamine-secreting tumors. The exclusion of pheochromocytoma in a patient with TTS has important therapeutic implications, since the administration of β-blockers may be extremely harmful in patients with catecholamine surge in the absence of adequate α-blockage. Keywords: adrenal incidentaloma; catecholamine; infarction; pheochromocytoma; tako-tsubo syndrome; ventricular dysfunction

Fatty acids composition of Colonnata Lard from two different swine breeds

The study compares the fatty acid composition of the Colonnata lard obtained from two different swine breeds, Large White (LW) and Cinta Senese (CS), during a one year long curing period. Samples of backfat were obtained from the carcass of three animals per breed and disposed into six different marble boxes according to the procedure of the disciplinary production of PGI "Lardo di Colonnata". During curing period individual lard samples were collected monthly from each marble box. The fatty acid composition of pig backfat reflected the differences in the dietary regimen and in the rearing system of the two breeds. LW swine, in fact, were fed a commercial concentrate and reared in an intensive system, whereas CS swine were fed a diet composed by a commercial concentrate supplemented with acorn and reared in an outdoor system. Lard from LW contained higher amount of saturated fatty acids than lard from CS, whereas the content of unsaturated fatty acids (mainly monounsaturated fatty acids) was lower. During the curing period the trend of lard fatty acids composition was different in the two breeds: the lard from CS seemed to be more susceptible to a faster hydrolysis of fatty acids than lard from LW, especially for the monounsaturated fatty acids, while the lard from LW seemed to be more susceptible to a faster hydrolysis of PUFA n-3

Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM)

Thyroid ultrasonography (US) is the gold standard for thyroid imaging and its widespread use is due to an optimal spatial resolution for superficial anatomic structures, a low cost and the lack of health risks. Thyroid US is a pivotal tool for the diagnosis and follow-up of autoimmune thyroid diseases, for assessing nodule size and echostructure and defining the risk of malignancy in thyroid nodules. The main limitation of US is the poor reproducibility, due to the variable experience of the operators and the different performance and settings of the equipments. Aim of this consensus statement is to standardize the report of thyroid US through the definition of common minimum requirements and a correct terminology. US patterns of autoimmune thyroid diseases are defined. US signs of malignancy in thyroid nodules are classified and scored in each nodule. We also propose a simplified nodule risk stratification, based on the predictive value of each US sign, classified and scored according to the strength of association with malignancy, but also to the estimated reproducibility among different operators

Parametrização do modelo DSSAT/CANEGRO para as cultivares brasileiras de cana-de-açúcar.

A parametrização do modelo DSSAT/CANEGRO para a realidade brasileira tem grande importância para a obtenção de uma ferramenta capaz de otimizar o planejamento da produção sucroalcooleira nacional e analisar os impactos do aquecimento global na cultura da cana-de-açúcar no Brasil. O trabalho foi realizado com as cultivares IAC 91-1099 e SP 89-1115. Os dados biométricos foram coletados na APTA em Piracicaba-SP e analisados na Embrapa Informática Agropecuária em Campinas-SP, comparando-se com os dados gerados pelo modelo. Verificou-se que é possível parametrizar os dados de perfilhamento e altura de colmo, com bons resultados, porém a parametrização do IAF necessita de mais estudos. Essas análises indicam possibilidades promissoras para o uso do modelo CANEGRO para as cultivares brasileiras.CBA 2009

Arquitetura foliar e coeficiente de extinção de radiacao solar para duas variedades de cana-de-açúcar.

O objetivo do trabalho foi avaliar um método computacional para a determinação do ângulo de inserção foliar (AIF) em cana-de-açúcar com base em imagens digitais, em comparação com medidas de campo segundo uma metodologia tradicional, para duas cultivares de cana-de-açúcar (IAC91-1099 e SP89-1115). Além dessa comparação, estimou-se o coeficiente de extinção (K) para radiação solar, observando-se a propagação do erro de estimativa do AIF nesta estimativa. Os ângulos medidos e os estimados não tiveram diferença estatisticamente significativa a 5% de probabilidade com o teste Tukey, com exceção da folha +2 na cultivar SP89-1115. Isso, contudo, não resultou em diferença na determinação do K medido e estimado. A cultivar SP89-1115 obteve K maior do que o estimado para a cultivar IAC91-1099, variando entre 0,44 e 0,74 considerando valores calculados para as 12:00. Considerando a variação horária de K, os valores oscilaram entre 0,5 e 6,5. Podemos concluir que o método computacional é valido para estimar o ângulo de inserção foliar e existe diferença entre as duas cultivares no ângulo de inserção ocasionando diferença no cálculo do K.CBA 2009

Identifying the favored mutation in a positive selective sweep.

Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations

Nutrient absorption in lambs fed diets containing different amounts of phosphorus

Objective. Evaluate the effect of increasing P intake on nutrient digestibility, and compare the true and apparent absorption coefficients of P and Ca in lambs. Materials and methods. Twenty-four Santa Ines sheep, with an average weight of 33.6 ± 1.6 kg, were distributed into four treatments (0, 2, 4 and 6 g/day of supplementary P) with forage: concentrate ratio of 70:30. The study of apparent nutrient digestibility was conducted during the first week, using the total feces collection method. During the second week, after injection of 7.4 MBq of 32P and 7.7 MBq of 45Ca, apparent (AAC) and true (TAC) absorption coefficients of P and Ca were determined. The lambs were kept in metabolic cages. Results. The increase in P intake did not affect (p>0.05) dry matter, crude protein, NDF or ADF digestibility, but the TAC of P and Ca and mineral matter digestibility decreased. The AAC was not affected (p=0.10). A cubic relationship was observed between P intake and TAC (TAC=2.16–1.95X+0.55X2-0.04X3; R2=0.38) and linear relationship with the TAC of Ca (TAC=0.559–0.03X; R2=0.26). TAC and AAC values were different (p<0.001). Conclusions. The increase in P intake doesn’t impact organic matter digestibility, but does affect P and Ca absorption. Apparent digestibility is not a reliable parameter to determine the efficiency of P and Ca absorption

Presence in the pre-surgical fine-needle aspiration of potential thyroid biomarkers previously identified in the post-surgical one.

Fine-needle aspiration biopsy (FNA) is usually applied to distinguish benign from malignant thyroid nodules. However, cytological analysis cannot always allow a proper diagnosis. We believe that the improvement of the diagnostic capability of pre-surgical FNA could avoid unnecessary thyroidectomy. In a previous study, we performed a proteome analysis to examine FNA collected after thyroidectomy. With the present study, we examined the applicability of these results on pre-surgical FNA. We collected pre-surgical FNA from 411 consecutive patients, and to obtain a correct comparison with our previous results, we processed only benign (n=114), papillary classical variant (cPTC) (n=34) and papillary tall cell variant (TcPTC) (n=14) FNA. We evaluated levels of five proteins previously found up-regulated in thyroid cancer with respect to benign nodules. ELISA and western blot (WB) analysis were used to assay levels of L-lactate dehydrogenase B chain (LDHB), Ferritin heavy chain, Ferritin light chain, Annexin A1 (ANXA1), and Moesin in FNA. ELISA assays and WB analysis confirmed the increase of LDHB, Moesin, and ANXA1 in pre-surgical FNA of thyroid papillary cancer. Sensitivity and specificity of ANXA1 were respectively 87 and 94\% for cPTC, 85 and 100\% for TcPTC. In conclusion, a proteomic analysis of FNA from patients with thyroid nodules may help to distinguish benign versus malignant thyroid nodules. Moreover, ANXA1 appears to be an ideal candidate given the high sensitivity and specificity obtained from ROC curve analysis

Efeito do parcelamento e época de fornecimento de nitrogênio na produção de materia seca na cultura do milho (Zea mays L.).

Pretendeu-se com este trabalho avaliar o efeito da época e do parcelamento do nitrogênio sobre a produção de materia seca total (raiz, colmo e folhas) na cultura do milho