897 research outputs found
Disorder Induced Localized States in Graphene
We consider the electronic structure near vacancies in the half-filled
honeycomb lattice. It is shown that vacancies induce the formation of localized
states. When particle-hole symmetry is broken, localized states become
resonances close to the Fermi level. We also study the problem of a finite
density of vacancies, obtaining the electronic density of states, and
discussing the issue of electronic localization in these systems. Our results
also have relevance for the problem of disorder in d-wave superconductors.Comment: Replaced with published version. 4 pages, 4 figures. Fig. 1 was
revise
Spray Drying: An Overview
Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries
Modeling disorder in graphene
We present a study of different models of local disorder in graphene. Our
focus is on the main effects that vacancies -- random, compensated and
uncompensated --, local impurities and substitutional impurities bring into the
electronic structure of graphene. By exploring these types of disorder and
their connections, we show that they introduce dramatic changes in the low
energy spectrum of graphene, viz. localized zero modes, strong resonances, gap
and pseudogap behavior, and non-dispersive midgap zero modes.Comment: 16 pages, lower resolution figure
Double Exchange Model for Magnetic Hexaborides
A microscopic theory for rare-earth ferromagnetic hexaborides, such as
Eu(1-x)Ca(x)B6, is proposed on the basis of the double-exchange Hamiltonian. In
these systems, the reduced carrier concentrations place the Fermi level near
the mobility edge, introduced in the spectral density by the disordered spin
background. We show that the transport properties such as Hall effect,
magnetoresitance, frequency dependent conductivity, and DC resistivity can be
quantitatively described within the model. We also make specific predictions
for the behavior of the Curie temperature, Tc, as a function of the plasma
frequency, omega_p.Comment: 4 pages, 3 figure
More than just a gut feeling : constraint-based genome-scale metabolic models for predicting functions of human intestinal microbes
The human gut is colonized with a myriad of microbes, with substantial interpersonal variation. This complex ecosystem is an integral part of the gastrointestinal tract and plays a major role in the maintenance of homeostasis. Its dysfunction has been correlated to a wide array of diseases, but the understanding of causal mechanisms is hampered by the limited amount of cultured microbes, poor understanding of phenotypes, and the limited knowledge about interspecies interactions. Genome-scale metabolic models (GEMs) have been used in many different fields, ranging from metabolic engineering to the prediction of interspecies interactions. We provide showcase examples for the application of GEMs for gut microbes and focus on (i) the prediction of minimal, synthetic, or defined media; (ii) the prediction of possible functions and phenotypes; and (iii) the prediction of interspecies interactions. All three applications are key in understanding the role of individual species in the gut ecosystem as well as the role of the microbiota as a whole. Using GEMs in the described fashions has led to designs of minimal growth media, an increased understanding of microbial phenotypes and their influence on the host immune system, and dietary interventions to improve human health. Ultimately, an increased understanding of the gut ecosystem will enable targeted interventions in gut microbial composition to restore homeostasis and appropriate host-microbe crosstalk.Peer reviewe
Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells
Quadruplex nucleic acids are promising targets for cancer therapy. In this study we used a fragment‐based approach to create new flexible G‐quadruplex (G4) DNA‐interactive small molecules with good calculated oral drug‐like properties, based on quinoline and triazole heterocycles. G4 melting temperature and polymerase chain reaction (PCR)‐stop assays showed that two of these compounds are selective G4 ligands, as they were able to induce and stabilize G4s in a dose‐ and DNA sequence‐dependent manner. Molecular docking studies have suggested plausible quadruplex binding to both the G‐quartet and groove, with the quinoline module playing the major role. Compounds were screened for cytotoxicity against four cancer cell lines, where 4,4′‐(4,4′‐(1,3‐phenylene)bis(1H‐1,2,3‐triazole‐4,1‐diyl))bis(1‐methylquinolin‐1‐ium) (1 d) showed the greater activity. Importantly, dose–response curves show that 1 d is cytotoxic in the human colon cancer HT‐29 cell line enriched in cancer stem‐like cells, a subpopulation of cells implicated in chemoresistance. Overall, this study identified a new small molecule as a promising lead for the development of drugs targeting G4 in cancer stem cells
Unleashing the potential of supercritical fluids for polymer processing in tissue engineering and regenerative medicine
One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces
to move from benchtop to bedside regards biomaterials development, despite the latest advances in
polymer processing technologies.
A variety of scaffolds processing techniques have been developed and include solvent casting and
particles leaching, compression molding and particle leaching, thermally induced phase separation, rapid
prototyping, among others. Supercritical fluids appear as an interesting alternative to the conventional
methods for processing biopolymers as they do not require the use of large amounts of organic solvents
and the processes can be conducted at mild temperatures. However, this processing technique has only
recently started to receive more attention from researchers. Different processing methods based on the
use of supercritical carbon dioxide have been proposed for the creation of novel architectures based on
natural and synthetic polymers and these will be unleashed in this paper.The research leading to these results has recieved funding from the European Union Seventh Framework Programme (FP7) under grant agreement no. KBBE-2010-266033 (project SPECIAL), no. NMP4-SL-2009-229292 (project Find & Bind), from FEDER through POCTEP Project 0330_IBEROMARE_1_P, from the Sixth Framework Programme (FP6) under grant agreement NMP3-CT-2004-500283 (project EXPERTISSUES), Portuguese Foundation fo Science and Technology (FCT) is also acknowledged. for PhD and Post-Doc fellowships of Ana Rits C. Duarte, Vitor E. Santo, Anabela Alves, Simone S. Silva, Joana Moreira-Silva and Tiage H. Silva.Ana Rita C. Duarte would like to acknowledgs Fundacao Luso-Americana para o Desenvolvimento for the travel grant awarded to present this work at the international Symposium of Supercritical Fluids - ISSF 2012
Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea,
behavioral disturbances and dementia, caused by a pathological expansion of the CAG
trinucleotide in the HTT gene. Several patients have been recognized with the typical HD
phenotype without the expected mutation. The objective of this study was to assess the
occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia
(SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis
(ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group
analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not
reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in
the group analyzed, and is attributable to the African ancestry of this population. However,
the etiology of the disease remains undetermined in the majority of the HD negative
patients with HD-like phenotype.
Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis,
Huntington’s disease-like 2
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