The Czech Republic: From the Center of Christendom to the Most Atheist Nation of the 21st Century. Part 1. The Persecuted Church: The Clandestine Catholic Church (Ecclesia Silentii) in Czechoslovakia During Communism 1948-1991

This research examines the most important historical, political, economic, social, cultural, and religious factors before, during, and after the reign of Communism in Czechoslovakia from 1918 to 2021 and their effect on the extreme increase in atheism and decrease in Christianity, particularly Roman Catholicism, in the present-day Czech Republic. It devotes special attention to the role of the Clandestine Catholic Church (Ecclesia Silentii) and the changing policies of the Holy See vis-à-vis this Church, examining these policies\u27 impact on the continuing decline of Roman Catholicism in the Czech Republic after the collapse of Communism. The article also deals with Pope Pius XII\u27s Secret Mandates of 1948-1950, the Second Vatican Council, and the Holy See\u27s Ostpolitik. Scholars, who previously relied only on the views of the Czechs, blame the unprecedented drop in Christianity, the near-total destruction of the Catholic Church, and the rise in atheism on the Czechoslovak communist government\u27s four decades of totalitarianism. Although the increase in atheism and decrease in Christianity were substantial during the era of Communism from 1948 to 1989, our data indicate that the decline in Christianity, particularly the historically predominating Roman Catholicism, did not commence with the 1948 communist coup d’état but traces its origins to the breakdown of the Austro-Hungarian Empire after the conclusion of WWI and the establishment of Czechoslovakia on October 28, 1918. What\u27s more, this research shows that the most significant and unprecedented steep deterioration of the Christian Faith, namely Roman Catholicism, did not occur during the era of Communism but only after the Czechoslovak communist government collapsed in 1989. This massive decay did not happen even during the most extraordinary communist persecution of the Catholic Church during the era of Stalinism in Czechoslovakia. This research further finds that the Holy See\u27s ill-advised policies and systematic, sustained, and prevalent failures in leadership, guidance, and teachings are responsible for the near destruction of the Roman Catholic Church and especially the end destruction of the Clandestine Catholic Church (Ecclesia Silentii), in the Czech and Slovak Republics after the fall of Communism. These failures furthermore contributed to the Czech Republic, the historical lands of Bohemia and Moravia that once were in the center of Christendom, degenerating into the most atheist country in Europe and the world today

The Czech Republic: From the Center of Christendom to the Most Atheist Nation of the 21st Century: Part II: The Martyred Church: The Clandestine Catholic Church (Ecclesia Silentii) in Czechoslovakia After Communism 1991-2021

This manuscript consists of two parts, Part I. and Part II. Part I., written by the same author and titled "THE PERSECUTED CHURCH: THE CLANDESTINE CATHOLIC CHURCH (ECCLESIA SILENTII) IN CZECHOSLOVAKIA DURING COMMUNISM 1948 – 1991," was published in the January issue of the Occasional Papers on Religion in Eastern Europe (OPREE), ISSN: 2693-2148.2 It includes a brief historical overview and introduces the Clandestine Catholic Church (Ecclesia Silentii) in Czechoslovakia during Communism from 1948 to 1991. Part II. directly follows Part I. and continues with the following sections: Results, Discussion, Conclusion, and References. Part II considers the collapse of the Czech Roman Catholic Church and the end destruction of the Clandestine Catholic Church by the Holy See, along with the process of secularization after the fall of communism in Czechoslovakia from 1991 to 2021

Centromeric Chromatin Assembly in Fission Yeast

Centromeres are specialised chromosome loci which play an important role in cell division because they serve as the sites of kinetochore assembly, and this ultimately enables chromosome segregation. Interestingly, the DNA sequence at the centromere is not conserved – in fact, it varies significantly between organisms. A centromere-specific histone H3 variant, CENP-A has been shown to be the epigenetic mark of functional centromeres and it is present across species. CENP-A deposition in each cell cycle is required to maintain the identity of the centromere. Ccp1, a NAP (Nucleosome Assembly Protein) family member, has been found to play a role in the loading of Cnp1 on fission yeast centromeres and to interact with Cnp1 by physically associating with it. The budding yeast ortholog of Ccp1, Vps75, functions as a regulatory subunit of a histone acetyltransferase Rtt109, so this project sought to explore the role of fission yeast Rtt109 in centromere function. Furthermore, the project investigated the role of Ccp1Vps75 in Cnp1CENP-A de- position, as well as the interaction between Ccp1Vps75 and Cnp20CENP-T, an inner kinetochore protein. In this thesis Ccp1Vps75 has been identified as a Cnp1CENP-A loading factor, and the data presented suggests that the ccp1Δ mutant has centromere clustering de- fects and that the centromeres may not cluster at the SPB in this mutant. This study has also found Cnp20CENP-T to interact with Ccp1Vps75 and that Ccp1Vps75 is involved in the maintenance of Cnp20CENP-T levels at the centromere. In this thesis it is also shown that S. pombe Ccp1 and S. cerevisiae Vps75 may not be true functional orthologs. In budding yeast Rtt109 and Vps75Ccp1 work to- gether to bring about correct acetylation of histone H3 at K9, K27 and K56[5, 6]. However, in fission yeast Rtt109 does not appear to be essential for the function of Ccp1Vps75 and they likely have separate functions. Furthermore, the results pre- sented in this thesis suggest that Ccp1Vps75 does not support the function of Rtt109 in regulating the resistance to genotoxic agents

The Czech Republic: From the Center of Christendom to the Most Atheist Nation of the 21st Century. Part 1. The Persecuted Church: The Clandestine Catholic Church (Ecclesia Silentii) in Czechoslovakia During Communism 1948-1991

This research examines the most important historical, political, economic, social, cultural, and religious factors before, during, and after the reign of Communism in Czechoslovakia from 1918 to 2021 and their effect on the extreme increase in atheism and decrease in Christianity, particularly Roman Catholicism, in the present-day Czech Republic. It devotes special attention to the role of the Clandestine Catholic Church (Ecclesia Silentii) and the changing policies of the Holy See vis-à-vis this Church, examining these policies' impact on the continuing decline of Roman Catholicism in the Czech Republic after the collapse of Communism. The article also deals with Pope Pius XII's Secret Mandates of 1948-1950, the Second Vatican Council, and the Holy See's Ostpolitik. Scholars, who previously relied only on the views of the Czechs, blame the unprecedented drop in Christianity, the near-total destruction of the Catholic Church, and the rise in atheism on the Czechoslovak communist government's four decades of totalitarianism. Although the increase in atheism and decrease in Christianity were substantial during the era of Communism from 1948 to 1989, our data indicate that the decline in Christianity, particularly the historically predominating Roman Catholicism, did not commence with the 1948 communist coup d’état but traces its origins to the breakdown of the Austro-Hungarian Empire after the conclusion of WWI and the establishment of Czechoslovakia on October 28, 1918. What's more, this research shows that the most significant and unprecedented steep deterioration of the Christian Faith, namely Roman Catholicism, did not occur during the era of Communism but only after the Czechoslovak communist government collapsed in 1989. This massive decay did not happen even during the most extraordinary communist persecution of the Catholic Church during the era of Stalinism in Czechoslovakia. This research further finds that the Holy See's ill-advised policies and systematic, sustained, and prevalent failures in leadership, guidance, and teachings are responsible for the near destruction of the Roman Catholic Church and especially the end destruction of the Clandestine Catholic Church (Ecclesia Silentii), in the Czech and Slovak Republics after the fall of Communism. These failures furthermore contributed to the Czech Republic, the historical lands of Bohemia and Moravia that once were in the center of Christendom, degenerating into the most atheist country in Europe and the world today

Dexamethasone regulates glutamine synthetase expression in rat skeletal muscles

The regulation of glutamine synthetase by glucocorticoids in rat skeletal muscles was studied. Administration of dexamethasone strikingly enhanced glutamine synthetase activity in plantaris and soleus muscles. The dexamethasone-mediated induction of glutamine synthetase activity was blocked to a significant extent by orally administered RU38486, a glucocorticoid antagonist, indicating the involvement of intracellular glucocorticoid receptors in the induction. Northern blot analysis revealed that dexamethasone-mediated enhancement of glutamine synthetase activity involves dramatically increased levels of glutamine synthetase mRNA. The induction of glutamine synthetase was selective in that glutaminase activity of soleus and plantaris muscles was not increased by dexamethasone. Furthermore, dexamethasone treatment resulted in only a small increase in glutamine synthetase activity in the heart. Accordingly, there was only a slight change in glutamine synthetase mRNA level in this tissue. Thus, glucocorticoids regulate glutamine synthetase gene expression in rat muscles at the transcriptional level via interaction with intracellular glutamine production by muscle and to mechanisms underlying glucocorticoid-induced muscle atrophy

Sustained vs episodic mobilization among conflict-generated diasporas

There is increased interest in the connectivity of migrants with both their host-lands and their original homelands. This article brings a social movement perspective to bear on the issue of diaspora mobilization. Why do conflict-generated diasporas from the same original homeland and living in the same host-land mobilize in sustained versus episodic ways? This article focuses on the sustained mobilization of Bosnian Muslims versus the episodic mobilization of Croats and Serbs in the Netherlands in the early 2010s. I argue that a traumatic issue that binds three actors – diaspora, host-state, and home-state – is central to such mobilization. This issue is the failure of Dutch peace-keeping forces to protect the Srebrenica enclave in 1995. Migration integration regimes, threats from radical right parties, host-state foreign policy, and transnational influences can trigger episodic diaspora mobilization, but not sustain it

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated. Methodology: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e.g., Stampa algorigthm), yielding a capture 97.08% of the variation in the IL-6 gene using four tagging SNPs. Principal findings/results: In a whole-brain analysis, the polymorphism rs1800795 (−174 C/G) showed a strong main effect of genotype (43 CC vs. 150 CG vs. 100 GG; x = 24, y = −10, z = −15; F(2,286) = 8.54, puncorrected = 0.0002; pAlphaSim-corrected = 0.002; cluster size k = 577) within the right hippocampus head. Homozygous carriers of the G-allele had significantly larger hippocampus gray matter volumes compared to heterozygous subjects. None of the other investigated SNPs showed a significant association with grey matter volume in whole-brain analyses. Conclusions/significance: These findings suggest a possible neuroprotective role of the G-allele of the SNP rs1800795 on hippocampal volumes. Studies on the role of this SNP in psychiatric populations and especially in those with an affected hippocampus (e.g., by maltreatment, stress) are warranted.Bernhard T Baune, Carsten Konrad, Dominik Grotegerd, Thomas Suslow, Eva Birosova, Patricia Ohrmann, Jochen Bauer, Volker Arolt, Walter Heindel, Katharina Domschke, Sonja Schöning, Astrid V Rauch, Christina Uhlmann, Harald Kugel and Udo Dannlowsk

Local Government Revenue Mobilisation in Anglophone Africa

This paper examines opportunities and constraints facing local revenue mobilisation in anglophone Africa, with an emphasis on urban settings. It discusses specific revenue instruments and their effects on economic efficiency, income distribution and accountability. In particular, it addresses political and administrative constraints facing various revenue instruments and factors affecting citizens’ compliance. The analysis is illustrated with examples from across anglophone Africa. A general conclusion emerging from the study is that local revenues mobilised in most local government authorities in Africa are necessary but not sufficient to develop and supply adequate services for the fast-growing population. On this basis, areas for further research on local government revenue mobilisation in Africa are identifiedDfI