Absorption accompanied with chemical reaction in trickle-bed reactors.

A new development in the field of internals in packed columns is the use of structured packing types. Recently, a new structured packing type coated with a thin alumina layer (KATAPAKTM) has been developed. In this report, the results of an experimental and theoretical study concerning the possible applicability of this new packing material for hydrogenation processes in a trickle-bed reactor is presented. The palladium catalyzed hydrogenation of α-methylstryrene is used as a model reaction to study hydrodynamics and mass transfer characteristics in a trickle-bed reactor under reactive conditions. Converstions at several process conditions are measured in a pilot plant in which 3 mm spheres as well KATAPAKTM is applied as packing materials. A comparison of the results of some physical absorption experiments with the results of hydrogenation experiments showed that the resistance in series model—in which the total resistance against mass transfer is calculated from the separate resistances—is not valid in systems where heterogeneous reactions at the solid surface can enhance the mass transfer-rate at the gas-liquid interphase. With the aid of a developed trickle-bed reactor model, based on liquid diffusion, simultaneous reaction at the solid surface and zero volume mixing points, the mass transfer phenomena in trickle-bed reactors in conditions where the resistance in series model fails can be explained and described. The numerically solved model calculates the hydrogen profiles in the liquid films of the reactor and over all single pass conversions at several process conditions. These conclusions are confirmed by the results of the simulation of a model reactor, i.e. the laminar film reactor with a catalytically active wall. From the results of the measurements it could be concluded that in trickle-flow conditions, the application of KATAPAKTM does not significantly improved on the overall performance of trickle-bed reactors. The increase of the physical absorption rate due to better mass transfer characteristics of structured packings compared to dumped packing types—as reported in literature—will be eliminated to a certain extent in reactive systems due to the enhancement effect of heterogeneous reactions in trickle-flow operation

Excellent impact performance of PVC pipeline materials in gas distribution networks after many years of service

It has been about fifty years ago since the first unplasticized poly(vinyl chloride) (uPVC) pipes were installed for use in gas distribution purposes. Currently, about 22,500 km of uPVC is still in use in the Dutch gas distribution network. The pipes were originally designed for a lifetime of 50 years, but due to positive experiences the question arises if (and how long) the lifetime can be extended without any concessions to safety. This is supported by the data of leak surveys presented in this paper. The amount of leaks per installed km of uPVC is even slightly lower than that of polyethylene or steel pipes. Only impact modified PVC has a better performance. The impact behaviour is presumed to be the limiting factor for the lifetime of uPVC. Therefore, the impact behaviour was studied as a function of the age. Two types of research have been carried out: instrumented falling weight tests were carried out on recently produced uPVC pipes (some of which were aged artificially) and tensile impact tests were carried out on excavated uPVC pipes which had been in service for 20 to 50 years. The overall conclusion that can be drawn from these experiments is that the most significant change in impact behaviour is likely to occur in the early stages, just after the production of the uPVC pipe. Physical ageing occurs on a logarithmic timescale, thus the changes occurring between the 20th and the 50th year of service are relatively small compared to the changes that occur in the first 20 years. This leads to the conclusion that uPVC pipes that currently show good impact behaviour, are expected to have good impact properties for many years to come

An exploration of the experiences of adolescents living with HIV

This research endeavours to voice the told and untold stories of adolescents who have been living with HIV and have to adhere to chronic disease management at the Kalafong Hospital’s Paediatric HIV Clinic in Pretoria, South Africa. Six adolescents who attend the clinic regularly were interviewed using a social constructionist narrative approach. Data was collected by means of two semi-structured individual interviews with each participant using expressive art (drawings and poetry). Collaborative exploration between the researcher and each adolescent made it possible to co-construct the meanings that the adolescents attach to their stories of HIV, which inform their identities. The three-dimensional space approach by Clandinin and Connelly (2000) was used to interpret their stories according to the aspects of temporality, context and identities. Adolescents constructed multiple identities in the various contexts they described, though HIV formed a central part of these identities. They attributed different meanings to HIV, such as sameness or difference. The stories raised awareness of the challenges and dilemmas they are faced with, such as disclosure, adherence to treatment, disease management and lack of support. The adolescents identified lack of communication and impersonal interactions with health care providers as barriers to disease management. They had conflicting ideas about antiretroviral therapy and the restrictions it placed on their lives. Based on our study it is recommended that clinics should provide ongoing support to HIV-infected adolescents to assist them in accepting the consequences of HIV infection and to provide assistance not only with disclosure of their status to friends, family and partners, but also with adherence to treatment. The results can enhance health care providers’ understanding of the real-life situation of adolescents attending the clinic for disease management.http://www.tandf.co.uk/journals/titles/17450128.aspgv201

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5–41% of breast cancers. Here, we investigated the genetic differences between HER2-positive and HER2-negative admixed breast cancer components. We performed an in-depth analysis to explore the potential heterogeneity in the somatic mutational landscape of each individual tumour component. Formalin-fixed, paraffin-embedded breast cancer tissue of ten patients with at least one HER2-negative and at least one HER2-positive component was microdissected. Targeted next-generation sequencing was performed using a customized 53-gene panel. Somatic mutations and copy number variations were analysed. Overall, the tumours showed a heterogeneous distribution of 12 deletions, 9 insertions, 32 missense variants and 7 nonsense variants in 26 different genes, which are (likely) pathogenic. Three splice site alterations were identified. One patient had an EGFR copy number gain restricted to a HER2-negative in situ component, resulting in EGFR protein overexpression. Two patients had FGFR1 copy number gains in at least one tumour component. Two patients had an 8q24 gain in at least one tumour component, resulting in a copy number increase in MYC and PVT1. One patient had a CCND1 copy number gain restricted to a HER2- negative tumour comp

Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ

Although Ductal Carcinoma In Situ (DCIS) is a non-obligate precursor to ipsilateral invasive breast cancer (iIBC), most DCIS lesions remain indolent. Hence, overdiagnosis and overtreatment of DCIS is a major concern. There is an urgent need for prognostic markers that can distinguish harmless from potentially hazardous DCIS. We hypothesized that features of the breast adipose tissue may be associated with risk of subsequent iIBC. We performed a case-control study nested in a population-based DCIS cohort, consisting of 2,658 women diagnosed with primary DCIS between 1989-2005, uniformly treated with breast conserving surgery (BCS) alone. We assessed breast adipose features with digital pathology (HALO®, Indica Labs) and related these to iIBC risk in 108 women that developed subsequent iIBC (cases) and 168 women who did not (controls) by conditional logistic regression, accounting for clinicopathological and immunohistochemistry variables. Large breast adipocyte size was significantly associated with iIBC risk (Odds Ratio (OR) 2.75, 95% confidence interval (95%CI)= 1.25 to 6.05). High Cyclooxygenase (COX)-2 protein expression in the DCIS cells was also associated with subsequent iIBC (OR 3.70 (95%CI= 1.59 to 8.64). DCIS with both high COX-2 expression and large breast adipocytes was associated with a 12-fold higher risk (OR 12.0, 95%CI= 3.10 to 46.3, P</p

Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk

Background: Ductal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will never become invasive. To prevent overtreatment, we need to distinguish harmless from potentially hazardous DCIS. We investigated whether the immune microenvironment (IME) in DCIS correlates with transition to iIBC.Methods: Patients were derived from a Dutch population-based cohort of 10,090 women with pure DCIS with a median follow-up time of 12 years. Density, composition and proximity to the closest DCIS cell of CD20+ B-cells, CD3+CD8+ T-cells, CD3+CD8- T-cells, CD3+FOXP3+ regulatory T-cells, CD68+ cells, and CD8+Ki67+ T-cells was assessed with multiplex immunofluorescence (mIF) with digital whole-slide analysis and compared between primary DCIS lesions of 77 women with subsequent iIBC (cases) and 64 without (controls).Results: Higher stromal density of analysed immune cell subsets was significantly associated with higher grade, ER negativity, HER-2 positivity, Ki67 ≥ 14%, periductal fibrosis and comedonecrosis (P Conclusion: IME features analysed by mIF in 141 patients from a well-annotated cohort of pure DCIS with long-term follow-up are no predictors of subsequent iIBC, but do correlate with other factors (grade, ER, HER2 status, Ki-67) known to be associated with invasive recurrences.</p

New System for the Acceleration of the Airflow in Wind Turbines

Background: This patent is based on the wind industry technology called Diffuser Augmented Wind Turbines (DAWTs). This technology consists of a horizontal axis wind turbine, which is housed inside a duct with diverging section in the direction of the free air stream. In this paper, a review of preceding patents related to this technology is carried out. Objective: This paper presents an innovative patent to improve the performance of horizontal axis wind turbines. In particular, this system is aimed at improving the performance of those turbines that otherwise might not be installed due to the low wind resource existing at certain locations. Methods: The most innovative elements of this patent are: (1) the semi-spherical grooves, which are mechanized on the surface of the two diffusers in order to guarantee a more energetic boundary layer; (2) the coaxial diffuser, which is located downwind following the first diffuser in order to increase the suction effect on the air mass close to the inlet; (3) the coaxial rings located around the first diffuser outlet, which are used to deflect the external airflow toward the turbine wake; and (4), the selforientating system to orientate the system by the prevailing wind direction. Results: An application of the patent for increasing the power generated by a horizontal axis wind turbine with three blades is presented. The patent is designed and its performance is evaluated by using a Computational Fluid Dynamics code. The numerical results show that this system rises the airflow going through the rotor of the turbine. Conclusion: The patented device is an original contribution aimed at enabling a more profitable installation of wind turbines in places where the wind resource is insufficient because of the wind shear caused both by the proximity of the earth and the obstacles on the earth surface.This work was supported by the OASIS Research Project that was cofinanced by CDTI (Spanish Science and Innovation Ministry) and developed with the Spanish companies: Iridium, OHL Concesiones, Abertis, Sice, Indra, Dragados, OHL, Geocisa, GMV, Asfaltos Augusta, Hidrofersa, Eipsa, PyG, CPS, AEC and Torre de Comares Arquitectos S.L and 16 research centres. The authors also acknowledge the partial funding with FEDER funds under the Research Project FC-15-GRUPIN14-004. Finally, we also thank Swanson Analysis Inc. for the use of ANSYS University Research programs as well as the Workbench simulation environment