6 research outputs found
Amino acid chlorides: A journey from instability and racemization toward broader utility in organic synthesis including peptides and their mimetics Dedicated to Professor Padmanabhan Balaram, Indian Institute of Science, Bangalore on the occasion of his superannuation
Get PDFAn Efficient and Epimerization Free Synthesis of C-Terminal Arylamides Derived from α-Amino Acids and Peptide Acids via T3P Activation
Full text linkT3P (propylphosphonic anhydride) mediated conversion of N α-protected amino/peptide acids into thioacids
No full textA general, mild and an efficient protocol, which makes use of T3P as an acid activator for the synthesis of N α-protected amino/peptide thioacids from corresponding acids in the presence of finely ground Na 2S as hydrosulfide ion donor is described. The protocol employed significantly increases the overall efficiency as the yield, reaction duration and purity of even sterically hindered amino acids. © 2012 Elsevier Ltd. All rights reserved
