Consecutive reactions with sulfoximines: a direct access to 2-sulfonimidoylylidene tetrahydrofurans and 6-sulfonimidoylmethyl- 3,4-dihydro-2H-pyrans

International audience2-Sulfonimidoylylidene tetrahydrofurans and 2-sulfonimidoylylidene-5-vinyl tetrahydrofurans were readily synthesized via a consecutive acylation/SN2 sequence with total regio- and chemoselectivity from Johnson's sulfoximine derivatives. The same consecutive reaction could also be applied to the expeditious synthesis of 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans

Consecutive Reactions with Sulfoximines: Straightforward Synthesis of Substituted 5,5-Spiroketals

International audienceAn efficient sysnthesis of 5,5-spiroketals, i.e. 1,6-dioxaspiro[4.4]nonane derivatives, is described from 2-(sulfonimidoylmethylene)tetrahydrofurans involving a consecutive epoxide opening / oxa-Michael spiroketalization sequence. This methodology was applied to the very direct synthesis of chalcogran, a beetle pheromone

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists.

International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave assisted 1,3-dipolar cycloaddition as key step is described. The binding on membranes of cells that over express A(1) adenosine receptors (A(1)AR) was also evaluated. Among them, four compounds increased cAMP production, in a dose-dependent manner acting as antagonists of the A(1)AR, while two compounds act as agonists

Exploration of novel chemical space: synthesis and in vitro evaluation of N-functionalized tertiary sulfonimidamides

An unprecedented set of structurally diverse sulfonimidamides (47 compounds) has been prepared by various N‐functionalization reactions of tertiary =NH sulfonimidamide 2 aa. These N‐functionalization reactions of model compound 2 aa include arylation, alkylation, trifluoromethylation, cyanation, sulfonylation, alkoxycarbonylation (carbamate formation) and aminocarbonylation (urea formation). Small molecule X‐ray analyses of selected N‐functionalized products are reported. To gain further insight into the properties of sulfonimidamides relevant to medicinal chemistry, a variety of structurally diverse reaction products were tested in selected in vitro assays. The described N‐functionalization reactions provide a short and efficient approach to structurally diverse sulfonimidamides which have been the subject of recent, growing interest in the life sciences

L'histoire de Qatna (Syrie) d'après les fouilles récentes

Virolleaud Charles. L'histoire de Qatna (Syrie) d'après les fouilles récentes. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 72ᵉ année, N. 4, 1928. pp. 312-313

Envoi de documents sur les dernières découvertes en Syrie

Virolleaud Charles. Envoi de documents sur les dernières découvertes en Syrie. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 66ᵉ année, N. 3, 1922. pp. 233-234

Hymne phénicien au dieu Nikal et aux déesses Kosarot provenant de Ras Shamra

Virolleaud Charles. Hymne phénicien au dieu Nikal et aux déesses Kosarot provenant de Ras Shamra. In: Syria. Tome 17 fascicule 3, 1936. pp. 209-228

Éloge funèbre de M. Louis Bréhier, membre libre non résidant

Virolleaud Charles. Éloge funèbre de M. Louis Bréhier, membre libre non résidant. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 95ᵉ année, N. 4, 1951. pp. 356-360

Note complémentaire sur le poème de Môt et Aleïn

Virolleaud Charles. Note complémentaire sur le poème de Môt et Aleïn. In: Syria. Tome 12 fascicule 4, 1931. pp. 350-357