755 research outputs found

    Controlled by the Corporate Narrative: Obama\u27s Education Policy, the Shock Doctrine, and Mechanisms of Capitalist Power

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    The contributors to this special issue of The Journal of Inquiry and Action provide insight into why the Obama administration’s educational policies manifest the dominance of neoliberal ideology over most elements of social life. The articles presented herein build on the work originally presented in The Phenomenon of Obama and the agenda for Education: Can hope audaciously trump neoliberalism? (Carr & Porfilio, 2011)

    The German car sharing market consumer perceptions and behaviour

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    Recently, a shift away from ownership towards pay-per-use concepts could be noticed throughout all industries. In the field of mobility, this trend is seen mainly in car sharing, a vehicle service for assigned members. The urban mobility sector has been transforming itself throughout the last years: car sharing has been growing tremendously, but there is still a big room to foster its position as sustainable mean of transport. In the following work project, the German car sharing market is put into focus, delivering profound insights about consumer perceptions and profiles. The objective is to give recommendations on how this sector can leverage and increase significance. This is done by an analysis about the value car sharing is offering to its consumers, while assessing their expectations and experiences by an empiricalquantitative approach. Recommendations to increase popularity for car sharing among consumers are elaborated based on the results of this project

    Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock

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    Intensive livestock production and management systems are associated with increased faecal-oral pathogen transmission which can contribute to a high prevalence of multiple Salmonella serovars in large dairy farms and feedlots. Outbreaks of salmonellosis in livestock often reflect a series of events that compromise host immunity and increase pathogen exposure. High risk groups in cattle include neonates and post partum cows (Anderson, et al., 2001; House, et al., 2001a; Fossler, et al., 2005a) and variation in susceptibility to salmonella infection has been observed in sheep entering feedlots according to property of origin, body condition, and time of year (Norris, et al., 1989a; Norris, et al., 1989b; Richards and Hyder, 1991; Kelly, 1995; Makin, 2011). The associated increase in the incidence of disease and contamination of livestock-derived food products imposes a significant risk to food safety via consumption of contaminated meat, milk, eggs and vegetables. The development and application of effective Salmonella vaccines offers a potential means of reducing industry associated losses and public health risks. Effective Salmonella vaccination therefore requires induction of protection against several Salmonella serovars and stimulation of both innate and acquired immune mechanisms. Vaccine prophylaxis is normally achieved through vaccinating animals several weeks prior to virulent pathogen exposure. This is not possible in neonates where exposure occurs at birth and in feedlots where livestock are sourced from diverse locations and vendors. Additionally, direct physical handling of livestock to administer vaccines contributes to stress and may lead to carcass damage. Conducting stressful procedures at feedlot induction when there is concurrent exposure to a diversity of pathogens contributes to an increased risk of disease. iii Traditional vaccination methods are labour intensive and associated with carcass damage and adverse reactions. Oral delivery of vaccines and medications via drinking water is a common practice in intensively managed poultry. Oral vaccine delivery via drinking water avoids the stress of additional handling and provides a means of rapidly vaccinating large numbers of animals. The efficacy of Salmonella vaccination is largely influenced by the diversity of Salmonella serovars encountered and the interval between immunisation and pathogen exposure, which may be short in field settings, e.g., following birth, during transport and following introduction into feedlots. The timing of virulent pathogen exposure may also have an impact on the safety of a Salmonella vaccine. It is imperative to develop livestock vaccines that are capable of safely eliciting potent states of cross-protective immunity against a diversity of serovars. This thesis examines the capacity of the dam S. Typhimurium vaccine (serogroup B) to elicit cross-protection against a virulent challenge in models of neonate and adult ruminant models of salmonellosis, as well as investigating in-water vaccine delivery. Cross-protective efficacy of the vaccine was evaluated against an emerging, clinically relevant, and multi-drug resistant strain of serovar Newport (serogroup C2-C3) that had been associated with clinical disease in calves and humans (CDC, 2002; Clark, 2004). Vaccinated calves challenged with S. Newport exhibited a significant attenuation of clinical disease and a concomitant reduction in S. Newport faecal shedding and colonisation of mesenteric lymph nodes and lungs compared to non-vaccinated control animals. The safety and efficacy of a S. Typhimurium dam vaccine in adult sheep was demonstrated via novel oral delivery in drinking water (ad libitum). The capacity of S. Typhimurium dam vaccine to be delivered in drinking water to protect livestock from virulent Salmonella challenge offers an effective, economical, stressor free Salmonella prophylaxis for intensive livestock production systems

    Math in Motion

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    Everything we know about the universe rests on the foundation of mathematics. Somehow, though, the magic of mathematics – the true power of numbers and their beautiful wildness – gets lost in math class. Children, our most magical thinkers, get turned off math in grade school and miss out on a language through which they could learn to read and change the world. VCU Math In Motion will generate a creative, dynamic STEM education initiative within the Richmond community using an innovative curriculum and a customized mobile unit to bring the beauty of math to Richmond region school children in grades 5-9, through partnerships across VCU and within the local school system

    Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies

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    Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living systematic review and meta-analysis to synthesize and triangulate the evidence from preclinical animal experiments and clinical studies on the efficacy, safety, and underlying mechanism of action of TAAR1 agonism for psychosis. Methods: Independent searches will be conducted in multiple electronic databases to identify clinical and animal experimental studies comparing TAAR1 agonists with licensed antipsychotics or other control conditions in individuals with psychosis or animal models for psychosis, respectively. The primary outcomes will be overall psychotic symptoms and their behavioural proxies in animals. Secondary outcomes will include side effects and neurobiological measures. Two independent reviewers will conduct study selection, data extraction using predefined forms, and risk of bias assessment using suitable tools based on the study design. Ontologies will be developed to facilitate study identification and data extraction. Data from clinical and animal studies will be synthesized separately using random-effects meta-analysis if appropriate, or synthesis without meta-analysis. Study characteristics will be investigated as potential sources of heterogeneity. Confidence in the evidence for each outcome and source of evidence will be evaluated, considering the summary of the association, potential concerns regarding internal and external validity, and reporting biases. When multiple sources of evidence are available for an outcome, an overall conclusion will be drawn in a triangulation meeting involving a multidisciplinary team of experts. We plan trimonthly updates of the review, and any modifications in the protocol will be documented. The review will be co-produced by multiple stakeholders aiming to produce impactful and relevant results and bridge the gap between preclinical and clinical research on psychosis

    Distribution and ecology of parent taxa of pollen lodged within the Latin American Pollen Database

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    The cornerstone of palaeoecological research, concerned with vegetation dynamics over the recent geological past, is a good understanding of the present-day ecology and distribution of the taxa. This is particularly necessary in areas of high floral diversity such as Latin America. Vegetation reconstructions, based on numerous pollen records, now exist with respect to all major vegetation associations from Latin America. With this ever-increasing number of sedimentary records becoming available, there is a need to collate this information and to provide information concerning ecology and distribution of the taxa concerned. The existing Latin American Pollen Database (LAPD) meets the first of these needs. Information concerning the ecology and distribution of the parent taxa responsible for producing the pollen, presently lodged within the LAPD, is the focus of this paper. The 'dictionary' describes the ecology and distribution of the parent taxa responsible for producing pollen identified within sedimentary records. These descriptions are based on a wide range of literature and extensive discussions with members of the palaeoecological community working in different parts of Latin America investigating a range of different vegetation types.Fil: Marchant, Robert. University of Amsterdam; Países BajosFil: Almeida, Lucía. Universidad Nacional Autónoma de México; MéxicoFil: Behling, Hermann. Center for Tropical Maritime Ecology; AlemaniaFil: Berrio, Juan Carlos. University of Amsterdam; Países BajosFil: Bush, Mark. West University Boulevard; Estados UnidosFil: Cleef, Antoine. University of Amsterdam; Países BajosFil: Duivenvoorden, Joost. University of Amsterdam; Países BajosFil: Kappelle, Maarten. Instituto Nacional de Biodiversidad (INBio); Costa RicaFil: De Oliveira, Paulo. Universidade de Sao Paulo; BrasilFil: de Oliveira, Ary Teixeira. Universidade Federal de Lavras; BrasilFil: Lozano García, Socorro. Universidad Nacional Autónoma de México; MéxicoFil: Hooghiemstra, Henry. University of Amsterdam; Países BajosFil: Ledru, Marie Pierre. Instituto de Geociencias; BrasilFil: Ludlow Wiechers, Beatriz. Universidad Nacional Autónoma de México; MéxicoFil: Markgraf, Vera. University of Colorado; Estados UnidosFil: Mancini, Maria Virginia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Laboratorio de Paleoecología y Palinología; ArgentinaFil: Paez, Marta Mercedes. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Laboratorio de Paleoecología y Palinología; ArgentinaFil: Prieto, Aldo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Laboratorio de Paleoecología y Palinología; ArgentinaFil: Rangel, Olando. Universidad Nacional de Colombia; ColombiaFil: Salgado Labouriau, Maria Lea. Universidade do Brasília; Brasi

    Trace amine-associated receptor 1 (TAAR1) agonists for psychosis:protocol for a living systematic review and meta-analysis of human and non-human studies

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    BACKGROUND: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living systematic review and meta-analysis to synthesize and triangulate the evidence from preclinical animal experiments and clinical studies on the efficacy, safety, and underlying mechanism of action of TAAR1 agonism for psychosis.METHODS: Independent searches will be conducted in multiple electronic databases to identify clinical and animal experimental studies comparing TAAR1 agonists with licensed antipsychotics or other control conditions in individuals with psychosis or animal models for psychosis, respectively. The primary outcomes will be overall psychotic symptoms and their behavioural proxies in animals. Secondary outcomes will include side effects and neurobiological measures. Two independent reviewers will conduct study selection, data extraction using predefined forms, and risk of bias assessment using suitable tools based on the study design. Ontologies will be developed to facilitate study identification and data extraction. Data from clinical and animal studies will be synthesized separately using random-effects meta-analysis if appropriate, or synthesis without meta-analysis. Study characteristics will be investigated as potential sources of heterogeneity. Confidence in the evidence for each outcome and source of evidence will be evaluated, considering the summary of the association, potential concerns regarding internal and external validity, and reporting biases. When multiple sources of evidence are available for an outcome, an overall conclusion will be drawn in a triangulation meeting involving a multidisciplinary team of experts. We plan trimonthly updates of the review, and any modifications in the protocol will be documented. The review will be co-produced by multiple stakeholders aiming to produce impactful and relevant results and bridge the gap between preclinical and clinical research on psychosis.PROTOCOL REGISTRATION: PROSPERO-ID: CRD42023451628.</p
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