Eu – Bois-l’Abbé

La baisse d’effectifs liée à la situation sanitaire exceptionnelle et la réduction de la période d’intervention en juin ont amoindri les résultats de la campagne de fouilles 2020. Trois opérations se sont succédé de la mi-juin à la fin du mois d’août et ont rythmé cette deuxième année de la triennale 2019-2021 (Mantel et al. 2022). Les espaces fouillés ont ensuite systématiquement fait l’objet d’un rebouchage raisonné et d’un engazonnement destinés à participer à la mise en valeur en vue de ..

Overview of adverse events related to invasive procedures in the intensive care unit

BackgroundThis study was conducted to determine the frequency, predictors, and clinical impact of adverse events (AEs) related to invasive procedures in the intensive care unit (ICU). Methods This was a prospective observational study of ICUs in a university hospital. Results A total of 893 patients requiring invasive procedures were admitted over a 1-year period. Among these, 310 patients (34.7%) experienced a total of 505 AEs. The mean number of AEs per patient was 1.6 ± 1.1 (range, 1-7). Infectious AEs were significantly more frequent than mechanical AEs (60.4% vs 39.6%; P = .01). Factors independently associated with AE occurrence were isolation of multidrug-resistant bacteria at ICU admission, >5 invasive procedures, and ICU length of stay >8 days. Thirty-three AEs (6.5%) resulted in severe clinical impact, including 24 deaths. Ventilator-associated pneumonia (VAP) accounted for 62.5% of the deaths related to AEs. Conclusions One-third of critically ill patients experienced AEs related to invasive procedures. Severe AEs were associated with 11% of all ICU deaths. VAP was the most frequent AE related to death. An improved assessment of the risk–benefit balance before each invasive procedure and increased efforts to decrease VAP prevalence are needed to reduce AE-related mortality

Eu – Bois-l’Abbé

La campagne 2017 s’inscrit dans le cadre d’une fouille programmée et d’une première année probatoire du PCR « Topographie générale et insertion territoriale de la ville de Briga », coordonné par Étienne Mantel, qui débutera en 2019. Un conseil scientifique, constitué de Jean-Yves Marc (université de Strasbourg), de Séverine Blin (CNRS) et de Matthieu Poux (université Lumière Lyon II), a été formé pour définir les choix scientifiques et les priorités de cette action. Avant de lancer un véritab..

Topographie générale et insertion territoriale de la ville antique de Briga

Initié en 2018, le projet de recherche collectif (PCR) « Topographie générale et insertion territoriale de la ville antique de Briga » coordonné par Étienne Mantel (Drac-SRA de Normandie) étudie le site archéologique du « Bois-l’Abbé », situé à Eu. Issus de différentes institutions, les membres de l’équipe actuelle poursuivent un double objectif : comprendre la structuration et l’évolution de la ville de manière dynamique, depuis ses origines protohistoriques jusqu’à son déplacement en fond ..

Eu – Bois l’Abbé

La campagne de la fouille programmée 2018 s’inscrit dans le cadre d’une seconde année probatoire du PCR « Topographie générale et insertion territoriale de la ville de Briga », coordonné par Étienne Mantel, qui sera effectif en 2019. Le conseil scientifique, constitué de Jean-Yves Marc (université de Strasbourg), Séverine Blin (CNRS), Matthieu Poux (université Lumière Lyon II), Thierry Dechezleprêtre (Conseil départemental des Vosges) et Laurent Popovitch (université de Bourgogne) a définitiv..

Étudier l’occupation d’une ville : les enjeux du PCR « Topographie générale et insertion territoriale de l’agglomération antique de Briga »

Les fouilles conduites depuis 2006 sur le site du « Bois-l’Abbé », situé sur la commune d’Eu (Seine-Maritime), ont permis de mettre en évidence que ce dernier ne consistait non pas en un sanctuaire isolé, comme l’évoquaient les précédents chercheurs, mais comme une agglomération nommée Briga, dont la superficie atteignait au moins 65 hectares à son apogée au début du iiie siècle. À la suite de ces découvertes, le Programme Collectif de Recherche « Topographie générale et insertion territoriale de l’agglomération antique de Briga », coordonné par Étienne Mantel (DRAC – SRA de Normandie), a été initié en 2018. Interdisciplinaire par nature, ce programme a pour objectif de fédérer des intervenants venant de différentes institutions (DRAC, Universités, INRAP et bénévoles) afin d’accroître les connaissances sur l’urbanisme, les origines, le développement et le déclin de cette agglomération encore inconnue jusqu’en 2006

Severe community-acquired adenovirus pneumonia in an immunocompetent 44-year-old woman: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>This case report describes a rare condition: community-acquired adenovirus pneumonia in an immunocompetent adult. The diagnosis was achieved by using a multiplex real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay and highlights the usefulness of these novel molecular diagnostic techniques in patients hospitalized with acute respiratory illness. We also performed a literature search for previously published cases and present a summary of the clinical, laboratory and radiological features of this condition.</p> <p>Case presentation</p> <p>A 44-year-old immunocompetent Caucasian woman was admitted to our hospital with an acute febrile respiratory illness associated with a rash. Her blood tests were non-specifically abnormal, and tests for bacterial pathogens were negative. Her condition rapidly deteriorated while she was in our hospital and required mechanical ventilation and inotropic support. A multiplex real-time RT-PCR assay performed on respiratory specimens to detect respiratory viruses was negative for influenza but positive for adenovirus DNA. The patient recovered on supportive treatment, and antibiotics were stopped after 5 days.</p> <p>Conclusions</p> <p>Community-acquired adenovirus pneumonia in immunocompetent adult civilians presents as a non-specific acute febrile respiratory illness followed by the abrupt onset of respiratory failure, often requiring mechanical ventilation. Its laboratory and radiological features are typical of viral infections but also are non-specific. Novel multiplex real-time RT-PCR testing for respiratory viruses enabled us to rapidly make the diagnosis in this case. The new technology could be used more widely in patients with acute respiratory illness and has potential utility for rationalization of the use of antibiotics and improving infection control measures.</p

Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery

ImportanceBefore surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.ObjectiveTo evaluate whether a continuation strategy vs a discontinuation strategy of RASIs before major noncardiac surgery results in decreased complications at 28 days after surgery.Design, setting, and participantsRandomized clinical trial that included patients who were being treated with a RASI for at least 3 months and were scheduled to undergo a major noncardiac surgery between January 2018 and April 2023 at 40 hospitals in France.InterventionPatients were randomized to continue use of RASIs (n = 1107) until the day of surgery or to discontinue use of RASIs 48 hours prior to surgery (ie, they would take the last dose 3 days before surgery) (n = 1115).Main outcomes and measuresThe primary outcome was a composite of all-cause mortality and major postoperative complications within 28 days after surgery. The key secondary outcomes were episodes of hypotension during surgery, acute kidney injury, postoperative organ failure, and length of stay in the hospital and intensive care unit during the 28 days after surgery.ResultsOf the 2222 patients (mean age, 67 years [SD, 10 years]; 65% were male), 46% were being treated with angiotensin-converting enzyme inhibitors at baseline and 54% were being treated with angiotensin receptor blockers. The rate of all-cause mortality and major postoperative complications was 22% (245 of 1115 patients) in the RASI discontinuation group and 22% (247 of 1107 patients) in the RASI continuation group (risk ratio, 1.02 [95% CI, 0.87-1.19]; P = .85). Episodes of hypotension during surgery occurred in 41% of the patients in the RASI discontinuation group and in 54% of the patients in the RASI continuation group (risk ratio, 1.31 [95% CI, 1.19-1.44]). There were no other differences in the trial outcomes.Conclusions and relevanceAmong patients who underwent major noncardiac surgery, a continuation strategy of RASIs before surgery was not associated with a higher rate of postoperative complications than a discontinuation strategy.Trial registrationClinicalTrials.gov Identifier: NCT03374449

La céramique du quartier nord

International audienc