Alignment and preliminary outcomes of an ELT-size instrument to a very large telescope: LINC-NIRVANA at LBT

LINC-NIRVANA (LN) is a high resolution, near infrared imager that uses a multiple field-of-view, layer-oriented, multi-conjugate AO system, consisting of four multi-pyramid wavefront sensors (two for each arm of the Large Binocular Telescope, each conjugated to a different altitude). The system employs up to 40 star probes, looking at up to 20 natural guide stars simultaneously. Its final goal is to perform Fizeau interferometric imaging, thereby achieving ELT-like spatial resolution (22.8 m baseline resolution). For this reason, LN is also equipped with a fringe tracker, a beam combiner and a NIR science camera, for a total of more than 250 optical components and an overall size of approximately 6x4x4.5 meters. This paper describes the tradeoffs evaluated in order to achieve the alignment of the system to the telescope. We note that LN is comparable in size to planned ELT instrumentation. The impact of such alignment strategies will be compared and the selected procedure, where the LBT telescope is, in fact, aligned to the instrument, will be described. Furthermore, results coming from early night-time commissioning of the system will be presented.Comment: 8 pages, 6 pages, AO4ELT5 Proceedings, 201

Data processing on simulated data for SHARK-NIR

A robust post processing technique is mandatory to analyse the coronagraphic high contrast imaging data. Angular Differential Imaging (ADI) and Principal Component Analysis (PCA) are the most used approaches to suppress the quasi-static structure in the Point Spread Function (PSF) in order to revealing planets at different separations from the host star. The focus of this work is to apply these two data reduction techniques to obtain the best limit detection for each coronagraphic setting that has been simulated for the SHARK-NIR, a coronagraphic camera that will be implemented at the Large Binocular Telescope (LBT). We investigated different seeing conditions ($0.4"-1"$) for stellar magnitude ranging from R=6 to R=14, with particular care in finding the best compromise between quasi-static speckle subtraction and planet detection.Comment: 9 pages, 8 figures, proceeding for the fifth Adaptive Optics for Extremely Large Telescopes (AO4ELT5) meeting in 201

CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer

The CDKN1B gene, encoding for the CDK inhibitor p27kip1, is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. Lessons learned from small intestine neuroendocrine tumors suggest that CDKN1B mutations could be subclonal, raising the question of whether a deeper sequencing approach could lead to the identification of higher numbers of patients with mutations. Here, we addressed this question and analyzed human cancer biopsies from breast (n = 396), ovarian (n = 110) and head and neck squamous carcinoma (n = 202) patients, using an ultra-deep sequencing approach. Notwithstanding this effort, the mutation rate of CDKN1B remained substantially aligned with values from the literature, showing that essentially only hormone receptor-positive breast cancer displayed CDKN1B mutations in a relevant number of cases (3%). However, the analysis of copy number variation showed that another fraction of luminal breast cancer displayed loss (8%) or gain (6%) of the CDKN1B gene, further reinforcing the idea that the function of p27kip1 is important in this type of tumor. Intriguingly, an enrichment for CDKN1B alterations was found in samples from premenopausal luminal breast cancer patients (n = 227, 4%) and in circulating cell-free DNA from metastatic luminal breast cancer patients (n = 59, 8.5%), suggesting that CDKN1B alterations could correlate with tumor aggressiveness and/or occur later during disease progression. Notably, many of the identified somatic mutations resulted in p27kip1 protein truncation, leading to loss of most of the protein or of its C-terminal domain. Using a gene-editing approach in a luminal breast cancer cell line, MCF-7, we observed that the expression of p27kip1 truncating mutants that lose the C-terminal domains failed to rescue most of the phenotypes induced by CDKN1B gene knockout, indicating that the functions retained by the C-terminal portion are critical for its role as an oncosuppressor, at least in luminal breast cancer. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland

A CHEOPS-enhanced view of the HD 3167 system

A. C. C. and T. G. W. acknowledge support from STFC consolidated grant numbers ST/R000824/1 and ST/V000861/1, and UKSA grant number ST/R003203/1.Much remains to be understood about the nature of exoplanets smaller than Neptune, most of which have been discovered in compact multi-planet systems. With its inner ultra-short period planet b aligned with the star and two larger outer planets d-c on polar orbits, the multi-planet system HD 3167 features a peculiar architecture and offers the possibility to investigate both dynamical and atmospheric evolution processes. To this purpose we combined multiple datasets of transit photometry and radial velocimetry (RV) to revise the properties of the system and inform models of its planets. This effort was spearheaded by CHEOPS observations of HD 3167b, which appear inconsistent with a purely rocky composition despite its extreme irradiation. Overall the precision on the planetary orbital periods are improved by an order of magnitude, and the uncertainties on the densities of the transiting planets b and c are decreased by a factor of 3. Internal structure and atmospheric simulations draw a contrasting picture between HD 3167d, likely a rocky super-Earth that lost its atmosphere through photo-evaporation, and HD 3167c, a mini-Neptune that kept a substantial primordial gaseous envelope. We detect a fourth, more massive planet on a larger orbit, likely coplanar with HD 3167d-c. Dynamical simulations indeed show that the outer planetary system d-c-e was tilted, as a whole, early in the system history, when HD 3167b was still dominated by the star influence and maintained its aligned orbit. RV data and direct imaging rule out that the companion that could be responsible for the present-day architecture is still bound to the HD 3167 system. Similar global studies of multi-planet systems will tell how many share the peculiar properties of the HD 3167 system, which remains a target of choice for follow-up observations and simulations. © 2022 EDP Sciences. All rights reserved.Publisher PDFPeer reviewe

CHEOPS and TESS view of the ultra-short period super-Earth TOI-561 b

Ultra-short period planets (USPs) are a unique class of super-Earths with an orbital period of less than a day and hence subject to intense radiation from their host star. While most of them are consistent with bare rocks, some show evidence of a heavyweight envelope, which could be a water layer or a secondary metal-rich atmosphere sustained by an outgassing surface. Much remains to be learned about the nature of USPs. The prime goal of the present work is to study the bulk planetary properties and atmosphere of TOI-561b, through the study of its transits and occultations. We obtained ultra-precise transit photometry of TOI-561b with CHEOPS and performed a joint analysis of this data with four TESS sectors. Our analysis of TOI-561b transit photometry put strong constraints on its properties, especially on its radius, Rp=1.42 +/- 0.02 R_Earth (at ~2% error). The internal structure modelling of the planet shows that the observations are consistent with negligible H/He atmosphere, however requiring other lighter materials, in addition to pure iron core and silicate mantle to explain the observed density. We find that this can be explained by the inclusion of a water layer in our model. We searched for variability in the measured Rp/R* over time to trace changes in the structure of the planetary envelope but none found within the data precision. In addition to the transit event, we tentatively detect occultation signal in the TESS data with an eclipse depth of ~27 +/- 11 ppm. Using the models of outgassed atmospheres from the literature we find that the thermal emission from the planet can mostly explain the observation. Based on this, we predict that NIR/MIR observations with JWST should be able to detect silicate species in the atmosphere of the planet. This could also reveal important clues about the planetary interior and help disentangle planet formation and evolution models.Comment: 17 pages, 10 + 3 figures, 4 tables, accepted for publication in A&A (abstract abbreviated

A CHEOPS-enhanced view of the HD3167 system

Much remains to be understood about the nature of exoplanets smaller than Neptune, most of which have been discovered in compact multi-planet systems. With its inner ultra-short period planet b aligned with the star and two larger outer planets d-c on polar orbits, the multi-planet system HD 3167 features a peculiar architecture and offers the possibility to investigate both dynamical and atmospheric evolution processes. To this purpose we combined multiple datasets of transit photometry and radial velocimetry (RV) to revise the properties of the system and inform models of its planets. This effort was spearheaded by CHEOPS observations of HD 3167b, which appear inconsistent with a purely rocky composition despite its extreme irradiation. Overall the precision on the planetary orbital periods are improved by an order of magnitude, and the uncertainties on the densities of the transiting planets b and c are decreased by a factor of 3. Internal structure and atmospheric simulations draw a contrasting picture between HD 3167d, likely a rocky super-Earth that lost its atmosphere through photo-evaporation, and HD 3167c, a mini-Neptune that kept a substantial primordial gaseous envelope. We detect a fourth, more massive planet on a larger orbit, likely coplanar with HD 3167d-c. Dynamical simulations indeed show that the outer planetary system d-c-e was tilted, as a whole, early in the system history, when HD 3167b was still dominated by the star influence and maintained its aligned orbit. RV data and direct imaging rule out that the companion that could be responsible for the present-day architecture is still bound to the HD\,3167 system. Similar global studies of multi-planet systems will tell how many share the peculiar properties of the HD3167 system, which remains a target of choice for follow-up observations and simulations.Comment: 22 pages, 23 pages, accepted for publication in A&A (18 August 2022). Updated author list in new versio

Refining the properties of the TOI-178 system with CHEOPS and TESS

The TOI-178 system consists of a nearby late K-dwarf transited by six planets in the super-Earth to mini-Neptune regime, with orbital periods between 1.9 and 20.7 days. All planets but the innermost one form a chain of Laplace resonances. Mass estimates derived from a preliminary radial velocity (RV) dataset suggest that the planetary densities do not decrease in a monotonic way with the orbital distance to the star, contrary to what one would expect based on simple formation and evolution models. To improve the characterisation of this key system and prepare for future studies (in particular with JWST), we perform a detailed photometric study based on 40 new CHEOPS visits, one new TESS sector, as well as previously published CHEOPS, TESS, and NGTS data. First we perform a global analysis of the 100 transits contained in our data to refine the transit parameters of the six planets and study their transit timing variations (TTVs). We then use our extensive dataset to place constraints on the radii and orbital periods of potential additional transiting planets in the system. Our analysis significantly refines the transit parameters of the six planets, most notably their radii, for which we now obtain relative precisions $\lesssim$3%, with the exception of the smallest planet $b$ for which the precision is 5.1%. Combined with the RV mass estimates, the measured TTVs allow us to constrain the eccentricities of planets $c$ to $g$, which are found to be all below 0.02, as expected from stability requirements. Taken alone, the TTVs also suggest a higher mass for planet $d$ than the one estimated from the RVs, which had been found to yield a surprisingly low density for this planet. However, the masses derived from the current TTV dataset are very prior-dependent and further observations, over a longer temporal baseline, are needed to deepen our understanding of this iconic planetary system.Comment: 20 pages, 5 figures, 9 tables. Accepted for publication in A&