Length Measurement of High-brightness Electron Beam thanks to the 3-Phase Method

ISBN 978-3-95450-132-8International audienceThe goal of 3-phase method is to determine the length of an electron beam without dedicated diagnostics by varying the measurement conditions of its energy spread, through a change in the RF phase of an accelerating structure. The originality here comes from the fact that it is applied on high-brightness electron beams of few MeV generated by RF photo-injectors. It allows testing the accuracy of 3-phase method, since the length to reconstruct is known as being that of the laser pulse generating the beam. It requires establishing the longitudinal transfer matrix of a RF photo-injector, which is difficult since the electron velocity vary from 0 to relativistic during its path*. The 3-phase method in RF photo-injector has been simulated by ASTRA and PARMELA codes, validating the principle of the method. First measurement has been done on PHIL accelerator at LAL, showing a good agreement with the expected length. I will then show results obtained at PITZ with a standing wave booster and a comparison with those coming from a Cerenkov detector. Finally, measurements at higher energy performed on the SOLEIL LINAC with travelling wave accelerating structures will be exposed

Titan's atmosphere as observed by Cassini/VIMS solar occultations: CH4_4, CO and evidence for C2_2H6_6 absorption

We present an analysis of the VIMS solar occultations dataset, which allows us to extract vertically resolved information on the characteristics of Titan's atmosphere between 100-700 km with a characteristic vertical resolution of 10 km. After a series of data treatment procedures, 4 occultations out of 10 are retained. This sample covers different seasons and latitudes of Titan. The transmittances show clearly the evolution of the haze and detect the detached layer at 310 km in Sept. 2011 at mid-northern latitudes. Through the inversion of the transmission spectra with a line-by-line radiative transfer code we retrieve the vertical distribution of CH$_4$ and CO mixing ratio. The two methane bands at 1.4 and 1.7 {\mu}m are always in good agreement and yield an average stratospheric abundance of $1.28\pm0.08$%. This is significantly less than the value of 1.48% obtained by the GCMS/Huygens instrument. The analysis of the residual spectra after the inversion shows that there are additional absorptions which affect a great part of the VIMS wavelength range. We attribute many of these additional bands to gaseous ethane, whose near-infrared spectrum is not well modeled yet. Ethane contributes significantly to the strong absorption between 3.2-3.5 {\mu}m that was previously attributed only to C-H stretching bands from aerosols. Ethane bands may affect the surface windows too, especially at 2.7 {\mu}m. Other residual bands are generated by stretching modes of C-H, C-C and C-N bonds. In addition to the C-H stretch from aliphatic hydrocarbons at 3.4 {\mu}m, we detect a strong and narrow absorption at 3.28 {\mu}m which we tentatively attribute to the presence of PAHs in the stratosphere. C-C and C-N stretching bands are possibly present between 4.3-4.5 {\mu}m. Finally, we obtain the CO mixing ratio between 70-170 km. The average result of $46\pm16$ ppm is in good agreement with previous studies.Comment: 51 pages, 28 figure

Seasonal Variations in Titan's Stratosphere Observed with Cassini/CIRS: Temperature, Trace Molecular Gas and Aerosol Mixing Ratio Profiles

Titan's northern spring equinox occurred in August 2009. General Circulation Models (e.g. Lebonnois et al., 2012) predict strong modifications of the global circulation in this period, with formation of two circulation cells instead of the pole-to-pole cell that occurred during northern winter. This winter single cell, which had its descending branch at the north pole, was at the origin of the enrichment of molecular abundances and high stratopause temperatures observed by Cassini/CIRS at high northern latitudes (e.g. Achterberg et al., 2011, Coustenis et al., 2010, Teanby et al., 2008, Vinatier et al., 2010). The predicted dynamical seasonal variations after the equinox have strong impact on the spatial distributions of trace gas, temperature and aerosol abundances. We will present here an analysis of CIRS limb-geometry datasets acquired in 2010 and 2011 that we used to monitor the seasonal evolution of the vertical profiles of temperature, molecular (C2H2, C2H6, HCN, ..) and aerosol abundances

EVOLUTION OF THE STRATOSPHERIC TEMPERATURE AND CHEMICAL COMPOSITION OVER ONE TITANIAN YEAR

Since the Voyager 1 (V1) flyby in 1980, Titans exploration from space and the ground has been ongoing for more than a full revolution of Saturn around the Sun (one Titan year or 29.5 Earth years was completed in May 2010). In this study we search for temporal variations affecting Titans atmospheric thermal and chemical structure within that year. We process Cassini CIRS data taken during the Titan flybys from 2006-2013 and compare them to the 1980 V1IRIS spectra (re-analyzed here). We also consider data from Earth-based and -orbiting observatories (such as from the ISO, re-visited). When we compare the CIRS 2010 and the IRIS data we find limited inter-annual variations, below the 25 or35 levels for the lower and middle, or the high latitudes, respectively. A return to the 1980 stratospheric temperatures and abundances is generally achieved from 50degN to 50degS, indicative of the solar radiation being the dominating energy source at 10 AU, as for the Earth, as predicted by GCM and photochemical models. However, some exceptions exist among the most complex hydrocarbons (C4H2 and C3H4), especially in the North. In the Southern latitudes, since 2012, we see a trend for an increase of several trace gases, possibly indicative of a seasonal atmospheric reversal. At the Northern latitudes we found enhanced abundances around the period of the northern spring equinox in mid-2009 (as in Bampasidis et al. 2012), which subsequently decreased (from 2010-2012) returning to values similar to those found in the V1 epoch a Titanian year before

MEASUREMENT OF LOW-CHARGED ELECTRON BEAM WITH A SCINTILLATOR SCREEN

Abstract Measuring electron beam charge lower than 1pC in an accelerator is very challenging since the traditional diagnostics, like Faraday Cup and ICT (Integrated Current Transformer), are limited in resolution to a few pC because of electronic noise. A way to simply measure lower charge would be then to use the linear relation, existing before saturation regime, between the incident charge on a scintillating screen and the total light intensity emitted in response by this screen. Measurements have been performed on PHIL accelerator at LAL, with charge lower than 200pC, with a LANEX screen located close to a Faraday Cup or an ICT. It shows a very good linear response of the screen down to the Faraday Cup and ICT resolution limits ( 3pC for the Faraday Cup and 10pC for the ICT) and therefore allows calibrating the screen for lower charge measurement with an estimated precision of 1% on the linear fit. A noise analysis enables estimating the ultimate screen resolution limit, which is actually dictated by the thermal noise of the CCD imaging the screen, around 10fC. Results of low charge measurements on PHIL will be shown and compared to those coming from a diamond detector installed on PHIL, in order to validate the measurement principle and cross-check both measurements. Such powerful and simple measurement may thereafter be used as a single-shot charge diagnostic for electron beam generated and accelerated by laser-plasma interaction and will be used in the context of the Dactomus projec

Characterization of relativistic electron bunch duration and travelling wave structure phase velocity based on momentum spectra measurements on the ARES linac at DESY

The ARES linac at DESY aims to generate and characterize ultrashort electron bunches (fs to sub-fs duration) with high momentum and arrival time stability for the purpose of applications related to accelerator R&D, e.g. development of advanced and compact diagnostics and accelerating structures, test of new accelerator components, medical applications studies, machine learning, etc. During its commissioning phase, the bunch duration characterization of the electron bunches generated at ARES has been performed with an RF-phasing technique relying on momentum spectra measurements, using only common accelerator elements (RF accelerating structures and magnetic spectrometers). The sensitivity of the method allowed highlighting different response times for Mo and Cs2Te cathodes. The measured electron bunch duration in a wide range of machine parameters shows excellent agreement overall with the simulation predictions, thus demonstrating a very good understanding of the ARES operation on the bunch duration aspect. The importance of a precise in-situ experimental determination of the phase velocity of the first travelling wave accelerating structure after the electron source, for which we propose a simple new beam-based method precise down to sub-permille variation respective to the speed of light in vacuum, is emphasized for this purpose. A minimum bunch duration of 20 fs rms, resolution-limited by the space charge forces, is reported. This is, to the best of our knowledge, around 4 times shorter than what has been previously experimentally demonstrated based on RF-phasing techniques with a single RF structure. The present study constitutes a strong basis for future time characterization down to the sub-fs level at ARES, using dedicated X-band transverse deflecting structures.Comment: 17 pages, 11 figures. To be submitted to Physical Review Accelerators and Beam

Status of Diamond Detector Development for Beam Halo Investigation at ATF2

Work supported by Chinese Scholarship Council - THPME092, ISBN 978-3-95450-132-8International audienceWe are developing a diamond detector for beam halo and Compton spectrum diagnostics after the interaction point (IP) of ATF2, a low energy (1.3 GeV) prototype of the final focus system for ILC and CLIC linear collider projects. Tests of a 500 μm thick sCVD diamond detector with a dimension of 4.5 mm×4.5 mm have been carried out with radioactive sources and with electron beam from PHIL low energy (<10 MeV) photo-injector at LAL. The tests at PHIL were done with different beam intensities in air, just after the exit window at the end of the beam line, to test the response of the diamond detector and the readout electronics. We have successfully detected signals from single electrons, using a 40 dB amplifier, and from an electron beam of 108 electrons, using a 24 dB attenuator. A diamond sensor with 4 strips has been designed and fabricated for installation in the vacuum chambers of ATF2 and PHIL, with the aim to scan both the beam halo (with 2 strips of 1.5 mm×4 mm) and the beam core (with 2 strips of 0.1 mm×4 mm) transverse distributions

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Immune cells are important components of the tumor microenvironment and influence tumor growth and evolution at all stages of carcinogenesis. Notably, it is now well established that the immune infiltrate in human tumors can correlate with prognosis and response to therapy. The analysis of the immune infiltrate in the tumor microenvironment has become a major challenge for the classification of patients and the response to treatment. The co-expression of inhibitory receptors such as Program Cell Death Protein 1 (PD1; also known as CD279), Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4), T-Cell Immunoglobulin and Mucin Containing Protein-3 (Tim-3; also known as CD366), and Lymphocyte Activation Gene 3 (Lag-3; also known as CD223), is a hallmark of T cell exhaustion. We developed a multiparametric in situ immunofluorescence staining to identify and quantify at the cellular level the co-expression of these inhibitory receptors. On a retrospective series of frozen tissue of renal cell carcinomas (RCC), using a fluorescence multispectral imaging technology coupled with an image analysis software, it was found that co-expression of PD-1 and Tim-3 on tumor infiltrating CD8 T cells is correlated with a poor prognosis in RCC. To our knowledge, this represents the first study demonstrating that this automated multiplex in situ technology may have some clinical relevance

Seasonal evolution of Titan’s stratosphere during the Cassini mission

Titan's stratosphere exhibits significant seasonal changes, including breakup and formation of polar vortices. Here we present the first analysis of midinfrared mapping observations from Cassini's Composite InfraRed Spectrometer to cover the entire mission (Lₛ=293–93°, 2004–2017)—midnorthern winter to northern summer solstice. The north polar winter vortex persisted well after equinox, starting breakup around Lₛ∼60° and fully dissipating by Lₛ∼90°. Absence of enriched polar air spreading to lower latitudes suggests large‐scale circulation changes and photochemistry control chemical evolution during vortex breakup. South polar vortex formation commenced soon after equinox and by Lₛ∼60° was more enriched in trace gases than the northern middle‐winter vortex and had temperatures ∼20 K colder. This suggests that early‐winter and middle‐winter vortices are dominated by different processes—radiative cooling and subsidence‐induced adiabatic heating respectively. By the end of the mission (Lₛ=93°) south polar conditions were approaching those observed in the north at Lₛ=293°, implying seasonal symmetry in Titan's vortices