El acceso al financiamiento bancario de las pequeñas y medianas empresas de la provincia de Mendoza y sus condicionantes. : las garantías requeridas y el rol de las sociedades de garantía recíproca

Este trabajo tiene como objetivo general analizar el grado de acceso al financiamiento bancario de las Pymes. Ademas se plantearon los siguientes objetivos específicos: Relevar las alternativas crediticias existentes en la actualidad en el mercado financiero, en particular las destinadas a proyectos de inversión y a potenciar la capacidad exportadora. Elaborar un diagnóstico de la situación de las Pymes frente a dichas fuentes de financiamiento, para evaluar en qué medida aprovechan las mismas. Identificar las causas que obstaculizan o impiden el acceso a los créditos de las Pymes. Precisar el rol de las Sociedades de Garantía Recíproca y su inserción real y potencial. Estudiar las alternativas para subsanar las barreras que dificultan o imposibilitan el acceso al crédito y diseñar mecanismos y herramientas eficientes para subsanarlos.Fil: Molina, Raúl A..Fil: Martinez, Elsa O.. Universidad Nacional de Cuyo. Facultad de Ciencias EconómicasFil: Sansone, Jorge. Universidad Nacional de Cuyo. Facultad de Ciencias EconómicasFil: Vinassa, Federico

Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase

Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator in the heart, has been demonstrated to be increased in this condition. We have previously demonstrated that elevated NHE1 activity induced cardiac hypertrophy in vivo. Furthermore, the overexpression of active NHE1 elicited modulation of gene expression in cardiomyocytes including an upregulation of myocardial osteopontin (OPN) expression. To determine the role of OPN in inducing NHE1-mediated cardiomyocyte hypertrophy, double transgenic mice expressing active NHE1 and OPN knockout were generated and assessed by echocardiography and the cardiac phenotype. Our studies showed that hearts expressing active NHE1 exhibited cardiac remodeling indicated by increased systolic and diastolic left ventricular internal diameter and increased ventricular volume. Moreover, these hearts demonstrated impaired function with decreased fractional shortening and ejection fraction. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNA was upregulated, and there was an increase in heart cell cross-sectional area confirming the cardiac hypertrophic effect. Moreover, NHE1 transgenic mice also showed increased collagen deposition, upregulation of CD44 and phosphorylation of p90 ribosomal s6 kinase (RSK), effects that were regressed in OPN knockout mice. In conclusion, we developed an interesting comparative model of active NHE1 transgenic mouse lines which express a dilated hypertrophic phenotype expressing CD44 and phosphorylated RSK, effects which were regressed in absence of OPN.Scopu

A comprehensive review on energy management strategies for electric vehicles considering degradation using aging models

Electrification in the transportation industry is becoming more important to face global warming and replace fossil fuels in the future. Among the available energy sources Li-ion battery and proton exchange membrane fuel cell (PEMFC) are the most promising energy sources. Therefore, employing them in fuel cell hybrid electric vehicles (FCHEVs) to combine their advantages is one of the favorable solutions. However, they still face a major challenge residing in their aging that cause the drop of system performance. On one hand, the degradation is the result of the interaction between several aging mechanisms that react differently with various operating conditions. On the other hand, a hybrid system requires an essential energy management strategy (EMS) for fuel economy and optimal power share. At the end, this EMS has an important impact on the lifetime of sources in term of reducing or favorizing the degradation. Therefore, it is important to consider the degradation in the objectives of the designed EMS. Since the degradation is usually neglected when designing an EMS, this paper tends to review the possible methods for designing a health-conscious EMS. Hence, this paper presents a summary of the main fuel cell (FC) and Li-ion battery aging mechanisms as well as the useful degradation models for state of health estimation. In addition, the existing works that consider the degradation of on-board energy sources in their approaches for increasing their durability are classified and analysed. Remaining challenges are detailed along with a discussion and outlooks about current and future trends of health-conscious EMS. Autho

A Fibre- vs. cereal grain-based diet: Which is better for horse welfare? Effects on intestinal permeability, muscle characteristics and oxidative status in horses reared for meat production

Horses reared for meat production are fed high amounts of cereal grains in comparison with horses raised for other purposes. Such feeding practice may lead to risk of poor welfare consequences. The aim of this study was to investigate the effects of two feeding practices on selected metabolic parameters and production aspects. Nineteen Bardigiano horses, 14.3 ± 0.7 months of age, were randomly assigned to two groups—one fed with high amounts of cereal grains (HCG; n = 9; 43% hay plus 57% cereal grain-based pelleted feed) vs. one fed with high amounts of fibre (HFG; n = 10; 70% hay plus 30% pelleted fibrous feed)—for 129 days. At slaught on abattoir, biological and tissue samples were collected to evaluate the microbiological contamination of mesenteric lymph nodes and liver; selected meat quality traits (chemical composition and fatty acid profile of the Longissimus thoracis et lumborum muscle); and the oxidative status of the horse. A linear mixed model was used: dietary treatment and sex were fixed effects and their interaction analysed on production and metabolic parameters as dependent variables. Results showed an increased intestinal permeability in the horses fed HCG compared to HFG, according to the significant increased total mesophilic aerobic bacteria counts in mesenteric lymph nodes (p = 0.04) and liver samples (p = 0.05). Horses in HCG showed increased muscle pH (p = 0.02), lighter muscle colour (L) (p = 0.01), increased intramuscular fat concentrations (p = 0.03), increased muscle glutathione peroxidase and superoxide dismutase activities (p = 0.01 and p = 0.03, respectively). Moreover, horses in HCG had lower muscle water holding capacity at interaction with sex (p = 0.03, lower in female), lower muscle protein content (p = 0.01), lower concentration of muscle PUFAs (p = 0.05) and lower plasma catalase activities (p = 0.05). Our results showed that feeding a high cereal grains diet can have global effects on horse physiology, and thus represents a threat for their welfare

Desert Hedgehog Promotes Ischemia-Induced Angiogenesis by Ensuring Peripheral Nerve Survival

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