Bio synthesis, Characterization of ZnO Nanoparticles from Scoparia dulcis L. plant extract and its in-vitro Antioxidant, Acetylcholinesterase Activity

The current investigation is focused on the use of green synthesis methods for zinc oxide nanoparticles (ZnO NPs) from Scoparia dulcis L. extract (SDE). SDE-mediated ZnO NPs (SDE-ZnO-NPs) were made using a simple and eco-friendly method that required little reaction time and calcinations temperature. UV-Vis, FTIR, X-ray powder diffraction, SEM, TEM & EDAX were used into characterizes the skeletal and synthetic properties concerning biosynthesized ZnO nonmaterial. The UV–Visible spectroscopy absorption peak for SDE-ZnO-NPs was found to be at 380 nm, confirming the production of ZnO NPs. The FTIR spectrum also revealed bioactive functional groups as well as metal-oxygen groups. Synthesized ZnO NPs had a rod shape in 200 nm, according to TEM examination. The Zn and O in the produced ZnO NPs were approved by the EDAX analysis. The XRD results revealed that it had a crystal structure that was similar to SDE-ZnO-NPs. The dose-related Acetylcholinesterase inhibitory action of SDE-ZnO NPs was determined utilizing the Ellman’s test. AChE activity of the synthesized nanoparticles showed potential inhibitory activity with IC50 values of 75.34 µg/mL. The antioxidant activity was investigated the biosynthesized ZnO-NPs using DPPH, ABTS assay

Antidandruff activity of Cassia auriculata and Cassia alata through fatty acids mediated inhibition of Malassezia furfur

Susceptibility of Malassezia furfur to certain medium chain fatty acids shed light onto novel strategies to control dandruff. This study explored antidandruff activity of the fatty acids and other bioactive compounds from flowers of Cassia auriculata and Cassia alata. The idea was supplementing the growth medium with fatty acids which are inhibitory to Malassezia so that plant-based antidandruff formulations could be developed based on the results. Chloroform and ethanolic flower extracts were tested there in vitro efficacy against M. furfur and the potential antidandruff compounds were identified by gas chromatography-mass spectrophotometry (GC-MS). Minimum inhibitory concentrations were determined for both the extracts and IC50 values of 50 and 88 µM for chloroform extract of C. auriculata and C. alata were recorded. For ethanol extract, IC50 values of 75 and 70 µM were exhibited by C. auriculata and C. alata, respectively. Inhibition of M. furfur through fatty acids from Cassia is the first report, and it is possible to include specific fatty acids in the growth media to inhibit the growth of Malassezia which could be later served as lead molecules in antidandruff formulations. Further, the presence of citronellol, pinitol, anthracenedione and chrysine in Cassia flower extracts and their antidandruff activity reported in this study needed further research on those compounds to formulate effective treatment of Malassezia associated diseases

Note on generalized topological spaces with hereditary classes

In this paper, we extend the study of $\Psi_\mathcal{H}$ operator  introduced and studied in [5] and rectify the errors in the paper. Moreover, characterizations of $\mu-$codense and strongly $\mu-$codense hereditary classes in generalized topological spaces are also given

Development and Evaluation of a Chloramphenicol Hypertonic Ophthalmic Solution

Hypertonic ophthalmic solutions are used to treat ocular diseases associated with edema. In this study, we developed a chloramphenicol hypertonic ophthalmic solution. These drops were developed based on the cosolvency and additional dielectric constant concepts. Two different solvents: PEG 300 and glycerol were used as cosolvents. Solubility curves were plotted. Based on the solubility curves, two different solutions were selected. These solutions were evaluated for physical parameters and accelerated stability. The results indicated that chloramphenicol was stable in these formulations. The selected blend of solutions was hypertonic. Thus, the solubility and stability of chloramphenicol was enhanced using a cosolvency technique so as to develop a chloramphenicol hypertonic ophthalmic solution

Protostylid: A case series

Human jaws and teeth display a high degree of morphological individuality as they represent personal, family and population characteristics. A protostylid is a supernumerary or accessory cusp located on the mesial half of the buccal surface on the molars that may seldom pose problems while its presence may not be a cause for alarm in most instances. This case report presents a rare finding of protostylid on the buccal surface of the primary molars in 4 children. From the perspective of forensic dentistry, this morphological feature, though uncommon, may be useful for classification and identification of victims in mass causalities and bite marks on bodies or inanimate objects

I Sent It: Where Does Slow Data Go to Wait?

Emerging applications like virtual reality (VR), augmented reality (AR), and 360-degree video aim to exploit the unprecedentedly low latencies promised by technologies like the tactile Internet and mobile 5G networks. Yet these promises are still unrealized. In order to fulfill them, it is crucial to understand where packet delays happen, which impacts protocol performance such as throughput and latency. In this work, we empirically find that sender-side protocol stack delays can cause high end-to-end latencies, though existing solutions primarily address network delays. Unfortunately, however, current latency diagnosis tools cannot even distinguish between delays on network links and delays in the end hosts. To close this gap, we present ELEMENT, a latency diagnosis framework that decomposes end-to-end TCP latency into endhost and network delays, without requiring admin privileges at the sender or receiver. We validate that ELEMENT achieves more than 90% accuracy in delay estimation compared to the ground truth in different production networks. To demonstrate ELEMENT's potential impact on real-world applications, we implement a relatively simple user-level library that uses ELEMENT to minimize delays. For evaluation, we integrate ELEMENT with legacy TCP applications and show that it can reduce latency by up to 10 times while maintaining throughput and fairness. We finally demonstrate that ELEMENT can significantly reduce the latency of a virtual reality application that needs extremely low latencies and high throughput

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Not AvailableQuality and nutritional value of food are important, since there is an increasing awareness on the need for consumption of healthy diet among the public. Fish and fishery products are vital constituents of a healthy diet as it includes essential fatty acids, amino acids, vitamins, minerals and other functional nutritional components. Although there is an increased awareness on the importance of exploring nutritive significance of fish in human nutrition, there is little information on the biochemical composition and nutritive values of fishes available in Gujarat coast. In the present study, four marine fishes of Gujarat coast such as dagger-tooth pike conger (Muraenesox cinereus), large scale tongue sole (Cynoglossus arel), goldband goatfish (Upeneus moluccensis) and saddle grunt (Pomadasys maculatus), which are abundantly available in West coast of Indian waters, were evaluated for their proximate composition and fatty acid content.Not Availabl

Novel ion exchange resin-based combination drug-delivery system for treatment of gastro esophageal reflux diseases

The present study involves preparation and characterization of a combination tablet of ranitidine in immediate release form and domperidone in sustained release form, using ion exchange resins. Ranitidine lowers acid secretion, while domperidone release over a prolonged period improves gastric motility thus justifying this combination in gastro esophageal reflux diseases (GERD) and ensuring patient compliance. Drug loading was carried out by batch method & resinates were characterized using FTIR, XRPD. Resinates were formulated as a combination tablet and evaluated for tablet properties & in vitro drug release. Resinates provided sustained release of domperidone and immediate release of ranitidine. IR and X-ray studies indicate complexation of drug and resin along with monomolecular distribution of drugs in amorphous form in the resin matrix. The tablets of resinate combination showed good tablet properties. In-vitro drug release gave desired release profiles and ex-vivo drug absorption studies carried out by placing everted rat intestine in dissolution medium indicated statistically significant similarity in absorption from test and marketed formulation. The novelty of this study is that the retardation in release of domperidone from resinates is achieved by presence of weak resin in the formulation.<br>O presente estudo envolve a preparação e a caracterização de associação do comprimido de ranitidina de liberação imediata e domperidona de liberação prolongada, utilizando resinas de troca iônica. A ranitidina diminui a secreção ácida, enquanto a liberação prolongada de domperidona melhora a motilidade gástica, justificando, dessa forma, a associação em doenças de refluxo gastroesofágico (DRGE) e garantindo a adesão do paciente. A carga de fármaco foi efetuada pelo método em batelada e os resinatos, caracterizados utilizando-se FTIR e XRPD. Os resinatos foram formulados como comprimido da associação e avaliados com relação às propriedades dos comprimidos e liberação do fármaco in vitro. Os resinatos proporcionaram a liberação prolongada da domperidona e a liberação imediata da ranitidina. IV e estudos de difração de raios X indicaram a complexação do fármaco e da resina junto com a distribuição monomolecular dos fármacos, em estado amorfo, na matriz da resina. Os comprimidos da associação do resinato apresentaram boas propriedades. Obtiveram-se os perfis de liberação in vitro e os estudos de absorção dos fármacos ex vivo realizados com intestino de rato em meio de dissolução indicaram semelhança significativa na absorção entre as formulações teste e comercializada. A inovação do trabalho é que o retardamento da liberação da domperidona dos resinatos é atingido pela presença de resina fraca na formulação