El seguro de responsabilidad civil profesional de abogados

Màster de Direcció d'Entitats Asseguradores i Financeres, Universitat de Barcelona, Facultat d'Economia i Empresa, Curs: 2019-2020, Tutor: Antonio Vicente Albanés MembrilloEl objetivo de este trabajo es realizar un análisis de la responsabilidad civil profesional de los abogados desde un punto de vista asegurador, analizando el marco legal que rige la actividad de la abogacía, la relación abogado-cliente, así como los supuestos habituales de responsabilidad derivados de errores profesionales. Por otro lado, se realiza un análisis jurisprudencial de las principales cuestiones de debate, todo ello orientado a dar una cobertura adecuada y acorde a esta tipología de riesgo, pero que a la vez permita a la aseguradora cumplir con sus objetivos

Aggregation of Descriptive Regularization Methods with Hardware/Software Co-Design for Remote Sensing Imaging

This study consider the problem of high-resolution imaging of the remote sensing (RS) environment formalized in terms of a nonlinear ill- posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the wavefield scattered from an extended remotely sensed scene (referred to as the scene image). However, the remote sensing techniques for reconstructive imaging in many RS application areas are relatively unacceptable for being implemented in a (near) real time implementation. In this work, we address a new aggregated descriptive-regularization (DR) method and the Hardware/Software (HW/SW) co-design for the SSP reconstruction from the uncertain speckle-corrupted measurement data in a computationally efficient parallel fashion that meets the (near) real time image processing requirements. The hardware design is performed via efficient systolic arrays (SAs). Finally, the efficiency both in resolution enhancement and in computational complexity reduction metrics of the aggregated descriptive-regularized and the HW/SW co-design method is presented via numerical simulations and by the performance analysis of the implementation based on a Xilinx Field Programmable Gate Array (FPGA) XC4VSX35-10ff668.Universidad de GuadalajaraUniversidad Autónoma de YucatánInstituto Tecnológico de Mérid

Special Issue on Applied Earth Observation and Remote Sensing in Latin America

This special Issue focused on recent research led by South American researchers and teams. It is a long overdue pos- sibility offered to researchers in this geographical area to share their excellent work with the international community. Accord- ingly, the response to the call for papers was overwhelming, with more than 60 papers submitted from eight countries. Eventually, 23 articles were accepted, among which 11 are authored from Brazil, while Argentina and Mexico contribute each with five papers, and Colombia and Ecuador have one arti- cle accepted each. Testifying the international breadth of these researches, seven of these contributions have coauthors from outside Latin America: two from Italy, and one from France, Canada, Finland, USA, and Germany. Before describing the contributions that have been selected for this issue, it is worth recalling briefly the history and current situation of remote sensing activities in the three major countries in the area, which, as mentioned, contribute to the large majority of the works published in the following pages.ITESO, A.C

Is selective 5-HT1F receptor agonism an entity apart from that of the triptans in antimigraine therapy?

Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP).The gold standard for acute migraine treatment are the triptans, 5-HT1B/1D/(1F) receptor agonists. Their actions are thought to be mediated through activation of: (i) 5-HT1B receptors in cranial blood vessels with subsequent cranial vasoconstriction; (ii) prejunctional 5-HT1D receptors on trigeminal fibers that inhibit trigeminal CGRP release; and (iii) 5-HT1B/1D/1F receptors in central nervous system involved in (anti)nociceptive modulation. Unfortunately, coronary arteries also express 5-HT1B receptors whose activation would produce coronary vasoconstriction; hence, triptans are contraindicated in patients with cardiovascular disease. In addition, since migraineurs have an increased cardiovascular risk, it is important to develop antimigraine drugs devoid of vascular (side) effects.Ditans, here defined as selective 5-HT1F receptor agonists, were developed on the basis that most of the triptans activate trigeminal 5-HT1F receptors, which may explain part of the triptans' antimigraine action. Amongst the ditans, lasmiditan: (i) fails to constrict human coronary arteries; and (ii) is effective for the acute treatment of migraine in preliminary Phase III clinical trials. Admittedly, the exact site of action is still unknown, but lasmiditan possess a high lipophilicity, which suggests a direct action on the central descending antinociceptive pathways. Furthermore, since 5-HT1F receptors are located on trigeminal fibers, they could modulate CGRP release.This review will be particularly focussed on the similarities and differences between the triptans and the ditans, their proposed sites of action, side effects and their cardiovascular risk profile

Gender aspects of CGRP in migraine

Background: Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. Aims: To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. Conclusions: Gender differences are evident in migraine. Several studies indicate that fluctuations of ovarian steroid hormone (mainly estrogen) levels modulate CGRP in the trigeminovascular system during different reproductive milestones. Such interactions need to be considered when conducting future animal and human experiments, since these differences may contribute to the development of gender-specific therapies

EBOCA: Evidences for BiOmedical Concepts Association Ontology

There is a large number of online documents data sources available nowadays. The lack of structure and the differences between formats are the main difficulties to automatically extract information from them, which also has a negative impact on its use and reuse. In the biomedical domain, the DISNET platform emerged to provide researchers with a resource to obtain information in the scope of human disease networks by means of large-scale heterogeneous sources. Specifically in this domain, it is critical to offer not only the information extracted from different sources, but also the evidence that supports it. This paper proposes EBOCA, an ontology that describes (i) biomedical domain concepts and associations between them, and (ii) evidences supporting these associations; with the objective of providing an schema to improve the publication and description of evidences and biomedical associations in this domain. The ontology has been successfully evaluated to ensure there are no errors, modelling pitfalls and that it meets the previously defined functional requirements. Test data coming from a subset of DISNET and automatic association extractions from texts has been transformed according to the proposed ontology to create a Knowledge Graph that can be used in real scenarios, and which has also been used for the evaluation of the presented ontology

Pharmacological Profile of the Purinergic P2Y Receptors That Modulate, in Response to ADPβS, the Vasodepressor Sensory CGRPergic Outflow in Pithed Rats

Calcitonin gene-related peptide (CGRP), an endogenous neuropeptide released from perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine triphosphate (ATP) stimulates the release of CGRP by activation of prejunctional P2X2/3 receptors, and adenosine 5′-O-2-thiodiphosphate (ADPβS), a stable adenosine diphosphate (ADP) analogue, produces vasodilator/vasodepressor responses by endothelial P2Y1 receptors. Since the role of ADP in the prejunctional modulation of the vasodepressor sensory CGRPergic drive and the receptors involved remain unknown, this study investigated whether ADPβS inhibits this CGRPergic drive. Accordingly, 132 male Wistar rats were pithed and subsequently divided into two sets. In set 1, ADPβS (5.6 and 10 µg/kg·min) inhibited the vasodepressor CGRPergic responses by electrical stimulation of the spinal T9–T12 segment. This inhibition by ADPβS (5.6 µg/kg·min) was reverted after i.v. administration of the purinergic antagonists MRS2500 (300 µg/kg; P2Y1) or MRS2211 (3000 µg/kg; P2Y13), but not by PSB0739 (300 µg/kg; P2Y12), MRS2211 (1000 µg/kg; P2Y13) or the KATP blocker glibenclamide (20 mg/kg). In set 2, ADPβS (5.6 µg/kg·min) failed to modify the vasodepressor responses to exogenous α-CGRP. These results suggest that ADPβS inhibits CGRP release in perivascular sensory nerves. This inhibition, apparently unrelated to activation of ATP-sensitive K+ channels, involves P2Y1 and probably P2Y13, but not P2Y12 receptors.</p

Enhancement and Edge-Preserving Denoising: An OpenCL-Based Approach for Remote Sensing Imagery

Image enhancement and edge-preserving denoising are relevant steps before classification or other postprocessing techniques for remote sensing images. However, multisensor array systems are able to simultaneously capture several low-resolution images from the same area on different wavelengths, forming a high spatial/spectral resolution image and raising a series of new challenges. In this paper, an open computing language based parallel implementation approach is presented for near real-time enhancement based on Bayesian maximum entropy (BME), as well as an edge-preserving denoising algorithm for remote sensing imagery, which uses the local linear Stein’s unbiased risk estimate (LLSURE). BME was selected for its results on synthetic aperture radar image enhancement, whereas LLSURE has shown better noise removal properties than other commonly used methods. Within this context, image processing methods are algorithmically adapted via parallel computing techniques and efficiently implemented using CPUs and commodity graphics processing units (GPUs). Experimental results demonstrate the reduction of computational load of real-world image processing for near real-time GPU adapted implementation.ITESO, A.C

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Background: Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascular effects of (S)- isometheptene and (R)-isometheptene, and the pharmacological profile of the more potent enantiomer. Methods: The effects of i.v. bolus injections (0.03, 0.1, 0.3, 1 and 3 mg/kg) of isometheptene racemate, (S)-isometheptene or (R)-isometheptene on heart rate and blood pressure were analyzed in control experiments. The enantiomer producing more pronounced tachycardic and/or vasopressor responses was further analyzed in rats receiving i.v. injections of prazosin (0.1 mg/kg), rauwolscine (0.3 mg/kg), propranolol (1 mg/kg) or intraperitoneal reserpine (5 mg/kg, -24 h). Results: Compared to (R)-isometheptene, (S)-isometheptene produced greater vasopressor responses, whilst both compounds equipotently increased heart rate. The tachycardic responses to (S)-isometheptene were abolished after propranolol, but remained unaffected by the other antagonists. In contrast, the vasopressor responses to (S)-isometheptene were practically abolished after prazosin. Interestingly, after reserpine, the tachycardic responses to (S)-isometheptene were abolished, whereas its vasopressor responses were attenuated and subsequently abolished by prazosin. Conclusions: The different cardiovascular effects of the isometheptene enantiomers are probably due to differences in their mechanism of action, namely: (i) a mixed sympathomimetic action for (S)-isometheptene (a tyramine-like action and a direct stimulation of α1-adrenoceptors); and (ii) exclusively a tyramine like action for (R)-isometheptene. Thus, (R)-isometheptene may represent a superior therapeutic benefit as an antimigraine agent

Desarrollo de una práctica de Estadística Descriptiva con GeoGebra

El presente trabajo pretende dar una pauta para emplear el potencial de las herramientas TIC con el propósito de facilitar en el aula y fuera de ella, el aprendizaje de conceptos propios de la estadística a un nivel universitario. Existen diversos programas computacionales capaces de realizar análisis estadísticos de alto nivel: SPSS, Minitab, Matlab, por mencionar algunos; estos programas funcionan muy bien cuando se trata de encontrar respuestas a planteamientos complicados o cuando se tiene un enorme banco de datos. Para emplear de la forma correcta este tipo de software y no malinterpretar sus resultados, es necesario en primer lugar, que el usuario entienda perfectamente los conceptos básicos de la estadística descriptiva, como son el análisis para datos agrupados y no agrupados, medidas de tendencia central y de dispersión, así como los diversos gráficos y tablas de datos que describen la frecuencia con la cual sucede un evento; para lo cual es necesario el uso de un software dinámico y en este caso diseñado específicamente para el aprendizaje didáctico de las matemáticas como lo es GeoGebra