Civil Conflict and antipoverty programmes: effects on demobilisation

Antipoverty programmes have been successful in helping millions of people afford betterlivelihoods -- While this is well known, little research has yet been conducted that examines the power of such programmes to influence outcomes in times of conflict, especially in countries where antipoverty programmes are implemented amidst disputes against illegal armed groups -- This paper focuses on the implementation of Familias en Accion, a flagship antipoverty programme in Colombia during the early 2000s when the country was experiencing the crudest peak in its long-lasting internal conflict -- Our estimations are based on a natural experiment that resulted from the rolling out of the programme which allowed us to identify a difference-in-differences approach -- Our results indicate that the programme had positive effects on the demobilisation of combatants -- The theoretical transmission channels of these effects are discussed and contrasted with the existing empirical evidenc

Quenched disorder forbids discontinuous transitions in nonequilibrium low-dimensional systems

Quenched disorder affects significantly the behavior of phase transitions. The Imry-Ma-Aizenman-Wehr-Berker argument prohibits first-order or discontinuous transitions and their concomitant phase coexistence in low-dimensional equilibrium systems in the presence of random fields. Instead, discontinuous transitions become rounded or even continuous once disorder is introduced. Here we show that phase coexistence and first-order phase transitions are also precluded in nonequilibrium low-dimensional systems with quenched disorder: discontinuous transitions in two-dimensional systems with absorbing states become continuous in the presence of quenched disorder. We also study the universal features of this disorder-induced criticality and find them to be compatible with the universality class of the directed percolation with quenched disorder. Thus, we conclude that first-order transitions do not exist in low-dimensional disordered systems, not even in genuinely nonequilibrium systems with absorbing states

Overfitting control inside cascade correlation neural networks applied to electricity contract price prediction

Prediction of electricity prices is considered a difficult task due to the number and complexity of factors that influence their performance, and their relationships. Neural networks cascade correlation - CASCOR allows to do a constructive learning and it captures better the characteristics of the data; however, it has a high tendency to overfitting. To control overfitting in some areas regularization techniques are used. However, in the literature there are no studies that: i) use regularization techniques to control overfitting in CASCOR networks, ii) use CASCOR networks in predicting of electrical series iii) compare the performance with tra­ditional neural networks or statistical models. The aim of this paper is to model and predict the behavior of the price series of electricity contracts in Colombia, using CASCOR networks and controlling the overfitting by regularization techniques.La predicción de precios de electricidad es considerada una tarea difí­cil debido a la cantidad y complejidad de los factores que influyen en su representación, y sus relaciones. Las redes neuronales tipo cascada correlación –CASCOR– permiten, realizar un aprendizaje constructivo, capturando mejor las características de los datos; sin embargo, presentan una alta tendencia al sobreajuste. Para el control del sobreajuste en algunos ámbitos se usan técnicas de regularización. No obstante, en la literatura no existen estudios que: i) Utilicen técnicas de regularización para el control de sobreajuste en redes CASCOR; ii) Usen redes CASCOR en la predicción de series de electricidad; iii) comparen el desempeño con redes neuronales tradicionales o modelos estadísticos. El objetivo de este artículo es modelar y predecir el comportamiento de la serie de precios de contratos de electricidad en Colombia, usando redes CASCOR y con­trolando el sobreajuste con técnicas de regularización

BIOMECHANICAL ASSESSMENT OF AERODYNAMIC RESISTANCE IN PROFFESSSIONAL CYCLISTS: METHODOLOGICAL ASPECTS

The aim of this study was to measure and compare the aerodynamic resistance (RA) in five different professional road cyclists obtained from a wind tunnel and to establish modification that into a performance improvement. Five professional cyclists from the Kelme-Costa Blanca Team were studied in five positions, four on the aerobike and one on the standard bike. From our results we conclude that establishing small modifications in the aerohandlebars, which result in a more profitable position, can reduce RA. The use of aerohelmet was not shown to be always useful. It is necessary to take into account the technique employed, corrected RA values with the anthropometric characteristics, static vs dynamic assessment when comparing professional cyclists RA

Influence of nutritional and environmental factors on ethanol and endopolygalacturonase co-production by Kluyveromyces marxianus CCEBI 2011

Ethanol and endopolygalacturonase (endoPG) are simultaneously produced by the yeast Kluyveromyces marxianusCCEBI 2011. The aim of this study was to determine the optimal combination of seven environmental and nutritional variables, as well as the influence of each one, with respect to the fermentation process in yeast cultures in which sugarcanejuice was the substrate. Simplex sequential optimization showed that after 15 runs the optimal conditions were: pH, 4.6; temperature, 31ºC; total reducing sugars (TRS), 125 g/l; (NH4)2SO4, 2.48 g/l; (NH4)2HPO4, 2.73 g/l; CaCl2, 0.33 g/l andMgSO4·7H2O, 0.54 g/l. Under these conditions, the ethanol concentration was 47.6 g/l and endoPG concentration was 9.8 U/ml, which represented increases of 22% and 10%, respectively, over the concentrations obtained under suboptimal conditions. Temperature and (NH4)2SO4 supplementation were the most significant factors influencing the co-production process. [Int Microbiol 2011; 14(1):41-49

Retinal and choroidal thickness in myopic young adults

The retinal and the choroidal thickness were measured at four locations along the horizontal direction (foveola, one nasal to the fovea and two temporal) in a group of 43 young adults (mean age: 27.1 ± 3.9 years), with ocular refraction ranging from emmetropia to high myopia (0 to −10D). Thickness values were obtained from OCT images centered at the foveal depression. The retinal thickness exhibited a correlation with refraction at all eccentricities but not at the fovea. When different subgroups of refraction were considered, the analysis of such correlations indicated that only the retinal thickness in the group of high myopia (refraction ≤ −6D) was statistically different from the other two groups (emmetropes: [−0.5, 0] D, and myopes: (−6, −0.5) D). No significant differences were found between emmetropic and myopic groups. In contrast to the retina, the choroidal thickness exhibited a significant correlation with refraction at the fovea, although such dependency only stood for high myopes (the choroid of myopes and emmetropes exhibited similar thickness). Correlation with refraction was also found at the nasal location, arising between emmetropic and high myopia groups. Other choroidal locations among groups did not exhibit relationship with the refraction. It is concluded that the differences in the choroid and retina thickness along the horizontal meridian as a function of refraction do not characterize the onset and progression of myopia at early stages, since they only manifest in the group of high myopia

Microencapsulation of ellagic acid from pomegranate husk and karaya gum by spray drying

Objective: The aim of this study was to obtain and characterize microcapsules with Ellagic Acid (EA) from pomegranate as core material and Karaya Gum (KG) as wall material. Methods: EA was obtained from dry pomegranate peel powder via methanolysis and quantified by HPLC. Microcapsules were obtained preparing a dispersion containing KG and EA in phosphate buffer pH 8. The dispersion was processed in a spray dryer under specific conditions (inlet temperature at 150 °C, feed flow at 30% and aspirator at 100 %) for obtaining of microcapsules. Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were used for characterization. Results: Obtained material contains 98.03±2.82 mg EA/g of pomegranate peel. FTIR showed that there were changes in the molecular structure of microcapsules referred to raw materials. SEM confirmed that particles obtained had micron-size (1-5 µm). DSC analysis showed that raw materials had glass transition temperatures of 79.58 and 83.41 °C and for microcapsules the value was67.25 °C. Conclusion: Methanolysis is a viable technique for the obtaining of EA from the peel of pomegranate. KG shows good potential for be used as wall material for EA microencapsulation

Bimodal effect of water on V2O5/TiO2 catalysts with different vanadium species in the simultaneous NO reduction and 1,2-dichlorobenzene oxidation

VOX/TiO2 catalysts with different vanadium loading were prepared in order to study the influence of vanadium species on the effect of water in the simultaneous NO reduction through NH3-SCR and o-DCB oxidation reactions. The presence of isolated, polymeric and crystalline species and their redox and acid properties were evaluated by N2-Adsorption, XRD, Raman, H2-TPR, XPS and NH3-TPD. Water has a bimodal and reversible effect in both NO reduction and o-DCB oxidation depending on vanadium species and temperature. In SCR, water has a detrimental effect at low temperature due to competitive adsorption with NO and NH3, while at high temperature it promotes an increase of NO conversion associated to the suppression of side-reactions, which increase the selectivity towards N2. In o-DCB oxidation, the effect of water is the sum of two contributions: one positive, related to the removal of surface adsorbed detrimental species; and one negative, associated to the competitive adsorption with o-DCB. Thus, at high temperature water acts as inhibitor, while at low temperature water has a promotional effect in the highly dispersed vanadium catalysts due to their tendency to suffer deactivation, mainly by carbonaceous materials. The presence of water also favors total oxidation and decreases the formation of chlorinated by products.MINECO/FEDER (CTQ2015-64616-P), MINECO/FEDER (BES-2016-077849), IT657-13, IT1297- 19, INF12/37, UFI 11/39, PID2019-107503RB-I00, MCIN/AEI/10.13039/50110001103

Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2

Alzheimer\u27s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. More than 200 pathogenic mutations have been identified in amyloid-β precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2). Additionally, common and rare variants occur within APP, PSEN1, and PSEN2 that may be risk factors, protective factors, or benign, non-pathogenic polymorphisms. Yet, to date, no single study has carefully examined the effect of all of the variants of unknown significance reported in APP, PSEN1 and PSEN2 on Aβ isoform levels in vitro. In this study, we analyzed Aβ isoform levels by ELISA in a cell-based system in which each reported pathogenic and risk variant in APP, PSEN1, and PSEN2 was expressed individually. In order to classify variants for which limited family history data is available, we have implemented an algorithm for determining pathogenicity using available information from multiple domains, including genetic, bioinformatic, and in vitro analyses. We identified 90 variants of unknown significance and classified 19 as likely pathogenic mutations. We also propose that five variants are possibly protective. In defining a subset of these variants as pathogenic, individuals from these families may eligible to enroll in observational studies and clinical trials