Active fault control in the distribution of Elevated Low Relief Topography in the Central-Western Pyrenees

The activity of normal faults in the Central-Western Pyrenees is mainly detected by the disruption of paleic landforms surviving to Plio-Quaternary incision: the remnants of a Low-Relief Topography (LRT) that probably originated asynchronically during the Oligocene and Miocene. We propose a new method for mapping the LRT remnants that combines automatic analysis of digital topography and cross-checking with regional databases of Quaternary landforms. We focus on an area where the location of the main-drainage divide seems to be influenced by the activity of the Bedous-Pic de Midi du Bigorre set of faults and by the North Maladeta Fault. Neotectonic markers defined by the remnants of LRT envelops are tectonically displaced up to ~700m by the previously identified faults, but also along new faults observed in between them. A western prolongation of the North Maladeta Fault has been identified for the first time, implying a 75km total trace length, almost twice the previously published value. A restoration of the fault block motion was performed assuming a regional uplift across the range, enhanced in the northern part of the Axial Zone. This uplift leads to an outer arch extension along the Maladeta-Bedous Fault System. The resulting paleo-topography shows a broad southern paleo-flank (up to ~120km long) with a gentle regional gradient (~1º) and a much shorter and steeper northern paleo-flank (~4º gradient, up to 30km-long). This configuration suggests that the LRT remnants now located North of the main divide were connected to the Ebro Basin. The results are supported by previous studies on age and source provenance of major alluvial systems mantling the northern and southern flanks of the chain

Projection to latent spaces disentangles specific cerebral morphometric patterns associated to aging and preclinical AD”,

Peer ReviewedPostprint (published version

UPC system for the 2015 MediaEval multimodal person discovery in broadcast TV task

This paper describes a system to identify people in broadcast TV shows in a purely unsupervised manner. The system outputs the identity of people that appear, talk and can be identified by using information appearing in the show (in our case, text with person names). Three types of monomodal technologies are used: speech diarization, video diarization and text detection / named entity recognition. These technologies are combined using a linear programming approach where some restrictions are imposed.Postprint (published version

Avaluació de l'actuació docent a la pràctica del "Potencial d'acció" de l'assignatura de Fisiologia i Fisiopatologia I del grau de Farmàcia

Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524En los últimos años, la implantación de la evaluación continua en las enseñanzas de Grado ha implicado la utilización de nuevas tecnologías de la información y la comunicación en la docencia. Sin embargo, hay que reflexionar y valorar si los resultados del aprendizaje de los estudiantes obtenidos mediante estas tecnologías son mejores que los obtenidos con metodologías tradicionales. De esta manera, en la asignatura de Fisiología y Fisiopatología I del Grado de Farmacia, el curso 2009-10 se planificó la realización de la práctica de simulación del potencial de acción a través del Campus Virtual (CV). Para alcanzar los objetivos de aprendizaje, los estudiantes tenían a su disposición en el CV el programa de simulación, junto con el guión de la práctica y una serie de ejercicios para resolver. Los resultados obtenidos en la evaluación de la práctica no fueron muy satisfactorios, por lo que el curso 2013-14 se complementó la práctica con un seminario y la evaluación se realizó de forma presencial. Sin embargo, los resultados no mejoraron. Por esta razón, el curso 2014-15, se ha vuelto a realizar la práctica de forma presencial utilizando el mismo programa de simulación y guión de prácticas. La variable modificada ha sido la realización de la práctica en el laboratorio con un profesor y en sesiones con un número reducido de estudiantes (10 como máximo). Al final de las prácticas, se ha evaluado el aprendizaje de los estudiantes mediante una prueba escrita tal y como se llevó a cabo en cursos anteriores. La prueba consiste en preguntas test (V/F) y una pregunta de extensión limitada. Para valorar cuál de las dos metodologías permite un mejor aprendizaje de los estudiantes, se han comparado las calificaciones obtenidas en los cursos 2013-14 y 2014-15. Los resultados ponen de manifiesto de manera significativa que la reorientación hacia una estrategia didáctica en grupos reducidos, ha permitido dirigir y tutorizar al estudiante hacia un mejor aprendizaje

Characteristic brain volumetric changes in the AD preclinical signature

Peer ReviewedPostprint (published version

Mycobacterium manresensis induces trained immunity in vitro

The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease. Our objective was to analyze whether heat-killed Mycobacterium manresensis (hkMm), an environmental mycobacterium, induces trained immunity and confers protection against SARS-CoV-2 infection. To this end, THP-1 cells and primary monocytes were trained with hkMm. The increased secretion of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, and IL-10, metabolic activity, and changes in epigenetic marks suggested hkMm-induced trained immunity in vitro. Healthcare workers at risk of SARS-CoV-2 infection were enrolled into the MANRECOVID19 clinical trial (NCT04452773) and were administered Nyaditum resae (NR, containing hkMm) or placebo. No significant differences in monocyte inflammatory responses or the incidence of SARS-CoV-2 infection were found between the groups, although NR modified the profile of circulating immune cell populations. Our results show that M. manresensis induces trained immunity in vitro but not in vivo when orally administered as NR daily for 14 days. Biological sciences; Molecular biology; Immunology; Microbiolog

Mycobacterium manresensis induces trained immunity in vitro

The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease. Our objective was to analyze whether heat-killed Mycobacterium manresensis (hkMm), an environmental mycobacterium, induces trained immunity and confers protection against SARS-CoV-2 infection. To this end, THP-1 cells and primary monocytes were trained with hkMm. The increased secretion of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, and IL-10, metabolic activity, and changes in epigenetic marks suggested hkMm-induced trained immunity in vitro. Healthcare workers at risk of SARS-CoV-2 infection were enrolled into the MANRECOVID19 clinical trial (NCT04452773) and were administered Nyaditum resae (NR, containing hkMm) or placebo. No significant differences in monocyte inflammatory responses or the incidence of SARS-CoV-2 infection were found between the groups, although NR modified the profile of circulating immune cell populations. Our results show that M. manresensis induces trained immunity in vitro but not in vivo when orally administered as NR daily for 14 days.The MANRECOVID19 clinical trial has been sponsored by the Reig Jofre Group. This research was funded by the Consorcio Centro de Investigación Biomédica en Red (CIBERES and CIBEREHD) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No 847762. MDH is supported by a Margarita Salas grant from NextGenerationEU. LS-M is supported by Juan de la Cierva fellowship (FJC2019-041213-I). NI-U is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00), EU HORIZON-HLTH-2021-CORONA-01 (grant 101046118), and institutional funding from Grifols, Pharma Mar, HIPRA, Amassence, and Palobiofarma. The Innate Immunity lab and the UTE are accredited by the Catalan Agency for Management of University and Research Grants (2017-SGR-490/2021-SGR-01186, 2021-SGR-00931, and 2017-SGR-500/2021 SGR 00920). IGTP is a member of the CERCA network of institutes supported by the Health Department of the Government of Catalonia.info:eu-repo/semantics/publishedVersio

Individuals With SARS-CoV-2 Infection During the First and Second Waves in Catalonia, Spain: Retrospective Observational Study Using Daily Updated Data

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Epidemiologia; ComparacióCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Epidemiología; ComparaciónCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Epidemiology; ComparisonA description of individuals with SARS-CoV-2 infection comparing the first and second waves could help adapt health services to manage this highly transmissible infection.Objective: We aimed to describe the epidemiology of individuals with suspected SARS-CoV-2 infection, and the characteristics of patients with a positive test comparing the first and second waves in Catalonia, Spain. Methods: This study had 2 stages. First, we analyzed daily updated data on SARS-CoV-2 infection in individuals from Girona (Catalonia). Second, we compared 2 retrospective cohorts of patients with a positive reverse-transcription polymerase chain reaction or rapid antigen test for SARS-CoV-2. The severity of patients with a positive test was defined by their admission to hospital, admission to intermediate respiratory care, admission to the intensive care unit, or death. The first wave was from March 1, 2020, to June 24, 2020, and the second wave was from June 25, 2020, to December 8, 2020.Results: The numbers of tests and cases were lower in the first wave than in the second wave (26,096 tests and 3140 cases in the first wave versus 140,332 tests and 11,800 cases in the second wave), but the percentage of positive results was higher in the first wave than in the second wave (12.0% versus 8.4%). Among individuals with a positive diagnostic test, 818 needed hospitalization in the first wave and 680 in the second; however, the percentage of hospitalized individuals was higher in the first wave than in the second wave (26.1% versus 5.8%). The group that was not admitted to hospital included older people and those with a higher percentage of comorbidities in the first wave, whereas the characteristics of the groups admitted to hospital were more alike.This work was supported by grants from the European Union ERDF funds (Network for Prevention and Health Promotion in Primary Care, RedIAPP–CARDIOCAT; RD16/0007/0004) and from the Agency for Management of University and Research Grants (AGAUR; 2017-SGR 1146). We thank Eric Tornabell for his technical support. We also thank all health care professionals for their ceaseless work to care for COVID-19 patients in this pandemic

Tobacco cessation among smokers under substance use treatment for alcohol and/or cannabis: study protocol and pilot study

Background: Approximately 80% of people with a substance use disorder (SUD) are smokers. Starting SUD treatment offers the opportunity to also quit smoking. The ACT-ATAC project aims to identify the predictors associated with smoking cessation among persons treated for alcohol and/or cannabis use disorder in Barcelona. This manuscript reports its methodology and the experience of carrying it out during the COVID-19 pandemic. Methods: Mixed methods project with three substudies. Substudy 1 (S1) comprises heterogeneous discussion groups among clinicians. S2 has two prospective cohorts composed of smokers under treatment for alcohol and/or cannabis use disorder and the clinicians in charge of these patients. Participating smokers will be followed for 12 months and interviewed about their substance use and the tobacco cessation services received using the Spanish version of the users' Knowledge, Attitudes, and Services (S-KAS) scale. The clinicians will be asked about their self-reported practices in smoking cessation using the Knowledge, Attitudes, and Practices (S-KAP) scale. S3 comprises heterogeneous discussion groups with smokers. Data will be triangulated using qualitative and quantitative analyses. To facilitate the recruitment process, the researchers have introduced several strategies (design clear protocols, set monthly online meetings, extend the project, provide gift cards, etc.). Discussion: The results of S1 were used to develop the questionnaires. S2 required some adjustments due to the COVID-19 pandemic, particularly the follow-up interviews being conducted by phone instead of face-to-face, and the recruitment rhythm was lower than expected. Recruitment will last until reaching at least 200-250 users. The fieldwork could not have been possible without the collaboration of the ACT-ATAC team and the introduction of several strategies