The Benzú rockshelter: a Middle Palaeolithic site on the North African coast

The rockshelter of Benzu ´ has a Middle–Upper Pleistocene stratigraphic sequence with ten levels, seven with evidence of human occupation. Speleothems have been dated by U/Th and the sedimentary levels by OSL and TL, showing that the sequence extends from 250 ka to 70 ka. In this paper, we summarise the results of geomorphology, chronostratigraphy and excavation, and provide preliminary results on the pollen, faunal and lithic remains. The location of the site on the North African coast of the Strait of Gibraltar offers the potential to throw light on contacts and relationships between prehistoric communities in North Africa and the South Iberian Peninsula, for whom the Strait may have served as a bridge rather than a barrier

Intimate partner violence is not identified as a health problem by health care workers

Objetivo: evaluar la opinión del personal sanitario de nuestro hospital frente al fenómeno de la violencia doméstica. Métodos: estudio descriptivo de prevalencia, utilizando un cuestionario diseñado ad hoc. Se preguntó a 321 profesionales, seleccionados aleatoriamente, acerca de la violencia doméstica y su relación con la salud. Resultados: respondieron 287 profesionales. La mayoría de encuestados (87,1%) consideró que era un problema importante, pero no lo consideraban un problema de salud. El 60% consideró que podía tener un papel relevante en la detección de esta situación. En general, valoraron como muy baja su preparación para atender a este tipo de pacientes. El personal de enfermería era más sensible al problema y se consideraba más preparado que el personal médico. Conclusiones: los profesionales de la salud están sensibilizados frente al problema de la violencia de género, pero no lo consideran un problema de salud y aducen falta de preparación para abordar este tema

Avance al estudio de la Cueva de Benzú (Ceuta). Nuevas perspectivas de investigación de sociedades tribales en el área norteafricana del Estrecho de Gibraltar

Las excavaciones en la Cueva de Benzú aportan interesantes datos para el estudio de las sociedades tribales. Está situada en la región Atlántica-Mediterránea, en el Norte de África. Tiene una datación en el VI milenio BC.The excavations in Benzu’s Cave provides interesting facts to the study of the tribal societies. It is placed between the Atlantic and the Mediterranean region, in the North of Africa. It is dated in the VI millennium BC.10 página

El abrigo de Benzú (Ceuta). Aportaciones al conocimiento de las sociedades con tecnología de Modo III en la región histórica del Estrecho de Gibraltar

El abrigo de Benzú se encuentra situado próximo a la ciudad de Ceuta, en el (norte) de África. Trabajamos en estos momentos en una fase final de la memoria científica de las actividades realizadas los últimos años. Por ello damos un balance, que todavía no es definitivo, de los datos geológicos, estratigráficos, cronológicos, ecológicos y de los recursos utilizados por las sociedades prehistóricas. Incidimos en datos tecnológicos de los productos arqueológicos y en los modos de vida. Las bases geológicas y paleoecológicas de la región histórica del Estrecho de Gibraltar ofrecen grandes semejanzas entre la orilla norteafricana y la europea. abrigo de Benzú cuenta con una secuencia de 7 estratos con tecnología muy definida en el concepto de Modo III. Las similitudes con los conjuntos del sur de la Península Ibérica son manifiestas. Destacamos también la explotación de recursos marinos por sociedades cazadoras-recolectoras desde el inicio de la secuencia en el Pleistoceno Medio. Con estas bases arqueológicas y el contexto de estudios recientes en la región norteafricana valoramos las posibles relaciones y contactos entre las sociedades de las dos orillas de la región histórica del Estrecho de Gibraltar

Emerging risk factors and the dose-response relationship between physical activity and lone atrial fibrillation: a prospective case-control study

A history of a parts per thousand yen2000 h of vigorous endurance training, tall stature, abdominal obesity, and OSA are frequently encountered as risk factors in patients with Ln-AF. Fewer than 2000 total hours of high-intensity endurance training associates with reduced Ln-AF risk

Relationship among Streptococcus gallolyticus Subsp. gallolyticus, Enterococcus faecalis and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series.

Objectives: The role of colorectal neoplasms (CRN) as a common potential source of recurrent Streptococcus gallolyticus subsp. gallolyticus (SGG) and Enterococcus faecalis (EF) endocarditis remains unstudied. We aimed to investigate what proportion of episodes of recurrent endocarditis are caused by a succession of SGG and EF, or vice versa, and to assess the role of a colonic source in such recurrent episodes. Methods: we conducted a retrospective analysis of two prospective endocarditis cohorts (1979-2019) from two Spanish hospitals, providing descriptive analyses of the major features of the endocarditis episodes, colonoscopy findings, and histologic results. Results: among 1552 IE episodes, 204 (13.1%) were caused by EF and 197 (12.7%) by SGG, respectively. There were 155 episodes (10%) of recurrent IE, 20 of which (12.9%) were due to a succession of SGG/EF IE in 10 patients (the first episode caused by SGG in eight cases, and by EF in two cases). The median follow-up was 86 (interquartile range 34-156) months. In 8/10 initial episodes, the causative microorganism was SGG, and all patients were diagnosed with CRN either during the initial episode or during follow-up. During the second episode of IE or follow-up, colonoscopies revealed CRN in six patients. Conclusions: There seems to be an association between SGG and EF in recurrent endocarditis that warrants further investigation. Our findings reinforce the need for systematically performing colonoscopy in the event of endocarditis caused by both microorganisms

The occupation of Benzu Cave (Ceuta) by Neolithic and Bronze Age Societies

Abstract This study presents the results of the archaeological investigation in Benzú Cave, located on the North African shore of the Strait of Gibraltar. The archaeological deposits, approximately 1 m deep, belong to two occupational levels dated to theNeolithic and the Bronze Age. Awide range of artifacts was found, and this led to an interdisciplinary study that led us to reach new conclusions concerning the material life, subsistence economy, and environment of the Neolithic and Bronze Age societies in northern Africa and the southern Iberian Peninsula.Résumé Cette étude présente les résultats des recherches archéologiques menées dans la grotte de Benzú, située sur la rive nord-africaine du détroit de Gibraltar. Les gisements archéologiques, d'environ un mètre de profondeur, appartiennent à deux niveaux d'occupation datant du néolithique et de l'âge du bronze. Une large gamme d'artefacts ont été trouvés, ce qui a conduit à une étude interdisciplinaire qui nous a amenés à tirer de nouvelles conclusions concernant la vie matérielle, l'économie de subsistance et l'environnement des sociétés du Néolithique et de l'Age du Bronze en Afrique du Nord et au sud de la Péninsule Ibérique

El Abrigo de Benzú (Ceuta). Un asentamiento de cazadores-recolectores del Pleistoceno medio y superior. Estratigrafía, estudio polínico y recursos hídricos

Aportación sobre Benzú al Simposio del Agua en Andalucía (2005

SOLTI-1805 TOT-HER3 Study Concept: A Window-of-Opportunity Trial of Patritumab Deruxtecan, a HER3 Directed Antibody Drug Conjugate, in Patients With Early Breast Cancer

Background: Preclinical data support a key role for the human epidermal growth factor receptor 3 (HER3) pathway in hormone receptor (HR)-positive breast cancer. Recently, new HER3 directed antibody drug conjugates have shown activity in breast cancer. Given the need to better understand the molecular biology, tumor microenvironment, and mechanisms of drug resistance in breast cancer, we designed this window-of-opportunity study with the HER3 directed antibody drug conjugate patritumab deruxtecan (HER3-DXd; U3-1402). Trial Design: Based on these data, a prospective, multicenter, single-arm, window-of-opportunity study was designed to evaluate the biological effect of patritumab deruxtecan in the treatment of naïve patients with HR-positive/HER2-negative early breast cancer whose primary tumors are ≥1 cm by ultrasound evaluation. Patients will be enrolled in four cohorts according to the mRNA-based ERBB3 expression by central assessment. The primary endpoint is a CelTIL score after one single dose. A translational research plan is also included to provide biological information and to evaluate secondary and exploratory objectives of the study