A systematic review of the safety of topical therapies for atopic dermatitis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75613/1/j.1365-2133.2006.07538.x.pd

Revision of the Afrotropical mylabrine genus Lydoceras Marseul, 1870 (Coleoptera, Meloidae)

The blister beetle genus Lydoceras Marseul, 1870, tribe Mylabrini, is revised. Its four species are redescribed and figured. Faunistic and ecological records of each species also are summarized. Results of a morphology-based cladistic analysis show Lydoceras lictor (Gerstäcker, 1885) and L. fasciatus (Fabricius, 1775) as most closely related. These two species and L. flavosellatus (Fairmaire, 1887) are placed in the nominate subgenus. The group occurs in eastern Africa and western Arabian Peninsula. The highly distinctive L. stanleyanus (Duvivier, 1890), endemic to central Africa, is placed in the resurrected subgenus Denierus Pic

Aegus chelifer Macleay 1819, an Asian stag beetle (Coleoptera Lucanidae) invading the Seychelles Islands: a threat for endemic saproxylic species?

An Indo-Malayan stag beetle, Aegus chelifer Macleay 1819, was found for the first time in the Seychelles (Mahé, Praslin, La Digue, Cerf ) during four surveys conducted between 2006 and 2009. The species had not been recorded in previous research on the insect fauna of these islands, even in the most recent and comprehensive studies. A. chelifer now appears to be common and widespread in the granitic islands of the archipelago, especially in Mahé, suggesting that a stable population occurs at least on this island. As all the records were made after the 2004 Indian Ocean tsunami, the occurrence of the species in the Seychelles could be explained by transoceanic dispersal from South East Asia by floating tree trunks, due to the action of ocean currents on logs removed from Asia by the tsunami. Key words: Lucanidae, Aegus, Seychelles, biological invasion, tropical islands, fauna, biogeography, dispersal

Cd200 baseline serum levels predict prognosis of chronic lymphocytic leukemia

Membrane‐bound CD200 is overexpressed in chronic lymphocytic leukemia (CLL), and there is some evidence that its soluble ectodomain (sCD200) could also be involved in the pathophysiology and the disease. However, very little is known about sCD200’s prognostic significance. sCD200 was tested at diagnosis in 272 patients with CLL and in 78 age‐ and sex-matched healthy subjects using a specific human CD200 (OX‐2 membrane glycoprotein) ELISA kit. A significantly higher concentration of sCD200 was found in CLL patients compared to controls. In our cohort, sCD200 was significantly higher in patients who were older than 66 years, with Binet stage C, unmutated IgVH and unfavorable (del11q or del17p) FISH. Time‐to‐first treatment and overall survival were significantly shorter in patients with higher sCD200 concentration, using as a cut‐off 1281 pg/mL, the median value for sCD200 concentration in the whole CLL cohort. However, the prognostic impact of sCD200 was not confirmed in multivariate analysis. Baseline sCD200 values appeared to have an impact on the response to chemotherapy or chemo‐immunotherapy, but not to targeted agents. Collectively, our data show that sCD200 serum levels correlate with more aggressive clinical and biological features and are able to predict a worse prognosis. This work supports the relevant role of CD200 not only as a diagnostic tool but also as a prognostic indicator and a potential therapeutic target in CLL