407 research outputs found

    Timelapse ultrasonic tomography for measuring damage localization in geomechanics laboratory tests.

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    Variation of mechanical properties in materials can be detected non-destructively using ultrasonic measurements. In particular, changes in elastic wave velocity can occur due to damage, i.e., micro-cracking and particles debonding. Here the challenge of characterizing damage in geomaterials, i.e., rocks and soils, is addressed. Geomaterials are naturally heterogeneous media in which the deformation can localize, so that few measurements of acoustic velocity across the sample are not sufficient to capture the heterogeneities. Therefore, an ultrasonic tomography procedure has been implemented to map the spatial and temporal variations in propagation velocity, which provides information on the damage process. Moreover, double beamforming has been successfully applied to identify and isolate multiple arrivals that are caused by strong heterogeneities (natural or induced by the deformation process). The applicability of the developed experimental technique to laboratory geomechanics testing is illustrated using data acquired on a sample of natural rock before and after being deformed under triaxial compression. The approach is then validated and extended to time-lapse monitoring using data acquired during plane strain compression of a sample including a well defined layer with different mechanical properties than the matrix

    Peers in Prison Settings (PiPS) Expert Symposium

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    A two-rigid block model for sliding gravity retaining walls

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    This paper presents a new two rigid block model for sliding gravity retaining walls. Some conceptual limitations of a direct application of Newmark's sliding block method to the case of retaining walls are discussed with reference to a simple scheme of two interacting rigid blocks on an inclined plane. In particular, it is shown that both the internal force between the blocks and their absolute acceleration are not constant during sliding, and must be computed by direct consideration of the dynamic equilibrium and kinematic constraints for the whole system. The same concepts are extended to the analysis of the active soil wedge-wall system, leading to an extremely simple procedure to compute the relative displacements of the wall when subjected to base accelerations exceeding the critical value. A comparison with the results of numerical analyses demonstrates that the proposed method is capable of describing fully the kinematics of the soil wedge-wall system under dynamic loading. On the contrary, direct application of Newmark's method may lead to inaccurate predictions of the final displacements, in excess or in defect depending on a coefficient, which emerges from direct consideration of the dynamic equilibrium of the whole system. This coefficient can be viewed as a corrective factor for the horizontal relative acceleration of the wall, related to the mechanical and geometrical properties of the soil-wall system

    Numerical modelling of centrifuge dynamic tests of circular tunnels in dry sand

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    This paper describes the numerical simulation of two dynamic centrifuge tests on reduced scale models of shallow tunnels in dry sand, carried out using both an advanced bounding surface plasticity constitutive soil model and a simple Mohr–Coulomb elastic-perfectly plastic model with embedded nonlinear and hysteretic behaviour. The predictive capabilities of the two constitutive models are assessed by comparing numerical predictions and experimental data in terms of accelerations at several positions in the model, and bending moment and hoop forces in the lining. Computed and recorded accelerations match well, and a quite good agreement is achieved also in terms of dynamic bending moments in the lining, while numerical and experimental values of the hoop force differ significantly with one another. The influence of the contact assumption between the tunnel and the soil is investigated by comparing the experimental data and the numerical results obtained with different interface conditions with the analytical solutions. The overall performance of the two models is very similar indicating that at least for dry sand, where shear-volumetric coupling is less relevant, even a simple model can provide an adequate representation of soil behaviour under dynamic condition

    Strategies for analyzing highly enriched IP-chip datasets

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    BACKGROUND: Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been employed to examine features such as protein binding and histone modifications on a genome-wide scale in a variety of cell types. Array data from the latter studies typically have a high proportion of enriched probes whose signals vary considerably (due to heterogeneity in the cell population), and this makes their normalization and downstream analysis difficult. RESULTS: Here we present strategies for analyzing such experiments, focusing our discussion on the analysis of Bromodeoxyruridine (BrdU) immunoprecipitation on tiling array (BrdU-IP-chip) datasets. BrdU-IP-chip experiments map large, recently replicated genomic regions and have similar characteristics to histone modification/location data. To prepare such data for downstream analysis we employ a dynamic programming algorithm that identifies a set of putative unenriched probes, which we use for both within-array and between-array normalization. We also introduce a second dynamic programming algorithm that incorporates a priori knowledge to identify and quantify positive signals in these datasets. CONCLUSION: Highly enriched IP-chip datasets are often difficult to analyze with traditional array normalization and analysis strategies. Here we present and test a set of analytical tools for their normalization and quantification that allows for accurate identification and analysis of enriched regions

    Factors that determine the effectiveness of peer interventions in prisons in England and Wales

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    Epidemiological assessment of the prison population globally shows undeniable health need, with research evidence consistently demonstrating that the prevalence of ill health is higher than rates reported in the wider community. Since a meeting convened by the World Health Organisation in the mid-1990s, prisons have been regarded as legitimate settings for health promotion and a myriad of interventions have been adopted to address prisoners’ health and social need. Peer-based approaches have been a common health intervention used within the prison system, but despite their popularity little evidence exists on the approach. This paper presents findings from an expert symposium – part of a wider study which included a systematic review – designed to gather expert opinion on whether and how peer–based approaches work within prisons and if they can contribute to improving the health of prisoners. Experts were selected from various fields including the prison service, academic research and third sector organisations. Expert evidence suggested that the magnitude of success of peer interventions in prison settings is contingent on understanding the contextual environment and a recognition that peer interventions are co-constructed with prison staff at all levels of the organisation. Implications for developing peer-based interventions in prison are given which assist in developing the concept, theory and practice of the health promoting prison

    An integrative study on asphondylia spp. (diptera: Cecidomyiidae), causing flower galls on lamiaceae, with description, phenology, and associated fungi of two new species

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    An integrative study on some species of Asphondylia was carried out. Two species of gall midges from Italy, Asphondylia rivelloi sp. nov. and Asphondylia micromeriae sp. nov. (Diptera: Cecidomyiidae), causing flower galls respectively on Clinopodium vulgare and Micromeria graeca (Lamiaceae), are described and illustrated. The characteristics of each developmental stage and induced galls are described, which allowed the discrimination of these new species in the complex of Asphondylia developing on Lamiaceae plants. Molecular data based on sequencing both nuclear (ITS2 and 28S-D2) and mitochondrial (COI) genes are also provided in support of this discrimination. Phylogeny based on nuclear markers is consistent with the new species, whereas COI phylogeny suggests introgression occurring between the two species. However, these species can also be easily identified using a morphological approach. Phenology of host plants and gall midges are described, and some peculiar characteristics allow the complete and confident discrimination and revision of the treated species. Gall-associated fungi were identified as Botryosphaeria dothidea, Alternaria spp., and Cladosporium spp
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