Asymptotic periodic solutions of differential equations with infinite delay

In this paper, by using the spectral theory of functions and properties of evolution semigroups, we establish conditions on the existence, and uniqueness of asymptotic 1-periodic solutions to a class of abstract differential equations with infinite delay of the form \begin{equation*} \frac{d u(t)}{d t}=A u(t)+L(u_t)+f(t) \end{equation*} where $A$ is the generator of a strongly continuous semigroup of linear operators, $L$ is a bounded linear operator from a phase space $\mathscr{B}$ to a Banach space $X$, $u_t$ is an element of $\mathscr{B}$ which is defined as $u_t(\theta)=u(t+\theta)$ for $\theta \leq 0$ and $f$ is asymptotic 1-periodic in the sense that $\lim\limits_{t \rightarrow \infty}(f(t+1)-$ $f(t))=0$. A Lotka-Volterra model with diffusion and infinite delay is considered to illustrate our results.Comment: 13 page

Deep Learning-Aided Multicarrier Systems

This paper proposes a deep learning (DL)-aided multicarrier (MC) system operating on fading channels, where both modulation and demodulation blocks are modeled by deep neural networks (DNNs), regarded as the encoder and decoder of an autoencoder (AE) architecture, respectively. Unlike existing AE-based systems, which incorporate domain knowledge of a channel equalizer to suppress the effects of wireless channels, the proposed scheme, termed as MC-AE, directly feeds the decoder with the channel state information and received signal, which are then processed in a fully data-driven manner. This new approach enables MC-AE to jointly learn the encoder and decoder to optimize the diversity and coding gains over fading channels. In particular, the block error rate of MC-AE is analyzed to show its higher performance gains than existing hand-crafted baselines, such as various recent index modulation-based MC schemes. We then extend MC-AE to multiuser scenarios, wherein the resultant system is termed as MU-MC-AE. Accordingly, two novel DNN structures for uplink and downlink MU-MC-AE transmissions are proposed, along with a novel cost function that ensures a fast training convergence and fairness among users. Finally, simulation results are provided to show the superiority of the proposed DL-based schemes over current baselines, in terms of both the error performance and receiver complexity

High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam

Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City

Saponins isolated from the Vietnamese sea cucumber Stichopus chloronotus.

Using various chromatographic methods, three triterpene saponins neothyonidioside (1), stichoposide D (2), and holothurin B (3), were isolated from the methanol extract of the sea cucumber Stichopus chloronotus. Their structures were elucidated by 1D and 2D-NMR experiments and comparison of their NMR data with reported values. Compound 1 was isolated from S. chloronotus for the first time

Antibiotic use and prescription and its effects on Enterobacteriaceae in the gut in children with mild respiratory infections in Ho Chi Minh City, Vietnam. A prospective observational outpatient study.

BACKGROUND AND OBJECTIVES: Treatment guidelines do not recommend antibiotic use for acute respiratory infections (ARI), except for streptococcal pharyngitis/tonsillitis and pneumonia. However, antibiotics are prescribed frequently for children with ARI, often in absence of evidence for bacterial infection. The objectives of this study were 1) to assess the appropriateness of antibiotic prescriptions for mild ARI in paediatric outpatients in relation to available guidelines and detected pathogens, 2) to assess antibiotic use on presentation using questionnaires and detection in urine 3) to assess the carriage rates and proportions of resistant intestinal Enterobacteriaceae before, during and after consultation. MATERIALS AND METHODS: Patients were prospectively enrolled in Children's Hospital 1, Ho Chi Minh City, Vietnam and diagnoses, prescribed therapy and outcome were recorded on first visit and on follow-up after 7 days. Respiratory bacterial and viral pathogens were detected using molecular assays. Antibiotic use before presentation was assessed using questionnaires and urine HPLC. The impact of antibiotic usage on intestinal Enterobacteriaceae was assessed with semi-quantitative culture on agar with and without antibiotics on presentation and after 7 and 28 days. RESULTS: A total of 563 patients were enrolled between February 2009 and February 2010. Antibiotics were prescribed for all except 2 of 563 patients. The majority were 2nd and 3rd generation oral cephalosporins and amoxicillin with or without clavulanic acid. Respiratory viruses were detected in respiratory specimens of 72.5% of patients. Antibiotic use was considered inappropriate in 90.1% and 67.5%, based on guidelines and detected pathogens, respectively. On presentation parents reported antibiotic use for 22% of patients, 41% of parents did not know and 37% denied antibiotic use. Among these three groups, six commonly used antibiotics were detected with HPLC in patients' urine in 49%, 40% and 14%, respectively. Temporary selection of 3rd generation cephalosporin resistant intestinal Enterobacteriaceae during antibiotic use was observed, with co-selection of resistance to aminoglycosides and fluoroquinolones. CONCLUSIONS: We report overuse and overprescription of antibiotics for uncomplicated ARI with selection of resistant intestinal Enterobacteriaceae, posing a risk for community transmission and persistence in a setting of a highly granular healthcare system and unrestricted access to antibiotics through private pharmacies. REGISTRATION: This study was registered at the International Standard Randomised Controlled Trials Number registry under number ISRCTN32862422: http://www.isrctn.com/ISRCTN32862422

A polyhydroxylated sterol and a saponin isolated from the starfish culcita novaeguineae

Using various chromatographic methods, a polyhydroxylated sterol 5α-cholestane-3β,6β,7α,8β,15α,16β,26-heptol (1) and an asterosaponin sodium salt of 6α-[(O-β-D-fucopyranosyl-(l®2)-O-β-D-galactopyranosyl-(l®4)-O-[β-D-quinovopyranosyl-(l®2)]-O-β-D-xylopyranosyl-(l®3)-O-β-D-quinovopyranosyl)oxy]-5α-pregn-9(11)-ene-20-one (2), were isolated from the methanol extract of the starfish Culcita novaeguineae. Their structures were elucidated by 1D and 2D-NMR experiments and comparison of their NMR data with reported values. Compounds 1 was isolated from         C. novaeguineae for the first time

The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam

Shigellosis is a disease caused by bacteria belonging to Shigella spp. and is a leading cause of bacterial gastrointestinal infections in infants in unindustrialized countries. The Shigellae are dynamic and capable of rapid change when placed under selective pressure in a human population. Extended spectrum beta lactamases (ESBLs) are enzymes capable of degrading cephalosporins (a group of antimicrobial agents) and the genes that encode them are common in pathogenic E. coli and other related organisms in industrialized countries. In southern Vietnam, we have isolated multiple cephalosporin-resistant Shigella that express ESBLs. Furthermore, over two years these strains have replaced strains isolated from patients with shigellosis that cannot express ESBLs. Our work describes the genes responsible for this characteristic and we investigate one of the elements carrying one of these genes. These finding have implications for treatment of shigellosis and support the growing necessity for vaccine development. Our findings also may be pertinent for other countries undergoing a similar economic transition to Vietnam's and the corresponding effect on bacterial populations