Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies

Background:Socioeconomic and racial/ethnic factors strongly influence cardiovascular disease outcomes and risk factors. C-reactive protein (CRP), a non-specific marker of inflammation, is associated with cardiovascular risk, and knowledge about its distribution in the population may help direct preventive efforts. A systematic review was undertaken to critically assess CRP levels according to socioeconomic and racial/ethnic factors. Methods:Medline was searched through December 2006 for population-based studies examining CRP levels among adults with respect to indicators of socioeconomic position (SEP) and/or race/ethnicity. Bibliographies from located studies were scanned and 26 experts in the field were contacted for unpublished work. Results:Thirty-two relevant articles were located. Cross-sectional (n = 20) and cohort studies (n = 11) were included, as was the control group of one trial. CRP levels were examined with respect to SEP and race/ethnicity in 25 and 15 analyses, respectively. Of 20 studies that were unadjusted or adjusted for demographic variables, 19 found inverse associations between CRP levels and SEP. Of 15 similar studies, 14 found differences between racial/ethnic groups such that whites had the lowest while blacks, Hispanics and South Asians had the highest CRP levels. Most studies also included adjustment for potential mediating variables in the causal chain between SEP or race/ethnicity and CRP. Most of these studies showed attenuated but still significant associations. Conclusion: Increasing poverty and non-white race was associated with elevated CRP levels among adults. Most analyses in the literature are underestimating the true effects of racial/ethnic and socioeconomic factors due to adjustment for mediating factors

Data Resource Profile: Countdown to 2015: Maternal, Newborn and Child Survival

The Countdown to 2015 country profiles present, in one place, comprehensive evidence to enable an assessment of a country's progress in improving reproductive, maternal, newborn and child health. Profiles are available for each of the 75 countries that together account for more than 95% of all maternal and child deaths. The two-page profiles are updated approximately every 2 years with new data and analyses. Profile data include demographics, mortality, nutritional status, coverage of evidence-based interventions, within-countries inequalities in coverage, measures of health system functionality, supportive policies and financing indicators. The main sources of data for the coverage, nutritional status and equity indicators are the US Agency for Internal Development (USAID)-supported demographic and health surveys and the United Nations Children's Fund (UNICEF)-supported multiple indicator cluster surveys. Data on coverage are first summarized and checked for quality by UNICEF, and data on equity in intervention coverage are summarized and checked by the Federal University of Pelotas. The mortality estimates are developed by the Inter-agency Group for Child Mortality Estimation and the Maternal Mortality Estimation Inter-Agency Group. The financing data are abstracted from datasets maintained by the Organization for Economic Co-operation and Development Assistance Committee, and the policies and health systems data are derived from a special compilation prepared by the World Health Organization. Associated country profiles include equity-specific profiles and one-page profiles prepared annually that report on the 11 indicators selected by the Commission on Information and Accountability for Women's and Children's Healt

Iniqüidades sociais na saúde e nutrição de crianças em países de renda baixa e média

OBJECTIVE: To describe the effects of social inequities on the health and nutrition of children in low and middle income countries. METHODS: We reviewed existing data on socioeconomic disparities within-countries relative to the use of services, nutritional status, morbidity, and mortality. A conceptual framework including five major hierarchical categories affecting inequities was adopted: socioeconomic context and position, differential exposure, differential vulnerability, differential health outcomes, and differential consequences. The search of the PubMed database since 1990 identified 244 articles related to the theme. Results were also analyzed from almost 100 recent national surveys, including Demographic Health Surveys and the UNICEF Multiple Indicator Cluster Surveys. RESULTS: Children from poor families are more likely, relative to those from better-off families, to be exposed to pathogenic agents; once they are exposed, they are more likely to become ill because of their lower resistance and lower coverage with preventive interventions. Once they become ill, they are less likely to have access to health services and the quality of these services is likely to be lower, with less access to life-saving treatments. As a consequence, children from poor family have higher mortality rates and are more likely to be undernourished. CONCLUSIONS: Except for child obesity and inadequate breastfeeding practices, all the other adverse conditions analyzed were more prevalent in children from less well-off families. Careful documentation of the multiple levels of determination of socioeconomic inequities in child health is essential for understanding the nature of this problem and for establishing interventions that can reduce these differences.OBJETIVO: Describir el efecto de las iniquidades sociales sobre la nutrición y salud de niños de países de renta baja y media. MÉTODOS: Fueron revisadas informaciones disponibles sobre disparidades socioeconómicas intra-países, relativas al uso de servicios de salud, estado nutricional, morbilidad y mortalidad. Se adoptó un modelo conceptual con cinco categorías jerárquicas en la producción de inequidades: contexto y posición socioeconómica, diferencias en la exposición, en la vulnerabilidad, en los hechos de salud y en las consecuencias. En investigación realizada en la base PubMed, en el período de 1990-2007 fueron encontrados 244 artículos relacionados al tema. Fueron también analizados los resultados de cerca de 100 pesquisas de ámbito nacional recientes, incluyendo Pesquisas Nacionales de Demografía y Salud y Pesquisas por Conglomerados de Múltiples Indicadores, del Fondo de las Naciones Unidas para la Infancia. RESULTADOS: Niños de familias pobres, en comparación con aquellas de familias más ricas, son más susceptibles a la exposición a agentes patogénicos; una vez expuestas, tienen un riesgo aumentado de enfermar, debido a su menor resistencia y menor cobertura de medidas preventivas. Una vez que se toman enfermos, tienen menor acceso a servicios de salud, la calidad de los servicios que logran utilizar tiende a ser inferior, con menor acceso a tratamientos médicos que garanticen su sobrevivencia. Como consecuencia, niños de familias más pobres presentan mayores tasas de mortalidad y mayor riesgo de ser subnutridas. CONCLUSIONES: Excepto obesidad infantil y prácticas inadecuadas de amamantamiento, todas las otras condiciones adversas analizadas tuvieron mayor prevalencia entre los niños de familias menos favorecidas. La documentación cuidadosa de los múltiples niveles de determinantes de las inequidades socioeconómicas en salud infantil es esencial para el entendimiento de la naturaleza del problema, y para el establecimiento de intervenciones que puedan reducir estas diferencias.OBJETIVO: Descrever o efeito das iniqüidades sociais sobre a nutrição e saúde de crianças de países de renda baixa e média. MÉTODOS: Foram revisadas informações disponíveis sobre disparidades socioeconômicas intra-países, relativas a uso de serviços de saúde, estado nutricional, morbidade e mortalidade. Adotou-se um modelo conceitual com cinco categorias hierárquicas na produção de iniqüidades: contexto e posição socioeconômica, diferenças na exposição, na vulnerabilidade, nos desfechos de saúde e nas conseqüências. Em pesquisa realizada na base PubMed, no período de 1990-2007 foram encontrados 244 artigos relacionados ao tema. Foram também analisados os resultados de cerca de 100 inquéritos de âmbito nacional recentes, incluindo Pesquisas Nacionais de Demografia e Saúde e Inquéritos por Conglomerados de Múltiplos Indicadores, do Fundo das Nações Unidas para a Infância. RESULTADOS: Crianças de famílias pobres, em comparação com aquelas de famílias mais ricas, são mais suscetíveis à exposição a agentes patogênicos; uma vez expostas, têm um risco aumentado de adoecer, devido à sua menor resistência e menor cobertura de medidas preventivas. Uma vez que se tornam doentes, têm menor acesso a serviços de saúde, a qualidade dos serviços que logram utilizar tende a ser inferior, com menor acesso a tratamentos médicos que garantam sua sobrevivência. Como conseqüência, crianças de famílias mais pobres apresentam maiores taxas de mortalidade e maior risco de serem subnutridas. CONCLUSÕES: Exceto obesidade infantil e práticas inadequadas de aleitamento materno, todas as outras condições adversas analisadas tiveram maior prevalência entre as crianças de famílias menos favorecidas. A documentação cuidadosa dos múltiplos níveis de determinantes das iniqüidades socioeconômicas em saúde infantil é essencial para o entendimento da natureza do problema, e para o estabelecimento de intervenções que possam reduzir estas diferenças

Are inequities decreasing? Birth registration for children under five in low-income and middle-income countries, 1999-2016.

INTRODUCTION: Although global birth registration coverage has improved from 58% to 71% among children under five globally, inequities in birth registration coverage by wealth, urban/rural location, maternal education and access to a health facility persist. Few studies examine whether inequities in birth registration in low-income and middle-income countries have changed over time. METHODS: We combined information on caregiver reported birth registration of 1.6 million children in 173 publicly available, nationally representative Demographic Health Surveys and Multiple Indicator Cluster Surveys across 67 low-income and middle-income countries between 1999 and 2016. For each survey, we calculated point estimates and 95% CIs for the percentage of children under 5 years without birth registration on average and stratified by sex, urban/rural location and wealth. For each sociodemographic variable, we estimated absolute measures of inequality. We then examined changes in non-registration and inequities between surveys, and annually. RESULTS: 14 out of 67 countries had achieved complete birth registration. Among the remaining 53 countries, 39 countries successfully decreased the percentage of children without birth registration. However, this reduction occurred alongside statistically significant increases in wealth inequities in 9 countries and statistically significant decreases in 10 countries. At the most recent survey, the percentage of children without birth registration was greater than 50% in 16 out of 67 countries. CONCLUSION: Although birth registration improved on average, progress in reducing wealth inequities has been limited. Findings highlight the importance of monitoring changes in inequities to improve birth registration, to monitor Sustainable Development Goal 16.9 and to strengthen Civil Registration and Vital Statistics systems

Publicações científicas e as relações Norte-Sul: racismo editorial?

The aim of the present study was to comment on the possible existence of editorial prejudice among the editors of scientific journals from Northern countries against Southern authors. We highlight that a study using bibliometric methods documented an important imbalance in terms of the international scientific production of health researchers from high-income countries (the "North") and those from low and middle-income countries (the "South"). In a survey of Brazilian researchers, three in every four blamed this imbalance, at least in part, on prejudice among international editors. This is supported by the fact that a very small percentage of editorial board members of international journals come from the South. Although prejudice can explain part of the imbalance, there are also specific measures that may increase the likelihood of a paper from the South being accepted in international journals. These include the need to invest in the quality of the written text, and to show empathy with editors and readers, emphasizing the contribution of the manuscript to the international literature. Finally, we discuss whether research carried out in the South should be published in national or international journals, and suggest that there are at least six dimensions to this choice. These include language and target audience; type of contribution to knowledge; generalizability; citation index; speed of publication; and open access. The rapid growth in the number of Brazilian contributions to the international health literature shows that editorial prejudice, although often present, can be effectively offset by research with solid methodology and good-quality presentation.O objetivo do estudo foi comentar a possível existência de preconceito editorial entre editores de revistas científicas de países do Norte contra autores do Sul. Destacou-se que em estudo por métodos bibliométricos ficou evidenciada a existência de um importante desequilíbrio entre a produção científica de pesquisadores de países de alta renda ("Norte") e daqueles trabalhando em instituições de países de renda média ou baixa ("Sul"). Há uma percepção generalizada entre autores brasileiros de que, em parte, isso seria devido a preconceito de editores de revistas internacionais contra autores do Sul - 75% de uma amostra de 244 autores que responderam a inquérito acreditam que exista preconceito. Essa impressão é reforçada pela observação de uma minoria dos membros de conselhos editoriais das principais revistas na área de saúde proveniente do Sul. Embora o preconceito possa explicar parte do problema, há também questões especificas e remediáveis que podem aumentar a probabilidade de publicar no exterior. Essas incluem investir na qualidade do texto e da redação, e mostrar empatia com editores e leitores, sinalizando claramente a contribuição que o artigo pode trazer para a literatura internacional. Finalmente, é abordada a questão de onde publicar: em periódicos nacionais ou internacionais. Foram propostos seis tópicos que devem ser levados em conta nessa opção: idioma e público-alvo; tipo de contribuição ao conhecimento; capacidade de generalização; índice de citações; velocidade de publicação; e acesso livre. O aumento rápido de publicações brasileiras em periódicos internacionais mostra que o preconceito editorial, embora existente, pode ser efetivamente vencido por trabalhos com metodologia sólida e apresentação de qualidade

Hipertensão arterial sistêmica em área urbana no sul do Brasil: prevalência e fatores de risco

Knowledge of the prevalence of systemic arterial hypertension and its risk factors can be of great value to health policy and planning activities. A cross-sectional study was carried out in Pelotas, southern Brazil, for the purpose of discovering the prevalence of hypertension and selected risk factors. A representative sample of 1,675 adults were studied. The prevalence of hypertension was of 19.8%. The following variables were significantly associated with hypertension after adjustment for confounding variables: black race, advanced age, low educational level, paternal and maternal history of hypertension, use of additional salt on cooked foods, and obesity. The strong association between social class and hypertension found by bivariant analysis was reduced in the multivariate analysis after adjustment for age, sex and race.O conhecimento da prevalência de hipertensão arterial sistêmica (HAS) e de seus fatores de risco pode ser de grande valor para orientar o planejamento das políticas de saúde. Para identificar a prevalência de HAS, e sua associação com fatores de risco, foi realizado estudo transversal de base populacional na cidade de Pelotas, no sul do Brasil, onde foram examinadas 1.657 pessoas. A prevalência de HAS foi de 19,8%. Os fatores de risco significativamente associados, após controle para fatores de confusão, foram: cor preta, idade avançada, baixa escolaridade, história paterna e materna de HAS, uso de sal adicional à mesa e obesidade. A classe social, que mostrou forte associação com HAS na análise bivariada, teve seu efeito reduzido na análise multivariada, quando houve ajuste por sexo, cor e idade

Socioeconomic inequalities in skilled birth attendance and child stunting in selected low and middle income countries: Wealth quintiles or deciles?

BACKGROUND: Wealth quintiles derived from household asset indices are routinely used for measuring socioeconomic inequalities in the health of women and children in low and middle-income countries. We explore whether the use of wealth deciles rather than quintiles may be advantageous. METHODS: We selected 46 countries with available national surveys carried out between 2003 and 2013 and with a sample size of at least 3000 children. The outcomes were prevalence of under-five stunting and delivery by a skilled birth attendant (SBA). Differences and ratios between extreme groups for deciles (D1 and D10) and quintiles (Q1 and Q5) were calculated, as well as two summary measures: the slope index of inequality (SII) and concentration index (CIX). RESULTS: In virtually all countries, stunting prevalence was highest among the poor, and there were larger differences between D1 and D10 than between Q1 and Q5. SBA coverage showed pro-rich patterns in all countries; in four countries the gap was greater than 80 pct points. With one exception, differences between extreme deciles were larger than between quintiles. Similar patterns emerged when using ratios instead of differences. The two summary measures provide very similar results for quintiles and deciles. Patterns of top or bottom inequality varied with national coverage levels. CONCLUSION: Researchers and policymakers should consider breakdowns by wealth deciles, when sample sizes allow. Use of deciles may contribute to advocacy efforts, monitoring inequalities over time, and targeting health interventions. Summary indices of inequalities were unaffected by the use of quintiles or deciles in their calculation