Opadanje stoka školjkaša Ruditapes philippinarum u uvalama sjevernog Jadrana:anketa o ekološkim i društveno-ekonomskim aspektima

The Manila clam, Ruditapes philippinarum, introduced in the Venice lagoons in 1983 and rapidly spread to the nearby coastal lagoons represents one of the most important commercially- exploited resources of this area. Abundance, size-class and biomass distribution of the wild population living in the Pialassa Baiona lagoon were assessed and related to the hydrological and sediment characteristics. Despite the lagoon being affected by eutrophication, chemical and thermal pollution, the clams were harvested by about thirty professional fishermen until 2003. The commercially available stock was estimated at 36.8 10 3 kg in July 2002, 29.3 10 3 kg in April 2003, and 10.3 10 3 kg in October 2003. Stock estimations and observed mortality were in good accordance with the fishermen data. The decline of the available stock could be due to both overfishing and the extraordinary summer heat wave occurred in 2003, which may have reduced larval recruitment and increased the mortality. Overall, the juvenile recruitment appeared insufficient to annually restore the natural stock. Although the national and regional high relevance of clams market, local harvesting of wild populations appeared marginal and inadequate to support a remunerative commercial activity, due to the variability and unpredictability of the annual yield and the lack of a sustainable management based on a production chain’s approach.Školjkaš Ruditapes philippinarum, zabilježena u Venecijanskoj laguni 1983. godine gdje se brzo proširila i na obližnje obalne lagune te predstavlja jedan od najvažnijih komercijalno iskorištenih resursa ovog područja. U laguni Pialassa Baiona procjenjene su abundancija, veličina klase i raspodjela biomase prirodnih populacija u odnosu na hidrološke i sedimentne karakteristike. Unatoč tome što je laguna bila pogođena eutrofikacijom, kemijskim i toplinskim zagađenjima, oko trideset profesionalnih ribara sakupljalo je školjke do 2003. godine. Dostupne zalihe stoka komercijalnih vrsta procijenjene su na 36,8 10, 3kg u srpnju 2002. godine, zatim na 29.3 10 3kg u travnju 2003. godine i na 10,3 10 3 kg u listopadu 2003. godine. Procjene zaliha i smrtnosti bile su u skladu s podacima ribara. Pad raspoloživih zaliha mogao bi biti posljedica prekomjernog izlova i izvanrednog ljetnoga toplinskog vala koji se dogodio 2003. godine, što je utjecalo na smanjenje novačenja ličinki i povećanje smrtnosti. Sveukupno gledano novačenje juvenilnih primjeraka nije bilo dovoljno za godišnje obnavljanje prirodnih zaliha. Iako je na nacionalnoj i regionalnoj razini velika važnost tržišta školjki, lokalna berba divljih populacija jest marginalna i neadekvatna za podupiranje profitabilne komercijalne aktivnosti, zbog varijabilnosti i nepredvidljivosti godišnjeg prinosa i nedostatka održivog upravljanja temeljenog na pristupu proizvodnog lanca

A Decidable Characterization of a Graphical Pi-calculus with Iterators

This paper presents the Pi-graphs, a visual paradigm for the modelling and verification of mobile systems. The language is a graphical variant of the Pi-calculus with iterators to express non-terminating behaviors. The operational semantics of Pi-graphs use ground notions of labelled transition and bisimulation, which means standard verification techniques can be applied. We show that bisimilarity is decidable for the proposed semantics, a result obtained thanks to an original notion of causal clock as well as the automatic garbage collection of unused names.Comment: In Proceedings INFINITY 2010, arXiv:1010.611

Process Control Parameters Evaluation Using Discrete Event Simulation for Business Process Optimization

The quest for manufacturing process improvement and higher levels of customer satisfaction mandates that organizations must be equipped with advanced tools and techniques in order to respond towards ever changing internal and external customer demands by maintaining the optimal process performance, lower cost and higher profit levels. A manufacturing process can be defined as a collection of activities designed to produce a specific output for a particular customer or market. To achieve internal and external objectives, significant process parameters must be identified and evaluated to optimize the process performance. This even becomes more important to deal with fierce competition and ever changing customer demands. This paper illustrates an integrated approach using design of experiments techniques and discrete event simulation (Simul8) to understand and optimize the system dynamic based on operational control parameter evaluation and their boundary conditions. Further, the proposed model is validated using a real world manufacturing process case study to optimize the manufacturing process performance. Discrete event simulation tool is used to mimic the real world scenario, which provides a flexible and powerful way to comprehensively understand the manufacturing process variations and allows controlled 'What-If´ analysis based on design of experiments approach. Finally, this paper discusses the potential applications of the proposed methodology in the cable industry in order to optimize the cable manufacturing process by regulating the operational control parameters such as dealing with various product configurations with different equipment settings, different product flows and work in process (WIP) space limitations

Systematic Review and Annotated Bibliography on Teaching in Higher Education Academies (HEAs) via Group Learning to Adapt with COVID-19

Student learning has been affected by the recent shift in education globally which has been attributed to adaptation to the recent COVID-19 pandemic. This study will look at these characteristics to better understand gender differences in e-learners’ self-efficacy, satisfaction, motivation, attitude, and performance on a worldwide scale. Due to the rapid COVID-19 pandemic, many educational institutions had to close, forcing many students to stay at home and enrol in online courses. Due to the practical laboratory sessions and workshops demanded by Science, Technology, Engineering, and Mathematics (STEM) modules and other related fields, education has faced difficulties during the COVID-19 pandemic. Understanding student involvement and its role in promoting a number of desirable outcomes, including academic outcomes like greater achievement, lower dropout rates, as well as various well-being and life outcomes, has therefore become increasingly important. This paper presents the scientometric review with an annotated bibliography on teaching styles through group learning in the higher education academies (HEAs) directed towards sustainable education. The current work also gives an annotated bibliography that seeks to compile and integrate the research on student participation, group learning, instructional strategies, equality, and diversity. Some evaluations and suggestions are also made in the study

Systematic Review and Annotated Bibliography on Teaching in Higher Education Academies (HEAs) via Group Learning to Adapt with COVID-19

Student learning has been affected by the recent shift in education globally which has been attributed to adaptation to the recent COVID-19 pandemic. This study will look at these characteristics to better understand gender differences in e-learners’ self-efficacy, satisfaction, motivation, attitude, and performance on a worldwide scale. Due to the rapid COVID-19 pandemic, many educational institutions had to close, forcing many students to stay at home and enrol in online courses. Due to the practical laboratory sessions and workshops demanded by Science, Technology, Engineering, and Mathematics (STEM) modules and other related fields, education has faced difficulties during the COVID-19 pandemic. Understanding student involvement and its role in promoting a number of desirable outcomes, including academic outcomes like greater achievement, lower dropout rates, as well as various well-being and life outcomes, has therefore become increasingly important. This paper presents the scientometric review with an annotated bibliography on teaching styles through group learning in the higher education academies (HEAs) directed towards sustainable education. The current work also gives an annotated bibliography that seeks to compile and integrate the research on student participation, group learning, instructional strategies, equality, and diversity. Some evaluations and suggestions are also made in the study

Linoleic Acid Improves Piezo2 Dysfunction in a Mouse Model of Angelman Syndrome

Angelman syndrome (AS) is a neurogenetic disorder characterized by intellectual disability and atypical behaviors. AS results from loss of expression of the E3 ubiquitin-protein ligase UBE3A from the maternal allele in neurons. Individuals with AS display impaired coordination, poor balance, and gait ataxia. PIEZO2 is a mechanosensitive ion channel essential for coordination and balance. Here, we report that PIEZO2 activity is reduced in Ube3a deficient male and female mouse sensory neurons, a human Merkel cell carcinoma cell line and female human iPSC-derived sensory neurons with UBE3A knock-down, and de-identified stem cell-derived neurons from individuals with AS. We find that loss of UBE3A decreases actin filaments and reduces PIEZO2 expression and function. A linoleic acid (LA)-enriched diet increases PIEZO2 activity, mechano-excitability, and improves gait in male AS mice. Finally, LA supplementation increases PIEZO2 function in stem cell-derived neurons from individuals with AS. We propose a mechanism whereby loss of UBE3A expression reduces PIEZO2 function and identified a fatty acid that enhances channel activity and ameliorates AS-associated mechano-sensory deficits

Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome

Angelman syndrome (AS) is a neurogenetic disorder characterized by intellectual disability and atypical behaviors. AS results from loss of expression of the E3 ubiquitin-protein ligase UBE3A from the maternal allele in neurons. Individuals with AS display impaired coordination, poor balance, and gait ataxia. PIEZO2 is a mechanosensitive ion channel essential for coordination and balance. Here, we report that PIEZO2 activity is reduced in Ube3a deficient male and female mouse sensory neurons, a human Merkel cell carcinoma cell line and female human iPSC-derived sensory neurons with UBE3A knock-down, and de-identified stem cell-derived neurons from individuals with AS. We find that loss of UBE3A decreases actin filaments and reduces PIEZO2 expression and function. A linoleic acid (LA)-enriched diet increases PIEZO2 activity, mechano-excitability, and improves gait in male AS mice. Finally, LA supplementation increases PIEZO2 function in stem cell-derived neurons from individuals with AS. We propose a mechanism whereby loss of UBE3A expression reduces PIEZO2 function and identified a fatty acid that enhances channel activity and ameliorates AS-associated mechano-sensory deficits.This work was supported by the Neuroscience Institute at UTHSC (Research Associate Matching Salary Support to J.L.), the Federico Baur endowed chair in Nanotechnology (to F.J.S.-V., 0020206BA1), a pilot research award from the Foundation for Prader-Willi Research (to L.T.R.), the Neuroscience Institute Research Supports Grant 2020 program (to V.V., and J.F.C.-M.), and the National Institutes of Health (R01GM133845 to V.V. and R01GM125629 to J.F.C.-M.)

Depressive and anxiety symptoms and COVID-19-related factors among men and women in Nigeria

Despite the greater adverse economic impacts in low and middle-income (LAMI) compared to high-income countries, fewer studies have investigated the associations between COVID-19-related stressor and mental health in LAMI countries. The objectives of this study were to determine the associations between COVID-19-related stressors and anxiety and depressive symptoms while controlling for known risk and protective factors and to investigate any sex differences. An online survey was carried out to assess sociodemographic, psychosocial (previous mental health conditions, sexual orientation, intimate partner violence and perceived social support) and COVID-19-related variables. Hierarchical linear regression was carried out with anxiety and depressive symptoms as separate outcomes. Of the COVID-19-related factors, testing positive for COVID-19 infection, having COVID-19 symptoms, having other medical conditions, self-isolating due to COVID-19 symptoms, worry about infection, perception of the pandemic as a threat to income and isolation during the lockdown were significantly associated with higher anxiety and depressive symptoms. Of these, worry about infection, isolation during lockdown and disruption due to the pandemic retained independent associations with both outcomes. The variance in anxiety and depressive symptoms explained by COVID-19-related factors was larger in women (11.8%) compared to men (6.1% and 0.8% respectively). COVID-19-related stressors are associated with higher anxiety and depressive symptoms, with these effects being larger in men compared to women. Enhancing social support can be an affordable strategy to mitigate this risk but this needs to be investigated using appropriate designs

Global priorities for climate change and mental health research.

BACKGROUND: Compared with other health areas, the mental health impacts of climate change have received less research attention. The literature on climate change and mental health is growing rapidly but is characterised by several limitations and research gaps. In a field where the need for designing evidence-based adaptation strategies is urgent, and research gaps are vast, implementing a broad, all-encompassing research agenda will require some strategic focus. METHODS: We followed a structured approach to prioritise future climate change and mental health research. We consulted with experts working across mental health and climate change, both within and outside of research and working in high, middle, and low-income countries, to garner consensus about the future research priorities for mental health and climate change. Experts were identified based on whether they had published work on climate change and mental health, worked in governmental and non-governmental organisations on climate change and mental health, and from the professional networks of the authors who have been active in the mental health and climate change space. RESULTS: Twenty-two experts participated from across low- and middle-income countries (n = 4) and high-income countries (n = 18). Our process identified ten key priorities for progressing research on mental health and climate change. CONCLUSION: While climate change is considered the biggest threat to global mental health in the coming century, tackling this threat could be the most significant opportunity to shape our mental health for centuries to come because of health co-benefits of transitioning to more sustainable ways of living. Research on the impacts of climate change on mental health and mental health-related systems will assist decision-makers to develop robust evidence-based mitigation and adaptation policies and plans with the potential for broad benefits to society and the environment

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO