Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 11

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 11, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

Polyethylene Glycol and Silica Coatings of Bismuth Nanoparticles: Synthesis, Characterization and Whole Serum Compatibilities

Cancer is responsible for about one fourth of mortalities in the United States daily, however, early diagnosis and treatment raised the five year survival rate since the 1970’s. The usage of X-ray contrast agents (XCAs) has been instrumental in the diagnosis of tumors, but the field still calls for an improved modality in XCAs, such as safe, affordable, lower dosage and targeted XCAs. Useful XCAs must be capable of avoiding the reticuloendothelial system (RES) through an increased circulation half-life time (t1/2), therefore, “evasive” nanoparticle shells have been previously constructed and studied. Researchers have demonstrated an increased t1/2 with the use of molecules such as polyethylene glycol (PEG) and silica. Evasion of RES and an increased t1/2 is primarily attributed to the decreased surface charge and robustness of said shells. Additionally, these properties prevent aggregation and foster further chemical modification for a targeting modality of XCAs. The following work aims to demonstrate a comprehensive synthesis and characterization of bismuth nanoparticles (BiNPs) enveloped by either silica or PEG. A qualitative approach using 1H-NMR and FT-IR strongly suggests said coatings on BiNPs. TEM images suggest a PEG coating was formed while TEM and EDS confirms silica coatings of BiNPs. Preliminary trials of these materials in whole mouse serum advocate silica coated BiNPs are capable of sustaining their integrity in whole serum for at least 3 hours whereas PEG coated BiNPs degrade before 12 hrs. Through an optimized synthesis of either material, conjugation of proteins on surfaces should introduce the targeting component of BiNPs

Ruta de la gestión educativa del CIDE ante el contexto COVID-19

Se presenta una propuesta innovadora de gestión educativa para atender los efectos del COVID-19, y que oriente las acciones hacia una cultura organizacional humana en el CIDE.An innovative educational management proposal is presented to address the effects of COVID-19 and to guide actions towards a human organizational culture at CIDE.Uma proposta inovadora de gestão educacional é apresentada para abordar os efeitos do COVID-19 e orientar ações em direção a uma cultura organizacional humana na CIDE.División de Educación para el Trabaj