Increasing the lensing figure of merit through higher order convergence moments

The unprecedented quality, the increased data set, and the wide area of ongoing and near future weak lensing surveys allows one to move beyond the standard two points statistics, thus making it worthwhile to investigate higher order probes. As an interesting step toward this direction, we explore the use of higher order moments (HOM) of the convergence field as a way to increase the lensing figure of merit (FoM). To this end, we rely on simulated convergence to first show that HOM can be measured and calibrated so that it is indeed possible to predict them for a given cosmological model provided suitable nuisance parameters are introduced and then marginalized over. We then forecast the accuracy on cosmological parameters from the use of HOM alone and in combination with standard shear power spectra tomography. It turns out that HOM allow one to break some common degeneracies, thus significantly boosting the overall FoM. We also qualitatively discuss possible systematics and how they can be dealt with

Minkowski Functionals of Convergence Maps and the Lensing Figure of Merit

Minkowski functionals (MFs) quantify the topological properties of a given field probing its departure from Gaussianity. We investigate their use on lensing convergence maps in order to see whether they can provide further insights on the underlying cosmology with respect to the standard second-order statistics, i.e., cosmic shear tomography. To this end, we first present a method to match theoretical predictions with measured MFs taking care of the shape noise, imperfections in the map reconstruction, and inaccurate description of the nonlinearities in the matter power spectrum and bispectrum. We validate this method against simulated maps reconstructed from shear fields generated by the MICE simulation. We then perform a Fisher matrix analysis to forecast the accuracy on cosmological parameters from a joint MFs and shear tomography analysis. It turns out that MFs are indeed helpful to break the $\Omega_{\rm m}$--$\sigma_8$ degeneracy thus generating a sort of chain reaction leading to an overall increase of the Figure of Merit.Comment: 16 pages, 5 figures. Matches published version in PR

Sediment transport and deposition during extreme sea storm events at the Salerno Bay (Tyrrhenian Sea): comparison of field data with numerical model results

Seismic stratigraphy and core litho-stratigraphy in the Salerno Bay inner shelf (Southern Tyrrhenian Sea) reveal significant storm deposition episodes over the last 1 ky. Three major events are preserved as decimetre thick silt/sand layers bounded at their base by erosional surfaces and sealed in the muddy marine sequences between 25 and 60 m of depth. Geochronology and chrono-stratigraphy on core sediment point towards a recurrence of major sea storms between 0.1 and 0.3 ky and put the last significant event in the 19th century, when no local meteorological time series is available. A modelling of extreme sea-storms with a return period of about 0.1 ky is here proposed based on historical hindcast and aims at explaining the occurrence of such unusual deep and thick sand deposits in the northern sector of the bay. Results highlight the vulnerability of the northern coast of the Salerno Bay to the south western sea storms which can drive waves up to about 8 m high and wave period of about 13 s. With these conditions an intense combined flow current is formed and might account for winnowing fine sand down to the depth of 40 m at least. The numerical model thus confirms a possible sand transport in the bottom boundary layer due to wave-current interaction and could corroborate the interpretation of the most recent sand layers, included in the cores, as being generated under extreme sea storm conditions

Decommissioning of Offshore Platforms in Adriatic Sea: The Total Removal Option from a Life Cycle Assessment Perspective

The international energy scenario to date is heavily based on fossil energy sources such as coal, oil or natural gas. According to the international ecological goals of the UNFCCC formalized in the legally binding treaty called the Paris Agreement, the next global challenges will be the decommissioning, dismantling or reconversion of the current fossil energy system into a new, more sustainable system that makes more efficient use of renewable energy technologies. Worldwide, there are about 6500 offshore oil and gas facilities and about 130 of them are located in the Mediterranean basin, mainly in the Adriatic and Ionian Seas: more than 110 offshore gas platforms have been installed in these areas since 1960. In this paper, using Life Cycle Assessment, the environmental and economic impacts of the total removal operations of an existing offshore platform in the context of the Adriatic Sea are assessed based on existing and registered decommissioning projects. In addition, the avoided impacts of primary steel production due to its recovery and recycling from the removed platform are assessed using the system boundary expansion method

Biological and molecular characterization of Aromia bungii (Faldermann, 1835) (Coleoptera: Cerambycidae), an emerging pest of stone fruits in Europe

The red-necked longhorn beetle (RLB) Aromia bungii (Fald.) is an emerging pest of stone fruit trees, native to East Asia, accidentally introduced in Europe (Germany and Italy) and Japan. Threatening seriously the stone fruit crops in Europe, RLB was added to both the EPPO A1 and priority pest lists of quarantine species. Molecular analyses highlighted that all specimens recovered in southern Italy share the same haplotype, different from the German one, supporting that the invasive process in Europe started from at least two independent introductions. To fill the existing gap of biological knowledge about A. bungii, several laboratory tests were carried out on specimens collected in the outbreak area of Naples (Italy). Results suggest a high biotic potential of the RLB Italian population. Females showed a short pre-oviposition period while the period of oviposition lasted about three weeks, with a rate of 24.2 eggs/day. Each female laid an average of 587.5 eggs and spawned the largest amount of eggs during the first week after emergence. Fed males live up to 62 days at 20 °C while fed females about 63 days at 25 °C. These results are crucial to draw up a multi-facet IPM approach against A. bungii in the outbreak areas

Calibration of colour gradient bias in shear measurement using HST/CANDELS data

Accurate shape measurements are essential to infer cosmological parameters from large area weak gravitational lensing studies. The compact diffraction-limited point-spread function (PSF) in space-based observations is greatly beneficial, but its chromaticity for a broad band observation can lead to new subtle effects that could hitherto be ignored: the PSF of a galaxy is no longer uniquely defined and spatial variations in the colours of galaxies result in biases in the inferred lensing signal. Taking Euclid as a reference, we show that this colourgradient bias (CG bias) can be quantified with high accuracy using available multi-colour Hubble Space Telescope (HST) data. In particular we study how noise in the HST observations might impact such measurements and find this to be negligible. We determine the CG bias using HST observations in the F606W and F814W filters and observe a correlation with the colour, in line with expectations, whereas the dependence with redshift is weak. The biases for individual galaxies are generally well below 1%, which may be reduced further using morphological information from the Euclid data. Our results demonstrate that CG bias should not be ignored, but it is possible to determine its amplitude with sufficient precision, so that it will not significantly bias the weak lensing measurements using Euclid data

HEP Applications Evaluation of the EDG Testbed and Middleware

Workpackage 8 of the European Datagrid project was formed in January 2001 with representatives from the four LHC experiments, and with experiment independent people from five of the six main EDG partners. In September 2002 WP8 was strengthened by the addition of effort from BaBar and D0. The original mandate of WP8 was, following the definition of short- and long-term requirements, to port experiment software to the EDG middleware and testbed environment. A major additional activity has been testing the basic functionality and performance of this environment. This paper reviews experiences and evaluations in the areas of job submission, data management, mass storage handling, information systems and monitoring. It also comments on the problems of remote debugging, the portability of code, and scaling problems with increasing numbers of jobs, sites and nodes. Reference is made to the pioneeering work of Atlas and CMS in integrating the use of the EDG Testbed into their data challenges. A forward look is made to essential software developments within EDG and to the necessary cooperation between EDG and LCG for the LCG prototype due in mid 2003.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics Conference (CHEP03), La Jolla, CA, USA, March 2003, 7 pages. PSN THCT00

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification

Multipotent adult resident cardiac stem cells (CSCs) were first identified by the expression of c-kit, the stem cell factor receptor. However, in the adult myocardium c-kit alone cannot distinguish CSCs from other c-kit-expressing (c-kitpos) cells. The adult heart indeed contains a heterogeneous mixture of c-kitpos cells, mainly composed of mast and endothelial/progenitor cells. This heterogeneity of cardiac c-kitpos cells has generated confusion and controversy about the existence and role of CSCs in the adult heart. Here, to unravel CSC identity within the heterogeneous c-kit-expressing cardiac cell population, c-kitpos cardiac cells were separated through CD45-positive or -negative sorting followed by c-kitpos sorting. The blood/endothelial lineage-committed (Lineagepos) CD45posc-kitpos cardiac cells were compared to CD45neg(Lineageneg/Linneg) c-kitpos cardiac cells for stemness and myogenic properties in vitro and in vivo. The majority (~90%) of the resident c-kitpos cardiac cells are blood/endothelial lineage-committed CD45posCD31posc-kitpos cells. In contrast, the LinnegCD45negc-kitpos cardiac cell cohort, which represents 10% of the total c-kitpos cells, contain all the cardiac cells with the properties of adult multipotent CSCs. These characteristics are absent from the c-kitneg and the blood/endothelial lineage-committed c-kitpos cardiac cells. Single Linnegc-kitpos cell-derived clones, which represent only 1–2% of total c-kitpos myocardial cells, when stimulated with TGF-β/Wnt molecules, acquire full transcriptome and protein expression, sarcomere organisation, spontaneous contraction and electrophysiological properties of differentiated cardiomyocytes (CMs). Genetically tagged cloned progeny of one Linnegc-kitpos cell when injected into the infarcted myocardium, results in significant regeneration of new CMs, arterioles and capillaries, derived from the injected cells. The CSC’s myogenic regenerative capacity is dependent on commitment to the CM lineage through activation of the SMAD2 pathway. Such regeneration was not apparent when blood/endothelial lineage-committed c-kitpos cardiac cells were injected. Thus, among the cardiac c-kitpos cell cohort only a very small fraction has the phenotype and the differentiation/regenerative potential characteristics of true multipotent CSCs

Polyglutamine tracts regulate autophagy

Expansions of polyglutamine (polyQ) tracts in different proteins cause 9 neurodegenerative conditions, such as Huntington disease and various ataxias. However, many normal mammalian proteins contain shorter polyQ tracts. As these are frequently conserved in multiple species, it is likely that some of these polyQ tracts have important but unknown biological functions. Here we review our recent study showing that the polyQ domain of the deubiquitinase ATXN3/ataxin-3 enables its interaction with BECN1/beclin 1, a key macroautophagy/autophagy initiator. ATXN3 regulates autophagy by deubiquitinating BECN1 and protecting it from proteasomal degradation. Interestingly, expanded polyQ tracts in other polyglutamine disease proteins compete with the shorter ATXN3 polyQ stretch and interfere with the ATXN3-BECN1 interaction. This competition results in decreased BECN1 levels and impaired starvation-induced autophagy, which phenocopies the loss of autophagic function mediated by ATXN3. Our findings describe a new autophagy-protective mechanism that may be altered in multiple neurodegenerative diseases.We are grateful to Wellcome Trust (Principal Research Fellowship to DCR.) (095317/Z/11/Z), Wellcome Trust Strategic Grant to Cambridge Institute for Medical Research (100140/Z/12/Z)), National Institute for Health Research Biomedical Research Center at Addenbrooke's Hospital, Addenbrooke's Charitable Trust and Federation of European Biochemical Societies (FEBS Long-Term Fellowship to A.A.) for funding