Drogas & Vida: A Alteração (DES) CONTROLADA pelos Dispositivos Biopolíticos

RESUMO O uso abusivo de substâncias psicoativas na contemporaneidade tem sido tema de grandes discussões e preocupações por parte da sociedade, principalmente por ser cotidianamente vinculado à violência e à criminalidade. Atualmente, um dos serviços mais procurados para tratamento ao usuário dependente de drogas são as internações em Comunidades Terapêuticas (CTs). Nos dispusemos a pesquisar e melhor conhecer os modos de funcionamento e práticas de produção de subjetividade que se inscrevem nas propostas via internação nas CTs. Encontrarmos nos mecanismos biopolíticos, de controle da vida, alguns caminhos que nos levam a compreender as fontes que ensejam a emergência das CTs. Identificamos como as estratégias capitalistas, com seus mecanismos e tecnologias, puderam provocar uma significativa mudança no modo de vida das populações ocidentais, constituindo populações de consumidores ávidos para a sustentação dessa nova ordem mundial. Por efeito, tem-se exigido e permitido um aumento das intervenções de aparelhos biopolíticos nos campos jurídico, médico e religioso inscritos em políticas públicas. As CTs emergem como alternativas a práticas biomédicas e prisões, entretanto sofrem significativa transformação ao longo do desenvolvimento de seus trabalhos. Em nossa pesquisa utilizamos a cartografia como um recurso que contribui com a construção de um caminho de análise a percorrer, participamos dos movimentos de algumas CTs e pudemos perceber que as normatizações se tornam cada vez mais presentes em suas práticas de atenção, por ações de mecanismos religiosos, transcendentes e disciplinares, diretamente intervindo nos processos produtores de subjetividade e construção de vida. Entendemos que o conhecimento acerca da multicausalidade e singularização presentes nos agenciamentos da drogadição é fundamental para quaisquer propostas coletivas de políticas de atenção a usuários de drogas. PALAVRAS-CHAVES: Biopolítica, subjetividade, drogas, dependência, Comunidades Terapêuticas, transcendência

High-resolution mid-infrared spectroscopy based on ultrafast Cr:ZnSe laser

High-resolution broadband direct frequency comb spectroscopy in the mid-infrared spectral region is an extremely powerful and versatile experimental technique that allows study of the molecular structure of gaseous compounds with multiple applicative and scientific implications. Here we present the first implementation of an ultrafast Cr:ZnSe mode-locked laser covering more than 7 THz at around the emission wavelength of 2.4 um, for direct frequency comb molecular spectroscopy with a frequency sampling of 220 MHz and a frequency resolution of 100 kHz. This technique is based on a scanning micro-cavity resonator with a Finesse of 12,000 and a diffraction reflecting grating. We demonstrate its application in high-precision spectroscopy of the acetylene molecule by retrieving line center frequencies of more than 68 roto-vibrational lines. Our technique paves the way for real time spectroscopic studies as well as for hyperspectral imaging techniques

Covalent functionalization enables good dispersion and anisotropic orientation of multi-walled carbon nanotubes in a poly(l-lactic acid) electrospun nanofibrous matrix boosting neuronal differentiation

A biocompatible porous scaffold obtained via electrospinning a nanocomposite solution of poly(l-lactic acid) and 4-methoxyphenyl functionalized multi-walled carbon nanotubes is presented here for the first time for the enhancement of neurite outgrowth. Optimization of blend preparation and deposition parameters paves the way to the obtainment of defect-free random networks of nanofibers with homogeneous diameters in the hundreds of nanometers length scale. The tailored covalent functionalization of nanotube surfaces allows a homogeneous dispersion of the nanofillers within the polymer matrix, diminishing their natural tendency to aggregate and form bundles. This results in a remarkable effect on the crystallization temperature, as evidenced through differential scanning calorimetry. Furthermore, transmission electron microscopy shows carbon nanotubes anisotropically aligned along the fiber axes, a feature believed to enhance neurite adhesion and growth. Indeed, microscopy images show neurites extension along the direction of nanofibers, highlighting the extreme relevance of scaffold morphology in engineering complex tissue environments. Furthermore, a remarkable effect on increasing the neurite outgrowth results when using the fibrous scaffold containing dispersed carbon nanotubes in comparison with an analogous one made of only polymer, providing further evidence of the key role played by carbon nanostructures in inducing neuronal differentiation

Instrumental evaluation of the upper limb: Control data and aging effects

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Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis.

Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc). Ultra-conserved regions (UCRs) are a class non-coding sequences that are conserved in humans, mice and rats. More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, and are altered at transcriptional level in tumorigenesis. To identify the T-UCR profiles that are dysregulated in Barretts mucosa transformation, microarray analysis was performed on a discovery set of 51 macro-dissected samples obtained from 14 long-segment BE patients. Results were validated in an independent series of esophageal biopsy/surgery specimens and in two murine models of Barretts esophagus (i.e. esophagogastric-duodenal anastomosis). Progression from normal to BE to adenocarcinoma was each associated with specific and mutually exclusive T-UCR signatures that included up-regulation of uc.58-, uc.202-, uc.207-, and uc.223- and down-regulation of uc.214+. A 9 T-UCR signature characterized BE versus Sq (with the down-regulation of uc.161-, uc.165-, and uc.327-, and the up-regulation of uc.153-, uc.158-, uc.206-, uc.274-, uc.472-, and uc.473-). Analogous BE-specific T-UCR profiles were shared by human and murine lesions. This study is the first demonstration of a role for T-UCRs in the transformation of Barretts mucosa

Asymmetric Fluid Criticality I: Scaling with Pressure Mixing

The thermodynamic behavior of a fluid near a vapor-liquid and, hence, asymmetric critical point is discussed within a general ``complete'' scaling theory incorporating pressure mixing in the nonlinear scaling fields as well as corrections to scaling. This theory allows for a Yang-Yang anomaly in which \mu_{\sigma}^{\prime\prime}(T), the second temperature derivative of the chemical potential along the phase boundary, diverges like the specific heat when T\to T_{\scriptsize c}; it also generates a leading singular term, |t|^{2\beta}, in the coexistence curve diameter, where t\equiv (T-T_{\scriptsize c}) /T_{\scriptsize c}. The behavior of various special loci, such as the critical isochore, the critical isotherm, the k-inflection loci, on which \chi^{(k)}\equiv \chi(\rho,T)/\rho^{k} (with \chi = \rho^{2} k_{\scriptsize B}TK_{T}) and C_{V}^{(k)}\equiv C_{V}(\rho,T)/\rho^{k} are maximal at fixed T, is carefully elucidated. These results are useful for analyzing simulations and experiments, since particular, nonuniversal values of k specify loci that approach the critical density most rapidly and reflect the pressure-mixing coefficient. Concrete illustrations are presented for the hard-core square-well fluid and for the restricted primitive model electrolyte. For comparison, a discussion of the classical (or Landau) theory is presented briefly and various interesting loci are determined explicitly and illustrated quantitatively for a van der Waals fluid.Comment: 21 pages in two-column format including 8 figure