UniPathway: a resource for the exploration and annotation of metabolic pathways

UniPathway (http://www.unipathway.org) is a fully manually curated resource for the representation and annotation of metabolic pathways. UniPathway provides explicit representations of enzyme-catalyzed and spontaneous chemical reactions, as well as a hierarchical representation of metabolic pathways. This hierarchy uses linear subpathways as the basic building block for the assembly of larger and more complex pathways, including species-specific pathway variants. All of the pathway data in UniPathway has been extensively cross-linked to existing pathway resources such as KEGG and MetaCyc, as well as sequence resources such as the UniProt KnowledgeBase (UniProtKB), for which UniPathway provides a controlled vocabulary for pathway annotation. We introduce here the basic concepts underlying the UniPathway resource, with the aim of allowing users to fully exploit the information provided by UniPathwa

FAKTOR – FAKTOR YANG MEMPENGARUHI PROFITABILITAS PERUSAHAAN SEKTOR FARMASI YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2013 - 2016

Penelitian ini bertujuan untuk melakukan pengujian tentang Faktor – Faktor Yang Mempengaruhi Profitabilitas Perusahaan Sektor Farmasi Yang Terdaftar Di Bursa Efek Indonesia Tahun 2013 - 2016. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 32 data perusahaan. Teknik analisis data yang digunakan untuk menguji hipotesis adalah dengan menggunakan Partial Least Square ( PLS). Hasil penelitian menunjukkan bahwa Perpuatan Aktiva Tetap berpengaruh terhadap ROA , ROE dan tidak berpengaruh terhadap NPM. Hutang Jangka Pendek tidak berpengaruh terhadap ROA ,ROE dan berpengaruh terhadap NPM. Hutang Jangka Panjang tidak berpengaruh terhadap ROA, ROE dan NPM. Ukuran Perusahaan (Size) tidak berpengaruh terhadap ROA, ROE dan NPM

APLIKASI PENDAFTARAN SISWA BARU PADA KUMON KOTA PALEMBANG SECARA ONLINE BERBASIS ANDROID

Aplikasi ini diperuntukkan untuk masyarakat agar bisa melakukan pendaftaran tanpa harus mengisi form terlebih dahulu serta aplikasi ini digunakan untuk melakukan pendaftaran siswa baru pada semua cabang KUMON yang ada di kota Palembang menghasilkan halaman login admin, dashboard admin, pendaftaraan siswa baru, dan form siswa pindah, serta form registrasi akun siswa, login siswa, form pendaftaran siswa, serta profile siswa

Evaluación formativa y logro de aprendizaje en ciencia y tecnología del 4º de secundaria de la I.E. 20955-14 - Huarochirí 2021

En el estudio titulado “Evaluación formativa y logro de aprendizaje en ciencia y tecnología del 4º de secundaria de la I.E. 20955-14 - Huarochirí 2021”, donde el objetivo general de la investigación es determinar la relación entre la evaluación formativa y los logros de aprendizaje en el área de ciencia y tecnología en el 4º de secundaria de la IE Nº 20955-14 Sagrado Corazón de Jesús - Ugel 15 - Huarochirí, 2021. El estudio es de tipo básico, el nivel es descriptivo correlacional, un diseño no-experimental transversal y enfoque cuantitativo, 50 alumnos de 4º de secundaria conformaron la muestra, utilizó como técnica la encuesta, el instrumento para recolectar los datos en la variable Evaluación formativa es el cuestionario, y en la variable Logro de aprendizaje el registro de notas académicas. Se utilizó el juicio de expertos para la validación del instrumento, se aplicó el alfa de Cronbach donde se obtuvo un 0.938 para la variable evaluación formativa, asegurando su alta confiabilidad. Sobre el objetivo general, se concluyó que existe relación entre ambas variables de manera significativa, dicho resultado se muestra en el estadístico de Spearman (Sig. bilateral=,000 <0,05, Rho = ,570**

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3.54). These hotspots may b

A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene expressions or mutations has been observed, revealing the underlying diversity of these cancers. Therefore, understanding the full extent of the HER2-positive disease heterogeneity still remains challenging. Here we carry out an in-depth genomic characterization of 64 HER2-positive breast tumour genomes that exhibit four subgroups, based on the expression data, with distinctive genomic features in terms of somatic mutations, copy-number changes or structural variations. The results suggest that, despite being clinically defined by a specific gene amplification, HER2-positive tumours melt into the whole luminal-basal breast cancer spectrum rather than standing apart. The results also lead to a refined ERBB2 amplicon of 106 kb and show that several cases of amplifications are compatible with a breakage-fusion-bridge mechanism

Kajian Ekonomi Penanganan Sedimen Pada Waduk Seri Di Sungai Brantas (Sengguruh, Sutami Dan Wlingi)

Sengguruh, Sutami and Wlingi, were series of three reservoirs in the upper Brantas River which have a high rate of sedimentation, thus research should be carried out to determine the proper method of sediment handling which could maintain the benefit function of reservoirs as well as feasible from economic perspective. Processing data and data analysis was performed to determine the condition of reservoir capacity, sedimentation rate, the amount of sediment handling and most feasible alternatives on sediment handling. The analyzes carried out in two phases, first phases to the existing condition and the second phases to four (4) alternatives of sediment handling at ten years project work. Alternative 1 is sediment handling with a volume of 1 million cum/year, while Alternative 2, Alternative 3, and Alternative 4 is sediment handling with volume equals to annual sedimentation rate with variation on different work method. The average sedimentation rate in those reservoirs on the last 20 years reaching a massive 1.7 million cum/ year. Hence, routine sediment handling with dredging and flushing work should to be done with minimal volume at 1.7 million cum/year. The result of economic analysis show that alternative 3 with B/C = 1.03, IRR = 17.35% and NPV = Rp. 6.37 Billion in the alternative with volume of sediment handled equals to sedimentation rate and feasible from economic perspective. Keywords: reservoir sedimentation, sediment handling, economic benefit

Flood management analysis in the Ngasinan River, Trenggalek Regency, Indonesia

Flood event occurs during the rainy season when water volume increases because rainwater flows through the water channel; due to water volume being larger than the water channel capacity, this event can cause flood inundation through residential areas. The Ngasinan catchment at Trenggalek Regency experienced a flood event that affected thousands of lives in October 2022, to reduce the impact of future floods, this study objective carried out recommendation plans for flood management in the Ngasinan River. The Ngasinan catchment hydrology, maximum annual rainfall from 230.0 mm to 585.0 mm, flood discharge design for the Ngasinan river (river length 21.73 km as main river drainage) are Q25 = 318.64 m3/s, Q100 = 394.96 m3/s. Hydraulic simulation using flood discharge design Q25 -Q100 showed that flood occurs in Ngasinan River sections especially those without embankments or at lower river elevations and cross-sections. Recommendation plans for the Ngasinan River flood management are river normalization, river embankment repairs, residential drainage system, and construction of dams/reservoirs/retarding basins, expected to restore the river’s storage capacity due to sedimentation and destructive flood discharge also to reduce flood discharge, protect river channel banks against flood discharge, and prevent overtopping water into nearby land