Resolving vertical and east-west horizontal motion from differential interferometric synthetic aperture radar : The L'Aquila earthquake

Analysis of surface coseismic displacement has already been obtained for the 6 April 2009 L'Aquila (central Italy) earthquake from differential interferometric synthetic aperture radar (DInSAR) data. Working jointly on ascending and descending DInSAR data makes for a step forward with respect to published preliminary estimates: we process data in order to retrieve a continuous displacement pattern, both in the vertical and horizontal directions, the latter being limited to the eastward component because of the low sensibility of the SAR images used to resolve northward motion. Our analysis provides new insights on the horizontal component of displacement, obtaining a clear picture of eastward displacement patterns over the epicentral area. This result is noteworthy, as until now little information has been available on horizontal displacement following normal-fault events in the central Apennines (Umbria-Marche, 1997, and L'Aquila, 2009), given the lack of dense GPS networks, the only available source of horizontal displacement data in this area. Inverted fault characteristics from such data also show noteworthy differences compared to previous studies, localizing the Paganica fault as the causative fault for the earthquake

First evidence of post-seismic deformation in the central Mediterranean: Crustal viscoelastic relaxation in the area of the 1980 Irpinia earthquake (Southern Italy)

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The nature and evolution of Nova Cygni 2006

AIMS: Nova Cyg 2006 has been intensively observed throughout its full outburst. We investigate the energetics and evolution of the central source and of the expanding ejecta, their chemical abundances and ionization structure, and the formation of dust. METHOD: We recorded low, medium, and/or high-resolution spectra (calibrated into accurate absolute fluxes) on 39 nights, along with 2353 photometric UBVRcIc measures on 313 nights, and complemented them with IR data from the literature. RESULTS: The nova displayed initially the normal photometric and spectroscopic evolution of a fast nova of the FeII-type. Pre-maximum, principal, diffuse-enhanced, and Orion absorption systems developed in a normal way. After the initial outburst, the nova progressively slowed its fading pace until the decline reversed and a second maximum was reached (eight months later), accompanied by large spectroscopic changes. Following the rapid decline from second maximum, the nova finally entered the nebular phase and formed optically thin dust. We computed the amount of formed dust and performed a photo-ionization analysis of the emission-line spectrum during the nebular phase, which showed a strong enrichment of the ejecta in nitrogen and oxygen, and none in neon, in agreement with theoretical predictions for the estimated 1.0 Msun white dwarf in Nova Cyg 2006. The similarities with the poorly investigated V1493 Nova Aql 1999a are discussed.Comment: in press in Astronomy and Astrophysic

Mapping Asbestos-Cement Roofing with Hyperspectral Remote Sensing over a Large Mountain Region of the Italian Western Alps

The World Health Organization estimates that 100 thousand people in the world die every year from asbestos-related cancers and more than 300 thousand European citizens are expected to die from asbestos-related mesothelioma by 2030. Both the European and the Italian legislations have banned the manufacture, importation, processing and distribution in commerce of asbestos-containing products and have recommended action plans for the safe removal of asbestos from public and private buildings. This paper describes the quantitative mapping of asbestos-cement covers over a large mountainous region of Italian Western Alps using the Multispectral Infrared and Visible Imaging Spectrometer sensor. A very large data set made up of 61 airborne transect strips covering 3263 km2 were processed to support the identification of buildings with asbestos-cement roofing, promoted by the Valle d’Aosta Autonomous Region with the support of the Regional Environmental Protection Agency. Results showed an overall mapping accuracy of 80%, in terms of asbestos-cement surface detected. The influence of topography on the classification’s accuracy suggested that even in high relief landscapes, the spatial resolution of data is the major source of errors and the smaller asbestos-cement covers were not detected or misclassified

2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki ) values in the sub-micromolar range and a good selectivity index (Ki\u2009MAO-A /Ki\u2009MAO-B >50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4\u2009a) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity

Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I2 receptor.

Agmatine, a divalent diamine with two positive charges at physiological pH, is transported into the matrix of liver mitochondria by an energy-dependent mechanism, the driving force of which is the electrical membrane potential. Its binding to mitochondrial membranes is studied by applying a thermodynamic treatment of ligand-receptor interactions on the analyses of Scatchard and Hill. The presence of two mono-coordinated binding sites S(1) and S(2), with a negative influence of S(2) on S(1), has been demonstrated. The calculated binding energy is characteristic for weak interactions. S(1) exhibits a lower binding capacity and higher binding affinity both of about two orders of magnitude than S(2). Experiments with idazoxan, a ligand of the mitochondrial imidazoline receptor I(2), demonstrate that S(1) site is localized on this receptor while S(2) is localized on the transport system. S(1) would act as a sensor of exogenous agmatine concentration, thus modulating the transport of the amine by its binding to S(2)

Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B

A library of monosubstituted chalcones (1-17) bearing electron-donating and electron-withdrawing groups on both aromatic rings were selected. The cell viability on human tumor cell lines was evaluated first. The compounds unable to induce detectable cytotoxicity (1, 13, and 14) were tested using the monoamine oxidase (MAO) activity assay. Interestingly, they inhibit MAO-B, acting as competitive inhibitors, with 13 and 14 showing the best profiles. In particular, 13 exhibited a potency higher than that of safinamide, taken as a reference. Docking studies and crystallographic analysis showed that in human MAO-B 13 binds with the halogen-substituted aromatic ring in the entrance cavity, similar to safinamide, whereas 14 is accommodated in the opposite way. The main conclusion of this cell biology, biochemistry, and structural study is to highlights 13 as a chalcone derivative that is worth consideration for the development of novel MAO-B-selective inhibitors for the treatment of neurodegenerative diseases

From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs

Monoamine oxidases (MAOs) are well-known pharmacological targets in neurological and neurodegenerative diseases. However, recent studies have revealed a new role for MAOs in certain types of cancer such as glioblastoma and prostate cancer, in which they have been found overexpressed. This finding is opening new frontiers for MAO inhibitors as potential antiproliferative agents. In light of our previous studies demonstrating how a polyamine scaffold can act as MAO inhibitor, our aim was to search for novel analogs with greater inhibitory potency for human MAOs and possibly with antiproliferative activity. A small in-house library of polyamine analogs (2-7) was selected to investigate the effect of constrained linkers between the inner amine functions of a polyamine backbone on the inhibitory potency. Compounds 4 and 5, characterized by a dianiline (4) or dianilide (5) moiety, emerged as the most potent, reversible, and mainly competitive MAO inhibitors (Ki < 1 μM). Additionally, they exhibited a high antiproliferative activity in the LN-229 human glioblastoma cell line (GI50 < 1 μM). The scaffold of compound 5 could represent a potential starting point for future development of anticancer agents endowed with MAO inhibitory activity