Simple scalable nucleotic FPGA based short read aligner for exhaustive search of substitution errors

With the advent of the new and continuously improving technologies, in a couple of years DNA sequencing can be as commonplace as a simple blood test. The growth of sequencing efficiency has a larger exponent than the Moore’s law of standard processors, hence alignment and further processing of sequenced data is the bottleneck. The usage of FPGA (Field Programmable Gate Arrays) technology may provide an efficient alternative. We propose a simple algorithm for DNA sequence alignment, which can be realized efficiently by nucleotic principal agents of Non.Neumann nature. The prototype FPGA implementation runs on a small Terasic DE1-SoC demo board with a Cyclone V chip. We present test results and furthermore analyse the theoretical scalability of this system, showing that the execution time is independent of the length of reference genome sequences. A special advantage of this parallel algorithm is that it performs exhaustive search producing all match variants up to a predetermined number of point (mutation) errors

Search for new phenomena in events with high jet multiplicity and low missing transverse momentum in proton–proton collisions at

A dedicated search is presented for new phenomena in inclusive 8- and 10-jet final states with low missing transverse momentum, with and without identification of jets originating from b quarks. The analysis is based on data from proton–proton collisions corresponding to an integrated luminosity of 19.7 fb−1 collected with the CMS detector at the LHC at √s = 8 TeV. The dominant multijet background expectations are obtained from low jet multiplicity control samples. Data agree well with the standard model background predictions, and limits are set in several benchmark models. Colorons (axigluons) with masses between 0.6 and 0.75 (up to 1.15) TeV are excluded at 95% confidence level. Similar exclusion limits for gluinos in R-parity violating supersymmetric scenarios are from 0.6 up to 1.1 TeV. These results comprise the first experimental probe of the coloron and axigluon models in multijet final states. © 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY licenseL

Production of ΛΛ-hyperons in inelastic p+p interactions at 158 GeV/c

Inclusive production of $$\Lambda$$ Λ -hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158  $${\mathrm{GeV}}\!/\!c$$ GeV / c . Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x $$_{_F}$$ F are presented. The mean multiplicity was estimated to be $$0.120\,{\pm }\,0.006\;(stat.)\;{\pm }0.010\;(sys.)$$ 0.120 ± 0.006 ( s t a t . ) ± 0.010 ( s y s . ) . The results are compared with previous measurements and predictions of the Epos, Urqmd and Fritiof models