Dearie Dear

https://digitalcommons.library.umaine.edu/mmb-vp/1292/thumbnail.jp

A method for risk analysis of nuclear reactor accidents

Originally presented as the first author's thesis, (Ph. D.)--in the M.I.T. Dept. of Nuclear Engineering, 1976Includes bibliographical references (pages 207-208)Prepared for the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research no. AT(49-24)-026

FRANTIC 5 (a version of FRANTIC II) : a computer code for evaluating system aging effect

"November 1986."Includes bibliographical referencesThe FRANTIC 5 code is a modification of the FRANTIC II code for time dependent unavailability analysis. FRANTIC 5 is specially adapted for modeling the aging effects on system and component performance. The FRANTIC 5 code uses the linear aging model, i.e., based on the assumption that component failure rates increase linearly in time. The constant failure rate and the aging acceleration rate for a component can be changed during the plant life, which allows the creation of different time scales for components as a function of the replacement or any significant maintenance or repair action on the component. FRANTIC 5 preserves most of the unique features of FRANTIC II, for example the modeling of periodic testing. The output from FRANTIC 5 consists of the system mean unavailabilities, tables of the system unavailabilities at designated time points and the system mean unavailabilities between consecutive tests. The code is applied for evaluation of aging effects of the Auxiliary Feedwater System of Arkansas Nuclear Unit 1. The usefulness of the method will depend upon the availability of the component aging data needed to develop the model parameters.Prepared for EG&G Idaho, Inc. special research subcontract no. C86-10094

Time dependent unavailability analysis to standby safety systems

"Prepared for Brookhaven National Laboratory."Includes bibliographical references (p. 280-284)Contract no. BNL-54668

Using Dissolved Organic Carbon Concentration and Character Data to Assess Land Use Change Effects on Coastal Waters

2016 South Carolina Water Resources Conference South Carolina Water Resources at a Crossroads: Response, Readiness and Recover

Nonuniform Neutron-Rich Matter and Coherent Neutrino Scattering

Nonuniform neutron-rich matter present in both core-collapse supernovae and neutron-star crusts is described in terms of a semiclassical model that reproduces nuclear-matter properties and includes long-range Coulomb interactions. The neutron-neutron correlation function and the corresponding static structure factor are calculated from molecular dynamics simulations involving 40,000 to 100,000 nucleons. The static structure factor describes coherent neutrino scattering which is expected to dominate the neutrino opacity. At low momentum transfers the static structure factor is found to be small because of ion screening. In contrast, at intermediate momentum transfers the static structure factor displays a large peak due to coherent scattering from all the neutrons in a cluster. This peak moves to higher momentum transfers and decreases in amplitude as the density increases. A large static structure factor at zero momentum transfer, indicative of large density fluctuations during a first-order phase transition, may increase the neutrino opacity. However, no evidence of such an increase has been found. Therefore, it is unlikely that the system undergoes a simple first-order phase transition. It is found that corrections to the commonly used single heavy nucleus approximation first appear at a density of the order of $10^{13}$ g/cm$^3$ and increase rapidly with increasing density. Thus, neutrino opacities are overestimated in the single heavy nucleus approximation relative to the complete molecular dynamics simulations.Comment: 17 pages, 23 included ps figure

Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours.

BACKGROUND: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) that can be targeted for therapy. Somatostatin receptor expression is routinely measured by molecular imaging but the resolution is insufficient to define heterogeneity. We hypothesised that SSTR expression could be measured on circulating tumour cells (CTCs) and used to investigate heterogeneity of expression and track changes during therapy. METHODS: MCF-7 cells were transfected with SSTR2 or 5 and spiked into donor blood for analysis by CellSearch. Optimum anti-SSTR antibody concentration and exposure time were determined, and flow cytometry was used to evaluate assay sensitivity. For clinical evaluation, blood was analysed by CellSearch, and SSTR2/5 immunohistochemistry was performed on matched tissue samples. RESULTS: Flow cytometry confirmed CellSearch was sensitive and that detection of SSTR was unaffected by the presence of somatostatin analogue up to a concentration of 100 ng ml(-l). Thirty-one NET patients were recruited: grade; G1 (29%), G2 (45%), G3 (13%), primary site; midgut (58%), pancreatic (39%). Overall, 87% had SSTR-positive tumours according to somatostatin receptor scintigraphy or 68-Ga-DOTATE PET/CT. Circulating tumour cells were detected in 21 out of 31 patients (68%), of which 33% had evidence of heterogeneous expression of either SSTR2 (n=5) or SSTR5 (n=2). CONCLUSIONS: Somatostatin receptors 2 and 5 are detectable on CTCs from NET patients and may be a useful biomarker for evaluating SSTR-targeted therapies and this is being prospectively evaluated in the Phase IV CALMNET trial (NCT02075606)

Ein Parameterschätzverfahren zur Defektdetektion an Balkenkonstruktionen

  &nbsp

Eczema Herpeticum and Clinical Criteria for Investigating Smallpox

Eczema herpeticum can clinically resemble smallpox. On the basis of the algorithm for rapid evaluation of patients with an acute generalized vesiculopustular rash illness, our patient met criteria for high risk for smallpox. The Tzanck preparation was critical for rapid diagnosis of herpetic infection and exclusion of smallpox