Quentovic, un port du haut Moyen Âge entre Boulonnais et Ponthieu

Prolégomènes En 2006 (année probatoire) et de 2008 à 2010, un premier PCR consacré au récolement des données et à la mise sur pied d’un dialogue interdisciplinaire a été consacré au portus et emporium de Quentovic, en basse Canche. Plusieurs réunions scientifiques, notamment publiées en 2010 par le CEGES – Lille-III, et plusieurs opérations d’archéologie préventives alternativement conduites par l’Inrap et Archéopole, autour de Visemarest, mais également le long de la rive droite de la Canche..

Combination of gemcitabine and cetuximab in patients with advanced cholangiocarcinoma: a phase II study

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Evaluation d’un dispositif d’ePortfolio universitaire en archéologie et histoire de l’art

Depuis l’année académique 2008-2009, le département d’histoire de l’art et d’archéologie de l’Université catholique de Louvain (UCL) a instauré un dispositif d’apprentissage auto-dirigé pour ses étudiants du premier cycle. Ce dispositif s’appuie sur l’engagement individuel de l’étudiant dans des activités culturelles et patrimoniales, dont il rend compte de manière critique et réflexive dans un portfolio électronique qui fait l’objet d’une évaluation formative régulière et d’une évaluation certificative à la fin des trois années du cycle. L’évaluation du dispositif, après deux années de pratique, démontre que les modalités d’accompagnement de la prise d’autonomie des étudiants, ainsi que l’évaluation formative de leur travail, contribuent largement à l’apprentissage de plusieurs compétences génériques essentielles dans la formation universitaire : l’esprit analytique, critique et de synthèse, la capacité à rédiger un texte de niveau universitaire et à argumenter. En revanche, les progrès réalisés en termes d’autonomie et de compétence réflexive apparaissent plus contrastés au sein de la population d’étudiants interrogés.The department of Archaeology and History of Art of the University of Louvain, Louvain-la-Neuve (UCL) established a self-directed learning project for its bachelor degree. The project is based on the commitment of each student in cultural and patrimonial activities. The students must report in a critical and reflexive way in an electronic portfolio which is gradualy and formatively assessed. At the end of the three years of the university degree, the portfolio is summatively assessed. After two years of implementation, the entire process has been surveyed. The results show that the modalities of supervision and evaluation contribute significantly to the learning of several core-competencies in university education: the ability to analyse, criticize and synthetize the information, to bring in appropriate arguments, and their skill to write universitary quality reports. However, the progress achieved in terms of autonomy and reflective capacity is more mixed in the population of surveyed students

Evaluation d’un dispositif d’ePortfolio universitaire en archéologie et histoire de l’art

Depuis l’année académique 2008-2009, le département d’histoire de l’art et d’archéologie de l’Université catholique de Louvain (UCL) a instauré un dispositif d’apprentissage auto-dirigé pour ses étudiants du premier cycle. Ce dispositif s’appuie sur l’engagement individuel de l’étudiant dans des activités culturelles et patrimoniales, dont il rend compte de manière critique et réflexive dans un portfolio électronique qui fait l’objet d’une évaluation formative régulière et d’une évaluation certificative à la fin des trois années du cycle. L’évaluation du dispositif, après deux années de pratique, démontre que les modalités d’accompagnement de la prise d’autonomie des étudiants, ainsi que l’évaluation formative de leur travail, contribuent largement à l’apprentissage de plusieurs compétences génériques essentielles dans la formation universitaire : l’esprit analytique, critique et de synthèse, la capacité à rédiger un texte de niveau universitaire et à argumenter. En revanche, les progrès réalisés en termes d’autonomie et de compétence réflexive apparaissent plus contrastés au sein de la population d’étudiants interrogés.The department of Archaeology and History of Art of the University of Louvain, Louvain-la-Neuve (UCL) established a self-directed learning project for its bachelor degree. The project is based on the commitment of each student in cultural and patrimonial activities. The students must report in a critical and reflexive way in an electronic portfolio which is gradualy and formatively assessed. At the end of the three years of the university degree, the portfolio is summatively assessed. After two years of implementation, the entire process has been surveyed. The results show that the modalities of supervision and evaluation contribute significantly to the learning of several core-competencies in university education: the ability to analyse, criticize and synthetize the information, to bring in appropriate arguments, and their skill to write universitary quality reports. However, the progress achieved in terms of autonomy and reflective capacity is more mixed in the population of surveyed students

Combination of gemcitabine and cetuximab in patients with advanced cholangiocarcinoma: a phase II study of the Belgian Group of Digestive Oncology

Background: Cholangiocarcinomas are uncommon tumours with a poor prognosis, that frequently present epidermal growth factor receptor overexpression. Methods: In a multi-centre phase II trial, patients with unresectable cholangiocarcinoma, naïve to chemotherapy, received Cetuximab (400 mg/m2 at week 1, then 250 mg/m2/week) and Gemcitabine (1 g/m2 on day 1, 8 and 15 every 4 weeks). Primary end point was progression-free survival (PFS) rate at 6 months, using a Simon 2-stage design. Moreover, we assessed the impact of KRAS status and skin toxic effect on efficacy. Results: Forty-four patients (41% locally advanced/59% metastatic) were enrolled. Median age was 61.5 years; ECOG PS was 0 (68%) or 1. Six months PFS reached 47%. Median OS was 13.5 months [95% confidence interval (CI) 9.8-31.8 months]. Nine patients (20.4%) had PR and disease-control rate was 79.5%. Grade 3/4-related toxic effects were haematological (52.2%), skin rash (13.6%) and fatigue (11.4%). KRAS mutations were found in 7 of 27 patients and had no influence on PFS. Skin toxic effect =grade 2 was associated with increased PFS (P = 0.05).Conclusion(s): Our study met its primary end point, suggesting that Gemcitabine-Cetuximab has activity in cholangiocarcinoma. KRAS status was not associated with PFS, unlike skin toxic effect, which could be used as a surrogate marker for efficacy

The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022

This article summarises expert discussion on the management of patients with hepatocellular carcinoma (HCC), which took place during the 24th World Gastrointestinal Cancer Congress (WGICC) in Barcelona, July 2022. A multidisciplinary approach is mandatory to ensure an optimal diagnosis and staging of HCC, planning of curative and therapeutic options, including surgical, embolisation, ablative strategies, or systemic therapy. Furthermore, in many patients with HCC, underlying liver cirrhosis represents a challenge and influences the therapeutic options

The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022

This article summarises expert discussion on the management of patients with hepatocellular carcinoma (HCC), which took place during the 24th World Gastrointestinal Cancer Congress (WGICC) in Barcelona, July 2022. A multidisciplinary approach is mandatory to ensure an optimal diagnosis and staging of HCC, planning of curative and therapeutic options, including surgical, embolisation, ablative strategies, or systemic therapy. Furthermore, in many patients with HCC, underlying liver cirrhosis represents a challenge and influences the therapeutic options.Peer reviewe

The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022

This article summarises expert discussion on the management of patients with hepatocellular carcinoma (HCC), which took place during the 24th World Gastrointestinal Cancer Congress (WGICC) in Barcelona, July 2022. A multidisciplinary approach is mandatory to ensure an optimal diagnosis and staging of HCC, planning of curative and therapeutic options, including surgical, embolisation, ablative strategies, or systemic therapy. Furthermore, in many patients with HCC, underlying liver cirrhosis represents a challenge and influences the therapeutic options

Les établissements du Haut Moyen Âge : nécropoles et indices d'occupation en Condroz

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