School administrators’ instructional leadership: Basis for pedagogical enhancement

A school organization like any other organization needs a strong leadership. The school heads should possess strong characteristics that is capable of building a school community, and as leaders, they set the directions of the school, and they are responsible in the over-all operation of the school. This paper was undertaken to determine the principals’ instructional leadership competence in terms of instructional leadership; learning environment; human resource management and development; parent involvement and community partnership; and school leadership management and operations. This research utilized the Descriptive-Quantitative Research Design which was confined among the selected secondary schools in one of the Divisions of the Department of Education in the Philippines. Based on the interpreted data taken from the principals’ rating in their  Office Performance Commitment Review Form (OPCRF) and using the DepEd Order no. 42 series of 2017 as the rubric in interpreting the principals’ rating, this study found out that the respondents’ instructional leadership is very satisfactory. It is safe to say that the principals are very satisfactorily contribute success to a  school’s improvement initiatives and in the overall effectiveness of their  school. &nbsp

A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Lethal Prostate Cancer

SummaryElucidating the determinants of aggressiveness in lethal prostate cancer may stimulate therapeutic strategies that improve clinical outcomes. We used experimental models and clinical databases to identify GATA2 as a regulator of chemotherapy resistance and tumorigenicity in this context. Mechanistically, direct upregulation of the growth hormone IGF2 emerged as a mediator of the aggressive properties regulated by GATA2. IGF2 in turn activated IGF1R and INSR as well as a downstream polykinase program. The characterization of this axis prompted a combination strategy whereby dual IGF1R/INSR inhibition restored the efficacy of chemotherapy and improved survival in preclinical models. These studies reveal a GATA2-IGF2 aggressiveness axis in lethal prostate cancer and identify a therapeutic opportunity in this challenging disease