Evaluation du Cursus Romand de Médecine de Famille (CRMF)

Le Cursus Romand de Médecine de Famille, appelé jusqu'en 2013 « Cursus Romand de Médecine Générale (CRMG), est né de la convergence de deux dynamiques. La première était locale : elle se situait autour du canton de Vaud avec le programme de formation postgraduée en médecine générale initié dans ce canton en 1999 sous l'impulsion du Dr. Fréchelin, du Prof. Pécoud et du Dr. Pilet. L'idée de départ de ce cursus strictement vaudois était de développer un programme de formation postgraduée permettant d'aider les médecins assistants à se former, mais également à promouvoir la médecine de famille et à créer une identité professionnelle forte. La seconde dynamique était politique : en 2005, lors d'une conférence de presse, la CDS annonce publiquement qu'une pénurie de médecins menace la Suisse. Parallèlement, le groupe de médecins ayant lancé le cursus Vaudois envisageait également d'étendre le territoire de la formation postgraduée de médecine générale, estimant que la formation postgrade des médecins de famille ne devait pas se cantonner aux cantons universitaires. [Extrait, p. 9]]]> Physician, Family/education ; Family Practice/education fre https://serval.unil.ch/resource/serval:BIB_3EED11016616.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3EED110166165 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3EED110166165 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_3EEDDB0840C2 2022-05-07T01:16:05Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_3EEDDB0840C2 Pivotal Advance: Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis info:doi:10.1189/jlb.0307180 info:eu-repo/semantics/altIdentifier/doi/10.1189/jlb.0307180 info:eu-repo/semantics/altIdentifier/pmid/17652447 Rajesh, M. Pan, H. Mukhopadhyay, P. Batkai, S. Osei-Hyiaman, D. Hasko, G. Liaudet, L. Gao, B. Pacher, P. info:eu-repo/semantics/article article 2007-07 Journal of Leukocyte Biology, pp. 1382-1389 info:eu-repo/semantics/altIdentifier/pissn/0741-5400 <![CDATA[In this study, we have investigated the role of the cannabinoid CB2 (CB2) receptor in an in vivo mouse model of hepatic ischemia/reperfusion (I/R) injury. In addition, we have assessed the role of the CB2 receptor in TNF-alpha-induced ICAM-1 and VCAM-1 expression in human liver sinusoidal endothelial cells (HLSECs) and in the adhesion of human neutrophils to HLSECs in vitro. The potent CB2 receptor agonist HU-308, given prior to the induction of I/R, significantly attenuated the extent of liver damage (measured by serum alanine aminotransferase and lactate dehydrogenase) and decreased serum and tissue TNF-alpha, MIP-1alpha, and MIP-2 levels, tissue lipid peroxidation, neutrophil infiltration, DNA fragmentation, and caspase 3 activity. The protective effect of HU-308 against liver damage was also preserved when given right after the ischemic episode. HU-308 also attenuated the TNF-alpha-induced ICAM-1 and VCAM-1 expression in HLSECs, which expressed CB2 receptors, and the adhesion of human neutrophils to HLSECs in vitro. These findings suggest that selective CB2 receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis

TissUExM protocol for ultrastructure expansion microscopy of zebrafish larvae and mouse embryos

Expansion microscopy of millimeter-large mechanically heterogeneous tissues, such as whole vertebrate embryos, has been limited, particularly when combined with post-expansion immunofluorescence. Here, we present a protocol to perform ultrastructure expansion microscopy of whole vertebrate embryos, optimized to perform post-expansion labeling. We describe steps for embedding and denaturing zebrafish larvae or mouse embryos. We then detail procedures for hydrogel handling and mounting. This protocol is particularly well suited for super-resolution imaging of macromolecular protein complexes in situ but does not preserve lipids. For complete details on the use and execution of this protocol, please refer to Steib et al.1

Evaluation de l’Unité de traitement des addictions Nord (UTAd) : période janvier-mars 2015

Ce rapport présente les résultats de l’évaluation de l’Unité de traitement des addictions (UTAd) au terme de sa phase pilote. L’évaluation a examiné, d’une part, la clientèle de l’UTAd et les prestations dont elle bénéficie et, d’autre part, les aspects de fonctionnement et d’organisation de l’Unité, ses missions et objectifs, ainsi que son intégration dans le réseau socio-sanitaire de la région Nord. Ce premier chapitre présente le mandat et les aspects méthodologiques de l’évaluation, ainsi que le contexte dans lequel s’inscrit la nouvelle structure qui est évaluée. Mandat: L’Institut universitaire de médecine sociale et préventive (IUMSP) de Lausanne a été chargé de l’évaluation de l’Unité de traitement des addictions (UTAd) sur mandat du Service de la Santé publique (SSP) au terme de sa phase pilote et en vue de sa pérennisation. L’évaluation porte sur les questions suivantes : • Comment s’est déroulé la mise en oeuvre du projet ? • Quelles sont les prestations effectivement délivrées par l’UTAd ? • Quel est le profil des usagers ? • En matière de gestion, quelles sont les ressources pour la bonne gouvernance dont il faudrait tenir compte en vue de la pérennisation de l’UTAd ? • Comment l’interdisciplinarité est-elle mise en place au sein de l’UTAd et quel est son fonctionnement ? • Dans quelle mesure l’UTAd travaille-t-elle avec le réseau? • Dans quelle mesure l’UTAd favorise-t-elle la continuité des soins dans le réseau de prestations socio-sanitaires du Nord vaudois

Evaluation du projet SPAS-PMU REVIAC

Le projet REVIAC: Le projet REVIAC (Réinsertion vie active) est un projet de collaboration entre le Service de prévoyance et d'aides sociales (SPAS) et la Policlinique médicale universitaire (PMU) pour améliorer les possibilités de démarches de réinsertion chez les bénéficiaires du revenu d'insertion (RI) avec certificat d'incapacité de travail. En effet, certains bénéficiaires ont des certificats médicaux d'incapacité récurrents et les assistants sociaux (AS) ne peuvent entreprendre les démarches nécessaires. Le projet développé par le SPAS et la PMU comprend deux axesa : ? La création à la PMU d'une consultation pour les bénéficiaires du RI dont l'état de santé compromet toute démarche d'insertion/d'activation. ? Le développement de l'information et de la formation : a) des médecins, principalement de premier recours, sur les thématiques sociales liées au RI et le réseau socio-sanitaire existant, et b) des assistants sociaux sur les pratiques des médecins traitants. Les objectifs du projet sont : Encourager l'élaboration de projets favorisant l'autonomie des bénéficiaires (autonomie sociale comme professionnelle et financière), compatibles avec leur état de santé, réalistes et réalisables ; Apporter un soutien médical aux bénéficiaires entrant dans une démarche d'insertion ou en cours d'insertion, en collaboration avec leurs médecins traitants ; Fournir aux AS les informations nécessaires leur permettant d'initier, au besoin, une collaboration avec l'AI dans le cadre de mesures de prévention et d'insertion ; Permettre aux AS de diriger et accompagner les bénéficiaires dont l'état de santé est incompatible avec une démarche d'insertion vers d'autres types de mesures ou d'autres prises en charge plus adéquates (rentes AI, etc.) ; Améliorer la collaboration entre les médecins traitants des bénéficiaires et les assistants sociaux en charge de leur dossier ; Proposer, à terme, le développement de nouvelles mesures adaptées aux problématiques de santé des bénéficiaires

Ionized regions in the central arcsecond of NGC 1068. YJHK spatially resolved spectroscopy

Context. Several bright emission line regions have been observed in the central 100 parsecs of the active galaxy NGC 1068. Aims. We aim to determine the properties and ionization mechanism of three regions of NGC 1068: the nucleus (B) and two clouds located at 0.3" and 0.7" north of it (C and D). Methods. We combined SPHERE (0.95 - 1.65 um) and SINFONI (1.5 - 2.45 um) spectra for the three regions B, C, and D. We compared these spectra to several CLOUDY photoionization models and to the MAPPINGS III Library of Fast Radiative Shock Models. Results. The emission line spectra of the three regions are almost identical to each other and contribute to most of the emission line flux in the nuclear region. The emitting media contain multiple phases, the most luminous of which have temperatures ranging from 104.8 K to 106 K. Central photoionization models can reproduce some features of the spectra, but the fast radiative shock model provides the best fit to the data. Conclusions. The similarity between the three regions indicates that they belong to the same class of objects. Based on our comparisons, we conclude that they are shock regions located where the jet of the active galactic nucleus impacts massive molecular clouds.Comment: A&A, Forthcoming article, accepted for publicatio

A 3D model for the stellar populations in the nuclei of NGC 1433,NGC 1566, and NGC 1808

Aims. We aim to characterize the properties of the stellar populations in the central few hundred parsecs of nearby galactic nuclei; specifically their age, mass, and 3D geometry. Methods. We use spatially resolved spectroscopic observations of NGC 1433, NGC 1566, and NGC 1808 obtained with SINFONI to constrain a 3D model composed of a spherically symmetric nuclear star cluster (NSC) and an extended thick stellar disk. We computed UV to mid-infrared single stellar population (UMISSP) spectra to determine the age of the stellar populations and construct synthetic observations for our model. To overcome degeneracies between key parameters, we simultaneously fit the spatially resolved line-of-sight velocity, line-of-sight-velocity-dispersion, low-spectral-resolution NIR continuum, and high-spectral-resolution CO absorption features for each pixel. Results. For the three objects, we derive the age and mass of the young and old stellar populations in the NSC and surrounding disk, as well as their 3D geometry: radius for the NSC; thickness, inclination, and position angle for the disk. These results are consistent with published independent measurements when available. Conclusions. The proposed method allows us to derive a consistent 3D model of the stellar populations in nearby galactic centers solely based on a near-infrared IFU observation

How to create Sgr A East: Where did the supernova explode?

Sgr A East is the supernova remnant closest to the centre of the Milky Way. Its age has been estimated to be either very young, around 1-2 kyr, or about 10 kyr, and its exact origin remains unclear. We aspire to create a simple model of a supernova explosion that reproduces the shape, size, and location of Sgr A East. Using a simplified hydrodynamical code, we simulated the evolution of a supernova remnant in the medium around the Galactic centre. The latter consists of a nearby massive molecular cloud with which Sgr A East is known to be interacting and a wind from the nuclear star cluster. Our preferred models of the Sgr A East remnant are compatible with an age of around 10 kyr. We also find suitable solutions for older ages, but not for ages younger than 5 kyr. Our simulations predict that the supernova exploded at a distance of about 3.5 pc from the Galactic centre, below the Galactic plane, slightly eastwards from the centre and 3 pc behind it.Comment: 13 pages, 15 figures, accepted by A&

Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are important factors modulating these pathways. In addition, live reporters reveal that Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process

The balancing roles of mechanical forces during left-right patterning and asymmetric morphogenesis

Left-right patterning and asymmetric morphogenesis arise from a complex set of molecular and cellular interactions that are particularly dynamic and associated with mechanical forces. How do mechanical forces translate into tissular asymmetries? Are these forces asymmetrical de novo, or do they build up from pre-existing asymmetries? Advances in developmental genetics, live imaging and cell biology have recently shed light on the origins of mechanical forces generated at the cell scale and their implication in asymmetric patterning and morphogenesis is now emerging. Here we ask when and how, molecular asymmetries and mechanical forces contribute to left-right patterning and organ asymmetries