2,908 research outputs found
HBsAg plasma level kinetics:a new role for an old marker as a therapy response predictor in vertically infected children on combination therapy
High-cycle fatigue strength of a pultruded composite material
Dealing with composites in polymeric matrix, the pultruded ones are among the more suitable for large production rates and volumes. For this reason, their use is increasing also in structural applications in civil and mechanical engineering.
However, their use is still limited by the partial knowledge of their fatigue behaviour; in many applications it is, indeed, required a duration of many millions of cycles, while most of the data that can be found in literature refer to a maximum number of cycles equal to 3 millions. In this paper a pultruded composite used for manufacturing structural beams is considered and its mechanical behaviour characterized by means of static and high-cycle fatigue tests. The results allowed to determine the S-N curve of the material and to assess the existence of a fatigue limit. Observations at the scanning electronic microscope (SEM) allowed to evaluate the damage mechanisms involved in the static and fatigue failure of the material
Integral field spectroscopy with SINFONI of VVDS galaxies. II. The mass-metallicity relation at 1.2 < z < 1.6
This work aims to provide a first insight into the mass-metallicity (MZ)
relation of star-forming galaxies at redshift z~1.4. To reach this goal, we
present a first set of nine VVDS galaxies observed with the NIR integral-field
spectrograph SINFONI on the VLT. Oxygen abundances are derived from empirical
indicators based on the ratio between strong nebular emission-lines (Halpha,
[NII]6584 and [SII]6717,6731). Stellar masses are deduced from SED fitting with
Charlot & Bruzual (2007) population synthesis models, and star formation rates
are derived from [OII]3727 and Halpha emission-line luminosities. We find a
typical shift of 0.2-0.4 dex towards lower metallicities for the z~1.4
galaxies, compared to the MZ-relation in the local universe as derived from
SDSS data. However, this small sample of eight galaxies does not show any clear
correlation between stellar mass and metallicity, unlike other larger samples
at different redshift (z~0, z~0.7, and z~2). Indeed, our galaxies lie just
under the relation at z~2 and show a small trend for more massive galaxies to
be more metallic (~0.1 logarithmic slope). There are two possible explanations
to account for these observations. First, the most massive galaxies present
higher specific star formation rates when compared to the global VVDS sample
which could explain the particularly low metallicity of these galaxies as
already shown in the SDSS sample. Second, inflow of metal-poor gas due to tidal
interactions could also explain the low metallicity of these galaxies as two of
these three galaxies show clear signatures of merging in their velocity fields.
Finally, we find that the metallicity of 4 galaxies is lower by ~0.2 to 0.4 dex
if we take into account the N/O abundance ratio in their metallicity estimate.Comment: 7 pages, 4 figures, accepted in A&A Comments: Comments: more accurate
results with better stellar mass estimate
Spontaneous Participation in Secondary Prevention Programs : The Role of Psychosocial Predictors
Disease prevention is a multifaceted construct that has been widely studied. Nevertheless, in spite of its importance, it is still not sufficiently considered by the general population. Since the reasons for this lack of consideration are not yet fully understood, we created an Online Prevention Survey (OPS) to investigate the role of both sociodemographic and psychological factors in predicting individuals\u2019 spontaneous participation in secondary prevention programs. The results revealed that younger people, men, manual workers, unemployed people, and those who do not regularly practise physical activity were less likely to spontaneously participate in such programs. Furthermore, an analysis of the psychological determinants of the willingness to participate in secondary prevention programs showed that depressive symptoms negatively predict it, while an individual\u2019s perception of receiving high social support acts as a positive predictor. Based on these results, we suggest the need for implementing new tailored approaches to promote prevention initiatives to those segments of the population which are more reluctant to spontaneously undertake prevention paths
Mucopexy-Recto Anal Lifting (MuRAL) in managing obstructed defecation syndrome associated with prolapsed hemorrhoids and rectocele : preliminary results
Purpose: Treatment of rectocele associated with prolapsed hemorrhoids is a debated topic. Transanal stapling achieved
good midterm results in patients with symptoms of obstructed defecation, nevertheless a number of severe complications
have been reported. The aim of this study was to evaluate the safety and efficacy of a new endorectal manual technique in
patients with obstructed defecation due to the combination of muco-hemorrhoidal prolapse and rectocele.
Methods: Patients enrolled after preoperative obstructed defecation syndrome (ODS) score, defecography and anoscopy
were submitted to the novel Mucopexy-Recto Anal Lifting (MuRAL) combined with a modified Block procedure, and
followed up by independent observers with digital exploration 3 weeks postoperatively, and digital exploration plus
anoscopy at 3, 6, and 12 months. Operative time, hospital stay, numerating rating scale (NRS), ODS, satisfaction scores,
and recurrence rate were recorded.
Results: Mean operative time was 35.7 minutes. Fifty-six patients completed 1-year follow-up: 7.1% had acute urinary
retention, NRS score was < 3 from the third postoperative day, mean time of daily activity resumption was 12 days, none
had persistent fecal urgency, 82% declared excellent/good satisfaction score, significant improvement of 6- and 12-month
ODS score, no recurrence of rectocele, and 7.1% recurrence of prolapsed hemorrhoids were observed.
Conclusion: MuRAL associated with modified Block technique gave no severe complications and resulted in a safe and
effective approach to symptomatic rectocele associated with muco-rectal prolapse. Further randomized studies, larger
series, and longer follow-up are needed.
[Ann Surg Treat Res 2020;98(5):277-282
Mucopexy-recto anal lifting: a standardized minimally invasive method of managing symptomatic hemorrhoids, with an innovative suturing technique and the HemorPex System®
BACKGROUND:
Conservative surgery of hemorrhoidal disease is less painful than traditional hemorrhoidectomy, and mucopexy has less risk of serious postoperative complications than stapled hemorrhoidopexy. The aim of this study was to evaluate the safety and effectiveness of a standardized, modified hemorrhoidopexy, named Mucopexy-Recto Anal Lifting (MuRAL) with the HemorPex System (HPS) in patients with symptomatic III and IV degree hemorrhoids.
METHODS:
Patients were enrolled from May 2013 to Dec 2015 and operated on with the MuRAL technique, based on arterial ligation and mucopexy at 6 locations, using a standardized clockwise/anti-clockwise rotation sequence of the HPS anoscope. Follow-up controls were carried out by independent observers, as follows: a digital exploration 3 weeks after the intervention, digital exploration plus proctoscopy at 3 and 12 months and repeated at a 12 months interval. Patients who did not strictly follow the postoperative controls were excluded from the study. Primary outcome measurement was the recurrence rate. Secondary measurements were: operative time, hospital stay, postoperative pain, postoperative symptoms and satisfaction score.
RESULTS:
We operated on 126 patients (72 males, mean age 53.9, range 29-83): 87 (69.6%) with III degree and 39 with IV degree hemorrhoids; 13 patients had a MuRAL as a revisional procedure of a previous operation for hemorrhoids. Mean duration of follow-up was 554 days (range 281-1219). Four patients were excluded from the study. One-year recurrence rate was 4.1%. The mean duration of the intervention was 29.5 minutes (range 23-60) and 92 patients (73%) were discharged during the same day of the operation. Pain VAS Score in the first, second and third postoperative day was 3.9, 2.5, and 1.9, respectively. Twenty-two patients (18%), all submitted to spinal anesthesia, had postoperative acute urinary retention. Fecal urgency, observed in 18.8% of patients at the first control, disappeared within one year after the operation. Mean time to return to normal activity was 8 days (range 5 -10). The patient satisfaction scores at one-year follow up were 31.1% excellent, 57.4% good, 7.4% fairly good and 4.1% poor. In patients with III degree hemorrhoids operative time was significantly shorter, postoperative pain better and transient fecal urgency lower than in IV degree patients. In our experience the standardization of MuRAL operation with HPS, turned out to be a safe and effective minimally invasive approach in managing symptomatic III and IV degree hemorrhoids, avoiding the risk of severe complications, with the possibility to perform a redo-MuRAL in the event of recurrence.
CONCLUSIONS:
In our series up to 88% of the patients reported a good, or excellent one-year satisfaction score. Further comparative randomized studies with longer follow-up period are needed
Effective absorbing column density in the gamma-ray burst afterglow X-ray spectra
We investigate the scaling relation between the observed amount of absorption
in the X-ray spectra of Gamma Ray Burst (GRB) afterglows and the absorber
redshift. Through dedicated numerical simulations of an ideal instrument, we
establish that this dependence has a power law shape with index 2.4. However,
for real instruments, this value depends on their low energy cut-off, spectral
resolution and on the detector spectral response in general. We thus provide
appropriate scaling laws for specific instruments. Finally, we discuss the
possibility to measure the absorber redshift from X-ray data alone. We find
that 10^5-10^6 counts in the 0.3-10 keV band are needed to constrain the
redshift with 10% accuracy. As a test case we discuss the XMM-Newton
observation of GRB 090618 at z=0.54. We are able to recover the correct
redshift of this burst with the expected accuracy.Comment: MNRAS accepted. 6 figures. 3 table
Diffuse Melanosis in Pericolic Lymph Nodes Associated With Laxative Abuse and Colorectal Cancer
On How to Unravel Bone Microscale Phenomena: A Mask-Guided Attention SR-microCT Image Classification Approach
When in doubt, Google it: distress-related information seeking in Italy during the COVID-19 pandemic
Background: Psychological health has been one of the aspects affected by the recent COVID-19 pandemic. We aim to evaluate the patterns of Google search for mental distress symptoms of Italian citizens during the various phases of the COVID-19 pandemic. Methods: We assessed Google searches for psychological-health related words. We gathered and analyzed data on daily search queries on depression, anxiety, and insomnia from Google Trends, in a time ranging from the Pre-COVID phase (beginning 25th January 2020) up to the second wave phase (ending 17th October 2020). We performed three general linear models on search trends of the three words and tested whether and to what extent official data about new cases of COVID-19, information searching on new cases, and the government health measures impacted on these trends. Results: Average daily search queries were higher for anxiety, followed by depression and insomnia. General linear models performed to assess differences in daily search queries for anxiety, depression and insomnia were significant, respectively [F(13, 253) = 6.80, P <.001]; [F(13, 253) = 10.25, P <.001]; [F(13, 253) = 6.61, P <.001]. Specifically, daily search queries differed among different phases of managing the COVID-19 outbreak: anxiety [F(5, 253) = 10.35, P <.001, np2 =.17]; depression [F(5, 253) = 13.59, P <.001, np2 =.21]; insomnia [F(5, 253) = 3.52, P =.004, np2 =.07]. Conclusions: Our study contributed to the investigation of online information-seeking behaviors of Italians regarding mental health throughout the entire phase of the pandemic and provides insights on the possible future trends of mental distress during upcoming pandemic phases
- …