HOM Damper Design for BNL EIC 197MHZ Crab Cavity

The interaction region (IR) crab cavity system is a special RF system to compensate the loss of luminosity due to a 25 mrad crossing angle at the interaction point (IP) for Brookhaven National Lab electron ion collider (BNL EIC). There will be six crab cavities, with four 197 MHz crab cavities and two 394 MHz crab cavities, installed on each side of the IP in the proton/ion ring, and one 394 MHz crab cavity on each side of the IP in the electron ring. Both rings share identical 394 MHz crab cavity design to minimize the cost and risk in designing a new RF system, and it will be scaled from 197 MHz crab cavity. In this paper, the higher order mode (HOM) damper design for 197 MHz crab cavity is introduced

The C-Band accelerating structures for SPARC photoinjector energy upgrade

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ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain

Introduction: Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the sufcient number of patients globally to elaborate solid conclusions and drive changes in clinical practice. The participation of Spain into large international academic trials has traditionally lagged behind of other European countries, mainly due to the burden of administrative tasks to open new studies, lack of fnancial support and limited research infrastructure in our hospitals. Methods: The objective of ECLIM-SEHOP platform (Ensayos Clínicos Internacionales Multicéntricos-SEHOP) is to overcome these difculties and position Spain among the European countries leading the advances in cancer and blood disorders, facilitate the access of our patients to novel diagnostic and therapeutic approaches and, most importantly, continue to improve survival and reducing long-term sequelae. ECLIM-SEHOP provides to the Spanish clinical investigators with the necessary infrastructural support to open and implement academic clinical trials and registries. Results: In less than 3 years from its inception, the platform has provided support to 20 clinical trials and 8 observational studies, including 8 trials and 4 observational studies where the platform performs all trial-related tasks (integral support: trial setup, monitoring, etc.) with more than 150 patients recruited since 2017 to these studies. In this manuscript, we provide baseline metrics for academic clinical trial performance that permit future comparisons. Conclusions: ECLIM-SEHOP facilitates Spanish children and adolescents diagnosed with cancer and blood disorders to access state-of-the-art diagnostic and therapeutic strategies

Treatment and outcome analysis of 639 relapsed non-hodgkin lymphomas in children and adolescents and resulting treatment recommendations

Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r NHL, hematopoietic stem cell transplantation (HSCT), risk factors associated with outcome, and to suggest treatment recommendations. Inclusion criteria were (i) refractory disease, disease progression or relapse of any NHL subtype except anaplastic large cell lymphoma, (ii) age < 18 years at initial diagnosis, (iii) diagnosis in/after January 2000. Data from 639 eligible patients were evaluable. The eight-year probability of overall survival was 34 ± 2% with highly significant differences according to NHL subtypes: 28 ± 3% for 254 Burkitt lymphoma/leukemia, 50 ± 6% for 98 diffuse large B-cell lymphomas, 57 ± 8% for 41 primary mediastinal large B-cell lymphomas, 27 ± 3% for 177 T-lymphoblastic lymphomas, 52 ± 10% for 34 precursor-B-cell lymphoblastic lymphomas and 30 ± 9% for 35 patients with rare NHL subtypes. Subtype-specific factors associated with survival and treatment recommendations are suggested. There were no survivors without HSCT, except in few very small subgroups. Conclusions: There is an urgent need to further improve survival in r/r NHL. The current study provides the largest real-world series, which underlines the role of HSCT and suggests treatment recommendations. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Optimization of the Double Quarter Wave Crab Cavity Prototype for Testing at SPS

The crab cavity program for LHC luminosity upgrade envisages the testing of at least one of the three competing crab cavities in the Super Proton Synchrotron (SPS) of CERN by 2016. This paper presents the design optimization of a Double Quarter Wave Crab Cavity (DQWCC) prototype suited for testing in SPS

Cyclinac medical accelerators using pulsed C6+/H2+ ion sources

20 páginas, 9 figuras, 2 tablas.-- Trabajo presentado al International Symposium on Electron Beam Ion Sources and Traps (EBIST2010), celebrado en Estocolmo (Suecia/ Abril 2010).-- This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.-- El PDF es la versión pre-print.-- et al.Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed `cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100–400 Hz). The source should deliver both C6+ and H2+ ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 108 fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.The authors warmly thank A.D.A.M. S.A. and the Vodafone Foundation for their generous financial support of TERA research activities.Peer reviewe

Design and vertical test of double quarter wave crab cavity for LHC luminosity upgrade

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