Clinical and pathological aspects and cerebellar lectin binding in cattle poisoned with Solanum fastigiatum var. fastigiatum and Solanum bonariense

Microscopic and lectin histochemical studies were performed using the cerebella of 33 natural cases of Solanum fastigiatum var. fastigiatum intoxication in the cattle from southern Brazil and 2 natural and 4 experimental cases of Solanum bonariense from Uruguay. The following biotinylated lectins were used in both cases: WGA, sWGA, BS-I, Con-A, RCA-I, DBA, and UEA-I, with the addition of LCA in S. fastigiatum poisoning cases. Histologically, the lesions consisted of fine vacuolization, distention of portions of the Purkinje cells, axonal spheroids measuring 14-50 m in the granular cell layer and adjacent white matter and, proliferation of the Bergmann?s glia. Lectin histochemistry revealed strong reactivity of stored material in Purkinje neurons with the lectins sWGA, Con-A, and LCA in S. fastigiatum cases. A similar pattern was found in S. bonariense cases with a most intense reactions to WGA, and less intense reaction to Con-A, whereas BS-I and RCA-I binding was absent to poor in these neurons in all the cases studied.Lectin reactivity in Purkinje cells between cases was independent of cell damage (from mild to severe loss of neurons). Both S. fastigiatum and S. bonariense have similar lectin binding,  suggesting a similar pathogenesis. Since comparable binding patterns have been described in animals poisoned with swainsonine-containing plants, perhaps the toxins in these plants contain related glycosidaseinhibiting toxins or inhibit glycoprotein and lysosomal metabolism through some related mechanism. The results of this study showed that in spontaneous poisoning by S. fastigiatum and S. bonariense in the cattle, the pattern of lectin binding is similar to those observed in S. fastigiatum experimental conditions.Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Santa Catarina; BrasilFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Verdes, José M.. Universidad de la República. Facultad de Ciencias; UruguayFil: Moraña, Antonio. Universidad de la República; UruguayFil: Barros, Claudio S.L.. Universidad de la República; Urugua

IAA : Información y actualidad astronómica (6)

Sumario : Investigación: Colisiones entre galaxias.-- Pulsación estelar: nuevas técnicas, nuevos avances.-- Ventana Abierta: The Black Hoyle.-- Charlas con...Ricardo Amils.-- Actualidad Científica: El “impactante” nacimiento de la Luna.-- Descubrimiento de agua en una nebulosa planetaria.-- Actividades IAA.-- Agenda.Esta revista se publica con la ayuda de la Acción Especial DIF 2001-4284-E del Programa Nacional de Difusión de la Ciencia y la Tecnología, del Ministerio de Ciencia y Tecnología.N

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Gipsy 3D: Analysis, visualization and vo-tools

4 pages, 1 figure.-- Editors: Bohlender, David A.; Durand, Daniel; Dowler, Patrick.-- This volume contains papers that were presented to the 18th annual conference on Astronomical Data Analysis Software and Systems (ADASS XVIII), which was held on 2--5 November in Québec City, QC, Canada.The scientific goals of the AMIGA project are based on the analysis of a significant amount of spectroscopic 3D data. In order to perform this work we present an initiative to develop a new VO compliant package, including present core applications and tasks offered by the Groningen Image Processing System (GIPSY), and new ones based on use cases elaborated in collaboration with advanced users. One of the main goals is to provide local interoperability between GIPSY (visualization and data analysis) and other VO software. The connectivity with the Virtual Observatory environment will provide general access to 3D data VO archives and services, maximizing the potential for scientific discovery.This work will be partially supported by the Spanish Ministry of Science and Innovation thanks to DGI Grant AYA2008-06181-C02- 01.Peer reviewe

Web services as building blocks for science gateways in astrophysics

An efficient exploitation of Distributed Computing Infrastructures (DCIs) is needed to deal with the data deluge that the scientific community is facing, in particular the Astrophysics one due to the emerging Square Kilometre Array (SKA) telescope that will reach data rates in the exascale domain. Hence, Science Gateways are being enriched with advanced tools that not only enable the scientists to build their experiments but also to optimize their adaptation to different infrastructures. In this work we present a method, called “two-level workflow system”, to build this kind of tools and we apply it to a set of analysis tasks of interest for some use applications to the SKA. This method uses the Software-as-a-Service model to keep the scientists insulated from technical complexity of DCIs, and the COMPSs programming model to achieve an efficient use of the computing resources. © 2016, Springer Science+Business Media Dordrecht.This work has been developed in the framework of AMIGA4GAS (AYA2011-30491-C02) and AMIGA5 (AYA2014-52013-C2-1-R), co-funded by MICINN and FEDER funds. It has been also supported by the Wf4Ever STREP Project (270129) funded under EU FP7 (ICT-2009.4.1) and the Galaxias y Cosmologia project funded by the Junta de Andalucia (TIC-114). This work has also benefited from IBERGRID and the EGI Federated Cloud.Peer reviewe

IAA : Información y actualidad astronómica (55) (2018)

REPORTAJES: El IAA, Centro de Excelencia Severo Ochoa.-- España, miembro de SKA.-- UPWARDS, tres años desentrañando los secretos del planeta rojo .-- 2018, lanzamiento de la misión BepiColombo .-- El principio antrópico .-- EL “MOBY DICK” DE… Rainer Schödel (IAA) .-- CIENCIA EN HISTORIAS…John Money o de la legalización de la tortura infantil .-- DECONSTRUCCIÓN Y otros ENSAYOS. Robótica avanzada para grandes cartografiados de galaxias .-- ACTUALIDAD .-- SALA LIMPIA .La página web de esta revista ha sido financiada por la Sociedad Española de Astronomía (SEA).N

Amphibian parasites of the Order Dermocystida (Ichthyosporea): current knowledge, taxonomic review and new records from Brazil

Amphibian parasites of the Order Dermocystida (Ichthyosporea) are widespread pathogens known mainly from Europe and North America, which cause primarily a disease of skin and subcutaneous tissue in their hosts. The taxonomy of these organisms has been problematic given their conserved morphology, similar clinical disease and pathology. Currently recognized taxa belong to the three closely related genera, Amphibiocystidium, Amphibiothecum, and Rhinosporidium, whereas species of Dermocystidium and Sphaerothecum destruens include fish parasites. Here, we review the taxonomy of Dermocystida based on a molecular phylogenetic analysis, principally of amphibian parasites, including DNA sequences obtained from amphibian hosts collected in the central-eastern region of South America. A new taxonomic arrangement is proposed, which includes the designation of type material for Dermocystidium pusula, synonymization of Amphibiothecum with Dermocystidium, and the restriction of Amphibiocystidium to its type species A. ranae. We also review the taxonomic status of Dermosporidium hylarum until the present work included in the synonymy of the human and animal pathogen R. seeberi, and considered herein as a valid taxon, however. In addition, a new species of Sphaerothecum parasitic to amphibians is described, being the first record of this genus in the southern hemisphere and in an amphibian host.Fil: Borteiro, Claudio. Universidad de la República; Uruguay. Museo Nacional de Historia Natural; UruguayFil: Baldo, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Maronna, Maximiliano M.. Universidade de Sao Paulo; BrasilFil: Pontes Baêta Da Costa, Délio. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Sabbag, Ariadne Fares. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Kolenc, Francisco. Museo Nacional de Historia Natural; UruguayFil: Debat, Claudio Martínez. Universidad de la República; UruguayFil: Haddad, Célio F. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Cruz, Juan Carlos. Universidad de la República; UruguayFil: Verdes, José Manuel. Universidad de la República; UruguayFil: Ubilla, Martín. Universidad de la República; Urugua