Accelerating the transition towards sustainable agriculture: The case of organic dairy farming in the Netherlands

CONTEXT: Regardless 30 years of similar regulations and a common internal market, the diffusion of organic farming strongly differs amongst European member states. While the share of organic farmland in 2018 in Denmark and Austria was respectively 9.8% and 24.7%, in the Netherlands it was only 2.3%. OBJECTIVE: The aim of this paper was to analyze what factors may determine the very different diffusion of organic dairy farming in the Netherlands, compared to Denmark and Austria. METHODS: We applied the Technological Innovation System (TIS) framework to the case of organic dairy farming in the Netherlands, for which a literature review and interviews with key actors within the dairy value chain were carried out. To identify potential leverage points for upscaling also interviews with key actors from Denmark and Austria were held. RESULTS AND CONCLUSIONS: Various barriers in the fulfilment of the seven TIS functions of Dutch organic dairy farming could be identified. With regard to the system function market formation a diversification in certified dairy products are signaled as important factors for upscaling. The function entrepreneurial activities will benefit from an reinforcement of governmental subsidies, since farmers who convert to organic run financial risks. Regarding the function guidance of the search, more consistent and systemic governmental support is needed, since the conversion to organic encompass a regime shift rather that supporting newcomers entering the sector. SIGNIFICANCE: By studying the blocking mechanisms that hinder diffusion of organic dairy, the paper provides several leverage points that may also be applicable to the arrested diffusion of organic farming in other countries as well as the larger sustainability transition in European agriculture

Accelerating the transition towards sustainable agriculture: The case of organic dairy farming in the Netherlands

CONTEXT: Regardless 30 years of similar regulations and a common internal market, the diffusion of organic farming strongly differs amongst European member states. While the share of organic farmland in 2018 in Denmark and Austria was respectively 9.8% and 24.7%, in the Netherlands it was only 2.3%. OBJECTIVE: The aim of this paper was to analyze what factors may determine the very different diffusion of organic dairy farming in the Netherlands, compared to Denmark and Austria. METHODS: We applied the Technological Innovation System (TIS) framework to the case of organic dairy farming in the Netherlands, for which a literature review and interviews with key actors within the dairy value chain were carried out. To identify potential leverage points for upscaling also interviews with key actors from Denmark and Austria were held. RESULTS AND CONCLUSIONS: Various barriers in the fulfilment of the seven TIS functions of Dutch organic dairy farming could be identified. With regard to the system function market formation a diversification in certified dairy products are signaled as important factors for upscaling. The function entrepreneurial activities will benefit from an reinforcement of governmental subsidies, since farmers who convert to organic run financial risks. Regarding the function guidance of the search, more consistent and systemic governmental support is needed, since the conversion to organic encompass a regime shift rather that supporting newcomers entering the sector. SIGNIFICANCE: By studying the blocking mechanisms that hinder diffusion of organic dairy, the paper provides several leverage points that may also be applicable to the arrested diffusion of organic farming in other countries as well as the larger sustainability transition in European agriculture

Fetal methotrexate syndrome : A systematic review of case reports

Methotrexate is a folic acid antagonist known to be teratogenic in humans. Several cases of congenital malformations after fetal exposure to methotrexate have been published, resulting in the establishment of the ‘fetal methotrexate syndrome’. However, it is unclear which congenital anomalies can truly be attributed to methotrexate exposure. The objective of this review is to delineate a consistent phenotype of the fetal methotrexate syndrome. We performed a systematic review that yielded 29 cases of (congenital) anomalies after in utero exposure to methotrexate and compared their malformation pattern to that of children and fetuses with congenital anomalies in general. Statistically significant higher proportions of microcephaly, craniosynostosis, tetralogy of Fallot, pulmonary valve atresia, limb reduction defects and syndactyly were found in the methotrexate group, indicating that these congenital anomalies are truly part of the fetal methotrexate syndrome. These results aid clinicians with diagnosing fetal methotrexate syndrome

Fetal methotrexate syndrome: A systematic review of case reports

Methotrexate is a folic acid antagonist known to be teratogenic in humans. Several cases of congenital malformations after fetal exposure to methotrexate have been published, resulting in the establishment of the ‘fetal methotrexate syndrome’. However, it is unclear which congenital anomalies can truly be attributed to methotrexate exposure. The objective of this review is to delineate a consistent phenotype of the fetal methotrexate syndrome. We performed a systematic review that yielded 29 cases of (congenital) anomalies after in utero exposure to methotrexate and compared their malformation pattern to that of children and fetuses with congenital anomalies in general. Statistically significant higher proportions of microcephaly, craniosynostosis, tetralogy of Fallot, pulmonary valve atresia, limb reduction defects and syndactyly were found in the methotrexate group, indicating that these congenital anomalies are truly part of the fetal methotrexate syndrome. These results aid clinicians with diagnosing fetal methotrexate syndrome

Fetal methotrexate syndrome: A systematic review of case reports

Methotrexate is a folic acid antagonist known to be teratogenic in humans. Several cases of congenital malformations after fetal exposure to methotrexate have been published, resulting in the establishment of the ‘fetal methotrexate syndrome’. However, it is unclear which congenital anomalies can truly be attributed to methotrexate exposure. The objective of this review is to delineate a consistent phenotype of the fetal methotrexate syndrome. We performed a systematic review that yielded 29 cases of (congenital) anomalies after in utero exposure to methotrexate and compared their malformation pattern to that of children and fetuses with congenital anomalies in general. Statistically significant higher proportions of microcephaly, craniosynostosis, tetralogy of Fallot, pulmonary valve atresia, limb reduction defects and syndactyly were found in the methotrexate group, indicating that these congenital anomalies are truly part of the fetal methotrexate syndrome. These results aid clinicians with diagnosing fetal methotrexate syndrome

Accelerating the transition towards sustainable agriculture: The case of organic dairy farming in the Netherlands

CONTEXT: Regardless 30 years of similar regulations and a common internal market, the diffusion of organic farming strongly differs amongst European member states. While the share of organic farmland in 2018 in Denmark and Austria was respectively 9.8% and 24.7%, in the Netherlands it was only 2.3%. OBJECTIVE: The aim of this paper was to analyze what factors may determine the very different diffusion of organic dairy farming in the Netherlands, compared to Denmark and Austria. METHODS: We applied the Technological Innovation System (TIS) framework to the case of organic dairy farming in the Netherlands, for which a literature review and interviews with key actors within the dairy value chain were carried out. To identify potential leverage points for upscaling also interviews with key actors from Denmark and Austria were held. RESULTS AND CONCLUSIONS: Various barriers in the fulfilment of the seven TIS functions of Dutch organic dairy farming could be identified. With regard to the system function market formation a diversification in certified dairy products are signaled as important factors for upscaling. The function entrepreneurial activities will benefit from an reinforcement of governmental subsidies, since farmers who convert to organic run financial risks. Regarding the function guidance of the search, more consistent and systemic governmental support is needed, since the conversion to organic encompass a regime shift rather that supporting newcomers entering the sector. SIGNIFICANCE: By studying the blocking mechanisms that hinder diffusion of organic dairy, the paper provides several leverage points that may also be applicable to the arrested diffusion of organic farming in other countries as well as the larger sustainability transition in European agriculture

Accelerating the transition towards sustainable agriculture: The case of organic dairy farming in the Netherlands

CONTEXT: Regardless 30 years of similar regulations and a common internal market, the diffusion of organic farming strongly differs amongst European member states. While the share of organic farmland in 2018 in Denmark and Austria was respectively 9.8% and 24.7%, in the Netherlands it was only 2.3%. OBJECTIVE: The aim of this paper was to analyze what factors may determine the very different diffusion of organic dairy farming in the Netherlands, compared to Denmark and Austria. METHODS: We applied the Technological Innovation System (TIS) framework to the case of organic dairy farming in the Netherlands, for which a literature review and interviews with key actors within the dairy value chain were carried out. To identify potential leverage points for upscaling also interviews with key actors from Denmark and Austria were held. RESULTS AND CONCLUSIONS: Various barriers in the fulfilment of the seven TIS functions of Dutch organic dairy farming could be identified. With regard to the system function market formation a diversification in certified dairy products are signaled as important factors for upscaling. The function entrepreneurial activities will benefit from an reinforcement of governmental subsidies, since farmers who convert to organic run financial risks. Regarding the function guidance of the search, more consistent and systemic governmental support is needed, since the conversion to organic encompass a regime shift rather that supporting newcomers entering the sector. SIGNIFICANCE: By studying the blocking mechanisms that hinder diffusion of organic dairy, the paper provides several leverage points that may also be applicable to the arrested diffusion of organic farming in other countries as well as the larger sustainability transition in European agriculture

JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome

Purpose: JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neurons. So far, 13 individuals sharing clinical features including intellectual disability (ID) were reported with de novo heterozygous deletions in 6p22–p24 encompassing the full length JARID2 gene (OMIM 601594). However, all published individuals to date have a deletion of at least one other adjoining gene, making it difficult to determine if JARID2 is the critical gene responsible for the shared features. We aim to confirm JARID2 as a human disease gene and further elucidate the associated clinical phenotype. Methods: Chromosome microarray analysis, exome sequencing, and an online matching platform (GeneMatcher) were used to identify individuals with single-nucleotide variants or deletions involving JARID2. Results: We report 16 individuals in 15 families with a deletion or single-nucleotide variant in JARID2. Several of these variants are likely to result in haploinsufficiency due to nonsense-mediated messenger RNA (mRNA) decay. All individuals have developmental delay and/or ID and share some overlapping clinical characteristics such as facial features with those who have larger deletions involving JARID2. Conclusion: We report that JARID2 haploinsufficiency leads to a clinically distinct neurodevelopmental syndrome, thus establishing gene–disease validity for the purpose of diagnostic reporting