Mass bounds in a model with a triplet Higgs

We perform an analysis of the Renormalization Group evolution of the couplings in an extension to the Standard Model which contains a real triplet in the Higgs sector. Insisting that the model remain valid up to 1 TeV allow us to map out the region of allowed mass for the Higgs bosons. We conclude that it is possible for there to be no light Higgs bosons without any otherwise dramatic deviation from the physics of the Standard Model.

Kesalahan Siswa SMP Kelas VII dalam Menyelesaikan Soal Operasi Hitung Bilangan Pecahan

This study aims to discover the types of fraction arithmetic operations and the factors that cause students to make mistakes in solving fractional arithmetic operations questions. This type of research is descriptive-qualitative research. The population in this study were class VII students of South Indralaya 1 Middle School, South Indralaya 2 Middle School, and South Indralaya 3 Public Middle School, with a total sample of 150 VII-grade students. The data collection technique was in the form of giving tests with as many as 12 questions as experts and interviews had validated. Data analysis used is data reduction, data presentation, and conclusions. The results showed that the most dominant type of fraction arithmetic operations in which students completing fraction arithmetic operations made mistakes was type 10 (a/b:c/d) 82 students, type 6 (c-a/b) 78 students, type 3 (c+a/b) 77 students, type 11 (c:a/b) 76 students, and type 12 (a/b:c) 71 students

Comparative context analysis of codon pairs on an ORFeome scale

Codon context is an important feature of gene primary structure that modulates mRNA decoding accuracy. We have developed an analytical software package and a graphical interface for comparative codon context analysis of all the open reading frames in a genome (the ORFeome). Using the complete ORFeome sequences of Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans and Escherichia coli, we show that this methodology permits large-scale codon context comparisons and provides new insight on the rules that govern the evolution of codon-pair context

Substance P induces localization of MIF/α1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladder

BACKGROUND: Macrophage migration inhibitory factor (MIF) is released into the intraluminal fluid during bladder inflammation in the rat complexed to α1-inhibitor-3 (A1-I3; a rodent proteinase inhibitor in the α-macroglobulin family). The location of A1-I3 in the bladder had not been investigated. Therefore, we examined the location of A1-I3 and MIF/A1-I3 complexes in the bladder and changes due to experimental inflammation. METHODS: Anesthetized male rats had bladders removed with no treatment (intact) or were injected with Substance P (SP; s.c.; saline vehicle). After one hour intraluminal fluid was removed, bladder was excised and MIF and A1-I3 levels were determined using ELISA and/or western-blotting. MIF co-immunoprecipitation determined MIF/A1-I3 complexes in the bladder. Bladder sections were immunostained for A1-I3 and MIF/A1-I3. RESULTS: A1-I3 immunostaining was observed in interstitial spaces throughout the bladder (including submucosa) but not urothelium in intact and saline-treated rats. RT-PCR showed that the bladder does not synthesize A1-I3, therefore, A1-I3 in the interstitial space of the bladder must be plasma derived. In SP-treated rats, A1-I3 in the bladder increased and A1-I3 was observed traversing through the urothelium. Umbrella cells that do not show MIF and/or A1-I3 immunostaining in intact or saline-treated rats, showed co-localization of MIF and A1-I3 after SP-treatment. Western blotting demonstrated that in the bladder MIF formed non-covalent interactions and also binds covalently to A1-I3 to form high molecular weight MIF/A1-I3 complexes (170, 130 and 75-kDa, respectively, verified by co-immunoprecipitation). SP-induced inflammation selectively reduced 170-kDa MIF/A1-I3 in the bladder while increasing 170 and 130-kDa MIF/A1-I3 in the intraluminal fluid. CONCLUSION: A1-I3 and MIF/A1-I3 complexes are resident in bladder interstitium. During SP-induced inflammation, MIF/A1-I3 complexes are released from the bladder into the lumen. Binding of MIF/A1-I3 complexes to urothelial cells during inflammation suggests these complexes participate in the inflammatory reaction through activation of receptors for MIF and/or for A1-I3

Efficiency of the EmERGE Pathway of Care in Five European HIV Centres

Objective: We aimed to calculate the efficiency of the EmERGE Pathway of Care in five European HIV clinics, developed and implemented for medically stable people living with HIV. Methods: Participants were followed up for 1 year before and after implementation of EmERGE, between April 2016 and October 2019. Micro-costing studies were performed in the outpatient services of the clinics. Unit costs for outpatient services were calculated in national currencies and converted to US$2018 OECD purchasing parity prices to enable between clinic comparisons in terms of outcomes and costs. Unit costs were linked to the mean use of services for medically stable people living with HIV, before and after implementation of EmERGE. Primary outcome measures were CD4 count and viral load; secondary outcomes were patient activation (PAM13) and quality of life (PROQOL-HIV). Out-of-pocket expenditure data were collected. Results: There were 2251 participants: 87-93$ purchasing parity prices. Primary and secondary outcome measures of participants did not change during the study. Conclusions: EmERGE is acceptable and provided cost savings in different socio-economic settings. Antiretroviral drug costs remain the main cost drivers in medically stable people living with HIV. While antiretroviral drug prices in local currencies did not differ that much between countries, conversion to US$ purchasing parity prices revealed antiretroviral drugs were more expensive in the least wealthy countries. This needs to be taken into consideration when countries negotiate drug prices with pharmaceutical vendors. Greater efficiencies can be anticipated by extending the use of the EmERGE Pathway to people with complex HIV infection or other chronic diseases. Extending such use should be systematically monitored, implementation should be evaluated and funding should be provided to monitor and evaluate future changes in service provision.info:eu-repo/semantics/publishedVersio

An?lisis de viabilidad del negocio de financiamiento colaborativo digital basado en juntas

Ante la necesidad de obtener un bien o servicio las entidades financieras ofrecen diversas propuestas que no terminan de satisfacer a los usuarios. Las elevadas tasas de los cr?ditos, cobros ocultos, lenguaje poco comprensible y la burocracia de los procesos enmarcan una problem?tica que motiva el planteamiento de un modelo de negocios que consiste en una soluci?n de financiamiento colectivo digital basado en juntas la cual permitir? acceder a una fuente de financiamiento con tasa asequible, informaci?n transparente, sin procesos burocr?ticos y que a su vez contribuya a fomentar la cultura de ahorro. Con el fin de validar el negocio se realiza un estudio de mercado en el que se consulta fuentes secundarias, se realiza entrevistas a usuarios potenciales y expertos en rubros relacionados al sistema financiero, fondos colectivos y Fintechs. Por otro lado, se analiza en el entorno las condiciones para el desarrollo del negocio. En dicho an?lisis resalta la Pandemia por el COVID-19, que incentiva la b?squeda de fuentes de financiamiento e impulsa la adopci?n de la tecnolog?a y transacciones en l?nea ante el distanciamiento social generando una nueva realidad propicia para la oferta de Junta+. Asimismo, se revisa el panorama legal de las empresas financieras-tecnol?gicas, Fintechs

Decrease of virulence for BALB/c mice produced by continuous subculturing of Nocardia brasiliensis

<p>Abstract</p> <p>Background</p> <p>Subculturing has been extensively used to attenuate human pathogens. In this work we studied the effect of continuous subculturing of <it>Nocardia brasiliensis </it>HUJEG-1 on virulence in a murine model.</p> <p>Methods</p> <p><it>Nocardia brasiliensis </it>HUJEG-1 was subcultured up to 130 times on brain heart infusion over four years. BALB/c mice were inoculated in the right foot pad with the bacteria subcultured 0, 40, 80, 100 and 130 times (T₀, T₄₀, T₈₀T₁₀₀and T₁₃₀). The induction of resistance was tested by using T₁₃₀to inoculate a group of mice followed by challenge with T0 12 weeks later. Biopsies were taken from the newly infected foot-pad and immunostained with antibodies against CD4, CD8 and CD14 in order to analyze the in situ immunological changes.</p> <p>Results</p> <p>When using T₄₀, T₈₀T₁₀₀and T₁₃₀as inoculums we observed lesions in 10, 5, 0 and 0 percent of the animals, respectively, at the end of 12 weeks. In contrast, their controls produced mycetoma in 80, 80, 70 and 60% of the inoculated animals. When studying the protection of T₁₃₀, we observed a partial resistance to the infection. Immunostaining revealed an intense CD4+ lymphocytic and macrophage infiltrate in healing lesions.</p> <p>Conclusions</p> <p>After 130 in vitro passages of <it>N. brasiliensis </it>HUJEG-1 a severe decrease in its virulence was observed. Immunization of BALB/c mice, with these attenuated cells, produced a state of partial resistance to infection with the non-subcultured isolate.</p

Comparison of Post-injection Site Pain Between Technetium Sulfur Colloid and Technetium Tilmanocept in Breast Cancer Patients Undergoing Sentinel Lymph Node Biopsy

BACKGROUND: No prior studies have examined injection pain associated with Technetium-99m Tilmanocept (TcTM). METHODS: This was a randomized, double-blinded study comparing postinjection site pain between filtered Technetium Sulfur Colloid (fTcSC) and TcTM in breast cancer lymphoscintigraphy. Pain was evaluated with a visual analogue scale (VAS) (0–100 mm) and the short-form McGill Pain Questionnaire (SF-MPQ). The primary endpoint was mean difference in VAS scores at 1-min postinjection between fTcSC and TcTM. Secondary endpoints included a comparison of SF-MPQ scores between the groups at 5 min postinjection and construction of a linear mixed effects model to evaluate the changes in pain during the 5-min postinjection period. RESULTS: Fifty-two patients underwent injection (27-fTcSC, 25-TcTM). At 1-min postinjection, patients who received fTcSC experienced a mean change in pain of 16.8 mm (standard deviation (SD) 19.5) compared with 0.2 mm (SD 7.3) in TcTM (p = 0.0002). At 5 min postinjection, the mean total score on the SF-MPQ was 2.8 (SD 3.0) for fTcSC versus 2.1 (SD 2.5) for TcTM (p = 0.36). In the mixed effects model, injection agent (p < 0.001), time (p < 0.001) and their interaction (p < 0.001) were associated with change in pain during the 5-min postinjection period. The model found fTcSC resulted in significantly more pain of 15.2 mm (p < 0.001), 11.3 mm (p = 0.001), and 7.5 mm (p = 0.013) at 1, 2, and 3 min postinjection, respectively. CONCLUSIONS: Injection with fTcSC causes significantly more pain during the first 3 min postinjection compared with TcTM in women undergoing lymphoscintigraphy for breast cancer

Influence of motor practices on university students’ emotional state [Influencia de las prácticas motrices sobre el estado emocional de estudiantes universitarios]

The emotional experience is a key aspect when promoting student’s well-being from the physical education. This study analyzed the effects of three kinds of motor practices without teammates or adversaries (games, body expression and introjections) on women and men’s emotional state. 358 students took part in this study (98 women, 27.37%, and 260 men, 72.63%) from four different Spanish universities. After each activity students filled out a questionnaire to validate the Games and Emotions Scale (GES), indicating the experienced intensity in positive, negative and ambiguous emotions. Data were analyzed by generalized estimating equations. It was confirmed that the three kinds of practices work as specific subdomains in the emotional experience. Men showed more intense emotions than women (p <.001), although both genders had a similar emotional behavior in motor expression and motor introjections practices. Women registered lower values in motor games. La vivencia emocional es un aspecto clave para promover el bienestar del alumnado desde la educación física. Este trabajo examinó los efectos de tres tipos de prácticas psicomotrices sin presencia de compañeros y de adversarios (juegos, expresión e introyección) sobre el estado emocional de mujeres y hombres. Participaron 358 estudiantes (98 mujeres, 27,37% y 260 hombres, 72,63%) de 4 universidades españolas. Tras cada actividad los estudiantes cumplimentaron el cuestionario validado de juegos y emociones (GES), indicando la intensidad experimentada en emociones positivas, negativas y ambiguas. Los datos se analizaron mediante ecuaciones de estimación generalizadas. Se confirmó que los tres tipos de prácticas funcionan como subdominios específicos en la vivencia emocional. Los hombres expresaron emociones más intensas (p < ,001) que las mujeres, aunque ambos sexos tuvieron un comportamiento emocional similar en la expresión e introyección. Las mujeres registraron valores inferiores en los juegos motores