Ecommerce in virtual worlds : a ‘just do it’ approach?

For the corporate world, virtual worlds (VWs) are still an unexplored land of opportunities. The fact that some big companies such as IBM and Sun Microsystems have devoted considerable funds and talent to taming the new territory has convinced others to step in. However and by the same token, the spectacular falls of some of these VWs ‘projects’ made other corporations hesitant or at least lukewarm about developing their own VW presence agenda

As neurotoxinas de clostridium sp.: os mecanismos de ação e a sua importância clínica

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasAs neurotoxinas produzidas por espécies do género Clostridium, responsáveis pelo tétano e botulismo, são classificadas como potentes metaloproteases constituídas por três domínios funcionais dotados de diferentes funções: ligação neuroespecífica; internalização neuronal; translocação membranar; atividade proteolítica do complexo proteico soluble N-ethylmaleimide fusion attachment protein Receptor (SNARE). Os sete serotipos de neurotoxinas botulínicas (BoNTs) inibem a libertação de acetilcolina ao nível dos terminais colinérgicos periféricos. A neurotoxina tetânica (TeNT), após ligação e internalização aos terminais colinérgicos periféricos sofre um transporte axonal reverso até à espinal medula onde inibe a libertação de ácido λ-aminobutírico (GABA) e glicina nos interneurónios inibitórios. A sinaptobrevina representa o local proteolítico das BoNTs dos serotipos B, D, F e G e da TeNT, enquanto que a SNAP-25 constitui o alvo de ação das BoNTs dos serotipos E, A e C. Para além da SNAP-25 a sintaxina 1 representa outro alvo proteolítico da BoNT do serotipo C. O botulismo é uma doença rara que tem como principal agente etiológico a espécie C. botulinum responsável pela síntese e secreção de BoNTs. A intoxicação alimentar e a colonização intestinal de crianças entre uma semana e um ano de idade representam as principais vias de exposição da doença, que se manifesta por uma paralisia muscular flácida generalizada associada a uma inibição do sistema parassimpático podendo na fase mais avançada da levar à morte por insuficiência respiratória. O tétano nos dias de hoje é uma doença endémica apenas para alguns países subdesenvolvidos. C. tetani representa o agente etiológico do tétano pela produção da TeNT. A contaminação de feridas com esporos bacterianos constitui a fonte de propagação da doença que se traduz numa hiperatividade generalizada dos músculos esqueléticos associada a espasmos e rigidez muscular. O comprometimento generalizado do sistema simpático representa a principal causa de morte da doença. Atualmente as BoNTs estão aprovadas para o tratamento de uma vasta gama de patologias associadas à hiperfunção dos terminais colinérgicos periféricos.The neurotoxins produced by species of the genus Clostridium, responsible for botulism and tetanus are potent metalloprotease classified as consisting of three functional domains endowed with different functions: neuro specific bond; neuronal internalization; membrane translocation; proteolytic activity of the SNARE (soluble N-ethylmaleimide fusion attachment protein Receptor) protein complex. Seven serotypes of botulinum neurotoxins (BoNTs) inhibit the release of acetylcholine at the level of peripheral cholinergic terminals. The tetanus neurotoxin (TeNT) and internalization following binding to peripheral cholinergic terminals undergoes a reverse axonal transport to the spinal cord, where it inhibits the release of λ-aminobutyric acid (GABA) and glycine in inhibitory interneurons. Synaptobrevin is the site of proteolytic BoNTs serotypes B, D, F and G and TeNT, while SNAP-25 is the action target of the BoNTs serotype E, A and C. In addition to SNAP-25 and syntaxin 1 represents another target for proteolytic BoNT serotype C. Botulism is a rare disease whose main etiologic agent C. botulinum responsible for the synthesis and secretion of BoNTs. Food poisoning and intestinal colonization in children between one week and one year of age represent the main ways of exposure of the disease, manifested by a widespread flaccid muscular paralysis associated with an inhibition of the parasympathetic system, may in advanced stage lead to death by respiratory failure. Tetanus today is endemic only some underdeveloped countries. C. tetani is the causative agent of tetanus for the production of TeNT. The contamination of wounds with bacterial spores is the source of spread of disease which translates into a general hyperactivity of skeletal muscles associated with muscle spasticity. The widespread involvement of the sympathetic nervous system is the leading cause of death from the disease. BoNTs are the currently approved for the treatment of a wide range of conditions associated with cholinergic hyperfunction of peripheral terminals

Las Cooperativas de Ahorro y Crédito en la Región San Martín. 2018

El presente informe monográfico titulada Las Cooperativas de Ahorro y Crédito en la Región San Martín. 2018, que tiene como objetivo describir la naturaleza de las cooperativas de ahorro y crédito (Coopac) que operan en la región San Martín. 2018. como alternativa de financiamiento para los grupos de personas de menores recursos económicos. La cual llenara un vació de conocimientos sobre estas organizaciones cooperativas, y que es necesario conocer para aprovechar las bondades de las cooperativas de ahorro y crédito como fuentes de financiamiento para sus asociados. La Cooperación representa un sistema económico que, además de nuevo y original, está totalmente opuesto a la economía liberal y capitalista. Mientras esta, en las relaciones que interviene aparece dominada por la idea del lucro, la Cooperación lleva consigo misma la finalidad de prestación de un servicio. Desde luego, por la sola incompatibilidad que se advierte entre el afán de lucro y la voluntad de prestar un servicio quedan ya puestas en evidencia dichas asociaciones de tipo mercantil. Partiendo de ello, con carácter general podría enunciarse el siguiente principio: todo lo que sea servicio y desinterés nos acercara a la Cooperación, todo lo que signifique afán de lucro y egoísmo individualista nos aproximara a la empresa capitalista. Pero tampoco este criterio diferenciador representa una solución definitiva, llegando a una conclusión: La cooperativa de ahorro y crédito (Coopac) es una organización financiera sin fines de lucro cuyos propietarios son sus propios socios los mismos que la gobiernan de acuerdo a principios democráticos y valores institucionales claramente establecidos. Tiene por finalidad fomentar el ahorro, usar los fondos mancomunados para conceder préstamos y brindar otros servicios afines a los socios y a sus familiasThis monographic report entitled The Savings and Credit Cooperatives in the San Martín Region. 2018, which aims to describe the nature of credit unions (Coopac) operating in the San Martín region. 2018. as an alternative financing for groups of people with fewer economic resources. Which will fill a gap of knowledge about these cooperative organizations, and that it is necessary to know in order to take advantage of the benefits of savings and credit cooperatives as sources of financing for their associates. Cooperation represents an economic system that, in addition to being new and original, is totally opposed to the liberal and capitalist economy. While this, in the relations that intervene is dominated by the idea of profit, the Cooperation carries with it the purpose of providing a service. Of course, due to the only incompatibility observed between the desire for profit and the willingness to provide a service, these commercial associations are already evident. Starting from this, the following principle could be stated in a general way: everything that is service and disinterestedness will bring us closer to Cooperation, everything that means a desire for profit and individualistic selfishness will bring us closer to the capitalist enterprise. But neither this differentiating criterion represents a definitive solution, reaching a conclusion: The credit and savings cooperative (Coopac) is a non-profit financial organization whose owners are their own partners who govern them according to democratic principles and values. Institutions clearly established. Its purpose is to encourage savings, use pooled funds to grant loans and provide other services related to members and their familiesTrabajo de suficiencia profesionalAp

As neurotoxinas de clostridium sp.: os mecanismos de ação e a sua importância clínica

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasAs neurotoxinas produzidas por espécies do género Clostridium, responsáveis pelo tétano e botulismo, são classificadas como potentes metaloproteases constituídas por três domínios funcionais dotados de diferentes funções: ligação neuroespecífica; internalização neuronal; translocação membranar; atividade proteolítica do complexo proteico soluble N-ethylmaleimide fusion attachment protein Receptor (SNARE). Os sete serotipos de neurotoxinas botulínicas (BoNTs) inibem a libertação de acetilcolina ao nível dos terminais colinérgicos periféricos. A neurotoxina tetânica (TeNT), após ligação e internalização aos terminais colinérgicos periféricos sofre um transporte axonal reverso até à espinal medula onde inibe a libertação de ácido λ-aminobutírico (GABA) e glicina nos interneurónios inibitórios. A sinaptobrevina representa o local proteolítico das BoNTs dos serotipos B, D, F e G e da TeNT, enquanto que a SNAP-25 constitui o alvo de ação das BoNTs dos serotipos E, A e C. Para além da SNAP-25 a sintaxina 1 representa outro alvo proteolítico da BoNT do serotipo C. O botulismo é uma doença rara que tem como principal agente etiológico a espécie C. botulinum responsável pela síntese e secreção de BoNTs. A intoxicação alimentar e a colonização intestinal de crianças entre uma semana e um ano de idade representam as principais vias de exposição da doença, que se manifesta por uma paralisia muscular flácida generalizada associada a uma inibição do sistema parassimpático podendo na fase mais avançada da levar à morte por insuficiência respiratória. O tétano nos dias de hoje é uma doença endémica apenas para alguns países subdesenvolvidos. C. tetani representa o agente etiológico do tétano pela produção da TeNT. A contaminação de feridas com esporos bacterianos constitui a fonte de propagação da doença que se traduz numa hiperatividade generalizada dos músculos esqueléticos associada a espasmos e rigidez muscular. O comprometimento generalizado do sistema simpático representa a principal causa de morte da doença. Atualmente as BoNTs estão aprovadas para o tratamento de uma vasta gama de patologias associadas à hiperfunção dos terminais colinérgicos periféricos.The neurotoxins produced by species of the genus Clostridium, responsible for botulism and tetanus are potent metalloprotease classified as consisting of three functional domains endowed with different functions: neuro specific bond; neuronal internalization; membrane translocation; proteolytic activity of the SNARE (soluble N-ethylmaleimide fusion attachment protein Receptor) protein complex. Seven serotypes of botulinum neurotoxins (BoNTs) inhibit the release of acetylcholine at the level of peripheral cholinergic terminals. The tetanus neurotoxin (TeNT) and internalization following binding to peripheral cholinergic terminals undergoes a reverse axonal transport to the spinal cord, where it inhibits the release of λ-aminobutyric acid (GABA) and glycine in inhibitory interneurons. Synaptobrevin is the site of proteolytic BoNTs serotypes B, D, F and G and TeNT, while SNAP-25 is the action target of the BoNTs serotype E, A and C. In addition to SNAP-25 and syntaxin 1 represents another target for proteolytic BoNT serotype C. Botulism is a rare disease whose main etiologic agent C. botulinum responsible for the synthesis and secretion of BoNTs. Food poisoning and intestinal colonization in children between one week and one year of age represent the main ways of exposure of the disease, manifested by a widespread flaccid muscular paralysis associated with an inhibition of the parasympathetic system, may in advanced stage lead to death by respiratory failure. Tetanus today is endemic only some underdeveloped countries. C. tetani is the causative agent of tetanus for the production of TeNT. The contamination of wounds with bacterial spores is the source of spread of disease which translates into a general hyperactivity of skeletal muscles associated with muscle spasticity. The widespread involvement of the sympathetic nervous system is the leading cause of death from the disease. BoNTs are the currently approved for the treatment of a wide range of conditions associated with cholinergic hyperfunction of peripheral terminals

Sistema de identificación de voz para el monitoreo de asistencia del personal médico y administrativo del Instituto regional de Oftalmología

La presente investigación tiene como objetivo general es mejorar el control de asistencia del personal médico y administrativo en el Instituto Regional de Oftalmología mediante la implementación de un Sistema de Identificación de Voz. Se utilizó el tipo de estudio aplicada y el diseño de investigación experimental. Para la elaboración del sistema se utilizaron diferentes herramientas tecnológicas como Java, MySQL y la metodología de reconocimiento de Patrones. Se determina el tiempo promedio de registro de Asistencia, con el sistema actual es de 279,43 segundos y con el sistema propuesto es de 27,32 segundos lo representa el 90,22 % del tiempo total. A demás el Promedio de Índice de error en la identificación antes con el sistema actual es de 42,22%, posteriormente al sistema implementado el índice se reduce a un 5,77%. Por último, el Nivel de Satisfacción de Administrativos, y Médicos con el sistema actual es de 28.56 y con el propuesto es de 40.52 puntos lo que determina un aumento de 11.97 puntos lo que representa el 41.91 %

Implementação do balanced scorecard em universidades públicas: estudo de caso aplicado à faculdade de motricidade humana

O controlo de gestão em universidades e faculdades públicas portuguesas tornou-se imprescindível na atualidade. Este estudo visa aprofundar o conhecimento sobre a avaliação de performance financeira e não financeira destas instituições e a utilização do Balanced Scorecard (BSC) como instrumento de monitorização da implementação da estratégia. Na revisão de literatura apresenta-se um resumo da experiência de utilização do BSC em algumas universidades mundiais: perspetivas, temas estratégicos, objetivos e indicadores utilizados. Seleciona-se a Faculdade de Motricidade Humana (FMH) como estudo de caso e são analisados dados internos obtidos através de entrevistas, relatórios de gestão e as atas mais relevantes dos conselhos representativos. Enquadrado pela legislação portuguesa e regime jurídico das instituições de ensino superior, através do Balanced Scorecard propõe-se um sistema de alinhamento dos objetivos organizacionais, desde a Missão e Visão, consubstanciada nos estatutos aprovados pela lei orgânica da Faculdade, até à avaliação de performance de três órgãos de gestão da FMH.The management control in Universities and Public Faculties in Portugal has become a priority in the current times. This study aims to expand the knowledge of financial and non-financial performance evaluations of these institutions and their use of the Balanced Scorecard (BSC) as an instrument to monitor the implementation of the strategy. Reviewing the literature we are confronted, succinctly, by the practical experience of using BSC in some worldwide universities: perspectives, strategic themes, objectives and the most commonly used indicators. We have chosen the Faculty of Motricidade Humana (FMH) as a study of the case, where internal data obtained through interviews are analyzed, as well as the most relevant management reports and council minutes. Structured within the Portuguese legislation and judicial regime of secondary school institutions, through the Balanced Scorecard we propose a system that aligns the organizational objectives, from the Mission and Vision, allied with approved statutes through the organic law of the Faculty, to the assessment of performance of three management departments in the FMH

Assessment of Job Satisfaction in Nurses: Contributions to Health Management

Background: Evidence reflects that job satisfaction is an indicator of the quality of health care. Health managers and decision-makers cannot neglect its importance and should promote organizational interventions for its assessment and improvement. Objective: This study aims to (i) compare the job satisfaction experienced by nurses with the one desired (ii) identify the lowest areas of current satisfaction and (iii) reflect in areas of lowest and higher job satisfaction. Method: A descriptive study carried out in September 2021 with thirty oncology nurses, who were asked to fill out an electronic questionnaire with the professional life wheel coaching tool. This coaching diagnostic tool assesses the current satisfaction level and the desired satisfaction level from 1 to 10. The inquired areas were: salary, career progression, relationships with managers, relationships with the team, relationships with patients/family, professional environment, feeling of institutional belonging, working conditions, appreciation/recognition, and professional fulfillment. Ethical assumptions were preserved. Results: The results suggest that oncology nurses have important levels of job dissatisfaction. The lowest values of experienced job satisfaction were related to career development, while the highest were related to team relationships. Regarding the desired job satisfaction, the salary was the area presenting the least need for correction. The relationship with patients and families was identified as the area with the greatest desire for improvement. There was a weak correlation between job satisfaction and age, and job satisfaction and professional experience. Discussion and Conclusion: The relationship with the team was one of the areas identified by nurses as significant for their levels of satisfaction, revealing the importance of promoting the development of healthful and effective relationships. Promoting relationships with patients and families is also important as this area was identified as a desire for greater professional development. Health care institutions and nurse managers aiming at the promotion of job satisfaction should plan interventions focusing on the areas of lower job satisfaction and towards younger nurses, who have less experience in clinical environments. Such an approach will likely allow the nurses to feel valued and will reduce the gap between experienced and desired job satisfaction.info:eu-repo/semantics/publishedVersio

Workplace stress in Portuguese oncology nurses delivering palliative care: A pilot study

Oncology nurses often face complex end-of-life issues, underlining their need for specific training in palliative care. In this context, nurses experience several emotional and psychological dilemmas, which are often difficult to manage and result in high levels of workplace stress. This study aimed to determine the levels and work-related factors of workplace stress among oncology nurses. A descriptive baseline study was performed as part of a large four-phase study based on quantitative data collected from Portuguese oncology nurses. Of the 32 participating nurses, most were women, and the mean age was 42.69 10.04 years. Overall, nurses revealed moderate levels of stress. Younger nurses with less professional experience had difficulties dealing with issues related to death and dying. This pilot study supported the development of a program of six Stress Management Training Workshops (SMTW) to reduce stress and increase adaptative strategies. Assessing workplace stress among oncology nurses should be the focus of intervention by managers and institutional leaders.info:eu-repo/semantics/publishedVersio