Impact of sublethal concentration of triazophos on regulation of protein metabolism in the fish Channa punctatus (Bloch)

The fresh water fish is an important human food source in India and the fish is constantly exposed to pesticides which are used extensively to control agricultural pests. Insecticide triazophos organophosphates (OP) altered protein metabolism in the liver, brain and kidney tissues of the fish Channa punctatus (Bloch). The total protein when exposed to different time periods decreased and free amino acids increased significantly. The enzymes which are involved in protein metabolism were altered significantly. The increase in activity of deaminases reveals the breakdown of nucleo-tides to yield excess energy to overcome the toxic pressure. Exposure to sublethal doses of triazophos extract caused significant (p < 0.05) time and dose dependent reduction in the levels of total protein,  acetylcholinesterase (AchE) and significant enhancement in the levels of total free amino acids, glutamine, adenosine monophosphate (AMP) deaminases,  adenosine deaminases, glutamate dehydrogenase (GDH), aspartate aminotransferase (AAT), alanine aminotransferase (ALAT) and alkaline acid phosphatases, and the activity of enzyme protease in both liver, brain and kidney tissues of fresh water fish C. punctatus.Key words: Triazophos (OP), Lc50, protein metabolism, enzyme activity, Channa punctatus

Structural and Magnetic Hysteresis Properties of Co-Zr Substituted Hexagonal Barium Ferrites

Co-Zr substituted M-type hexagonal barium ferrites, with chemical formula BaCoxZrxFe12-2xO19 (where x = 0.0, 0.2, 0.4, 0.6, 0.8 and 1.0), have been synthesized by double sintering ceramic method. The crystallographic properties, grain morphology and magnetic properties of these ferrites have been investigated by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Vibrating Sample Magnetometer (VSM). The XRD patterns confirm the single phase with hexagonal structure of prepared ferrites. The magnetic properties have been investigated as a function of Co and Zr ion composition at an applied field in the range of 20 KOe. These studies indicate that the saturation magnetization (Ms) in the samples increases initially up to the Co-Zr composition of x=0.6 and decreases thereafter. On the other hand, the coercivity (Hc) and Remanent magnetization (Mr) are found to decrease continuously with increasing Co-Zr content. This property is most useful in permanent magnetic recording. The observed results are explained on the basis of site occupation of Co and Zr ions in the samples

Effect of integrated nutrient management on nitrogen dynamics in soil of rice -potato based cropping sequence

The integrated nutrient management (INM) has profound influence on sustaining crop productivity and fertility status of soil. The manurial field experiment was conducted at Paschim Medinipur, West Bengal for evaluating the performance of chemical fertilizer and organic manure on nitrogen availability in different forms in soil and also on the content of nitrogen in different parts of rice (Oryza sativa cv. Annada) and potato (Solanum tuberosum cv. Kufrijyoti) during different growth stages. Application of FYM and RDF150 in combination had good impact on nitrogen dynamics related to crop growth among other treatment combinations. FYM and RDF150 alone also imparted good impact on nutrient availability and yield of two experiment crops (rice and potato). Experiment revealed that incorporation of commercial concentrated organic manure with RDF150 exerted good impact besides FYM combination with inorganic fertilizers

EFFECT OF MOMORDICA CHARANTIA AND SYZYGIUM CUMINI EXTRACT ON SERUM ELECTROLYTES IN ALLOXAN INDUCED DIABETIC RATS

Objective: Diabetes is a group of disorders characterized by high blood glucose levels. Disturbances in serum electrolytes like sodium (Na+) and potassium (K+) are found in diabetes. The purpose of the study was to investigate the disturbances in concentrations of serum electrolytes in hyperglycemic crisis and the effect of syzygium cumini and momordica charantia standardized aqueous extracts on serum electrolytes (Na+and K+) in normal and diabetic rats.Methods: Diabetes is induced by intraperitoneal injection of alloxan at a dose of 120 mg/kg b. w in rats. Rats were divided into 5 groups (normal control, disease control, metformin, test 1 and test 2). In test groups 1 and 2, SASESC (standardized aqueous seed extract of syzygium cumini) and SAFEMC (standardized aqueous fruit extract of momordica charantia) were respectively administered orally to alloxan induced diabetic rats, and their serum electrolyte levels were observed at 1st, 4th, 7th and 14th days.Results: By the 14thday, the Na+ and K+ levels in groups 4 and 5 were almost normal. However, in group 3 (standard), Na+levels were relatively lower and K+ levels were relatively higher than groups 4 and 5 (test). In group 2 (disease control) as compared to group 1 (normal control), a decrease in Na+ and increase in K+ levels was observed even on day 14.Conclusion: Treatment with anti diabetic drugs like metformin, syzygium cumini (test-1), momordica charantia (test-2) restored the electrolyte levels almost back to normal over a period of study (14 d). There was significant (**P<0.01, *P<0.05) normalization of electrolyte levels in diabetic rats. It was concluded that syzygium cumini and momordica charantia showed better efficiency in restoring the electrolyte imbalance as compared to metformin during our study

PROMISING AYURVEDIC HERBS IN THE MANAGEMENT OF KITIBHA (PSORIASIS)- A REVIEW

Psoriasis is one of the commonest skin disorders seen in routine clinical scenario, in entire world around 80 million people suffering from psoriasis. Psoriasis is differentiated by patches of abnormal skin. These skin patches are typically red, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete body coverage. It typically presents as red patches with white scales on top. Areas of the body most commonly affected are the back of the forearms, chin, navel area, and scalp. Diagnosis is typically based on the signs and symptoms. Men and women are affected with equal frequency. The disease may begin at any age, but typically starts in adulthood. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease and depression. Psoriatic arthritis affects up to 30 percent of individuals with Psoriasis. It is noted that around 2% of population are touching with Psoriasis. In present study review on Herbs frequently used in treating psoriasis were compiled. The Herbs Nimba, Stri Kutaja, Guduchi, Daruharidra, Bhallataka Haritaki, Aragvadha, Amalaki, Karveera, Saptaparna, Khadira, Vasa, Guggulu, Chitraka & Katuki are reviewed to be having Vata or Kapha balancing properties. The pharmacological studies showing that Nimbidin of Neem having anti psoriatic property, The Methanolic and ethanolic extracts of Stri Kutaja and Guduchi are having anti oxidant and anti psychotic properties which are helpful in reducing the symptoms of psoriasis.

Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study

A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of OciBest, an extract of Ocimum tenuiflorum Linn. in symptomatic control of general stress. The participants received either placebo (n = 79) or OciBest (n = 71; 1200 mg of actives per day) for six weeks. The severity of stress-related symptoms was self-evaluated by patients at weeks 0, 2, 4 and 6 of the trial period using a symptom rating scale. After six weeks of intervention, scores of symptoms such as forgetfulness, sexual problems of recent origin, frequent feeling of exhaustion, and frequent sleep problems of recent origin decreased significantly (P ≤ 0.05) in OciBest group as compared with placebo group. Also, the total symptom scores of OciBest group revealed significant reduction (P ≤ 0.05) as compared to placebo group. The overall improvement in OciBest group was found to be 1.6 times or 39% more in the control of general stress symptoms with respect to placebo. No adverse events were reported during the study. The findings revealed that OciBest was found to be effective and well tolerated by all the patients over the six weeks of study period

DESIGN AND IMPLEMENTATION OF MICROCONTROLLER BASED AUTOMATED WATER LEVEL INDICATOR

In this paper we present the idea of water level checking and administration inside of the connection of electrical conductivity of the water. All the more particularly, we explore the microcontroller based water level detecting and controlling in a wired and remote environment. Water Level administration methodology would help in diminishing the home force utilization and additionally water flood. Besides, it can show the measure of water in the tank that can bolster Global Water sorts including cell dataloggers, satellite information transmission frameworks for remote water observing framework. Also, phones with relative high calculation force and great graphical client interface got to be accessible as of late. From the clients point of view it is required to reuse such important asset in a versatile application. At long last, we proposed a web and cell based observing administration convention would decide and faculties water level all inclusive

Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study

A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of OciBest, an extract of Ocimum tenuiflorum Linn. in symptomatic control of general stress. The participants received either placebo (n = 79) or OciBest (n = 71; 1200 mg of actives per day) for six weeks. The severity of stress-related symptoms was self-evaluated by patients at weeks 0, 2, 4 and 6 of the trial period using a symptom rating scale. After six weeks of intervention, scores of symptoms such as forgetfulness, sexual problems of recent origin, frequent feeling of exhaustion, and frequent sleep problems of recent origin decreased significantly (P ≤ 0.05) in OciBest group as compared with placebo group. Also, the total symptom scores of OciBest group revealed significant reduction (P ≤ 0.05) as compared to placebo group. The overall improvement in OciBest group was found to be 1.6 times or 39% more in the control of general stress symptoms with respect to placebo. No adverse events were reported during the study. The findings revealed that OciBest was found to be effective and well tolerated by all the patients over the six weeks of study period

Facile synthesis of 3-(4-oxo-4<em>H</em>-pyrido[1,2-a]pyrimidin-3-yl)-1-phenyl-1 <em>H</em>-pyrazole-4-carbaldehyde and its condensation with various active methylene groups

984-989Vilsmeier-Haack formylation of 3-acetyl-4H-pyrido[1,2-a]pyrimidin-4-one 5a-b gives thepyrazole aldehyde i.e.,3-(4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde 6a-b which on condensation with various active methylene group containing compounds 7-10 gives the corresponding Knoevenagel products i.e., 11a,b-14a,b respectively. Structures of all the Knoevenagel products are assigned based on spectral and analytical data

An Event Detection Mechanism with Deep Feature Extraction and Optimal Loss Function Based XGBoost Classifier

Purpose: Interoceptions are a combination of sensation, integration, and interpretation of internal bodily signals. Interoceptions are bidirectionally related to the human being mental and physiological health, and well-being. Sleep and different interoceptive modalities are proven to share common relations. Heartbeat Evoked Potential (HEP) is known as a robust readout to interoceptive processes. In this study, we focused on the relation between HEP modulations and sleep-related disorders. Materials and Methods: We investigated four different sleep-related disorders, including insomnia, rapid eye movement behavior disorder, periodic limb movements and nocturnal frontal lobe epilepsy, and provided HEP signals of multiple Electroencephalogram (EEG) channels over the right hemisphere to compare these disorders with the control group. Here, we investigated and compared the results of 35 subjects, including seven subjects for the control group and seven subjects for each of above-mentioned sleep disorders. Results: By comparing HEP responses of the control group with sleep-related patients’ groups, statistically significant HEP differences were detected over right hemisphere EEG channels, including FP2, F4, C4, P4, and O2 channels. These significant differences were also observed over the grand average HEP amplitude activity of channels over the right hemisphere in the sleep-related disorders as well. Conclusion: Our results between the control group and groups of patients suffering from sleep-related disorders demonstrated that during different stages of sleep, HEPs show significant differences over multiple right hemisphere EEG channels. Interestingly, by comparing different sleep disorders with each other, we observed that each of these HEP differences’ patterns over specific channels and during certain sleep stages bear considerable resemblances to each other