Constitutional problem concerning vat dyes

Based on the lectures delivered as the Cooch-Behar Professor for 1948

The BG News March 3, 2010

The BGSU campus student newspaper March 3, 2010. Volume 100 - Issue 111https://scholarworks.bgsu.edu/bg-news/9214/thumbnail.jp

An optimal control approach to cell tracking

Cell tracking is of vital importance in many biological studies, hence robust cell tracking algorithms are needed for inference of dynamic features from (static) in vivo and in vitro experimental imaging data of cells migrating. In recent years much attention has been focused on the modelling of cell motility from physical principles and the development of state-of-the art numerical methods for the simulation of the model equations. Despite this, the vast majority of cell tracking algorithms proposed to date focus solely on the imaging data itself and do not attempt to incorporate any physical knowledge on cell migration into the tracking procedure. In this study, we present a mathematical approach for cell tracking, in which we formulate the cell tracking problem as an inverse problem for fitting a mathematical model for cell motility to experimental imaging data. The novelty of this approach is that the physics underlying the model for cell migration is encoded in the tracking algorithm. To illustrate this we focus on an example of Zebrafish (Danio rerio's larvae) Neutrophil migration and contrast an ad-hoc approach to cell tracking based on interpolation with the model fitting approach we propose in this study

Identification of critical residues in loop E in the 5-HT(3AS)R binding site

BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity. A large number of studies have explored the structure-function relationships of members of this family, particularly the nicotinic and GABA receptors. This information can be utilized to gain additional insights into specific structural and functional features of other receptors in this family. RESULTS: Thirteen amino acids in the mouse 5-HT(3AS)R that correspond to the putative E binding loop of the nicotinic α7 receptor were chosen for mutagenesis. Due to the presence of a highly conserved glycine in this region, it has been suggested that this binding loop is comprised of a hairpin turn and may form a portion of the ligand-binding site in this ion channel family. Mutation of the conserved glycine (G147) to alanine eliminated binding of the 5-HT(3)R antagonist [(3)H]granisetron. Three tyrosine residues (Y140, Y142 and Y152) also significantly altered the binding of 5-HT(3)R ligands. Mutations in neighboring residues had little or no effect on binding of these ligands to the 5-HT(3AS)R. CONCLUSION: Our data supports a role for the putative E-loop region of the 5-HT(3)R in the binding of 5-HT, mCPBG, d-tc and lerisetron. 5-HT and mCPBG interact with Y142, d-tc with Y140 and lerisetron with both Y142 and Y152. Our data also provides support for the hypothesis that this region of the receptor is present in a loop structure

On a whale washed ashore at Calicut

A dead whale was washed ashore at a place called Kannanparambu, about Ix km. south of South Beach, one of the fish landing centres of Calicut on the afternoon of 25th May 1966. The whale was first noticed that morning off Vellayil fish landing centre with its ventral portion rising out of water surface. The fishermen at first mistook the same for an upturned boat, but as they observed it at close quarters, they could recognise the whale (Fig. 1). On an examination, it was found to be in a putrefied state, though not in an advanced state of decomposition

The Indian Mackerel; Technology and Industry

The chemical composition of fresh mackerel is reported by Chari (1948) as follows: Edible portion 61.60% Water 77.30% Protein 18.92% Fat 1,69% Ash 1.58% Phosphorus 0.69% Calcium (Ca 0) 0.62% Iron mg per 100 g 4.45% Venkataraman and Chari (1951) have given figure of average chemical composition as revealed by analyses carried over a period of 2 years from 1947 to 1949, which are mentioned below: Water 73.45% Protein 20.95% Fat 3.29% Ash 1.66