A scalable method to quantify the relationship between urban form and socio-economic indexes

The world is undergoing a process of fast and unprecedented urbanisation. It is reported that by 2050 66% of the entire world population will live in cities. Although this phenomenon is generally considered beneficial, it is also causing housing crises and more inequality worldwide. In the past, the relationship between design features of cities and socio-economic levels of their residents has been investigated using both qualitative and quantitative methods. However, both sets of works had significant limitations as the former lacked generalizability and replicability, while the latter had a too narrow focus, since they tended to analyse single aspects of the urban environment rather than a more complex set of metrics. This might have been caused by the lack of data availability. Nowadays, though, larger and freely accessible repositories of data can be used for this purpose. In this paper, we propose a scalable method that delves deeper into the relationship between features of cities and socio-economics. The method uses openly accessible datasets to extract multiple metrics of urban form and then models the relationship between urban form and socio-economic levels through spatial regression analysis. We applied this method to the six major conurbations (i.e., London, Manchester, Birmingham, Liverpool, Leeds, and Newcastle) of the United Kingdom (UK) and found that urban form could explain up to 70% of the variance of the English official socio-economic index, the Index of Multiple Deprivation (IMD). In particular, results suggest that more deprived UK neighbourhoods are characterised by higher population density, larger portions of unbuilt land, more dead-end roads, and a more regular street pattern

City form and well-being: what makes London neighborhoods good places to live?

What is the relationship between urban form and citizens’ well-being? In this paper, we propose a quantitative approach to help answer this question, inspired by theories developed within the fields of architecture and population health. The method extracts a rich set of metrics of urban form and well-being from openly accessible datasets. Using linear regression analysis, we identify a model which can explain 30% of the variance of well-being when applied to Greater London, UK. Outcomes of this research can inform the discussion on how to design cities which foster the wellbeing of their residents

Years of life that could be saved from prevention of hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. AIM: To assess how many years of life are lost after HCC diagnosis. METHODS: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. RESULTS: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour <2 cm results in 3.7 years-of-life lost while the diagnosis when a single tumour 65 2 cm or 2/3 nodules still within the Milan criteria, results in 5.0 years-of-life lost, representing the loss of only approximately 5.5% and 7.2%, respectively, of the entire lifespan from birth. CONCLUSIONS: Hepatocellular carcinoma occurrence results in the loss of a considerable number of years-of-life, especially for younger patients. In recent years, the increased possibility of effectively treating this tumour has improved life expectancy, thus reducing years-of-life lost

Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

107noNonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome and may evolve into hepatocellular carcinoma (HCC). Only scanty clinical information is available on HCC in NAFLD. The aim of this multicenter observational prospective study was to assess the clinical features of patients with NAFLD-related HCC (NAFLD-HCC) and to compare them to those of hepatitis C virus (HCV)-related HCC. A total of 756 patients with either NAFLD (145) or HCV-related chronic liver disease (611) were enrolled in secondary care Italian centers. Survival was modeled according to clinical parameters, lead-time bias, and propensity analysis. Compared to HCV, HCC in NAFLD patients had a larger volume, showed more often an infiltrative pattern, and was detected outside specific surveillance. Cirrhosis was present in only about 50% of NAFLD-HCC patients, in contrast to the near totality of HCV-HCC. Regardless of tumor stage, survival was significantly shorter (P = 0.017) in patients with NAFLD-HCC, 25.5 months (95% confidence interval 21.9-29.1), than in those with HCV-HCC, 33.7 months (95% confidence interval 31.9-35.4). To eliminate possible confounders, a propensity score analysis was performed, which showed no more significant difference between the two groups. Additionally, analysis of patients within Milan criteria submitted to curative treatments did not show any difference in survival between NAFLD-HCC and HCV-HCC (respectively, 38.6 versus 41.0 months, P = nonsignificant) Conclusions: NAFLD-HCC is more often detected at a later tumor stage and could arise also in the absence of cirrhosis, but after patient matching, it has a similar survival rate compared to HCV infection; a future challenge will be to identify patients with NAFLD who require more stringent surveillance in order to offer the most timely and effective treatment. (Hepatology 2016;63:827-838)openopenPiscaglia F.; Svegliati-Baroni G.; Barchetti A.; Pecorelli A.; Marinelli S.; Tiribelli C.; Bellentani S.; Bernardi M.; Biselli M.; Caraceni P.; Domenicali M.; Garuti F.; Gramenzi A.; Lenzi B.; Magalotti D.; Cescon M.; Ravaioli M.; Del Poggio P.; Olmi S.; Rapaccini G.L.; Balsamo C.; Di Nolfo M.A.; Vavassori E.; Alberti A.; Benvegnau L.; Gatta A.; Giacomin A.; Vanin V.; Pozzan C.; Maddalo G.; Giampalma E.; Cappelli A.; Golfieri R.; Mosconi C.; Renzulli M.; Roselli P.; Dell'isola S.; Ialungo A.M.; Risso D.; Marenco S.; Sammito G.; Bruzzone L.; Bosco G.; Grieco A.; Pompili M.; Rinninella E.; Siciliano M.; Chiaramonte M.; Guarino M.; Camma C.; Maida M.; Costantino A.; Barcellona M.R.; Schiada L.; Gemini S.; Lanzi A.; Stefanini G.F.; Dall'aglio A.C.; Cappa F.M.; Suzzi A.; Mussetto A.; Treossi O.; Missale G.; Porro E.; Mismas V.; Vivaldi C.; Bolondi L.; Zoli M.; Granito A.; Malagotti D.; Tovoli F.; Trevisani F.; Venerandi L.; Brandi G.; Cucchetti A.; Bugianesi E.; Vanni E.; Mezzabotta L.; Cabibbo G.; Petta S.; Fracanzani A.; Fargion S.; Marra F.; Fani B.; Biasini E.; Sacco R.; Morisco F.; Caporaso N.; Colombo M.; D'ambrosio R.; Croce L.S.; Patti R.; Giannini E.G.; Loria P.; Lonardo A.; Baldelli E.; Miele L.; Farinati F.; Borzio M.; Dionigi E.; Soardo G.; Caturelli E.; Ciccarese F.; Virdone R.; Affronti A.; Foschi F.G.; Borzio F.Piscaglia, F.; Svegliati-Baroni, G.; Barchetti, A.; Pecorelli, A.; Marinelli, S.; Tiribelli, C.; Bellentani, S.; Bernardi, M.; Biselli, M.; Caraceni, P.; Domenicali, M.; Garuti, F.; Gramenzi, A.; Lenzi, B.; Magalotti, D.; Cescon, M.; Ravaioli, M.; Del Poggio, P.; Olmi, S.; Rapaccini, G. L.; Balsamo, C.; Di Nolfo, M. A.; Vavassori, E.; Alberti, A.; Benvegnau, L.; Gatta, A.; Giacomin, A.; Vanin, V.; Pozzan, C.; Maddalo, G.; Giampalma, E.; Cappelli, A.; Golfieri, R.; Mosconi, C.; Renzulli, M.; Roselli, P.; Dell'Isola, S.; Ialungo, A. M.; Risso, D.; Marenco, S.; Sammito, G.; Bruzzone, L.; Bosco, G.; Grieco, A.; Pompili, M.; Rinninella, E.; Siciliano, M.; Chiaramonte, M.; Guarino, M.; Camma, C.; Maida, M.; Costantino, A.; Barcellona, M. R.; Schiada, L.; Gemini, S.; Lanzi, A.; Stefanini, G. F.; Dall'Aglio, A. C.; Cappa, F. M.; Suzzi, A.; Mussetto, A.; Treossi, O.; Missale, G.; Porro, E.; Mismas, V.; Vivaldi, C.; Bolondi, L.; Zoli, M.; Granito, A.; Malagotti, D.; Tovoli, F.; Trevisani, F.; Venerandi, L.; Brandi, G.; Cucchetti, A.; Bugianesi, E.; Vanni, E.; Mezzabotta, L.; Cabibbo, G.; Petta, S.; Fracanzani, A.; Fargion, S.; Marra, F.; Fani, B.; Biasini, E.; Sacco, R.; Morisco, F.; Caporaso, N.; Colombo, M.; D'Ambrosio, R.; Croce, L. S.; Patti, R.; Giannini, E. G.; Loria, P.; Lonardo, A.; Baldelli, E.; Miele, L.; Farinati, F.; Borzio, M.; Dionigi, E.; Soardo, G.; Caturelli, E.; Ciccarese, F.; Virdone, R.; Affronti, A.; Foschi, F. G.; Borzio, F

Laser ablation is superior to TACE in large-sized hepatocellular carcinoma: A pilot case-control study

Background:Limited therapies are available for large ( 6540 mm) unresectable hepatocellular carcinoma (HCC). Currently, the standard treatment with transarterial chemoembolisation (TACE) is unsatisfactory with high recurrence rate and limited effect on survival. Laser Ablation (LA) has emerged as a relatively new technique characterized by high efficacy and good safety. This study is aimed to evaluate the efficacy of LA in comparison to TACE in patients with large HCC. Methods: Eighty-two patients with a single HCC nodule 6540 mm (BCLC stage A or B) were enrolled in this case-control study. Forty-one patients were treated with LA and 41 patients were treated with TACE. Response to therapy was evaluated according to the mRECIST criteria. Survival was calculated with Kaplan-Meier from the time of cancer diagnosis to death with values censored at the date of the last follow-up. Results: Twenty-six (63.4%) and 8 (19.5%) patients had a complete response after LA and TACE, respectively (p &lt; 0.001). Subsequently we stratified the HCCs in 3 categories according to the nodule size: 40-50 mm, 51-60 mm, and &gt; 60 mm. LA resulted superior to TACE especially in nodules ranging between 51 and 60 mm in diameter, with a complete response rate post-LA and post-TACE of 75% and 14.3%, respectively (p = 0.0133). The 36 months cumulative survival rate in patients treated with LA and TACE was 55.4% and 48.8%, respectively. The disease recurrence rates after LA and TACE were 19.5% and 75.0%, respectively. Conclusions: LA is a more effective therapeutic option than TACE in patients with solitary large HCC

Iron ore deposits in the central Southern Alps (Lombardy, Italy): lithostratigraphic and metallogenic reassessment

The central Southern Alps host a very extensive metallogenic province including different metalliferous districts which are characterised by the prevailing presence of Fe, Pb-Zn ores, fluorite, and barite. The dominant iron district showing siderite-ankerite and minor hematite and sulphides is strictly space- and time-controlled. It runs from east to west, between Lake Lugano and Lake Iseo (Giudicarie Line), and includes several iron deposits, both of syngenetic-stratiform and epigenetic vein and dissemination type (fig. 1; tabs. 1, 2, 3). Such deposits were formed during a metallogenic epoch involving the Ordovician-Silurian upper portion of the crystalline basement and the volcano-sedimentary cover formations defined, from bottom to top, by: (i) the Carboniferous-Lower Permian Basal Conglomerate Fm, (ii) the Lower Permian Collio Fm, (iii) the Upper Permian Verrucano Lombardo Fm, (iv) the Lower Triassic Servino Fm. Concerning ore genesis (the depositional environment, transport of hydrothermal fluids, generation of hydrothermal ore fluids and constituents) of the syngenetic-strati form iron mineralization in the different lithostratigraphic sequences, the following observations can be deduced: (a) the presence of a common sub-littoral marine coastal to more distal depositional environment which was CO2-rich and locally hypersaline. This was set in a shallow carbonate-producing shelf zone with contributions of terrigenous as well as magmatogenic material. Local environments include lacustrine and evaporitic (upper member of the Collio Formation), together with a continental alluvial environment for the placer deposit of the >; (b) with respect to iron concentration in the depositional sites, there is evidence for a cyclic transport mechanism by hydrothermal systems, strictly connected to synsedimentary transtensive tectonics; (c) the generation of hydrothermal iron-enriched fluids can be referred to the dissolved content of both accessory and essential iron-bearing minerals of pre-existing rocks, leached and transported under suitable Eh-pH conditions. The genetic points common to epigenetic vein and disseminated mineralization are: (a) fault systems and fractures and permeable lithologies such as conglomerates, sandstones, cataclasites can act as suitable sites of deposition; (b) because of the spatial relationships existing between the epigenetic deposits and the late-Hercynian heat engines, the main mobilisation of the metal solutions (of meteoric, metamorphic and diagenetic origin) can be assumed to be hydrothermal >; a minor remobilization > of meteoric waters and chiefly of syn- to late-diagenetic hydrothermal fluids entirely affects every iron formation, especially the Servino Fm, which marks the upper limit of the iron metallogenesis; (c) the iron source can be envisaged in the leaching of any kind of pre-existing rocks, including the iron formations occurring within the sequence. On the question of iron source, the metal zoning of the basement of the Southern Central Alps can be taken into account (BRIGO & OMENETTO, 1979). Such basement is defined, from west to east, respectively, by a Au-zone (Strona Ceneri Zone), a Fe-zone (central Southern Alps), a pyrite-zone (Trentino Alto Adige Region), and a Cu-pyrite-zone (Cadore-Belluno Province). With respect to a general picture of the iron metallogenesis in the Alps, it is important to notice (BRIGO, 1998) that the deposits in the central Southern Alps are correlated with the iron deposits of the >, Styria, in the Northern Grauwacken Zone (THALMANN, 1979; SCHULZ et alii, 1997). On taking the recent investigations of the Authors into account, together with a critical literature revision of geology and of ore geology (JERVIS, 1873; CURIONI, 1877; CORNELIUS, 1916; STELLA, 1921; PENTA, 1952; MICHELETTI, 1954; GILLIERON, 1959; ASSERETO & CASATI, 1965; OMENETTO & BRIGO, 1974; FRIZZO & OMENETTO, 1974; FUMASOLI, 1974; BRIGO & OMENETTO, 1979; BERTOTTI et alii, 1993; CASSINIS el alii, 1997; SCIUNNACH et alii, 1999; SPALLA & GOSSO, 1999; SPALLA et alii, 1999; JADOUL et alii, 2000; SPALLA et alii, 2000), as well as an important re-evaluation of the extensive series of scientific works of historical, technological and archaeological nature (MAIRONI DA PONTE, 1803; ARRIGONI, 1840; CESA BIANCHI, 1874; FRUMENTO, 1952-1963; SQUARZINA, 1960; COLOMBO, 1976; TIZZONI, 1994-1995, 1997), it is possible to attain considerable evidence for a general theory concerning the origin of stratiform iron-bearing mineralizations or stratigraphic markers in different geological units especially occurring in the crystalline basement. As a consequence, the extension of this iron-bearing district in the Alps consisting of a dense distribution of small concentrations attains about 1900 km(2); such a pattern accounts for the presence of intense mining, metallurgical and artisanal activities which have taken place beginning from a remote origin until the first half of the XXth century, accounting for the present world-wide important social and economic position of Lombardy region

Measuring urban deprivation from user generated content

Measuring socioeconomic deprivation of cities in an accurate and timely fashion has become a priority for governments around the world, as the massive urbanization process we are witnessing is causing high levels of inequalities which require intervention. Traditionally, deprivation indexes have been derived from census data, which is however very expensive to obtain, and thus acquired only every few years. Alternative computational methods have been proposed in recent years to automatically extract proxies of deprivation at a fine spatiotemporal level of granularity; however, they usually require access to datasets (e.g., call details records) that are not publicly available to governments and agencies. To remedy this, we propose a new method to automatically mine deprivation at a fine level of spatio-temporal granularity that only requires access to freely available user-generated content. More precisely, the method needs access to datasets describing what urban elements are present in the physical environment; examples of such datasets are Foursquare and OpenStreetMap. Using these datasets, we quantitatively describe neighborhoods by means of a metric, called Offering Advantage, that reflects which urban elements are distinctive features of each neighborhood. We then use that metric to (i) build accurate classifiers of urban deprivation and (ii) interpret the outcomes through thematic analysis. We apply the method to three UK urban areas of different scale and elaborate on the results in terms of precision and recall