An evaluation of the Goddard Space Flight Center Library

The character and degree of coincidence between the current and future missions, programs, and projects of the Goddard Space Flight Center and the current and future collection, services, and facilities of its library were determined from structured interviews and discussions with various classes of facility personnel. In addition to the tabulation and interpretation of the data from the structured interview survey, five types of statistical analyses were performed to corroborate (or contradict) the survey results and to produce useful information not readily attainable through survey material. Conclusions reached regarding compatability between needs and holdings, services and buildings, library hours of operation, methods of early detection and anticipation of changing holdings requirements, and the impact of near future programs are presented along with a list of statistics needing collection, organization, and interpretation on a continuing or longitudinal basis

Smart LiFePO4 battery modules in a fast charge application for local public transportation

This paper describes the research effort jointly carried out by the University of Pisa and ENEA on electrochemical energy storage systems based on Lithium-ion batteries, particularly the Lithium-Iron-Phosphate cells. In more detail, the paper first illustrates the design and experimental characterization of a family of 12 V modules, each of them provided with an electronic management system, to be used for electric traction. Then, the sizing of the energy storage system for an electric bus providing a service with 'fast and frequent' charge phases is described

Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia

Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global burden of disease. Among putative novel treatments, glycine-centered therapeutics (i.e. sarcosine, glycine itself, D-Serine, and bitopertin) have been proposed, based on a strong preclinical rationale with, however, mixed clinical results. Therefore, a better appraisal of glycine interaction with the other major players of SCZ pathophysiology and specifically in the framework of dopamine – glutamate interactions is warranted. New methodological approaches at cutting edge of technology and drug discovery have been applied to study the role of glycine in glutamate signaling, both at presynaptic and post-synaptic level and have been instrumental for unveiling the role of glycine in dopamine-glutamate interaction. Glycine is a non-essential amino acid that plays a critical role in both inhibitory and excitatory neurotransmission. In caudal areas of central nervous system (CNS), such as spinal cord and brainstem, glycine acts as a powerful inhibitory neurotransmitter through binding to its receptor, i.e. the Glycine Receptor (GlyR). However, glycine also works as a co-agonist of the N-Methyl-D-Aspartate receptor (NMDAR) in excitatory glutamatergic neurotransmission. Glycine concentration in the synaptic cleft is finely tuned by glycine transporters, i.e. GlyT1 and GlyT2, that regulate the neurotransmitter's reuptake, with the first considered a highly potential target for psychosis therapy. Reciprocal regulation of dopamine and glycine in forebrain, glycine modulation of glutamate, glycine signaling interaction with postsynaptic density proteins at glutamatergic synapse, and human genetics of glycinergic pathways in SCZ are tackled in order to highlight the exploitation of this neurotransmitters and related molecules in SCZ and TRS

Design of the battery management system of LiFePO4 batteries for electric off-road vehicles

This paper describes the design of a modular battery management system for electric off-road vehicles, where lithiumion batteries are expected to be widely used. A massive electrification of off-road vehicles can be enabled by the availability of a standard battery module, provided with an effective management unit. The design and some preliminary experimental results of the module management unit are discussed in this paper. The unit contains a high current active equalizer that enables the dynamic charge equalization among cells and maximizes the usable capacity of the battery

Experimental Analysis of an Electric Minibus with Small Battery and Fast Charge Policy

The lead-acid battery of an electric minibus has been replaced with a smaller size lithium-ion battery system consisting of standard 12 V modules and a hierarchical battery management system. The minibus has experimentally been tested to show that the reduced battery capacity, which also cuts costs, does not affect the daily operational mission. This is assuming that the driving phases are alternated with fast charging periods. Experiments show that fast charging of 8 min guarantees up to 1 h of operation

The obstetric syndromes: Clinical relevance of placental hormones

Preterm delivery, preeclampsia and intrauterine growth restriction are the major diseases of pregnancy. A key role in their pathogenesis is played by the placenta, which is the source of hormones and other important regulatory molecules providing the metabolic and endocrine homeostasis of the fetal-placental unit. Since obstetric syndromes are characterized by important maternal and neonatal morbidity and mortality worldwide, numerous efforts have been made over the years to prevent and treat them. Due to their complex pathogenesis, however, the therapy is poor and not very effective. Therefore, great emphasis is currently given to the prevention of these diseases through the identification of biochemical and biophysical markers, among which placental factors play a crucial role. The increasing knowledge of the role of placental molecules can indeed lead to the development of new therapeutic and diagnostic tools. © 2013 Expert Reviews Ltd

Metasurface dome for above-the-horizon grating lobes reduction in 5G-NR systems

The use of fifth-generation (5G) new radio (NR) spectrum around 26 GHz is currently raising the quest on its compatibility with the well-established Earth exploration-satellite service, which may be blinded by the spurious radiation emitted above the horizon (AtH) by base station (BS) antennas. Indeed, AtH grating lobes are often present during cell scanning due to the large interelement spacing in BS array antennas for achieving higher gains with a reduced number of RF chains. In this letter, we propose an approach based on an electrically thin metasurface-based dome for the reduction of AtH grating lobes in 5G-NR BS antennas. The proposed scanning range shifting approach exploits the natural lower amplitude of the grating lobes when the antenna array scans in an angular region closer to the broadside direction. The grating lobe reduction is here demonstrated considering a 1x4 phased linear antenna array operating under dual-liner +/- 45 degrees-slant polarization. A simple design procedure for designing the metasurface dome is reported, together with the antenna performances, evaluated through a proper set of numerical experiments. It is shown that the grating lobe radiation toward the satellite region is significantly reduced, whereas the overall insertion loss is moderate

Implementation of the fast charging concept for electric local public transport: The case-study of a minibus

This paper shows an effective implementation of the fast charging concept in the electric local public transport context. An electric minibus powered with a lead-acid battery is considered as a case-study. Its traction battery is redesigned using 12 V standard lithium-iron-phosphate modules to benefit from the higher performance of the lithium battery technology compared to the lead-acid one. The minibus can achieve a continuous operation characterised by 20 min of traveling alternated with 10 min of standstill for fast recharging of the battery. Experiments performed on a single module of the battery show that the load profile is sustained without appreciable issues both in temperature and life degradation of the lithium cells

DAMEWARE - Data Mining & Exploration Web Application Resource

Astronomy is undergoing through a methodological revolution triggered by an unprecedented wealth of complex and accurate data. DAMEWARE (DAta Mining & Exploration Web Application and REsource) is a general purpose, Web-based, Virtual Observatory compliant, distributed data mining framework specialized in massive data sets exploration with machine learning methods. We present the DAMEWARE (DAta Mining & Exploration Web Application REsource) which allows the scientific community to perform data mining and exploratory experiments on massive data sets, by using a simple web browser. DAMEWARE offers several tools which can be seen as working environments where to choose data analysis functionalities such as clustering, classification, regression, feature extraction etc., together with models and algorithms