The control of state regional aids by the European competition policy and its effects on economic and social cohesion

The economic activity of the countries which make up the European Union (EU) is being profoundly affected by the advance in the process of integration. The consolidation of the Single European Market (SEM) and the process of transition towards Economic and Monetary Union (EMU) are two elements which affect the economic evolution of all of teh countries and regions of the EU. The impact of this greater economic integration is expected to be reflected with different intensity in each of them, according to their own economic structures and their capacity of adaptation to the necessary convergence. The effect of this process on the development of the regions, in itself already unequal, has caused growing concern about the reinforcement of economic and social cohesion within the EU, as was reflected in the Treaty of the European Union. In this way, the steps taken towards a growing integration are complemented by a greater development of structural policies. The reinforcement of these policies, and in particular of regional policy, confers special importance to the analysis of its instruments, above all, to that of the programs for regional economic incentives. Economic incentive programs constitute one of the most widely used tools of regional policy among the member nations of the EU. Given the fact that this assistance is aimed at companies, it is subject to meet Community regulations on competition and, at the same time, as a measure for regional development, play a role in the attainment of economic and social cohesion. In this paper the most important aspects of this last component will be analyzed in terms of regional assistance in order to then proceed to the study of its effects on the correction of interregional inequality.

Aula inversa y el desarrollo de las operaciones aritméticas en estudiantes de una institución educativa privada, Guayaquil 2022

En la presente investigación académica se determinó la relación de influencia del aula inversa y el desarrollo de las operaciones aritméticas siendo las dos variables de la investigación. La metodología aplicada para el tipo y diseño de investigación fue no experimental, correlacional y transversal con un enfoque cuantitativo, la técnica que se aplicó en el Centro Educativo “Espíritu Santo” se llevó a cabo en el grupo de estudio de 100 participantes a través de la encuesta y el instrumento utilizado fue el cuestionario creado por la misma autora. Estos instrumentos mostraron resultados favorables y se demostró que si hay relación la dimensión de la flexibilidad mediante la prueba Rho=0.398 con un valor de significancia (0.000); la otra dimensión para establecer si hay relación era el modelo pedagógico determinando mediante la prueba de Rho de Spearman de 0.619 y su valor de significancia (0.000); La siguiente dimensión fue diseño de contenido Rho=0.576 y el valor de significancia (0.001) permitiendo conocer que si existe relación significativa con el desarrollo de las operaciones aritméticas. Concluyendo la investigación que sí existe una relación significativa entre el aula inversa y el desarrollo de las operaciones aritméticas en una institución educativa Guayaquil, 202

\u3ci\u3ePASSALUS COARCTATUS\u3c/i\u3e PERCHERON, 1835 (COLEOPTERA: PASSALIDAE): REDESCRIPTION AND NEW DISTRIBUTIONAL RECORDS

Passalus (Passalus) coarctatus Percheron, 1835 was described from Brazil without precise locality data; except for its inclusion in catalogues, nothing is known of this species and only one publication has provided specific locality data. We provide precise localities for P. coarctatus in Trinidad and Tobago, Venezuela, Brazil and Bolivia, we describe the third instar larva, discuss its taxonomic status and correct errors of previous publications. Passalus (Passalus) coarctatus Percheron, 1835 fue descrita de Brasil sin datos precisos de localidad; exceptuando su inclusión en catálogos, no se conoce nada de esta especie y solo un trabajo publicado ha suministrado registros específicos de localidad. Proporcionamos localidades precisas para P. coarctatus en Trinidad y Tobago, Venezuela, Brasil y Bolivia, describimos la larva de tercer estadio, discutimos su estatus taxonómico y enmendamos errores de publicaciones anteriores

Phase noise cancellation in polarisation-maintaining fibre links

The distribution of ultra-narrow linewidth laser radiation is an integral part of many challenging metrological applications. Changes in the optical pathlength induced by environmental disturbances compromise the stability and accuracy of optical fibre networks distributing the laser light and call for active phase noise cancellation. Here we present a laboratory scale optical (at 578 nm) fibre network featuring all polarisation maintaining fibres in a setup with low optical powers available and tracking voltage-controlled oscillators implemented. The stability and accuracy of this system reach performance levels below 1 * 10^(-19) after 10 000 s of averagingComment: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in "Phase noise cancellation in polarisation-maintaining fibre links", Rauf et al., Review of Scientific Instruments, 89, 033103 (2018) and may be found at https://doi.org/10.1063/1.501651

Selection of microalgae species for the treatment of marine aquaculture effluents: the SUNRAS project

Fisheries and aquaculture are a major source of employment and income on which the livelihoods of 10-12% of the world's population are based. However, the production process has to be improved in order to increase the sustainability. The ratio of Kg of wild fish needed to produce one kilogram of fish called Fish In Fish Out (FIFO), the carbon and water footprint and the discharge of nitrogen and phosphorus into the environment are certain points that must be resolved to increase the sustainability of this industry. Microalgae and aquaculture have traditionally been grown in both freshwater and seawater, two activities that have always been linked due to microalgae are part of the food chain as primary producers and feed different species in larval stages. They are now playing an increasingly important role in the world of wastewater treatment but in the field of aquaculture, this technology is less technologically advanced and often linked to extensive systems. Since the main problem of alternative sources of proteins and fatty acids of terrestrial origin do not have adequate profiles, some authors propose the use of microalgae as a potential substitute for fishmeal and fish oil

Diseño de un programa de resiliencia para disminuir la violencia escolar en estudiantes de nivel secundario, Chiclayo - 2020

El presente estudio tuvo como principal objetivo diseñar un programa de resiliencia que disminuya la violencia escolar en estudiantes de nivel secundario, Chiclayo 2020, para lo cual se empleó un enfoque de investigación cuantitativo, un tipo descriptivo propositivo y un diseño no experimental transeccional. En base a lo descrito, se logró elaborar el programa de resiliencia “Reintegrándonos” para lo cual se analizó teóricamente dicha variable seleccionando lo propuesto por Wolin y Wolin (1993). Así mismo, se analizaron los antecedentes de estudio lo cual permitió determinar la relación inversa entre las variables tratadas, concluyendo que al desarrollar la resiliencia en los adolescentes se logrará disminuir la violencia escolar. Dicho programa constó de 16 sesiones con un tiempo de aplicación aproximado de 45 minutos por cada una de ellas, este puede ser aplicado en estudiantes del nivel secundario cuyas edades oscilen entre los 12 y 17 años, las cuales corresponden a la etapa de la adolescencia. Así mismo, los participantes deberán contar con la aprobación de sus padres o apoderados a través del consentimiento informado. Finalmente, fue preciso resaltar que el programa elaborado fue validado mediante el criterio de tres jueces expertos quienes confirmaron la correcta elaboración del mismo y legitimaron su aplicación para la población de adolescentes de la ciudad de Chiclayo

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser‐2808 aggravates Ca 2+ ‐dependent cardiomyopathy by exacerbating diastolic Ca 2+ release

Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (PKA) at Ser‐2808 is suggested to mediate the physiological ‘fight or flight’ response and contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca 2+ . In the present study, we examined the potential role of RyR2 phosphorylation at Ser‐2808 in the progression of Ca 2+ ‐dependent cardiomyopathy (CCM) by using mice genetically modified to feature elevated SR Ca 2+ leak while expressing RyR2s that cannot be phosphorylated at this site (S2808A). Surprisingly, rather than alleviating the disease phenotype, constitutive dephosphorylation of Ser‐2808 aggravated CCM as manifested by shortened survival, deteriorated in vivo cardiac function, exacerbated SR Ca 2+ leak and mitochondrial injury. Notably, the deteriorations of cardiac function, myocyte Ca 2+ handling, and mitochondria integrity were consistently worse in mice with heterozygous ablation of Ser‐2808 than in mice with complete ablation. Wild‐type (WT) and CCM myocytes expressing unmutated RyR2s exhibited a high level of baseline phosphorylation at Ser‐2808. Exposure of these CCM cells to protein phosphatase 1 caused a transitory increase in Ca 2+ leak attributable to partial dephosphorylation of RyR2 tetramers at Ser‐2808 from more fully phosphorylated state. Thus, exacerbated Ca 2+ leak through partially dephosphorylated RyR2s accounts for the prevalence of the disease phenotype in the heterozygous S2808A CCM mice. These results do not support the importance of RyR2 hyperphosphorylation in Ca 2+ ‐dependent heart disease, and rather suggest roles for the opposite process, the RyR2 dephosphorylation at this residue in physiological and pathophysiological Ca 2+ signalling.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106986/1/tjp6067.pd

Sensor-as-a-Service: Convergence of Sensor Analytic Point Solutions (SNAPS) and Pay-A-Penny-Per-Use (PAPPU) Paradigm as a Catalyst for Democratization of Healthcare in Underserved Communities

In this manuscript, we discuss relevant socioeconomic factors for developing and implementing sensor analytic point solutions (SNAPS) as point-of-care tools to serve impoverished communities. The distinct economic, environmental, cultural, and ethical paradigms that affect economically disadvantaged users add complexity to the process of technology development and deployment beyond the science and engineering issues. We begin by contextualizing the environmental burden of disease in select low-income regions around the world, including environmental hazards at work, home, and the broader community environment, where SNAPS may be helpful in the prevention and mitigation of human exposure to harmful biological vectors and chemical agents. We offer examples of SNAPS designed for economically disadvantaged users, specifically for supporting decision-making in cases of tuberculosis (TB) infection and mercury exposure. We follow-up by discussing the economic challenges that are involved in the phased implementation of diagnostic tools in low-income markets and describe a micropayment-based systems-as-a-service approach (pay-a-penny-per-use—PAPPU), which may be catalytic for the adoption of low-end, low-margin, low-research, and the development SNAPS. Finally, we provide some insights into the social and ethical considerations for the assimilation of SNAPS to improve health outcomes in marginalized communities

Metodologías ágiles: percepción de los profesionales de la ciudad de Lima

La presente investigación tuvo como objetivo identificar los requisitos, beneficios, limitaciones y estrategias de adopción que presentan las metodologías ágiles aplicadas en las empresas privadas de la ciudad de Lima. El enfoque de la investigación fue cuantitativo, descriptivo, no experimental y transversal, empleando como herramienta de recolección de datos una encuesta online, desarrollada mediante la plataforma Google Forms y validada por siete especialistas en temas de agilidad; la cual fue realizada a 283 profesionales de diversas áreas que se encontraban trabajando con metodologías ágiles en empresas privadas de la ciudad de Lima, que contaban con experiencia en temas de agilidad. Los resultados obtenidos respondieron a la pregunta general y específicas de la investigación, mostrando los siguientes hallazgos: los profesionales encuestados refieren que sus empresas cumplen con promover un cambio del mindset de la organización, con definir facilitadores (coach ágiles) para la transición hacia la aplicación de metodologías ágiles y reestructuran el modelo de trabajo de los empleados y de los líderes, como requisitos para adoptar metodologías ágiles. Asimismo, coinciden en que la mejora en la productividad es el beneficio que más se está reflejando en sus organizaciones como consecuencia de la aplicación de metodologías ágiles; mientras que los obstáculos más citados se relacionan a un arraigo a las metodologías tradicionales asociado a la resistencia al cambio y la cultura dentro de la organización. Finalmente, coincidieron en que las estrategias más utilizadas para la adopción de metodologías ágiles en sus empresas fueron “Bottom up”, seguido por la estrategia “Up and Top Down”, destacando como las metodologías ágiles más utilizadas el SCRUM y KANBAN. Estos hallazgos podrán ser empleados en futuras investigaciones, sumado al valor de proporcionar una base informativa para las empresas que deseen emprender un camino hacia la agilidad, a través de los datos sobre los requisitos, limitaciones, y estrategias que han seguido otras empresas para aplicar y gozar de los beneficios de las metodologías ágiles.The objective of this research was to identify the requirements, benefits, limitations and adoption strategies presented by the agile methodologies applied in private companies in the city of Lima. The research focus was quantitative, descriptive, non-experimental and cross-sectional, using an online survey, created using the Google Forms platform and validated by seven agility specialists, as a data collection tool; which was carried out to 283 professionals from various areas who were working with agile methodologies in private companies in the city of Lima, as well as who had experience in agility. The results obtained answered the general and specific research question, showing the following findings: the professionals surveyed report that their companies comply with promoting a change in the organization's mindset, with defining facilitators (agile coaches) for the transition to the application of agile methodologies and restructure the work model of employees and leaders, as requirements to adopt agile methodologies. Likewise, they agree that the improvement in productivity is the benefit that is most reflected in their organizations as a consequence of the application of agile methodologies; while the most cited obstacles are related to an attachment to traditional methodologies associated with resistance to change and culture within the organization. Finally, they agreed that the most used strategies for the adoption of agile methodologies in their companies were “Bottom up”, followed by the “Up and Top Down” strategy, highlighting SCRUM and KANBAN as the most used agile methodologies. These findings may be used in future research, added to the value of providing an informative base for companies that wish to embark on a path to agility, through data on the requirements, limitations, and strategies that other companies have followed to apply and enjoy the benefits of agile methodologies.Tesi