Increasing demand for reproductive health services in a Peruvian clinic

Over the past few years, well-established family planning (FP) organizations in developing countries, such as INPPARES, the IPPF affiliate in Peru, have strived to implement the Cairo Agenda. In the process of including reproductive health (RH) in FP care, they have dedicated human resources and infrastructure to provide RH services seldom offered in the past. The problem these organizations now face is to increase use of the newly available RH care. Currently, clients seeking FP services may leave clinics unaware of the other RH care provided. At a time when international donors are phasing out financial assistance, the partially idle infrastructure that these NGOs maintain is a drain of their scant resources. To increase demand for such services, INPPARES developed an interactive pamphlet that asked questions about a client’s health and informed them about the various services at its Patres clinic in Lima, Peru. Results of the post-test-only experiment conducted to evaluate the impact of the folder on client behavior are summarized in this report

Influencia de la ceniza de madera y cemento tipo I en la estabilización de suelos con fines de cimentación, Trujillo, 2022

Esta investigación tuvo como propósito principal evaluar como influye la ceniza de madera y cemento tipo I en la estabilización de suelos con fines de cimentación. El tipo de investigación por propósito fue aplicada, nivel explicativo, su diseño de investigación fue cuasiexperimental; la población estuvo constituida por el terreno ubicado en AA.HH Alto Salaverry - La Libertad, la muestra estuvo conformada por 03 calicatas para adquirir suelo natural (B) que fueron combinadas con ceniza de madera de ladrilleras (CM) en dosis (9%, 14%, 17% y 19%) y cemento tipo I (CEM-T1) en única dosis de 10% en función al peso del suelo, siendo un global de 60 muestras para los ensayos respectivos. Los resultados indicaron que se tuvo una clasificación SP-SM, su IP no presentó por el tipo de suelo y no afecto las combinaciones, aumentó su OCH de 9.78% del patrón hasta un 13.10% con 76%B+14%CM+10%CEM-TI, aumentó su MDS de 1.843gr/cm3 del patrón hasta un 1.883gr/cm3 con 81%B+9%CM+10%CEM-TI y la capacidad admisible del suelo aumentó un 37.84% hasta un 1.53 kg/cm2 con 81%B+9%CM+10%CEM-TI. Se concluyó que la estabilización con ceniza de madera y cemento tipo I presentó mejora en la resistencia de capacidad de suelo con un máximo de 81%B+9%CM+10%CEM-TI

Comercio electrónico y rentabilidad de una empresa gastronómica de Trujillo, 2021

La presente investigación, tiene por finalidad determinar el efecto del comercio electrónico en la rentabilidad de una empresa gastronómica de Trujillo en el 2021, es por ello que se consideró un enfoque cuantitativo, con diseño no experimental, transversal, con alcance correlacional. Se consideró a una población y muestra a una empresa gastronómica, aplicando como técnica la ficha de registro como instrumento para recolectar datos. En los resultados se obtuvo que el nivel de participación de comercio electrónico en el 2020 superó a los años anteriores debido a las restricciones impuestas por la pandemia del COVID-19, además del incremento en las ventas utilizando medios digitales y diversos medios de pago. Se concluye que el comercio electrónico ayuda a promover e incrementar las ventas, lo que se puede ver reflejado en la rentabilidad por ventas con 46.83%, la rentabilidad económica con 17.33% y la rentabilidad financiera con 35.68% en el año 2021 y en comparación al 2020, por ello, influye de manera positiva y como resultado genera mayor rentabilidad de la empresa

Tensiones dialécticas de sostenibilidad y salud durante la pandemia de COVID-19: un relato de América Latina

17 páginasThe purpose of this article is to discuss the relationship between sustainability and health in the context of the coronavirus pandemic in Latin America, the region with the second highest number of deaths due to COVID-19. After performing a dialectical analysis on mass media discourses about the pandemic, we argue that sustainability must be understood in relation to tensions such as (a) health and economy, (b) isolation and interconnectedness of health management, and (c) access to and excess of information about the pandemic. Based on this analysis, we suggest that if health is to be considered a fourth pillar of sustainability, it needs to be approached in close connection with these inseparable and irreducible tensions in order to broaden the way in which it has been approached in global sustainable development agendas and to recognize the role of individuals and communities in health issues.El propósito de este artículo es discutir la relación entre sostenibilidad y salud en el contexto de la pandemia del coronavirus en América Latina, la región con el segundo mayor número de muertes por COVID-19. Luego de realizar un análisis dialéctico sobre los discursos de los medios de comunicación sobre la pandemia, argumentamos que la sustentabilidad debe entenderse en relación con tensiones tales como (a) salud y economía, (b) aislamiento e interconexión de la gestión de la salud, y (c) acceso y exceso de información sobre la pandemia. Con base en este análisis, sugerimos que si la salud se considera un cuarto pilar de la sostenibilidad

An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles ▿

Norwalk virus (NV) is an enteric pathogen from the genus Norovirus and a major cause of nonbacterial gastroenteritis in humans. NV virus-like particles (VLPs) are known to elicit systemic and mucosal immune responses when delivered nasally; however, the correlates of immune protection are unknown, and codelivery with a safe and immunogenic mucosal adjuvant may enhance protective anti-NV immune responses. Resiquimod (R848), an imidazoquinoline-based Toll-like receptor 7 and/or 8 (TLR7/8) agonist, is being evaluated as an adjuvant in FDA-approved clinical vaccine trials. As such, we evaluated the adjuvant activity of two imidazoquinoline-based TLR7 and TLR7/8 agonists when codelivered intranasally with plant-derived NV VLPs. We also compared the activity of these agonists to the gold standard mucosal adjuvant, cholera toxin (CT). Our results indicate that codelivery with the TLR7 agonist, gardiquimod (GARD), induces NV VLP-specific serum IgG and IgG isotype responses and mucosal IgA responses in the gastrointestinal, respiratory, and reproductive tracts that are superior to those induced by R848 and comparable to those induced by the mucosal adjuvant CT. This study supports the continued investigation of GARD as a mucosal adjuvant for NV VLPs and possible use for other VLP-based vaccines for which immune responses at distal mucosal sites (e.g., respiratory and reproductive tracts) are desired

A comprehensive transcriptional map of primate brain development.

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey

A comprehensive transcriptional map of primate brain development

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high resolution transcriptional atlas of rhesus monkey brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical parcellation of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons, and cortical layers and areas acquire adult-like molecular profiles surprisingly late postnatally. Disparate cell populations exhibit distinct developmental timing but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, and approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny