1,737 research outputs found
Psychometric properties of the Caregiver Preparedness Scale in caregivers of stroke survivors
Objective: To evaluate the psychometric characteristics of the Caregiver Preparedness Scale (CPS) in
caregivers of stroke survivors.
Background: Caregiver preparedness can have an important impact on both the caregiver and the stroke
survivor. The validity and reliability of the CPS has not been tested for the stroke-caregiver population.
Methods: We used a cross-sectional design to study a sample of 156 caregivers of stroke survivors.
Construct validity of the CPS was evaluated by confirmatory factor analysis (CFA). Internal consistency
and test-retest reliability were also evaluated.
Results: Caregivers were, on average, 54 year old (SD ¼ 13.2) and most were women (64.7%). CFA supported
the unidimensionality of the scale (comparative fit index ¼ 0.98). Reliability was also supported:
item-reliability index and itemetotal correlations above 0.30; composite reliability index ¼ 0.93;
Cronbach’s alpha ¼ 0.94; factor score determinacy ¼ 0.97; and test-retest reliability ¼ 0.92.
Conclusion: The CPS is valid and reliable in caregivers of stroke survivors. Scores on this scale may assist
health-care providers in identifying caregivers with less preparedness to provide specific interventions
INFN Camera demonstrator for the Cherenkov Telescope Array
The Cherenkov Telescope Array is a world-wide project for a new generation of
ground-based Cherenkov telescopes of the Imaging class with the aim of
exploring the highest energy region of the electromagnetic spectrum. With two
planned arrays, one for each hemisphere, it will guarantee a good sky coverage
in the energy range from a few tens of GeV to hundreds of TeV, with improved
angular resolution and a sensitivity in the TeV energy region better by one
order of magnitude than the currently operating arrays. In order to cover this
wide energy range, three different telescope types are envisaged, with
different mirror sizes and focal plane features. In particular, for the highest
energies a possible design is a dual-mirror Schwarzschild-Couder optical
scheme, with a compact focal plane. A silicon photomultiplier (SiPM) based
camera is being proposed as a solution to match the dimensions of the pixel
(angular size of ~ 0.17 degrees). INFN is developing a camera demonstrator made
by 9 Photo Sensor Modules (PSMs, 64 pixels each, with total coverage 1/4 of the
focal plane) equipped with FBK (Fondazione Bruno Kessler, Italy) Near
UltraViolet High Fill factor SiPMs and Front-End Electronics (FEE) based on a
Target 7 ASIC, a 16 channels fast sampler (up to 2GS/s) with deep buffer,
self-trigger and on-demand digitization capabilities specifically developed for
this purpose. The pixel dimensions of mm lead to a very compact
design with challenging problems of thermal dissipation. A modular structure,
made by copper frames hosting one PSM and the corresponding FEE, has been
conceived, with a water cooling system to keep the required working
temperature. The actual design, the adopted technical solutions and the
achieved results for this demonstrator are presented and discussed.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
G-band Spectral Synthesis in Solar Magnetic Concentrations
Narrow band imaging in the G-band is commonly used to trace the small
magnetic field concentrations of the Sun, although the mechanism that makes
them bright has remained unclear. We carry out LTE syntheses of the G-band in
an assorted set of semi-empirical model magnetic concentrations. The syntheses
include all CH lines as well as the main atomic lines within the band-pass. The
model atmospheres produce bright G-band spectra having many properties in
common with the observed G-band bright points. In particular, the contrast
referred to the quiet Sun is about twice the contrast in continuum wavelengths.
The agreement with observations does not depend on the specificities of the
model atmosphere, rather it holds from single fluxtubes to MIcro-Structured
Magnetic Atmospheres. However, the agreement requires that the real G-band
bright points are not spatially resolved, even in the best observations. Since
the predicted G-band intensities exceed by far the observed values, we foresee
a notable increase of contrast of the G-band images upon improvement of the
angular resolution. According to the LTE modeling, the G-band spectrum emerges
from the deep photosphere that produces the continuum. Our syntheses also
predict solar magnetic concentrations showing up in continuum images but not in
the G-band . Finally, we have examined the importance of the CH
photo-dissociation in setting the amount of G-band absorption. It turns out to
play a minor role.Comment: To appear in ApJ, 554 n2 Jun 20, 33 pages and 9 figure
An atomic scale study of Si-doped AlAs by cross-sectional scanning tunneling microscopy and density functional theory
Silicon (Si) donors in GaAs have been the topic of extensive studies since Si
is the most common and well understood n-type dopant in III-V semiconductor
devices and substrates. The indirect bandgap of AlAs compared to the direct one
of GaAs leads to interesting effects when introducing Si dopants. Here we
present a study of cross-sectional scanning tunneling microscopy (X-STM) and
density functional theory (DFT) calculations to study Si donors in AlAs at the
atomic scale. Based on their crystal symmetry and contrast strengths, we
identify Si donors up to four layers below the (110) surface of AlAs.
Interestingly, their short-range local density of states (LDOS) is very similar
to Si atoms in the (110) surface of GaAs. Additionally we show high-resolution
images of Si donors in all these layers. For empty state imaging, the
experimental and simulated STM images based on DFT show excellent agreement for
Si donor up to two layers below the surface
Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice
Background
Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations. The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone involved in mitochondrial calcium homeostasis and pain hypersensitivity. This receptor plays a key role in paclitaxel-induced neuropathic pain, but it is not known whether it also modulates mitochondrial abnormalities.
In this study, we used a mouse model of paclitaxel-induced neuropathic pain to test the involvement of the σ1R in the mitochondrial abnormalities associated with paclitaxel, by using genetic (σ1R knockout mice) and pharmacological (σ1R antagonist) approaches.Results
Paclitaxel administration to wild-type (WT) mice produced cold- and mechanical-allodynia, and an increase in the frequency of swollen and vacuolated mitochondria in myelinated A-fibers, but not in C-fibers, of the saphenous nerve. Behavioral and mitochondrial alterations were marked at 10 days after paclitaxel-administration and had resolved at day 28. In contrast, paclitaxel treatment did not induce allodynia or mitochondrial abnormalities in σ1R knockout mice. Moreover, the prophylactic treatment of WT mice with BD-1063 also prevented the neuropathic pain and mitochondrial abnormalities induced by paclitaxel.Conclusions
These results suggest that activation of the σ1R is necessary for development of the sensory nerve mitochondrial damage and neuropathic pain produced by paclitaxel. Therefore, σ1R antagonists might have therapeutic value for the prevention of paclitaxel-induced neuropathy.This study was partially supported by grant P11-CTS-7649 and grant CTS-109 from Junta de AndalucÃa, FEDER funds, a grant from Esteve, and a grant from the Centro para el Desarrollo Tecnológico Industrial (NeoGenius Pharma project). F. R. Nieto was supported by a FPU grant from the Spanish Ministerio de Educación y Ciencia (MEC) and C. M. Cendán by the Research Program of the University of Granada
HLA Genes in Mayos Population from Northeast Mexico
HLA class I and class II alleles have been studied in 60 unrelated people belonging to Mayos ethnic group, which lives in the Mexican Pacific Sinaloa State. Mayos HLA profile was compared to other Amerindians and worldwide populations’ profile. A total of 14,896 chromosomes were used for comparisons. Genetic distances between populations, Neigbour-Joining dendrograms and correspondence analyses were performed to determine the genetic relationship among population. The new specific Mayo HLA haplotypes found are: HLA-A*02-B*35-DRB1*1406-DQB1*0301; HLA-A*02-B*48-DRB1*0404-DQB1*0302; HLA-A*24-B*51-DRB1*0407-DQB1*0302 and HLA-A*02-B*08-DRB1*0407-DQB1*0302. However, the typical Meso American HLADRB1*0407 represents a 40% of all DRB1 alleles. While common HLA characteristics are found in Amerindian distant ethnic groups, still new group specific HLA haplotypes are being found, suggesting that a common founder effect (i.e. high DRB1*0407) is noticed. Moreover, new HLA haplotypes are almost certainly appearing along time probably due to specific pathogen (?) selection for diversity. Mayo language is close to the Tarahumara one (another geographically close group); notwithstanding both groups are not genetically close according to our results, showing again the different evolution of genes and languages, which do not correlate. Finally, Sinaloa is one of the Mexican States in which more European genes are found. However, the results presented in this paper, where no European HLA genes are seen in Mayos, should have a bearing in establishing transplant programs and in HLA and disease studies
Global and regional IUCN Red List Assessments: 1
In this contribution, the conservation status assessment of six plant species according to IUCN categories and criteria are presented. It includes the assessment at global level of Linaria tonzigii Lona, Allium garganicum Brullo, Pavone, Salmeri & Terrasi, Ferula arrigonii Bocchieri, Orchis patens Desf. subsp. patens and Armeria saviana Selvi and the assessment at regional level (Italy) of Viola jordanii Hanry
Plantes vasculaires nouvelles ou rares pour la Tunisie presentes sur les iles (Galite, Zembra, Kuriat, Monastir, Kerkennah, Kneiss, Djerba)
Vascular plants new or rare for Tunisia occurring on the islands (Galite, Zembra, Kuriat, Monastir, Kerkennah, Kneiss, Djerba). - This study concerns the indigenous vascular plants newly reported for Tunisia and discovered on the islands during some field trips performed since 2014. Five native taxa are new to Tunisia: Bellis perennis, Carthamus creticus, Moraea mediterranea, Asplenium balearicum and Galium minutulum, the latter two also being new to North Africa. Information on 24 rare or poorly known taxa, most often of great biogeographical interest, is given, too. Most of these were discovered on the islands of the eastern coast (Kuriat, Monastir, Kerkennah, Kneiss, Djerba), but also on the northern islands of Zembra and La Galite. The new chorological data underline the first-rate conservation importance of these islands and islets for the preservation of the overall coastal biodiversity of Tunisia
Aerosols from anthropogenic and biogenic sources and their interactions – modeling aerosol formation, optical properties, and impacts over the central Amazon basin
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