Aneurysmal Degeneration of the Brachial Artery after Vascular Access Creation: Surgical Treatment Results

True peripheral artery aneurysms proximal to a longstanding arteriovenous fistula is a well-recognized complication. Late aneurysmal degeneration is rare. This study analyzed the characteristics, therapeutic options, and outcomes of true donor brachial artery aneurysms (DBAA) after arteriovenous fistula (AVF) for hemodialysis. We retrospectively collected the data of patients with DBAA after AVF creation, surgically repaired between January 2001 and September 2015. We excluded patients with pseudoaneurysms, anastomotic aneurysms, and infected aneurysms. We recorded patient's demographics, type of access, aneurysm characteristics, symptoms, treatment, and follow-up. Ten patients were treated for aneurysmal degeneration of the brachial artery. Average aneurysm diameter was 37.5 mm. All cases had, at least, one previous distal AVF, ligated or thrombosed, at the time of diagnosis. The first access was created in mean 137 months before the diagnosis of DBAA. Nine patients had previous medical history of renal transplant and were under immunosuppressive therapy. All patients were symptomatic at the time of diagnosis. In all cases, the treatment was aneurysmectomy followed by interposition bypass. One patient developed a postoperative hematoma with the need of surgical drainage. At 50 months of follow-up, one patient was submitted to percutaneous angioplasty due to an anastomotic stenosis. No other complications occurred during the entire follow-up period (mean: 69 months). The pathogenesis underlying DBAA remains unclear. Increased blood flow after AVF creation, immunosuppressive therapy, and ligation/thrombosis of the AVF may contribute to aneurysm formation. Surgical treatment by aneurysmectomy and bypass, with autogenous conducts, is a safe and effective option.info:eu-repo/semantics/publishedVersio

Self-perceived oral health assessment of institutionalized elderly of Viseu

Background: Self-perception of oral health is a multidimensional measure that, reflects the subjective experience of individuals about their physical and psychosocial well-being, determines the search for prevention and dental treatments.Objective: The assessment of the self-perception of oral health status of institutionalized elderly through the Geriatric Oral Health Assessment Index (GOHAI) and the verification of the association between the GOHAI and the various socio-demographic variables and oral health behaviors analyzed. Participants and methods: With this study we intended to conduct a cross-sectional observational epidemiological study with institutionalized elderly. Data were collected from a sample of 56 institutionalized elderly of the Mariana Seixas Foundation and the Viscondessa São Caetano Nursing Home in Viseu, Portugal. For this we used a questionnaire that allows to evaluate the self-perception of oral health, the Geriatric Oral Health Assessment Index (GOHAI). Results: It was found that the elderly generally favorably assessed their oral health, with 42.9% of the participants having a high self-perception of their oral health (values between 34-36); 28.6% have a moderate perception (values between 30-33) and the same percentage of individuals (28.6%) have a low perception (values below 30) of their oral health. The GOHAI scores obtained are associated with gender, educational level and oral health behaviors. Conclusion: Literacy can influence the level of self-perception of oral health. Therefore, the development of measures to assess oral health status is essential for the evolution of scientific knowledge based on geriatric dentistry in order to determine oral health promotion strategies among the institutionalized elderly.info:eu-repo/semantics/publishedVersio

GROWTH PERFORMANCE OF MEAT MALE QUAILS (COTURNIX SP.) OF TWO LINES UNDER TWO NUTRITIONAL ENVIRONMENTS

Com o objetivo de avaliar o efeito de duas linhagens (italiana e japonesa) e de dois níveis de proteína bruta (20 e 26% PB) sobre o desempenho para corte foram utilizados 144 machos de codorna, criados em gaiola de 1 a 49 dias. Foram alojadas nove aves por gaiola, sorteadas de acordo com um esquema fatorial 2 x 2 em delineamento inteiramente aleatorizado com quatro repetições. O desempenho foi avaliado semanalmente. A linhagem italiana apresentou maiores peso médio, ganho de peso médio e consumo médio do que a japonesa. O consumo médio relativo e a conversão alimentar da linhagem italiana foram menores, indicando melhor capacidade de utilização do alimento. Abstract Male quails (144) were reared from 1 to 49 days in cages, to evaluate the effect of line (Italian and Japanese), and crude protein level (20 and 26% CP) upon growth performance for meat production. Nine birds were housed per cage, sorted out according to a 2 x 2 factorial scheme in an entirely randomized design with 4 repetitions. Growth performance was evaluated weekly. The Italian line had higher mean body weight, mean gain weight and mean feed intake than the Japanese line. The Italian line showed lower or equal means of feed intake adjusted for body weight, indicating that it had better feed utilization. Mean feed conversion of the italian line was better than that of the Japanese line

pfmdr1 amplification is related to increased Plasmodium falciparum In Vitro sensitivity to the Bisquinoline Piperaquine

The 4-aminoquinoline bisquinoline piperaquine is an important partner drug in one of the presently recommended artemisinin combination therapies. Recent clinical trials have confirmed its high efficacy in combination with dihydroartemisinin. Resistance to piperaquine alone has, however, been documented. Amplification in copy number of the Plasmodium falciparum multidrug resistance locus on chromosome 5, containing the pfmdr1 gene, has been shown to confer resistance to structurally unrelated antimalarials. Through the determination of the 50% inhibitory concentrations (IC(50)s) and IC(90)s for piperaquine and chloroquine in a set of 46 adapted P. falciparum cultures originating from the Thai-Burmese border, we have characterized the regions around the pfmdr1 gene and identified a significant association between the presence of pfmdr1 duplications and enhanced sensitivity to piperaquine (P = 0.005 for IC50 and P = 0.002 for IC90) and chloroquine, reaching statistical significance at IC(90)s (P = 0.026). These results substantiate the potential importance of pfmdr1 copy number amplifications in the efficacy of the combination therapy piperaquine-dihydroartemisinin. It supports the rational use of 4-aminoquinolines and artemisinin-based compounds, as they independently select for mutually incompatible combinations of mutations.Swedish Development Cooperation Agency-Department for Research Cooperation [SWE 2005-0017, SWE 2005-4596, SWE-2007-174, SWE-2005-4027]; Fundacao para a Ciencia e Tecnologia (FCT)/Ministerio da Ciencia e Ensino Superior, Portugal-MCES [SFRH/BPD/76614/2011]; Wellcome Trust of Great Britaininfo:eu-repo/semantics/publishedVersio

Genetic diversity by molecular markers in lines of phaseolus vulgaris from VCU experiments at Embrapa Rice and Beans breeding program.

This study aimed to characterize the diversity and to determine the genetic differentiation within lines and cultivars from VCU 2009/2010, based on a set of SSR markers. Twenty-three lines (10 from ?Preto?, 12 from ?Carioca? and one from special grains group) and nine cultivars (four from ?Preto? and five from ?Carioca? group) comprised VCU from 2009/2010

Explorando...: a complexidade do corpo humano: guião didáctico para professores: 1º ciclo

O presente livro faz parte da Coleção “Ensino Experimental das Ciências”, um conjunto de textos concebidos para apoiar a formação de professores(as) com vista à generalização do ensino das Ciências no 1.º Ciclo do Ensino Básico (CEB). Trata-se de um livro de suporte à Educação em Ciências para os primeiros níveis de escolaridade desenvolvido tendo por base orientações recentes a nível nacional e internacional

Stereological Estimation of Mean Nuclear Volume as a Prognostic Factor in Canine Mast Cell Tumors

Cutaneous mast cell tumour (MCT) Patnaik and Kiupel grading schemes rely on qualitative and semiquantitative features susceptible to interobserver variability. Stereological estimation of volume-weighted mean nuclear volume (MNV) provides information about both size and variability of nuclear size, which has been proven to have a prognostic value in other solid tumours. The objective was to compare MNV with MCT grade and biological behaviour. Fifty-six MCTs were graded according to Patnaik and Kiupel by consensus of three experienced pathologists.Clinical history of dogs treated with surgical excision alone was collected with a minimum follow-up period of 1 year (n=31).MNV was estimated using the point-intercept method on vertical sections in 10 microscopical fields, with an approximately constant distance proportional to overall sectional area. Animals were divided according to outcome: group 1, no recurrence; group 2, local recurrence, lymph node or distant metastasis. The present study suggests that estimation of MNV on routine histological sections may objectively improve the detection of more aggressive MCTs

Caracterização de germoplasma cultivado de Phaseolus vulgaris que compõem ensaios de VCU utilizando marcadores microssatélites.

O objetivo desse estudo foi o de caracterizar a variabilidade genética de linhagens de feijoeiro comum que compõem diversos ensaios de VCU do programa de melhoramento genético da Embrapa Arroz e Feijão utilizando marcadores microssatélites em sistemas de amplificação simultânea e detecção semi-automatizada dos perfis genéticos gerados.CONAFE

Avaliação do Impacte do Programa de Formação em Ensino Experimental das Ciências: Um estudo de âmbito nacional: Relatório Final

O Programa de Formação em Ensino Experimental das Ciências para Professores do 1.º Ciclo do Ensino Básico (PFEEC), desenvolveu-se ao longo de quatro anos letivos, entre 2006 e 2010, envolvendo um plano de formação contínua, de âmbito nacional, e a produção e disponibilização de recursos didáticos para Formadores de Professores e para Professores do 1.º ciclo. O programa alicerçou-se no reconhecimento de que o Ensino Experimental das Ciências, nos primeiros anos de escolaridade, é fundamental para o desenvolvimento da literacia científica dos alunos e para o desenvolvimento de capacidades necessárias ao exercício de uma cidadania informada. Todos os materiais produzidos no âmbito deste Programa estão ao dispor de toda a comunidade educativa, na página da DGE, podendo ser utilizados na Formação de Professores bem como na prática letiva dos professores deste nível de ensino. O programa envolveu ainda a dotação financeira das escolas de 1.º ciclo participantes para o apetrechamento do equipamento laboratorial considerado imprescindível ao desenvolvimento do trabalho experimental neste nível de escolaridade. Participaram no Programa um total de 5141 professores formandos, 4245 escolas e 149 359 alunos. Tendo em conta o conhecimento científico-pedagógico proporcionado aos professores por este Programa, bem como o apetrechamento das escolas envolvidas e os recursos produzidos, considerou-se importante levar a efeito um estudo, que permitisse avaliar o seu impacte nas práticas docentes e nos resultados de aprendizagens dos alunos. O relatório final que agora se apresenta é o resultado desse estudo, o qual foi coordenado pela Professora Isabel Martins, a quem competiu constituir e dirigir a equipa de investigação. Nele se descreve o modo como o estudo de avaliação, conduzido a nível nacional, foi desenvolvido, bem como os resultados e conclusões alcançados