Hypoglycemic Detection by Human Breath: A Mobile Health App that Alerts Diabetics of Low Blood Glucose

Low blood glucose (BG) or hypoglycemia (HYPO) can lead to severe health complications such as weakness and unconsciousness. To avoid problems BG self-management is needed. We developed a non-invasive breathing system (HYPOalert) to detect HYPO in human-breath, that sends warning alerts and data visualization to monitor progress. This paper presents two HYPOalert prototype iterations with testing results. Of 14 Type 1/2 diabetics tested, only 10% were pleased with existing monitoring systems and 85% expressed interest in using HYPOalert more than 20x a day. The usability study showed that 92% agreed-strongly agreed with the HYPOalert design, including color/menus/navigation/typography; and 64% felt positive about the apps consistency, flexibility, and info architecture. A post-test survey provided a satisfaction score: 6.64/10, with an open-ended interview showing that HYPOalert could positively impact lifestyle practices, self-managing, and help advance an understanding of the disease

The effects of creatine supplementation on sprint running performance and selected hormonal responses

The purpose of this study was to determine the influence of short-term creatine supplementation on sprint running performance (100 and 200 m) and circulating hormone [growth hormone (GH), testosterone and cortisol] concentrations. Twenty amateur male runners were randomly divided into a creatine supplementation group, or placebo group. Subjects were provided with capsules containing either creatine monohydrate or identical powdered cellulose placebo. Daily creatine monohydrate supplementation was 20 g/day parceled into three equal dosages to be consumed with each major meal. Subjects were tested for performance and resting blood hormone concentrations before and after six days. A double-blind research design was employed in this study. After this creatine loading, the mean running performance time of the creatine supplementation group decreased significantly in the 100 m, but not the 200 m. Serum GH, testosterone, and cortisol concentrations were not affected by creatine supplementation. It can therefore be concluded that although short-term creatine supplementation was found to improve sprint performance in the 100 m in amateur runners, this performance improvement did not appear to be hormonally mediated.Key words:  Sprint performance; Creatine supplementation; Hormonal responses; Creatine loading. 

The effects of creatine supplementation on performance and hormonal response in amateur swimmers

Objectifs Le but de cette étude était de déterminer l’influence à court terme d’une supplémentation en créatine sur la performance lors de sprints en natation (50 et 100 m) et sur les réponses hormonales (hormone de croissance, testostérone et le cortisol). Méthodes Vingt nageurs amateurs ont ingéré du monohydrate de créatine (CR) ou un placebo (PL) pendant six jours pendant lesquels ils ont poursuivi leur entraînement de natation. Les performances et les réponses hormonales ont été enregistrées le jour précédent et après cette période de charge orale en créatine. Résultats Le temps de nage moyen du groupe CR sur 50 m était significativement diminué (53,1 ± 3,73 secondes avant charge vs 50,7 ± 2,84 secondes après supplémentation). L’hormone de croissance et le cortisol n’ont pas été affectés par cette charge en créatine. En revanche, la concentration de testostérone était significativement plus élevée dans CR par rapport à PL après la période de supplémentation (p < 0,05). Conclusion Nos résultats suggèrent qu’une supplémentation de courte durée en créatine a amélioré de manière significative la performance lors de sprints sur 50 m chez des nageurs amateurs sans que l’on puisse imputer de manière objective une médiation hormonale.Mots clés Nageurs; Supplémentation en créatine; Hormones anabolisante

On the use of optical flow for scene change detection and description

We propose the use of optical flow information as a method for detecting and describing changes in the environment, from the perspective of a mobile camera. We analyze the characteristics of the optical flow signal and demonstrate how robust flow vectors can be generated and used for the detection of depth discontinuities and appearance changes at key locations. To successfully achieve this task, a full discussion on camera positioning, distortion compensation, noise filtering, and parameter estimation is presented. We then extract statistical attributes from the flow signal to describe the location of the scene changes. We also employ clustering and dominant shape of vectors to increase the descriptiveness. Once a database of nodes (where a node is a detected scene change) and their corresponding flow features is created, matching can be performed whenever nodes are encountered, such that topological localization can be achieved. We retrieve the most likely node according to the Mahalanobis and Chi-square distances between the current frame and the database. The results illustrate the applicability of the technique for detecting and describing scene changes in diverse lighting conditions, considering indoor and outdoor environments and different robot platforms

Functionalized graphene oxide tablets for sample preparation of drugs in biological fluids: Extraction of ritonavir, a HIV protease inhibitor, from human saliva and plasma using LC–MS/MS

In this work, graphene oxide-based tablets (GO-Tabs) were prepared by applying a thin layer of functionalized GO on a polyethylene substrate. The GO was functionalized with amine groups (-NH2 ) by poly(ethylene glycol)bis(3-aminopropyl) terminated (GO-NH2 -PEG-NH2 ). The functionalized GO-Tabs were used for the extraction of ritonavir (RTV) in human saliva samples. RTV in plasma and saliva samples was analyzed using LC-MS/MS. Gradient LC system with MS/MS in the positive-ion mode [electrospray ionization (ESI+)] was used. The transitions m/z 721 → 269.0 and m/z 614 → 421 were used for RTV and the internal standard indinavir, respectively. This study determined the human immunodeficiency virus protease inhibitor RTV in human saliva samples using functionalized GO-Tab and LC-MS/MS, and the method was validated. The standard calibration curve for plasma and saliva samples was constructed from 5.0 to 2000 nmol L-1 . The limit of detection was 0.1 nmol L-1 , and the limit of quantification was 5.0 nmol L-1 in both plasma and saliva matrices. The intra- and inter-assay precision values were found to be between 1.5 and 5.8%, and the accuracy values ranged from 88.0 to 108% utilizing saliva and plasma samples. The extraction recovery was more than 80%, and the presented functionalized GO-Tabs could be reused for more than 10 extractions without deterioration in recovery