Efficiency of the using singulyar at treatment of the bronchial asthma beside children

Using singulyar for reinforcement base treatment beside children allows to reach checking on clinical symptoms of the bronchial asthma and vastly perfect the factors to functions of the external breathing at more short periods

Is vascular endothelial growth factor a useful biomarker in giant cell arteritis?

Objectives To assess the performance of circulating vascular endothelial growth factor (VEGF) levels as a tool for diagnosing giant cell arteritis (GCA) in a cohort of patients referred for assessment of suspected GCA. Methods We selected 298 patients recruited to the multicentre study Temporal Artery Biopsy versus Ultrasound in diagnosis of suspected GCA (TABUL). In a random subset of 26 biopsy-proven GCA cases and 26 controls, serum from weeks 0, 2 and 26 was analysed for VEGF concentration using ELISA. VEGF concentration at week 0 was used to generate a receiver-operating characteristic curve and thereby identify a cut-off for an abnormal result which was used to analyse the full patient cohort. Sections of paraffin-embedded temporal artery were stained by immunohistochemistry for VEGF. Results The mean (95% CI) VEGF concentration at week 0 was 873 pg/mL (631 to 1110) in 26 patients versus 476 pg/mL (328 to 625) in 26 controls (p=0.017). This difference was not observed at any other time point. The optimal cut-off of 713 pg/mL was applied to the whole patient cohort (n=298), yielding sensitivity of 32% and specificity of 85%. This was not improved by combination with any clinical parameters. When patients with biopsy-proven GCA were compared with controls, sensitivity was 58% and specificity remained 85%. Sections of biopsy from biopsy-positive GCA showed intense staining in the adventitia which was not seen in controls. Conclusions Serum VEGF concentration predicts biopsy positivity but is not useful for differentiating clinical cases of GCA from controls. Further studies into VEGF as a prognostic marker and therapeutic target are warranted. Trial registration number NCT00974883; Post-results

Анкилозирующий спондилоартрит в ревматологической практике Карелии

The paper describes the pathological aspects of an inflammatory process in ankylosing spondyloarthritis (AS), the role of muscle spasm in maintaining the intensity of pain syndrome and stiffness, the need for the early diagnosis of AS, and the significance of the early use of nonster-oidal anti-inflammatory drugs in these patients. The results of clinical trials and the authorsX data demonstrate the high efficacy and good tolerance of nimesulide (nise) in AS.Представлены патоморфологические аспекты воспалительного процесса при анкилозирующем спондилоартрите (АС), роль мышечного спазма в поддержании интенсивности болевого синдрома и скованности, необходимость ранней диагностики АС, значение раннего применения нестероидных противовоспалительных препаратов у таких пациентов. Результаты клинических исследований и собственные данные авторов демонстрируют высокую эффективность и хорошую переносимость нимесулида (найз) при АС

Presenilin Controls CBP Levels in the Adult Drosophila Central Nervous System

Background: Dominant mutations in both human Presenilin (Psn) genes have been correlated with the formation of amyloid plaques and development of familial early-onset Alzheimer’s disease (AD). However, a definitive mechanism whereby plaque formation causes the pathology of familial and sporadic forms of AD has remained elusive. Recent discoveries of several substrates for Psn protease activity have sparked alternative hypotheses for the pathophysiology underlying AD. CBP (CREB-binding protein) is a haplo-insufficient transcriptional co-activator with histone acetly-transferase (HAT) activity that has been proposed to be a downstream target of Psn signaling. Individuals with altered CBP have cognitive deficits that have been linked to several neurological disorders. Methodology/Principal Findings: Using a transgenic RNA-interference strategy to selectively silence CBP, Psn, and Notch in adult Drosophila, we provide evidence for the first time that Psn is required for normal CBP levels and for maintaining specific global acetylations at lysine 8 of histone 4 (H4K8ac) in the central nervous system (CNS). In addition, flies conditionally compromised for the adult-expression of CBP display an altered geotaxis behavior that may reflect a neurological defect. Conclusions/Significance: Our data support a model in which Psn regulates CBP levels in the adult fly brain in a manner that is independent of Notch signaling. Although we do not understand the molecular mechanism underlying th

A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila

The larval salivary gland of Drosophila melanogaster synthesizes and secretes glue glycoproteins that cement developing animals to a solid surface during metamorphosis. The steroid hormone 20-hydroxyecdysone (20E) is an essential signaling molecule that modulates most of the physiological functions of the larval gland. At the end of larval development, it is known that 20E—signaling through a nuclear receptor heterodimer consisting of EcR and USP—induces the early and late puffing cascade of the polytene chromosomes and causes the exocytosis of stored glue granules into the lumen of the gland. It has also been reported that an earlier pulse of hormone induces the temporally and spatially specific transcriptional activation of the glue genes; however, the receptor responsible for triggering this response has not been characterized. Here we show that the coordinated expression of the glue genes midway through the third instar is mediated by 20E acting to induce genes of the Broad Complex (BRC) through a receptor that is not an EcR/USP heterodimer. This result is novel because it demonstrates for the first time that at least some 20E-mediated, mid-larval, developmental responses are controlled by an uncharacterized receptor that does not contain an RXR-like component

The concept of creating a modern terminal and warehouse complex as a tool for the development of transport and logistics infrastructure

Структура магистерской диссертации включает в себя введение, три главы, заключение, список использованных источников и приложения. Во введении обоснован выбор темы исследования, ее актуальность, сформулированы цель и задачи работы, определены предмет и объект исследования, его теоретические и методологические основы, источники получения информации, сформулирована научная новизна. В первой главе рассмотрены подходы ученых к определению понятия девелопмента, выделены виды девелопмента и особенности его функционирования. Во второй главе проанализирован рынок складской недвижимости. Представлена классификация складской недвижимости. А также выявлены основные проблемы транспортно-логистической инфраструктуры региона. В третьей главе подробно описан проект создания терминально-складского комплекса. Описаны характеристики планируемой застройки, этапы реализации проекта и проведен анализ финансовых результатов проекта. В заключении сформулированы основные выводы и обобщены результаты исследования.Structure of master's thesis includes introduction, three chapters, conclusion, list of used sources and applications. In the introduction the choice of the research topic, its topicality, formulates the goal and objectives, defined the subject and object of research, its theoretical and methodological foundations, sources of information, formulated the scientific novelty. In the first Chapter the approaches of scientists to definition of the concept of development, highlighted the types of development and peculiarities of its functioning. The second Chapter analyzes the market of warehouse real estate. The classification of warehouses. As well as the basic problems of transport and logistics infrastructure of the region. The third Chapter describes in detail the project of creation of terminal and warehouse complex. Describes the characteristics of the proposed development, the stages of the project and the analysis of the financial results of the project. In conclusion the main conclusions and summarizes the results of the stud

Verifying hardening techniques for distributed electronic systems in critical applications

Resumen del póster presentado a la 15th European Conference on Radiation and Its Effects on Components and Systems, celebrada en Moscu (Rusia) del 14 al 18 de septiembre de 2015.-- et al.Distributed Electronic Systems used for executing concurrently intensive data acquisition (sensing) and control tasks (actuating) are spread thorough several applications. Health-care, automotive, communications, space and other industries are developing and including these systems because of their competitiveness in terms of cost, performance and reliability. Robustness of distributed electronic systems against ionizing radiation is often estimated based upon single nodes reliabilities. In this paper a proposal is presented for on-line reporting the SEU/SEFI appearance on these systems, while checking the self-recovery capability of the system and its components.Peer Reviewe